Suchergebnisse - "Tan, Josephine M.E."

Control of murine brown adipocyte development by GATA6 von Jun, Seoyoung, Angueira, Anthony R, Fein, Ethan C, Tan, Josephine M E, Weller, Angela H, Cheng, Lan, Batmanov, Kirill, Ishibashi, Jeff, Sakers, Alexander P, Stine, Rachel R, Seale, Patrick

“… Brown adipose tissue (BAT) is a thermogenic organ that protects animals against hypothermia and obesity. BAT derives from the multipotent paraxial mesoderm; …”
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Differential use of E2 ubiquitin conjugating enzymes for regulated degradation of the rate-limiting enzymes HMGCR and SQLE in cholesterol biosynthesis von Tan, Josephine M.E., Cook, Emma C.L., van den Berg, Marlene, Scheij, Saskia, Zelcer, Noam, Loregger, Anke

“… Cholesterol is an essential lipid for cellular function and membrane integrity, and hence its cellular levels and distribution must be tightly regulated …”
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SPRING is a Dedicated Licensing Factor for SREBP-Specific Activation by S1P von Hendrix, Sebastian, Tan, Josephine M. E., Ndoj, Klevis, Kingma, Jenina, Valiloo, Masoud, Zijlstra, Lobke F., Ottenhoff, Roelof, Seidah, Nabil G., Loregger, Anke, Kober, Daniel L., Zelcer, Noam

“… SREBP transcription factors are central regulators of lipid metabolism. Their proteolytic activation requires ER to the Golgi translocation and subsequent …”
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Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism von Loregger, Anke, Raaben, Matthijs, Nieuwenhuis, Joppe, Tan, Josephine M. E., Jae, Lucas T., van den Hengel, Lisa G., Hendrix, Sebastian, van den Berg, Marlene, Scheij, Saskia, Song, Ji-Ying, Huijbers, Ivo J., Kroese, Lona J., Ottenhoff, Roelof, van Weeghel, Michel, van de Sluis, Bart, Brummelkamp, Thijn, Zelcer, Noam

“… The sterol-regulatory element binding proteins (SREBP) are central transcriptional regulators of lipid metabolism. Using haploid genetic screens we identify …”
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Beyond the polymerase-γ theory: Production of ROS as a mode of NRTI-induced mitochondrial toxicity von Smith, Reuben L., Tan, Josephine M. E., Jonker, Martijs J., Jongejan, Aldo, Buissink, Thomas, Veldhuijzen, Steve, van Kampen, Antoine H. C., Brul, Stanley, van der Spek, Hans

“… Use of some HIV-1 nucleoside reverse transcriptase inhibitors (NRTI) is associated with severe adverse events. However, the exact mechanisms behind their …”
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PRDM16 regulates smooth muscle cell identity and atherosclerotic plaque composition von Tan, Josephine M E, Cheng, Lan, Calhoun, Ryan P, Weller, Angela H, Drareni, Karima, Fong, Skylar, Barbara, Eirlys, Lim, Hee-Woong, Xue, Chenyi, Winter, Hanna, Auguste, Gaëlle, Miller, Clint L, Reilly, Muredach P, Maegdefessel, Lars, Lutgens, Esther, Seale, Patrick

“… Vascular smooth muscle cells (SMCs) undergo phenotype switching to acquire various fates in response to pathological stimuli. Among these, 'synthetic' …”
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PRDM16 controls smooth muscle cell fate in atherosclerosis von Tan, Josephine M E, Cheng, Lan, Calhoun, Ryan P, Weller, Angela H, Drareni, Karima, Fong, Skylar, Barbara, Eirlys, Lim, Hee-Woong, Xue, Chenyi, Winter, Hanna, Auguste, Gaëlle, Miller, Clint L, Reilly, Muredach P, Maegdefessel, Lars, Lutgens, Esther, Seale, Patrick

“… Vascular smooth muscle cells (SMCs) normally exist in a contractile state but can undergo fate switching to produce various cell phenotypes in response to …”
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Intermolecular proteolytic processing of SPRING and Site-1-protease regulate SREBP signaling von Hendrix, Sebastian, Tan, Josephine M.E., Ndoj, Klevis, Valiloo, Masoud, Zijlstra, Lobke F., Ottenhoff, Roelof, Seidah, Nabil G., Loregger, Anke, Zelcer, Noam

“… The SREBP transcription factors are central regulators of fatty acid and cholesterol metabolism. Produced as membrane-resident precursor proteins in the ER, …”
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