Výsledky vyhľadávania - "Tanger, Ellen"

Deletion of Polycomb Repressive Complex 2 From Mouse Intestine Causes Loss of Stem Cells Autor Koppens, Martijn A J, Bounova, Gergana, Gargiulo, Gaetano, Tanger, Ellen, Janssen, Hans, Cornelissen-Steijger, Paulien, Blom, Marleen, Song, Ji-Ying, Wessels, Lodewyk F A, van Lohuizen, Maarten

“…The polycomb repressive complex 2 (PRC2) regulates differentiation by contributing to repression of gene expression and thereby stabilizing the fate of stem…”
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Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells Autor Lancini, Cesare, van den Berk, Paul C M, Vissers, Joseph H A, Gargiulo, Gaetano, Song, Ji-Ying, Hulsman, Danielle, Serresi, Michela, Tanger, Ellen, Blom, Marleen, Vens, Conchita, van Lohuizen, Maarten, Jacobs, Heinz, Citterio, Elisabetta

“…Histone ubiquitination at DNA breaks is required for activation of the DNA damage response (DDR) and DNA repair. How the dynamic removal of this modification…”
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Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer Autor Nacerddine, Karim, Beaudry, Jean-Bernard, Ginjala, Vasudeva, Westerman, Bart, Mattiroli, Francesca, Song, Ji-Ying, van der Poel, Henk, Ponz, Olga Balagué, Pritchard, Colin, Cornelissen-Steijger, Paulien, Zevenhoven, John, Tanger, Ellen, Sixma, Titia K., Ganesan, Shridar, van Lohuizen, Maarten

“…Prostate cancer (PCa) is a major lethal malignancy in men, but the molecular events and their interplay underlying prostate carcinogenesis remain poorly…”
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Retinal degeneration depends on Bmi1 function and reactivation of cell cycle proteins Autor Zencak, Dusan, Schouwey, Karine, Chen, Danian, Ekström, Per, Tanger, Ellen, Bremner, Rod, van Lohuizen, Maarten, Arsenijevic, Yvan

“…The epigenetic regulator Bmi1 controls proliferation in many organs. Reexpression of cell cycle proteins such as cyclin-dependent kinases (CDKs) is a hallmark…”
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Bmi1 regulates stem cells and proliferation and differentiation of committed cells in mammary epithelium Autor Pietersen, Alexandra M, Evers, Bastiaan, Prasad, Asheeta A, Tanger, Ellen, Cornelissen-Steijger, Paulien, Jonkers, Jos, van Lohuizen, Maarten

“…PolycombGroup (PcG) proteins are epigenetic silencers involved in maintaining cellular identity, and their deregulation can result in cancer [1]. Mice without…”
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Polycomb group gene Ezh2 regulates mammary gland morphogenesis and maintains the luminal progenitor pool Autor Michalak, Ewa Malgorzata, Nacerddine, Karim, Pietersen, Alexandra, Beuger, Vincent, Pawlitzky, Inka, Cornelissen‐Steijger, Paulien, Wientjens, Ellen, Tanger, Ellen, Seibler, Jost, van Lohuizen, Maarten, Jonkers, Jos

“…ABSTRACT Specification of the cellular hierarchy in the mammary gland involves complex signaling that remains poorly defined. Polycomb group proteins are known…”
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Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice Autor Bruggeman, Sophia W M, Valk-Lingbeek, Merel E, van der Stoop, Petra P M, Jacobs, Jacqueline J L, Kieboom, Karin, Tanger, Ellen, Hulsman, Danielle, Leung, Carly, Arsenijevic, Yvan, Marino, Silvia, van Lohuizen, Maarten

“…The Polycomb group (PcG) gene Bmi1 promotes cell proliferation and stem cell self-renewal by repressing the Ink4a/Arf locus. We used a genetic approach to…”
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GFAP-Cre-Mediated Transgenic Activation of Bmi1 Results in Pituitary Tumors Autor Westerman, Bart A., Blom, Marleen, Tanger, Ellen, van der Valk, Martin, Song, Ji-Ying, van Santen, Marije, Gadiot, Jules, Cornelissen-Steijger, Paulien, Zevenhoven, John, Prosser, Haydn M., Uren, Anthony, Aronica, Eleonora, van Lohuizen, Maarten

“…Bmi1 is a member of the polycomb repressive complex 1 and plays different roles during embryonic development, depending on the developmental context. Bmi1 over…”
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TRIM28 Is an Epigenetic Barrier to Induced Pluripotent Stem Cell Reprogramming Autor Miles, Denise Catherine, de Vries, Nienke Alexandra, Gisler, Santiago, Lieftink, Cor, Akhtar, Waseem, Gogola, Ewa, Pawlitzky, Inka, Hulsman, Danielle, Tanger, Ellen, Koppens, Martijn, Beijersbergen, Roderick Leonardus, van Lohuizen, Maarten

