Search Results - "Stratigopoulou, Maria"

Base Excision Repair in the Immune System: Small DNA Lesions With Big Consequences by Stratigopoulou, Maria, van Dam, Tijmen P., Guikema, Jeroen E. J.

“…The integrity of the genome is under constant threat of environmental and endogenous agents that cause DNA damage. Endogenous damage is particularly pervasive,…”
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Exploring the impact of clonal definition on B-cell diversity: implications for the analysis of immune repertoires by Pelissier, Aurelien, Luo, Siyuan, Stratigopoulou, Maria, Guikema, Jeroen E. J., Rodríguez Martínez, María

“…The adaptive immune system has the extraordinary ability to produce a broad range of immunoglobulins that can bind a wide variety of antigens. During adaptive…”
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Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation by Spanjaard, Aldo, Stratigopoulou, Maria, de Groot, Daniël, Aslam, Muhammad, van den Berk, Paul C. M., Stappenbelt, Chantal, Ayidah, Matilda, Catsman, Joyce J. I., Pardieck, Iris N., Kreft, Maaike, Arens, Ramon, Guikema, Jeroen E. J., Jacobs, Heinz

“…The development and differentiation of B cells is intimately linked to cell proliferation and the generation of diverse immunoglobulin gene ( Ig ) repertoires…”
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Systematic evaluation of B-cell clonal family inference approaches by Balashova, Daria, van Schaik, Barbera D. C., Stratigopoulou, Maria, Guikema, Jeroen E. J., Caniels, Tom G., Claireaux, Mathieu, van Gils, Marit J., Musters, Anne, Anang, Dornatien C., de Vries, Niek, Greiff, Victor, van Kampen, Antoine H. C.

“…The reconstruction of clonal families (CFs) in B-cell receptor (BCR) repertoire analysis is a crucial step to understand the adaptive immune system and how it…”
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Understanding repertoire sequencing data through a multiscale computational model of the germinal center by García-Valiente, Rodrigo, Merino Tejero, Elena, Stratigopoulou, Maria, Balashova, Daria, Jongejan, Aldo, Lashgari, Danial, Pélissier, Aurélien, Caniels, Tom G., Claireaux, Mathieu A. F., Musters, Anne, van Gils, Marit J., Rodríguez Martínez, María, de Vries, Niek, Meyer-Hermann, Michael, Guikema, Jeroen E. J., Hoefsloot, Huub, van Kampen, Antoine H. C.

“…Sequencing of B-cell and T-cell immune receptor repertoires helps us to understand the adaptive immune response, although it only provides information about…”
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Convergent evolution and B-cell recirculation in germinal centers in a human lymph node by Pelissier, Aurelien, Stratigopoulou, Maria, Donner, Naomi, Dimitriadis, Evangelos, Bende, Richard J, Guikema, Jeroen E, Rodriguez Martinez, Maria, van Noesel, Carel JM

“…Germinal centers (GCs) play a central role in generating an effective immune response against infectious pathogens, and failures in their regulating mechanisms…”
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Quantifying B-cell Clonal Diversity In Repertoire Data by Pelissier, Aurelien, Luo, Siyuan, Stratigopoulou, Maria, Guikema, Jeroen, Maria Rodriguez Martinez

“…The adaptive immune system has the extraordinary ability to produce a broad range of immunoglobulins that can bind a wide variety of antigens. During adaptive…”
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Convergent Evolution and B-Cell Recirculation in Germinal Centers in a Human Lymph Node by Pelissier, Aurelien, Stratigopoulou, Maria, Donner, Naomi, Dimitriadis, Evangelos, Bende, Richard J, Guikema, Jeroen E, Maria Rodriguez Martinez, Carel J M Van Noesel

“…Germinal centers (GCs) are specialized compartments within the secondary lymphoid organs where B cells proliferate, differentiate, and mutate their antibody…”
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DNA polymerase β prevents AID-instigated mutagenic non-canonical mismatch DNA repair by Mahnoush Bahjat, Stratigopoulou, Maria, Pilzecker, Bas, Van Dam, Tijmen P, Mobach, Simon, Bende, Richard J, Carel Jm Van Noesel, Jacobs, Heinz E, Guikema, Jeroen E

“…In B cells, the error-prone repair of activation-induced cytidine deaminase (AID)-induced lesions in immunoglobulin variable genes cause somatic hypermutation…”
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