Výsledky vyhľadávania - "Tacchetti, Carlo"

BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation Autor Bononi, Angela, Giorgi, Carlotta, Patergnani, Simone, Larson, David, Verbruggen, Kaitlyn, Tanji, Mika, Pellegrini, Laura, Signorato, Valentina, Olivetto, Federica, Pastorino, Sandra, Nasu, Masaki, Napolitano, Andrea, Gaudino, Giovanni, Morris, Paul, Sakamoto, Greg, Ferris, Laura K., Danese, Alberto, Raimondi, Andrea, Tacchetti, Carlo, Kuchay, Shafi, Pass, Harvey I., Affar, El Bachir, Yang, Haining, Pinton, Paolo, Carbone, Michele

“…BRCA1-associated protein 1 (BAP1) regulates calcium flux in the endoplasmic reticulum to facilitate the execution of apoptosis, unveiling a new facet of the…”
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Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity Autor Loffreda, Alessia, Jacchetti, Emanuela, Antunes, Sofia, Rainone, Paolo, Daniele, Tiziana, Morisaki, Tatsuya, Bianchi, Marco E., Tacchetti, Carlo, Mazza, Davide

“…Live-cell microscopy has highlighted that transcription factors bind transiently to chromatin but it is not clear if the duration of these binding interactions…”
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Chromatin organization drives the search mechanism of nuclear factors Autor Mazzocca, Matteo, Loffreda, Alessia, Colombo, Emanuele, Fillot, Tom, Gnani, Daniela, Falletta, Paola, Monteleone, Emanuele, Capozi, Serena, Bertrand, Edouard, Legube, Gaelle, Lavagnino, Zeno, Tacchetti, Carlo, Mazza, Davide

“…Nuclear factors rapidly scan the genome for their targets, but the role of nuclear organization in such search is uncharted. Here we analyzed how multiple…”
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SARS-CoV-2 Entry: At the Crossroads of CD147 and ACE2 Autor Fenizia, Claudio, Galbiati, Silvia, Vanetti, Claudia, Vago, Riccardo, Clerici, Mario, Tacchetti, Carlo, Daniele, Tiziana

“…In late 2019, the betacoronavirus SARS-CoV-2 was identified as the viral agent responsible for the coronavirus disease 2019 (COVID-19) pandemic. Coronaviruses…”
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Mitochondria and melanosomes establish physical contacts modulated by Mfn2 and involved in organelle biogenesis Autor Daniele, Tiziana, Hurbain, Ilse, Vago, Riccardo, Casari, Giorgio, Raposo, Graça, Tacchetti, Carlo, Schiaffino, Maria Vittoria

“…To efficiently supply ATP to sites of high-energy demand and finely regulate calcium signaling, mitochondria adapt their metabolism, shape, and distribution…”
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Proteome Profiling of Neuroblastoma-Derived Exosomes Reveal the Expression of Proteins Potentially Involved in Tumor Progression Autor Marimpietri, Danilo, Petretto, Andrea, Raffaghello, Lizzia, Pezzolo, Annalisa, Gagliani, Cristina, Tacchetti, Carlo, Mauri, Pierluigi, Melioli, Giovanni, Pistoia, Vito

“…Neuroblastoma (NB) is the most common extracranial solid tumor in childhood, with grim prognosis in a half of patients. Exosomes are nanometer-sized membrane…”
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The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptor Autor Vaccari, Thomas, Duchi, Serena, Cortese, Katia, Tacchetti, Carlo, Bilder, David

“…Evidence indicates that endosomal entry promotes signaling by the Notch receptor, but the mechanisms involved are not clear. In a search for factors that…”
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PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development Autor Missiroli, Sonia, Bonora, Massimo, Patergnani, Simone, Poletti, Federica, Perrone, Mariasole, Gafà, Roberta, Magri, Eros, Raimondi, Andrea, Lanza, Giovanni, Tacchetti, Carlo, Kroemer, Guido, Pandolfi, Pier Paolo, Pinton, Paolo, Giorgi, Carlotta

