Search Results - "Swaroop, Anand"

Pluripotent stem cell‐derived retinal organoids for disease modeling and development of therapies by Kruczek, Kamil, Swaroop, Anand

“…Retinal diseases constitute a genetically and phenotypically diverse group of clinical conditions leading to vision impairment or blindness with limited…”
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Transcriptional regulation of photoreceptor development and homeostasis in the mammalian retina by Swaroop, Anand, Kim, Douglas, Forrest, Douglas

“…Key Points Vision begins in the retina at the rod and cone photoreceptors, which are sensory neurons with specialized visual pigments for capturing light…”
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Primary cilia biogenesis and associated retinal ciliopathies by Chen, Holly Y., Kelley, Ryan A., Li, Tiansen, Swaroop, Anand

“…[Display omitted] The primary cilium is a ubiquitous microtubule-based organelle that senses external environment and modulates diverse signaling pathways in…”
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Epigenetic control of gene regulation during development and disease: A view from the retina by Corso-Díaz, Ximena, Jaeger, Catherine, Chaitankar, Vijender, Swaroop, Anand

“…Complex biological processes, such as organogenesis and homeostasis, are stringently regulated by genetic programs that are fine-tuned by epigenetic factors to…”
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Dietary Nutrient Intake and Progression to Late Age-Related Macular Degeneration in the Age-Related Eye Disease Studies 1 and 2 by Agrón, Elvira, Mares, Julie, Clemons, Traci E, Swaroop, Anand, Chew, Emily Y, Keenan, Tiarnan D L

“…To analyze associations between the dietary intake of multiple nutrients and risk of progression to late age-related macular degeneration (AMD), its subtypes,…”
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Nrl knockdown by AAV-delivered CRISPR/Cas9 prevents retinal degeneration in mice by Yu, Wenhan, Mookherjee, Suddhasil, Chaitankar, Vijender, Hiriyanna, Suja, Kim, Jung-Woong, Brooks, Matthew, Ataeijannati, Yasaman, Sun, Xun, Dong, Lijin, Li, Tiansen, Swaroop, Anand, Wu, Zhijian

“…In retinitis pigmentosa, loss of cone photoreceptors leads to blindness, and preservation of cone function is a major therapeutic goal. However, cone loss is…”
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Free radical scavenging, antioxidant and cancer chemoprevention by grape seed proanthocyanidin: an overview by Bagchi, Debasis, Swaroop, Anand, Preuss, Harry G, Bagchi, Manashi

“…A large number of investigations have demonstrated a broad spectrum of pharmacological and therapeutic benefits of grape seed proanthocyanidins (GSP) against…”
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High-resolution genome topology of human retina uncovers super enhancer-promoter interactions at tissue-specific and multifactorial disease loci by Marchal, Claire, Singh, Nivedita, Batz, Zachary, Advani, Jayshree, Jaeger, Catherine, Corso-Díaz, Ximena, Swaroop, Anand

“…Chromatin organization and enhancer-promoter contacts establish unique spatiotemporal gene expression patterns in distinct cell types. Non-coding genetic…”
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Transcriptome Dynamics of Developing Photoreceptors in Three‐Dimensional Retina Cultures Recapitulates Temporal Sequence of Human Cone and Rod Differentiation Revealing Cell Surface Markers and Gene Networks by Kaewkhaw, Rossukon, Kaya, Koray Dogan, Brooks, Matthew, Homma, Kohei, Zou, Jizhong, Chaitankar, Vijender, Rao, Mahendra, Swaroop, Anand

“…The derivation of three‐dimensional (3D) stratified neural retina from pluripotent stem cells has permitted investigations of human photoreceptors. We have…”
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Deep-learning-based prediction of late age-related macular degeneration progression by Yan, Qi, Weeks, Daniel E., Xin, Hongyi, Swaroop, Anand, Chew, Emily Y., Huang, Heng, Ding, Ying, Chen, Wei

“…Both genetic and environmental factors influence the etiology of age-related macular degeneration (AMD), a leading cause of blindness. AMD severity is…”
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Age-related macular degeneration: genetics and biology coming together by Fritsche, Lars G, Fariss, Robert N, Stambolian, Dwight, Abecasis, Gonçalo R, Curcio, Christine A, Swaroop, Anand

