Suchergebnisse - "Swindells, Mark"

LigPlot+: multiple ligand-protein interaction diagrams for drug discovery von Laskowski, Roman A, Swindells, Mark B

“… We describe a graphical system for automatically generating multiple 2D diagrams of ligand-protein interactions from 3D coordinates. The diagrams portray the …”
Weitere Angaben

abYsis: Integrated Antibody Sequence and Structure—Management, Analysis, and Prediction von Swindells, Mark B., Porter, Craig T., Couch, Matthew, Hurst, Jacob, Abhinandan, K.R., Nielsen, Jens H., Macindoe, Gary, Hetherington, James, Martin, Andrew C.R.

“… abYsis is a web-based antibody research system that includes an integrated database of antibody sequence and structure data. The system can be interrogated in …”
Volltext

Inferring Function Using Patterns of Native Disorder in Proteins von Lobley, Anna, Swindells, Mark B, Orengo, Christine A, Jones, David T

“… Natively unstructured regions are a common feature of eukaryotic proteomes. Between 30% and 60% of proteins are predicted to contain long stretches of …”
Volltext

A randomized controlled trial of real versus sham acupuncture for basal thumb joint arthritis von Barnard, Anna, Jansen, Victoria, Swindells, Mark G, Arundell, Melanie, Burke, Frank D

“… We report a single-blinded randomized controlled trial comparing acupuncture to sham (non-penetrating) needling for relief of symptoms of basal thumb joint …”
Weitere Angaben

Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19 von Redhead, Martin A., Owen, C. David, Brewitz, Lennart, Collette, Amelia H., Lukacik, Petra, Strain-Damerell, Claire, Robinson, Sean W., Collins, Patrick M., Schäfer, Philipp, Swindells, Mark, Radoux, Chris J., Hopkins, Iva Navratilova, Fearon, Daren, Douangamath, Alice, von Delft, Frank, Malla, Tika R., Vangeel, Laura, Vercruysse, Thomas, Thibaut, Jan, Leyssen, Pieter, Nguyen, Tu-Trinh, Hull, Mitchell, Tumber, Anthony, Hallett, David J., Schofield, Christopher J., Stuart, David I., Hopkins, Andrew L., Walsh, Martin A.

“… Effective agents to treat coronavirus infection are urgently required, not only to treat COVID-19, but to prepare for future outbreaks. Repurposed anti-virals …”
Volltext

Publisher Correction: Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19 von Redhead, Martin A., Owen, C. David, Brewitz, Lennart, Collette, Amelia H., Lukacik, Petra, Strain-Damerell, Claire, Robinson, Sean W., Collins, Patrick M., Schäfer, Philipp, Swindells, Mark, Radoux, Chris J., Hopkins, Iva Navratilova, Fearon, Daren, Douangamath, Alice, von Delft, Frank, Malla, Tika R., Vangeel, Laura, Vercruysse, Thomas, Thibaut, Jan, Leyssen, Pieter, Nguyen, Tu-Trinh, Hull, Mitchell, Tumber, Anthony, Hallett, David J., Schofield, Christopher J., Stuart, David I., Hopkins, Andrew L., Walsh, Martin A.

Volltext

Value of serial ultrasound imaging in conservative management of epididymo-cutaneous fistula in a person with cervical spinal cord injury von Subramanian, Vaidyanathan, Soni, Bakul, Hughes, Peter, Swindells, Mark

“… Epididymo-cutaneous fistula was seen in a person with cervical spinal cord injury and neuropathic bladder. This patient developed left epididymitis; then he …”
Volltext

Getting the most from PSI–BLAST von Jones, David T, Swindells, Mark B

“… Most biologists now conduct sequence searches as a matter of course. But how do we know that a relationship predicted by a homology search is a true, rather …”
Volltext

Early blood profiles of virus infection in a monkey model for Lassa fever von Djavani, Mahmoud M, Crasta, Oswald R, Zapata, Juan Carlos, Fei, Zhangjun, Folkerts, Otto, Sobral, Bruno, Swindells, Mark, Bryant, Joseph, Davis, Harry, Pauza, C David, Lukashevich, Igor S, Hammamieh, Rasha, Jett, Marti, Salvato, Maria S

