Výsledky vyhledávání - "TYMS"

Association between 5'-UTR and 3'-UTR Polymorphisms of the TYMS Gene and Breast Cancer in Kurdish Women of Iraq Autor Mohamad, Kazhal Shekh

“…Breast cancer is a common cancer found among women worldwide. Many polymorphisms can play a role in the development of this disease. The study was conducted to…”
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Therapeutic potential of Clostridium butyricum anticancer effects in colorectal cancer Autor Xu, Hui, Luo, Haidan, Zhang, Jiayu, Li, Kai, Lee, Mong-Hong

“…Probiotic roles of Clostridium butyricum (C.B) are involved in regulating disease and cancers, yet the mechanistic basis for these regulatory roles remains…”
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Investigation of TYMS (rs 2853542) polymorphism and Cytomegalovirus in patients with Acute Lymphoblastic Leukemia Autor Hmeed, Elaf Zuhair, Mtashar, Baan Abdulatif, Ghiath, Yusra, Al-Alwany, Shakir H. Mohammed, Hussein, Mohanad Salam, Faraj, Yusur Falah

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Germline thymidylate synthase deficiency impacts nucleotide metabolism and causes dyskeratosis congenita Autor Tummala, Hemanth, Walne, Amanda, Buccafusca, Roberto, Alnajar, Jenna, Szabo, Anita, Robinson, Peter, McConkie-Rosell, Allyn, Wilson, Meredith, Crowley, Suzanne, Kinsler, Veronica, Ewins, Anna-Maria, Madapura, Pradeepa M, Patel, Manthan, Pontikos, Nikolas, Codd, Veryan, Vulliamy, Tom, Dokal, Inderjeet

“…Dyskeratosis congenita (DC) is an inherited bone-marrow-failure disorder characterized by a triad of mucocutaneous features that include abnormal skin…”
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Long non-coding RNA TUG1 mediates 5-fluorouracil resistance by acting as a ceRNA of miR-197-3p in colorectal cancer Autor Wang, Meng, Hu, Hanqing, Wang, Yuliuming, Huang, Quanlong, Huang, Rui, Chen, Yinggang, Ma, Tianyi, Qiao, Tianyu, Zhang, Qian, Wu, Hongyu, Chen, Qingmin, Han, Dong, Wang, Guiyu, Wang, Xishan

“…One major reason for the failure of advanced colorectal cancer (CRC) treatment is the occurrence of chemoresistance to fluoropyrimidine (Fu)-based…”
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Exploring the impact of MiR-92a-3p on FOLFOX chemoresistance biomarker genes in colon cancer cell lines Autor Escalante, Paula I., Quiñones, Luis A., Contreras, Héctor R.

“…Introduction: One of the primary obstacles faced by individuals with advanced colorectal cancer (CRC) is the potential development of acquired chemoresistance…”
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Thymidylate synthase disruption to limit cell proliferation in cell therapies Autor Sartori-Maldonado, Rocio, Montaser, Hossam, Soppa, Inkeri, Eurola, Solja, Juutila, Juhana, Balaz, Melanie, Puttonen, Henri, Otonkoski, Timo, Saarimäki-Vire, Jonna, Wartiovaara, Kirmo

“…Stem and progenitor cells hold great promise for regenerative medicine and gene therapy approaches. However, transplantations of living cells entail a…”
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MTHFR c.665C>T guided fluoropyrimidine therapy in cancer: gender-dependent effect on dose requirements Autor Ioannou, Charalampia, Ragia, Georgia, Balgkouranidou, Ioanna, Xenidis, Nikolaos, Amarantidis, Kyriakos, Koukaki, Triantafyllia, Biziota, Eirini, Kakolyris, Stylianos, Manolopoulos, Vangelis G

“…The fluoropyrimidine derivatives 5-Fluorouracil and Capecitabine are widely used for the treatment of solid tumors. Fluoropyrimidine metabolism involves a…”
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Identification and Validation of TYMS as a Potential Biomarker for Risk of Metastasis Development in Hepatocellular Carcinoma Autor Li, Shuai, Zhao, Jingyuan, Lv, Linlin, Dong, Deshi

“…Metastasis is the major cause of hepatocellular carcinoma (HCC) mortality. Unfortunately, there are few reports on effective biomarkers for HCC metastasis…”
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TYMS presents a novel biomarker for diagnosis and prognosis in patients with pancreatic cancer Autor Fu, Zhuo, Jiao, Yan, Li, Yanqing, Ji, Bai, Jia, Baoxing, Liu, Bin

“…Pancreatic cancer is one of the most malignant tumors worldwide. DNA replication plays a critical role in the occurrence and development of pancreatic cancer…”
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Significance of TYMS Polymorphism rs3819102 as a Prognostic Marker for Nonsmoking Lung Cancer Patients of the Han Ethnicity in China Autor Wu, Junjie, Du, Wei, Xu, Chang, Cheng, Zhiyuan, Sun, Zhenyu, Guo, Shicheng, Li, Qiang, Song, Yuanlin, Shen, Bo, Bao, Yang, Wu, Junjie

