Výsledky vyhľadávania - "Teske, Gwendoline"

NLRX1 dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity Autor Stokman, Geurt, Kors, Lotte, Bakker, Pieter J, Rampanelli, Elena, Claessen, Nike, Teske, Gwendoline J D, Butter, Loes, van Andel, Harmen, van den Bergh Weerman, Marius A, Larsen, Per W B, Dessing, Mark C, Zuurbier, Coert J, Girardin, Stephen E, Florquin, Sandrine, Leemans, Jaklien C

“…Mitochondrial dysfunction is the most prominent source of oxidative stress in acute and chronic kidney disease. NLRX1 is a receptor of the innate immune system…”
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Release of extracellular DNA influences renal ischemia reperfusion injury by platelet activation and formation of neutrophil extracellular traps Autor Jansen, Marcel P B, Emal, Diba, Teske, Gwendoline J D, Dessing, Mark C, Florquin, Sandrine, Roelofs, Joris J T H

“…Acute kidney injury is often the result of ischemia reperfusion injury, which leads to activation of coagulation and inflammation, resulting in necrosis of…”
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A tissue-specific role for Nlrp3 in tubular epithelial repair after renal ischemia/reperfusion Autor Bakker, Pieter J, Butter, Loes M, Claessen, Nike, Teske, Gwendoline J D, Sutterwala, Fayyaz S, Florquin, Sandrine, Leemans, Jaklien C

“…Ischemia/reperfusion injury is a major cause of acute kidney injury. Improving renal repair would represent a therapeutic strategy to prevent renal…”
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Depletion of Gut Microbiota Protects against Renal Ischemia-Reperfusion Injury Autor Emal, Diba, Rampanelli, Elena, Stroo, Ingrid, Butter, Loes M, Teske, Gwendoline J, Claessen, Nike, Stokman, Geurt, Florquin, Sandrine, Leemans, Jaklien C, Dessing, Mark C

“…An accumulating body of evidence shows that gut microbiota fulfill an important role in health and disease by modulating local and systemic immunity. The…”
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TLR9 Mediates Remote Liver Injury following Severe Renal Ischemia Reperfusion Autor Bakker, Pieter J., Scantlebery, Angelique M., Butter, Loes M., Claessen, Nike, Teske, Gwendoline J. D., van der Poll, Tom, Florquin, Sandrine, Leemans, Jaklien C.

“…Ischemia reperfusion injury is a common cause of acute kidney injury and is characterized by tubular damage. Mitochondrial DNA is released upon severe tissue…”
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Nlrp3 is a key modulator of diet-induced nephropathy and renal cholesterol accumulation Autor Bakker, Pieter J., Butter, Loes M., Kors, Lotte, Teske, Gwendoline J.D., Aten, Jan, Sutterwala, Fayyaz S., Florquin, Sandrine, Leemans, Jaklien C.

“…Metabolic syndrome (MetSyn) is a major health concern and associates with the development of kidney disease. The mechanisms linking MetSyn to renal disease…”
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The Role of Toll-Like Receptor 2 in Inflammation and Fibrosis during Progressive Renal Injury Autor Leemans, Jaklien C., Butter, Loes M., Pulskens, Wilco P. C., Teske, Gwendoline J. D., Claessen, Nike, van der Poll, Tom, Florquin, Sandrine

“…Tissue fibrosis and chronic inflammation are common causes of progressive organ damage, including progressive renal disease, leading to loss of physiological…”
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Blood pressure influences end-stage renal disease of Cd151 knockout mice Autor Sachs, Norman, Claessen, Nike, Aten, Jan, Kreft, Maaike, Teske, Gwendoline J.D., Koeman, Anneke, Zuurbier, Coert J., Janssen, Hans, Sonnenberg, Arnoud

“…Podocytes of the kidney adhere tightly to the underlying glomerular basement membrane (GBM) in order to maintain a functional filtration barrier. The clinical…”
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Toll-Like Receptor-4 Coordinates the Innate Immune Response of the Kidney to Renal Ischemia/Reperfusion Injury Autor Pulskens, Wilco P., Teske, Gwendoline J., Butter, Loes M., Roelofs, Joris J., van der Poll, Tom, Florquin, Sandrine, Leemans, Jaklien C.

“…Toll-like receptors (TLRs) can detect endogenous danger molecules released upon tissue injury resulting in the induction of a proinflammatory response. One of…”
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Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome Autor Iyer, Shankar S, Pulskens, Wilco P, Sadler, Jeffrey J, Butter, Loes M, Teske, Gwendoline J, Ulland, Tyler K, Eisenbarth, Stephanie C, Florquin, Sandrine, Flavell, Richard A, Leemans, Jaklien C, Sutterwala, Fayyaz S

“…Dying cells are capable of activating the innate immune system and inducing a sterile inflammatory response. Here, we show that necrotic cells are sensed by…”
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Deficiency for the Chemokine Monocyte Chemoattractant Protein-1 Aggravates Tubular Damage after Renal Ischemia/Reperfusion Injury Autor Stroo, Ingrid, Claessen, Nike, Teske, Gwendoline J. D., Butter, Loes M., Florquin, Sandrine, Leemans, Jaklien C.