“… Acute arenavirus disease in primates, like Lassa hemorrhagic fever in humans, begins with flu-like symptoms and leads to death approximately 2 weeks after …”
Weitere Angaben

NMR structure of the histidine kinase domain of the E. coli osmosensor EnvZ von Tanaka, Toshiyuki, Saha, Soumitra K., Tomomori, Chieri, Ishima, Rieko, Liu, Dingjiang, Tong, Kit I., Park, Heiyoung, Dutta, Rinku, Qin, Ling, Swindells, Mark B., Yamazaki, Toshimasa, Ono, Akira M., Kainosho, Masatsune, Inouye, Masayori, Ikura, Mitsuhiko

“… Bacteria live in capricious environments, in which they must continuously sense external conditions in order to adjust their shape, motility and physiology 1  …”
Volltext

Effective function annotation through catalytic residue conservation von George, Richard A, Spriggs, Ruth V, Bartlett, Gail J, Gutteridge, Alex, MacArthur, Malcolm W, Porter, Craig T, Al-Lazikani, Bissan, Thornton, Janet M, Swindells, Mark B

“… Because of the extreme impact of genome sequencing projects, protein sequences without accompanying experimental data now dominate public databases. Homology …”
Weitere Angaben

Elastic intramedullary nailing in unstable fractures of the paediatric tibial diaphysis: A systematic review von Swindells, Mark G., Rajan, R. A.

“… Purpose The majority of paediatric tibial fractures can be managed conservatively. However, there is a small but significant group of patients that require …”
Volltext

Solution structure of Calmodulin-W-7 complex: the basis of diversity in molecular recognition von Osawa, Masanori, Swindells, Mark B, Tanikawa, Jun, Tanaka, Toshiyuki, Mase, Toshiyasu, Furuya, Toshio, Ikura, Mitsuhiko

“… The solution structure of calcium-bound calmodulin (CaM) complexed with an antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), has been …”
Volltext

Pediatric advanced appendicitis: open versus laparoscopic approach von Nwokoma, Ngozi Joy, Swindells, Mark G, Pahl, Karoline, Mathur, Azad B, Minocha, Ashish, Kulkarni, Milind, Tsang, Thomas

“… Optimal surgical approach for advanced pediatric appendicectomy remains controversial. We compare the open versus the laparoscopic approach. Retrospective case …”
Weitere Angaben

SCOPEC: a database of protein catalytic domains von George, Richard A., Spriggs, Ruth V., Thornton, Janet M., Al-Lazikani, Bissan, Swindells, Mark B.

“… Motivation: Domains are the units of protein structure, function and evolution. It is therefore essential to utilize knowledge of domains when studying the …”
Volltext

Vector geometry mapping. A method to characterize the conformation of helix-loop-helix calcium-binding proteins von Yap, Kyoko L, Ames, James B, Swindells, Mark B, Ikura, Mitsuhiko

Weitere Angaben

Diversity of conformational states and changes within the EF-hand protein superfamily von Yap, Kyoko L., Ames, James B., Swindells, Mark B., Ikura, Mitsuhiko

“… The EF‐hand motif, which assumes a helix‐loop‐helix structure normally responsible for Ca2+ binding, is found in a large number of functionally diverse Ca2+ …”
Volltext

Acute radial artery ischemia following therapeutic steroid injection von Swindells, Mark G, Tehrani, Hamid, Goodwin-Walters, Anna, Sassoon, Elaine M

“… Intra-arterial corticosteroid injection at the wrist can have devastating consequences. Anatomic arterial variation of the hand can lead to atypical …”
Weitere Angaben

GENIUS II: a high-throughput database system for linking ORFs in complete genomes to known protein three-dimensional structures von Yabuki, Yukimitsu, Mukai, Yuri, Swindells, Mark B., Suwa, Makiko

“… GENIUS II is an automated database system in which open reading frames (ORFs) in complete genomes are assigned to known protein three-dimensional (3D) …”
Volltext

Domain assignment for protein structures using a consensus approach: Characterization and analysis von Jones, Susan, Stewart, Michael, Michie, Alex, Swindells, Mark B., Orengo, Chirstine, Thornton, Janet M.

“… A consensus approach for the assignment of structural domains in proteins is presented. The approach combines a number of previously published algorithms, and …”
Volltext