Výsledky vyhľadávania - "Succinates - pharmacology"

Protein targeting by the itaconate family in immunity and inflammation Autor Day, Emily A, O'Neill, Luke A J

“… As such, itaconate has recently been the subject of intense research interest. The artificial derivatives, including 4-Octyl Itaconate (4-OI…”
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Serotonin signals through a gut-liver axis to regulate hepatic steatosis Autor Choi, Wonsuk, Namkung, Jun, Hwang, Inseon, Kim, Hyeongseok, Lim, Ajin, Park, Hye Jung, Lee, Hye Won, Han, Kwang-Hyub, Park, Seongyeol, Jeong, Ji-Seon, Bang, Geul, Kim, Young Hwan, Yadav, Vijay K., Karsenty, Gerard, Ju, Young Seok, Choi, Chan, Suh, Jae Myoung, Park, Jun Yong, Park, Sangkyu, Kim, Hail

“…Nonalcoholic fatty liver disease (NAFLD) is increasing in worldwide prevalence, closely tracking the obesity epidemic, but specific pharmaceutical treatments…”
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Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage Autor Nowicka-Sans, Beata, Protack, Tricia, Lin, Zeyu, Li, Zhufang, Zhang, Sharon, Sun, Yongnian, Samanta, Himadri, Terry, Brian, Liu, Zheng, Chen, Yan, Sin, Ny, Sit, Sing-Yuen, Swidorski, Jacob J, Chen, Jie, Venables, Brian L, Healy, Matthew, Meanwell, Nicholas A, Cockett, Mark, Hanumegowda, Umesh, Regueiro-Ren, Alicia, Krystal, Mark, Dicker, Ira B

“…). A first-generation MI, bevirimat, showed clinical efficacy in early-phase studies, but ∼50% of subjects had viruses with reduced susceptibility associated with naturally occurring polymorphisms in Gag near the site of MI action…”
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Succinylated Gelatin Improves the Theranostic Potential of Radiolabeled Exendin-4 in Insulinoma Patients Autor Buitinga, Mijke, Jansen, Tom, van der Kroon, Inge, Woliner-van der Weg, Wietske, Boss, Marti, Janssen, Marcel, Aarntzen, Erik, Béhé, Martin, Wild, Damian, Visser, Eric, Brom, Maarten, Gotthardt, Martin

“…Being highly expressed in insulinomas, the glucagonlike peptide-1 receptor (GLP-1R) is a potential target for diagnosis, localization, and treatment with the…”
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Mexidol, Cytoflavin, and succinic acid derivatives as antihypoxic, anti-ischemic metabolic modulators, and ergogenic aids in athletes and consideration of their potential as performance enhancing drugs Autor Jędrejko, Karol, Catlin, Oliver, Stewart, Timothy, Muszyńska, Bożena

“…Emoxypine (ethylmethylhydroxypyridine) is a synthetic derivative of vitamin B . Emoxypine succinate is a registered drug in Russia and Ukraine under various…”
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Succinylated gelatin substantially increases en bloc resection size in colonic EMR: a randomized, blinded trial in a porcine model Autor Moss, Alan, Bourke, Michael J., Kwan, Vu, Tran, Kayla, Godfrey, Craig, McKay, Gary, Hopper, Andrew D.

“…Succinylated gelatin (SG) is an inexpensive colloid that may combine ease of use with the advantages of a colloid to potentially increase EMR specimen size,…”
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Multiple-Dose Study to Evaluate Pharmacokinetics, Pharmacodynamics, and Safety in Healthy Subjects: A Comparison of Controlled-Release Sarpogrelate and Immediate-Release Sarpogrelate Autor Lee, Soo-Yun, Kim, Jung-Ryul, Jung, Jin Ah, Kim, Tae-Eun, Lee, Soo-Youn, Huh, Wooseong, Lee, Jae-Won, Jun, Hun, Ko, Jae-Wook

“…) and immediate-release (IR) formulations after multiple-dose administration. Methods: This study was a randomized, open-label, 2-period, 2-treatment, crossover study in healthy subjects…”
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Succinate recovers mitochondrial oxygen consumption in septic rat skeletal muscle Autor Protti, Alessandro, Carré, Jane, Frost, Matthew T, Taylor, Valerie, Stidwill, Raymond, Rudiger, Alain, Singer, Mervyn

“…Mitochondrial dysfunction, particularly affecting complex I of the respiratory chain, could play a fundamental role in the development of multiple organ…”
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Structural basis of phospholipase A 2 -like myotoxin inhibition by chicoric acid, a novel potent inhibitor of ophidian toxins Autor Cardoso, Fábio F, Borges, Rafael J, Dreyer, Thiago R, Salvador, Guilherme H M, Cavalcante, Walter L G, Pai, Maeli Dal, Gallacci, Márcia, Fontes, Marcos R M