“…Since the discovery of induced pluripotent stem cells there has been intense interest in understanding the mechanisms that allow a somatic cell to be…”
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Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas Autor Leung, Carly, Lingbeek, Merel, Shakhova, Olga, Liu, James, Tanger, Ellen, Saremaslani, Parvin, van Lohuizen, Maarten, Marino, Silvia

“…Overexpression of the polycomb group gene Bmi1 promotes cell proliferation and induces leukaemia through repression of Cdkn2a (also known as ink4a/Arf ) tumour…”
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Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma Autor Bruggeman, Sophia W M, Hulsman, Danielle, Tanger, Ellen, Buckle, Tessa, Blom, Marleen, Zevenhoven, John, van Tellingen, Olaf, van Lohuizen, Maarten

“…The Polycomb group and oncogene Bmi1 is required for the proliferation of various differentiated cells and for the self-renewal of stem cells and leukemic…”
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USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells Autor van den Berk, Paul, Lancini, Cesare, Company, Carlos, Serresi, Michela, Sanchez-Bailon, Maria Pilar, Hulsman, Danielle, Pritchard, Colin, Song, Ji-Ying, Schmitt, Matthias Jürgen, Tanger, Ellen, Popp, Oliver, Mertins, Philipp, Huijbers, Ivo J., Jacobs, Heinz, van Lohuizen, Maarten, Gargiulo, Gaetano, Citterio, Elisabetta

“…Altering ubiquitination by disruption of deubiquitinating enzymes (DUBs) affects hematopoietic stem cell (HSC) maintenance. However, comprehensive knowledge of…”
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Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks Autor Uren, Anthony G, Kool, Jaap, Matentzoglu, Konstantin, de Ridder, Jeroen, Mattison, Jenny, van Uitert, Miranda, Lagcher, Wendy, Sie, Daoud, Tanger, Ellen, Cox, Tony, Reinders, Marcel, Hubbard, Tim J, Rogers, Jane, Jonkers, Jos, Wessels, Lodewyk, Adams, David J, van Lohuizen, Maarten, Berns, Anton

“…p53 and p19(ARF) are tumor suppressors frequently mutated in human tumors. In a high-throughput screen in mice for mutations collaborating with either p53 or…”
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A new transgenic mouse model for conditional overexpression of the Polycomb Group protein EZH2 Autor Koppens, Martijn A. J., Tanger, Ellen, Nacerddine, Karim, Westerman, Bart, Song, Ji-Ying, van Lohuizen, Maarten

“…The Polycomb Group protein EZH2 is upregulated in most prostate cancers, and its overexpression is associated with poor prognosis. Most insights into the…”
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Bmi1 loss produces an increase in astroglial cells and a decrease in neural stem cell population and proliferation Autor Zencak, Dusan, Lingbeek, Merel, Kostic, Corinne, Tekaya, Meriem, Tanger, Ellen, Hornfeld, Dana, Jaquet, Muriel, Munier, Francis L, Schorderet, Daniel F, van Lohuizen, Maarten, Arsenijevic, Yvan

“…The polycomb transcriptional repressor Bmi1 promotes cell cycle progression, controls cell senescence, and is implicated in brain development. Loss of Bmi1…”
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Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer Autor Nacerddine, Karim, Beaudry, Jean-Bernard, Ginjala, Vasudeva, Westerman, Bart, Mattiroli, Francesca, Song, Ji-Ying, Van Der Poel, Henk, Ponz, Olga Balague, Pritchard, Colin, Cornelissen-Steijger, Paulien, Zevenhoven, John, Tanger, Ellen, Sixma, Titia K, Ganesan, Shridar, Van Lohuizen, Maarten

“…Prostate cancer (PCa) is a major lethal malignancy in men, but the molecular events and their interplay underlying prostate carcinogenesis remain poorly…”
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BMI1 loss delays photoreceptor degeneration in Rd1 mice. Bmi1 loss and neuroprotection in Rd1 mice Autor Zencak, Dusan, Crippa, Sylvain V, Tekaya, Meriem, Tanger, Ellen, Schorderet, Daniel E, Munier, Francis L, van Lohuizen, Maarten, Arsenijevic, Yvan

“…Retinitis pigmentosa (RP) is a heterogeneous group of genetic disorders leading to blindness, which remain untreatable at present. Rd1 mice represent a…”
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USP15 deubiquitinase safeguards hematopoiesis and genome integrity in hematopoietic stem cells and leukemia cells Autor Van Den Berk, Paul, Lancini, Cesare, Company, Carlos, Serresi, Michela, Hulsman, Danielle, Pritchard, Colin, Ji-Ying, Song, Schmitt, Matthias Jurgen, Tanger, Ellen, Huijbers, Ivo J, Jacobs, Heinz, Maarten Van Lohuizen, Gargiulo, Gaetano, Citterio, Elisabetta

“…Altering ubiquitination by disruption of individual deubiquitinating enzymes (DUBs) has proven to affect hematopoietic stem cell (HSC) maintenance. However,…”
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