“…Genetic and genomic studies have enhanced our understanding of complex neurodegenerative diseases that exert a devastating impact on individuals and society…”
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Molecular Anatomy of the Developing Human Retina by Hoshino, Akina, Ratnapriya, Rinki, Brooks, Matthew J, Chaitankar, Vijender, Wilken, Matthew S, Zhang, Chi, Starostik, Margaret R, Gieser, Linn, La Torre, Anna, Nishio, Mario, Bates, Olivia, Walton, Ashley, Bermingham-McDonogh, Olivia, Glass, Ian A, Wong, Rachel O L, Swaroop, Anand, Reh, Thomas A

“…Clinical and genetic heterogeneity associated with retinal diseases makes stem-cell-based therapies an attractive strategy for personalized medicine. However,…”
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Stage-specific dynamic reorganization of genome topology shapes transcriptional neighborhoods in developing human retinal organoids by Qu, Zepeng, Batz, Zachary, Singh, Nivedita, Marchal, Claire, Swaroop, Anand

“…We have generated a high-resolution Hi-C map of developing human retinal organoids to elucidate spatiotemporal dynamics of genomic architecture and its…”
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HiCRes: a computational method to estimate and predict the genomic resolution of Hi-C libraries by Marchal, Claire, Singh, Nivedita, Corso-Díaz, Ximena, Swaroop, Anand

“…Abstract Three-dimensional (3D) conformation of the chromatin is crucial to stringently regulate gene expression patterns and DNA replication in a cell-type…”
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Biology and therapy of inherited retinal degenerative disease: insights from mouse models by Veleri, Shobi, Lazar, Csilla H., Chang, Bo, Sieving, Paul A., Banin, Eyal, Swaroop, Anand

“…Retinal neurodegeneration associated with the dysfunction or death of photoreceptors is a major cause of incurable vision loss. Tremendous progress has been…”
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Minireview: the role of nuclear receptors in photoreceptor differentiation and disease by Forrest, Douglas, Swaroop, Anand

“…Rod and cone photoreceptors are specialized sensory cells that mediate vision. Transcriptional controls are critical for the development and long-term survival…”
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Recruitment of Rod Photoreceptors from Short-Wavelength-Sensitive Cones during the Evolution of Nocturnal Vision in Mammals by Kim, Jung-Woong, Yang, Hyun-Jin, Oel, Adam Phillip, Brooks, Matthew John, Jia, Li, Plachetzki, David Charles, Li, Wei, Allison, William Ted, Swaroop, Anand

“…Vertebrate ancestors had only cone-like photoreceptors. The duplex retina evolved in jawless vertebrates with the advent of highly photosensitive rod-like…”
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Accelerated and Improved Differentiation of Retinal Organoids from Pluripotent Stem Cells in Rotating-Wall Vessel Bioreactors by DiStefano, Tyler, Chen, Holly Yu, Panebianco, Christopher, Kaya, Koray Dogan, Brooks, Matthew J., Gieser, Linn, Morgan, Nicole Y., Pohida, Tom, Swaroop, Anand

“…Pluripotent stem cells can be differentiated into 3D retinal organoids, with major cell types self-patterning into a polarized, laminated architecture. In…”
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Sex-specific attenuation of photoreceptor degeneration by reserpine in a rhodopsin P23H rat model of autosomal dominant retinitis pigmentosa by Song, Hyun Beom, Campello, Laura, Mondal, Anupam, Chen, Holly Y, English, Milton A, Glen, Michael, Vanlandingham, Phillip, Farjo, Rafal, Swaroop, Anand

“…Inherited retinal degenerations (IRDs) constitute a group of clinically and genetically diverse vision-impairing disorders. Retinitis pigmentosa (RP), the most…”
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Maf-family bZIP transcription factor NRL interacts with RNA-binding proteins and R-loops in retinal photoreceptors by Corso Diaz, Ximena, Liang, Xulong, Preston, Kiam, Tegshee, Bilguun, English, Milton A, Nellissery, Jacob, Yadav, Sharda Prasad, Marchal, Claire, Swaroop, Anand

“…RNA-binding proteins (RBPs) perform diverse functions including the regulation of chromatin dynamics and the coupling of transcription with RNA processing…”
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