“…Specific compounds found in vegetal species have been demonstrated to be efficient inhibitors of snake toxins, such as phospholipase A -like (PLA -like)…”
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Carboxypeptidase U (TAFIa): a metallocarboxypeptidase with a distinct role in haemostasis and a possible risk factor for thrombotic disease Autor Leurs, Judith, Hendriks, Dirk

“…Since the discovery of Carboxypeptidase U (CPU) in 1988, considerable information has been gathered about its biochemistry and function in physiological and…”
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Effect of the potent CYP2D6 inhibitor sarpogrelate on the pharmacokinetics and pharmacodynamics of metoprolol in healthy male Korean volunteers Autor Cho, Doo-Yeoun, Bae, Soo Hyeon, Lee, Joeng Kee, Park, Jung Bae, Kim, Yang-Weon, Lee, Sukhyang, Oh, Euichaul, Kim, Bom-Taeck, Bae, Soo Kyung

“… Here, we evaluated the effect of sarpogrelate on the pharmacokinetics and pharmacodynamics of metoprolol in healthy subjects. 2…”
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Effect of Remaxol on the efficiency of standard treatment for infiltrative pulmonary tuberculosis Autor Volchegorsky, I A, Novoselov, P N, Ushkareva, E V

“…To investigate the effect of Remaxol on the efficiency of standard treatment in patients with infiltrative pulmonary tuberculosis (IPT). The results of…”
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Treatment of hepatic insufficiency in benign mechanical jaundice Autor Stupin, V A, Basarbolieva, Zh V, Agapov, M A, Laipanov, B K, Khokonov, M A, Klimiashvili, A D, Rodoman, G V

“… The study included 124 patients of whom 74 were given remaxol. 50 control subjects received basal therapy…”
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Effect of cytoflavin on the clinical and autonomic-psychological manifestations of hypertensive disease Autor Belova, L A, Mashin, V V, Kolotik-Kameneva, O Yu, Belova, N V

“…To evaluate the impact of incorporating cytoflavin in a treatment regimen for patients with different stages of hypertensive disease (HD). The results of…”
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Effects of oral single-dose administration of sarpogrelate hydrochloride on saturation O(2) of calf muscle during plantar flexion exercise Autor Horiuchi, Masahiro, Okita, Koichi, Takada, Shingo, Omokawa, Masashi, Suga, Tadashi, Morita, Noriteru, Hirabayashi, Kagami, Yokota, Takashi, Kinugawa, Shintaro, Tsutsui, Hiroyuki

“…)) of calf muscle in healthy subjects experiencing simulated peripheral arterial disease (0.6 ankle brachial pressure index…”
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A Comparison of 4% Succinylated Gelatin Solution versus Normal Saline in Stable Normovolaemic Sheep: Global Haemodynamic, Regional Blood Flow and Oxygen Delivery Effects Autor Wan, L., Bellomo, R., May, C. N.

“… The subjects were seven merino cross-ewes. We implanted flow probes around the aorta, coronary, renal and mesenteric arteries…”
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Metabolic correction of dyslipidemia in patients with nonalcoholic fatty liver disease as a new therapy policy Autor Stel'makh, V V, Kozlov, V K

“…To study the impact of infusion therapy with the metabolic modulator remaxol on lipid metabolic parameters and target organ (liver, kidney) function in…”
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Osmoprotectant-dependent expression of plcH, encoding the hemolytic phospholipase C, is subject to novel catabolite repression control in Pseudomonas aeruginosa PAO1 Autor Sage, A E, Vasil, M L

“… aeruginosa, it seemed possible that induction of plcH is subject to catabolite repression control (CRC…”
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Increased hypothalamic 5-HT2A receptor gene expression and effects of pharmacologic 5-HT2A receptor inactivation in obese Ay mice Autor Nonogaki, Katsunori, Nozue, Kana, Oka, Yoshitomo

“…, an adipokine, in diabetic subjects. Here, we report that systemic administration of sarpogrelate, a 5-HT2A receptor antagonist, suppressed appetite and increased hypothalamic pro-opiomelanocortin and cocaine- and amphetamine-regulated…”
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Improvement of exercise capacity by sarpogrelate as a result of augmented collateral circulation in patients with effort angina Autor Tanaka, T, Fujita, M, Nakae, I, Tamaki, S, Hasegawa, K, Kihara, Y, Nohara, R, Sasayama, S

“… of the collateral network has the potential to cause collateral vasoconstriction. The subjects consisted of 22 patients with effort angina and reproducible ischemic threshold…”
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