“…The precise molecular mechanisms that coordinate apoptosis and autophagy in cancer remain to be determined. Here, we provide evidence that the tumor suppressor…”
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Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments Autor Lampugnani, Maria Grazia, Orsenigo, Fabrizio, Gagliani, Maria Cristina, Tacchetti, Carlo, Dejana, Elisabetta

“…Receptor endocytosis is a fundamental step in controlling the magnitude, duration, and nature of cell signaling events. Confluent endothelial cells are contact…”
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Persistent cAMP-Signals Triggered by Internalized G-Protein–Coupled Receptors Autor Calebiro, Davide, Nikolaev, Viacheslav O., Gagliani, Maria Cristina, de Filippis, Tiziana, Dees, Christian, Tacchetti, Carlo, Persani, Luca, Lohse, Martin J.

“…G-protein-coupled receptors (GPCRs) are generally thought to signal to second messengers like cyclic AMP (cAMP) from the cell surface and to become…”
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Reticulon 3-dependent ER-PM contact sites control EGFR nonclathrin endocytosis Autor Caldieri, Giusi, Barbieri, Elisa, Nappo, Gilda, Raimondi, Andrea, Bonora, Massimo, Conte, Alexia, Verhoef, Lisette G G C, Confalonieri, Stefano, Malabarba, Maria Grazia, Bianchi, Fabrizio, Cuomo, Alessandro, Bonaldi, Tiziana, Martini, Emanuele, Mazza, Davide, Pinton, Paolo, Tacchetti, Carlo, Polo, Simona, Di Fiore, Pier Paolo, Sigismund, Sara

“…The integration of endocytic routes is critical to regulate receptor signaling. A nonclathrin endocytic (NCE) pathway of the epidermal growth factor receptor…”
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PML regulates apoptosis at endoplasmic reticulum by modulating calcium release Autor Giorgi, Carlotta, Ito, Keisuke, Lin, Hui-Kuan, Santangelo, Clara, Wieckowski, Mariusz R, Lebiedzinska, Magdalena, Bononi, Angela, Bonora, Massimo, Duszynski, Jerzy, Bernardi, Rosa, Rizzuto, Rosario, Tacchetti, Carlo, Pinton, Paolo, Pandolfi, Pier Paolo

“…The promyelocytic leukemia (PML) tumor suppressor is a pleiotropic modulator of apoptosis. However, the molecular basis for such a diverse proapoptotic role is…”
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Cyclosporine A Inhibits Viral Infection and Release as Well as Cytokine Production in Lung Cells by Three SARS-CoV-2 Variants Autor Fenizia, Claudio, Galbiati, Silvia, Vanetti, Claudia, Vago, Riccardo, Clerici, Mario, Tacchetti, Carlo, Daniele, Tiziana

“…SARS-CoV-2 is the most recently identified member of the betacoronavirus genus responsible for the COVID-19 pandemic. Repurposing of available drugs has been a…”
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A block of autophagy in lysosomal storage disorders Autor Settembre, Carmine, Fraldi, Alessandro, Jahreiss, Luca, Spampanato, Carmine, Venturi, Consuelo, Medina, Diego, de Pablo, Raquel, Tacchetti, Carlo, Rubinsztein, David C, Ballabio, Andrea

“…Most lysosomal storage disorders (LSDs) are caused by deficiencies of lysosomal hydrolases. While LSDs were among the first inherited diseases for which the…”
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Chest CT–derived pulmonary artery enlargement at the admission predicts overall survival in COVID-19 patients: insight from 1461 consecutive patients in Italy Autor Esposito, Antonio, Palmisano, Anna, Toselli, Marco, Vignale, Davide, Cereda, Alberto, Rancoita, Paola Maria Vittoria, Leone, Riccardo, Nicoletti, Valeria, Gnasso, Chiara, Monello, Alberto, Biagi, Andrea, Turchio, Piergiorgio, Landoni, Giovanni, Gallone, Guglielmo, Monti, Giacomo, Casella, Gianni, Iannopollo, Gianmarco, Nannini, Tommaso, Patelli, Gianluigi, Di Mare, Luisa, Loffi, Marco, Sergio, Pietro, Ippolito, Davide, Sironi, Sandro, Pontone, Gianluca, Andreini, Daniele, Mancini, Elisabetta Maria, Di Serio, Clelia, De Cobelli, Francesco, Ciceri, Fabio, Zangrillo, Alberto, Colombo, Antonio, Tacchetti, Carlo, Giannini, Francesco