“…Temporal expression of chemokines is a crucial factor in the regulation of renal ischemia/reperfusion (I/R) injury and repair. Beside their role in the…”
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Nlrp3 Prevents Early Renal Interstitial Edema and Vascular Permeability in Unilateral Ureteral Obstruction Autor Pulskens, Wilco P., Butter, Loes M., Teske, Gwendoline J., Claessen, Nike, Dessing, Mark C., Flavell, Richard A., Sutterwala, Fayyaz S., Florquin, Sandrine, Leemans, Jaklien C.

“…Progressive renal disease is characterized by tubulo-interstitial injury with ongoing inflammation and fibrosis. The Nlrp3 inflammasome contributes to these…”
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The dysregulation of metabolic pathways and induction of the pentose phosphate pathway in renal ischaemia–reperfusion injury Autor Scantlebery, Angelique ML, Tammaro, Alessandra, Mills, James D, Rampanelli, Elena, Kors, Lotte, Teske, Gwendoline J, Butter, Loes M, Liebisch, Gerhard, Schmitz, Gerd, Florquin, Sandrine, Leemans, Jaklien C, Roelofs, Joris JTH

“…Lipid accumulation is associated with various forms of acute renal injury; however, the causative factors and pathways underpinning this lipid accumulation…”
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Epac-Rap signaling reduces oxidative stress in the tubular epithelium Autor Stokman, Geurt, Qin, Yu, Booij, Tijmen H, Ramaiahgari, Sreenivasa, Lacombe, Marie, Dolman, M Emmy M, van Dorenmalen, Kim M A, Teske, Gwendoline J D, Florquin, Sandrine, Schwede, Frank, van de Water, Bob, Kok, Robbert J, Price, Leo S

“…Activation of Rap1 by exchange protein activated by cAMP (Epac) promotes cell adhesion and actin cytoskeletal polarization. Pharmacologic activation of…”
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TLR4 promotes fibrosis but attenuates tubular damage in progressive renal injury Autor Pulskens, Wilco P, Rampanelli, Elena, Teske, Gwendoline J, Butter, Loes M, Claessen, Nike, Luirink, Ilse K, van der Poll, Tom, Florquin, Sandrine, Leemans, Jaklien C

“…Toll-like receptors (TLRs) can orchestrate an inflammatory response upon activation by pathogen-associated motifs and release of endogenous stress ligands…”
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The calcium-binding protein complex S100A8/A9 has a crucial role in controlling macrophage-mediated renal repair following ischemia/reperfusion Autor Dessing, Mark C., Tammaro, Alessandra, Pulskens, Wilco P., Teske, Gwendoline J., Butter, Loes M., Claessen, Nike, van Eijk, Marco, van der Poll, Tom, Vogl, Thomas, Roth, Johannes, Florquin, Sandrine, Leemans, Jaklien C.

“…Upon ischemia/reperfusion (I/R)-induced injury, several damage-associated molecular patterns are expressed including the calcium-binding protein S100A8/A9…”
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The toll interleukin-1 receptor (IL-1R) 8/single Ig domain IL-1R-related molecule modulates the renal response to bacterial infection Autor Leemans, Jaklien C, Butter, Loes M, Teske, Gwendoline J D, Stroo, Ingrid, Pulskens, Wilco P, Florquin, Sandrine

“…Our immune system has to constantly strike a balance between activation and inhibition of an inflammatory response to combat invading pathogens and avoid…”
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Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney Autor Leemans, Jaklien C., Stokman, Geurt, Claessen, Nike, Rouschop, Kasper M., Teske, Gwendoline J.D., Kirschning, Carsten J., Akira, Shizuo, van der Poll, Tom, Weening, Jan J., Florquin, Sandrine

“…TLRs are conserved pattern recognition receptors that detect motifs of pathogens and host material released during injury. For unknown reasons, renal TLR2 mRNA…”
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SDF-1 provides morphological and functional protection against renal ischaemia/reperfusion injury Autor Stokman, Geurt, Stroo, Ingrid, Claessen, Nike, Teske, Gwendoline J D, Florquin, Sandrine, Leemans, Jaklien C

“…The chemokine stromal cell-derived factor-1 (SDF-1) is thought to be involved in mediating tissue repair by promoting migration of bone marrow stem or…”
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Stem Cell Factor Expression after Renal Ischemia Promotes Tubular Epithelial Survival Autor Stokman, Geurt, Stroo, Ingrid, Claessen, Nike, Teske, Gwendoline J. D., Weening, Jan J., Leemans, Jaklien C., Florquin, Sandrine

“…Renal ischemia leads to apoptosis of tubular epithelial cells and results in decreased renal function. Tissue repair involves re-epithelialization of the…”
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