“…With high incidence and mortality rates, lung cancer is now one of the most common cancers in the world. The 5-year survival rate of lung cancer patients is…”
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Identification of Potential Hub Genes and miRNA-mRNA Pairs Related to the Progression and Prognosis of Cervical Cancer Through Integrated Bioinformatics Analysis Autor Fu, Mingxu, Pei, Yongyan, Lu, Fang, Jiang, Huici, Bi, Yingying, Cheng, Jiajing, Qin, Jinlong

“…In recent years, the incidence and mortality of cervical cancer have increased worldwide. At the same time, increasing data have confirmed that miRNA-mRNA…”
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CAPRIN1/TYMS/MTHFD2 axis promotes EMT process in nasopharyngeal carcinoma development Autor Wang, Kunrong, Yu, Hanbing, Guo, Shuang, Sun, Guihu, Cao, Hongwei, Xing, Dongsheng, Li, Dawei, Yan, Aihui

“…Nasopharyngeal carcinoma (NPC) is a type of malignant tumor occurring in the nasopharynx. It frequently leads to treatment failure after metastasis, often…”
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Impact of TYMS gene polymorphism on the outcome of methotrexate treatment in a sample of Iraqi rheumatoid arthritis patients - identification of novel single nucleotide polymorphism: Cross-sectional study Autor Mutlak, Qassim Mahdi, Kasim, Ali Abdulhussain, Aljanabi, Ali Saleh

“…The current work aims to evaluate the association between genetic mutations in thymidylate synthetase (TYMS gene in exon1 and partial regions of promotor and…”
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TYMS‐ENOSF1 Dyskeratosis Congenita in a Patient With Ring Chromosome 18: A Case Report Autor Shams, Rayad B., Nieman, Elizabeth L., Perilla‐Young, Yezmin, Morrell, Dean S., Hildebrandt, Clara

“…ABSTRACT Dyskeratosis Congenita (DC) is a rare genetic syndrome due to variants in genes involved in telomeric regulation and maintenance, impacting multiple…”
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Pairing structural reconstruction with catalytic competence to evaluate the mechanisms of key enzymes in the folate‐mediated one‐carbon pathway Autor Zhao, Li Na, Kaldis, Philipp

“…Mammalian metabolism comprises a series of interlinking pathways that include two major cycles: the folate and methionine cycles. The folate‐mediated metabolic…”
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Engineered multitargeting exosomes carrying miR-323a-3p for CRC therapy Autor Pang, Yechun, Chen, Xingshi, Xu, Baiying, Zhang, Yuanzhou, Liang, Shunshun, Hu, Jingying, Liu, Rui, Luo, Xiaoying, Wang, Yunfeng

“…Colorectal cancer (CRC) is in the forefront of malignancies for its high incidence and mortality. 5-Fluorouracil (5-FU) is one of the most widely used…”
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Pleckstrin-2 promotes the progression of colorectal cancer via YTHDF2-mediated TYMS mRNA stability Autor Zhou, Qian, Li, Yanxia, Li, Xiaomei, Zhang, Shujing, Wang, Ying, Li, Zhuoran, Wang, Xia, Li, Yuan, Li, Jingxin, Lu, Chunhua, Shen, Yuemao, Zhao, Baobing

“…High expression of nucleotide synthetic enzyme thymidylate synthase (TYMS) is responsible for the resistance to fluorouracil (FU) treatment and worse survival…”
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Investigation of DPYD, MTHFR and TYMS polymorphisms on 5-fluorouracil related toxicities in colorectal cancer Autor Cevik, Mehtap, Namal, Esat, Sener, Nur Dinc, Koksal, Ulkuhan Iner, Cagatay, Penbe, Deliorman, Gokce, Ciftci, Cavlan, Karaalp, Atila, Susleyici, Belgin

“…Aim: To investigate the association of DPYD, MTHFR and TYMS polymorphisms on 5-fluorouracil (5-FU) related toxicities and patient survival. Materials &…”
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Evaluating the role of ENOSF1 and TYMS variants as predictors in fluoropyrimidine-related toxicities: An IPD meta-analysis Autor Hamzic, Seid, Kummer, Dominic, Froehlich, Tanja K., Joerger, Markus, Aebi, Stefan, Palles, Claire, Thomlinson, Ian, Meulendijks, Didier, Schellens, Jan H.M., García-González, Xandra, López-Fernández, Luis A., Amstutz, Ursula, Largiadèr, Carlo R.

“…[Display omitted] To assess the proposed associations of the c.742-227G>A (rs2612091) polymorphism within the Enolase Superfamily Member 1 gene (ENOSF1) and…”
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