“…Objectives Enlarged main pulmonary artery diameter (MPAD) resulted to be associated with pulmonary hypertension and mortality in a non-COVID-19 setting. The…”
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PML restrains p53 activity and cellular senescence in clear cell renal cell carcinoma Autor Simoni, Matilde, Menegazzi, Chiara, Fracassi, Cristina, Biffi, Claudia C, Genova, Francesca, Tenace, Nazario Pio, Lucianò, Roberta, Raimondi, Andrea, Tacchetti, Carlo, Brugarolas, James, Mazza, Davide, Bernardi, Rosa

“…Clear-cell renal cell carcinoma (ccRCC), the major subtype of RCC, is frequently diagnosed at late/metastatic stage with 13% 5-year disease-free survival…”
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A tripartite organelle platform links growth factor receptor signaling to mitochondrial metabolism Autor Mesa, Deborah, Barbieri, Elisa, Raimondi, Andrea, Freddi, Stefano, Miloro, Giorgia, Jendrisek, Gorana, Caldieri, Giusi, Quarto, Micaela, Schiano Lomoriello, Irene, Malabarba, Maria Grazia, Bresci, Arianna, Manetti, Francesco, Vernuccio, Federico, Abdo, Hind, Scita, Giorgio, Lanzetti, Letizia, Polli, Dario, Tacchetti, Carlo, Pinton, Paolo, Bonora, Massimo, Di Fiore, Pier Paolo, Sigismund, Sara

“…One open question in the biology of growth factor receptors is how a quantitative input (i.e., ligand concentration) is decoded by the cell to produce specific…”
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Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling Autor Pascolutti, Roberta, Algisi, Veronica, Conte, Alexia, Raimondi, Andrea, Pasham, Mithun, Upadhyayula, Srigokul, Gaudin, Raphael, Maritzen, Tanja, Barbieri, Elisa, Caldieri, Giusi, Tordonato, Chiara, Confalonieri, Stefano, Freddi, Stefano, Malabarba, Maria Grazia, Maspero, Elena, Polo, Simona, Tacchetti, Carlo, Haucke, Volker, Kirchhausen, Tom, Di Fiore, Pier Paolo, Sigismund, Sara

“…Adaptor protein 2 (AP2) is a major constituent of clathrin-coated pits (CCPs). Whether it is essential for all forms of clathrin-mediated endocytosis (CME) in…”
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Identification of a membrane-less compartment regulating invadosome function and motility Autor Sala, Kristyna, Raimondi, Andrea, Tonoli, Diletta, Tacchetti, Carlo, de Curtis, Ivan

“…Depletion of liprin-α1, ERC1 or LL5 scaffolds inhibits extracellular matrix degradation by invasive cells. These proteins co-accumulate near invadosomes in…”
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Autophagy regulates UBC9 levels during viral-mediated tumorigenesis Autor Mattoscio, Domenico, Casadio, Chiara, Miccolo, Claudia, Maffini, Fausto, Raimondi, Andrea, Tacchetti, Carlo, Gheit, Tarik, Tagliabue, Marta, Galimberti, Viviana E., De Lorenzi, Francesca, Pawlita, Michael, Chiesa, Fausto, Ansarin, Mohssen, Tommasino, Massimo, Chiocca, Susanna

“…UBC9, the sole E2-conjugating enzyme required for SUMOylation, is a key regulator of essential cellular functions and, as such, is frequently altered in…”
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