Suchergebnisse - "Strachan, David P"

Trends in worldwide asthma prevalence von Asher, M Innes, García-Marcos, Luis, Pearce, Neil E, Strachan, David P

“… This review of trends in worldwide asthma prevalence starts with defining how asthma prevalence is measured in populations and how it is analysed. Four …”
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Persistent variations in national asthma mortality, hospital admissions and prevalence by socioeconomic status and region in England von Gupta, Ramyani P, Mukherjee, Mome, Sheikh, Aziz, Strachan, David P

“… BackgroundThe UK-wide National Review of Asthma Deaths sought to identify avoidable factors from the high numbers of deaths, but did not examine variation by …”
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Are noise and air pollution related to the incidence of dementia? A cohort study in London, England von Carey, Iain M, Anderson, H Ross, Atkinson, Richard W, Beevers, Sean D, Cook, Derek G, Strachan, David P, Dajnak, David, Gulliver, John, Kelly, Frank J

“… ObjectiveTo investigate whether the incidence of dementia is related to residential levels of air and noise pollution in London.DesignRetrospective cohort …”
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Fast and accurate imputation of summary statistics enhances evidence of functional enrichment von Pasaniuc, Bogdan, Zaitlen, Noah, Shi, Huwenbo, Bhatia, Gaurav, Gusev, Alexander, Pickrell, Joseph, Hirschhorn, Joel, Strachan, David P., Patterson, Nick, Price, Alkes L.

“… Motivation: Imputation using external reference panels (e.g. 1000 Genomes) is a widely used approach for increasing power in genome-wide association studies …”
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The Global Asthma Network rationale and methods for Phase I global surveillance: prevalence, severity, management and risk factors von Ellwood, Philippa, Asher, M Innes, Billo, Nils E, Bissell, Karen, Chiang, Chen-Yuan, Ellwood, Eamon M, El-Sony, Asma, García-Marcos, Luis, Mallol, Javier, Marks, Guy B, Pearce, Neil E, Strachan, David P

“… The Global Asthma Network (GAN), established in 2012, followed the International Study of Asthma and Allergies in Childhood (ISAAC). ISAAC Phase One involved …”
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The hygiene hypothesis for allergy – conception and evolution von Perkin, Michael R, Strachan, David P

“… In 1989, a short paper entitled “Hay fever, hygiene and household size” observed that British children from larger families were less likely to develop hay …”
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Risk factors for excess all-cause mortality during the first wave of the COVID-19 pandemic in England: A retrospective cohort study of primary care data von Carey, Iain M., Cook, Derek G., Harris, Tess, DeWilde, Stephen, Chaudhry, Umar A. R., Strachan, David P.

“… The COVID-19 pandemic's first wave in England during spring 2020 resulted in an approximate 50% increase in all-cause mortality. Previously, risk factors such …”
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Meta-analysis identifies seven susceptibility loci involved in the atopic march von Marenholz, Ingo, Esparza-Gordillo, Jorge, Rüschendorf, Franz, Bauerfeind, Anja, Strachan, David P., Spycher, Ben D., Baurecht, Hansjörg, Margaritte-Jeannin, Patricia, Sääf, Annika, Kerkhof, Marjan, Ege, Markus, Baltic, Svetlana, Matheson, Melanie C., Li, Jin, Michel, Sven, Ang, Wei Q., McArdle, Wendy, Arnold, Andreas, Homuth, Georg, Demenais, Florence, Bouzigon, Emmanuelle, Söderhäll, Cilla, Pershagen, Göran, de Jongste, Johan C., Postma, Dirkje S., Braun-Fahrländer, Charlotte, Horak, Elisabeth, Ogorodova, Ludmila M., Puzyrev, Valery P., Bragina, Elena Yu, Hudson, Thomas J., Morin, Charles, Duffy, David L., Marks, Guy B., Robertson, Colin F., Montgomery, Grant W., Musk, Bill, Thompson, Philip J., Martin, Nicholas G., James, Alan, Sleiman, Patrick, Toskala, Elina, Rodriguez, Elke, Fölster-Holst, Regina, Franke, Andre, Lieb, Wolfgang, Gieger, Christian, Heinzmann, Andrea, Rietschel, Ernst, Keil, Thomas, Cichon, Sven, Nöthen, Markus M., Pennell, Craig E., Sly, Peter D., Schmidt, Carsten O., Matanovic, Anja, Schneider, Valentin, Heinig, Matthias, Hübner, Norbert, Holt, Patrick G., Lau, Susanne, Kabesch, Michael, Weidinger, Stefan, Hakonarson, Hakon, Ferreira, Manuel A. R., Laprise, Catherine, Freidin, Maxim B., Genuneit, Jon, Koppelman, Gerard H., Melén, Erik, Dizier, Marie- Hélène, Henderson, A John, Lee, Young Ae

“… Eczema often precedes the development of asthma in a disease course called the ‘atopic march’. To unravel the genes underlying this characteristic pattern of …”
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Vitamin D levels and susceptibility to asthma, elevated immunoglobulin E levels, and atopic dermatitis: A Mendelian randomization study von Manousaki, Despoina, Paternoster, Lavinia, Standl, Marie, Moffatt, Miriam F., Farrall, Martin, Bouzigon, Emmanuelle, Strachan, David P., Demenais, Florence, Lathrop, Mark, Cookson, William O. C. M., Richards, J. Brent

“… Low circulating vitamin D levels have been associated with risk of asthma, atopic dermatitis, and elevated total immunoglobulin E (IgE). These epidemiological …”
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Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys von Asher, M Innes, Montefort, Stephen, Björkstén, Bengt, Lai, Christopher KW, Strachan, David P, Weiland, Stephan K, Williams, Hywel

“… Data for trends in prevalence of asthma, allergic rhinoconjunctivitis, and eczema over time are scarce. We repeated the International Study of Asthma and …”
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Genome-Wide Association Study of Blood Pressure Extremes Identifies Variant near UMOD Associated with Hypertension von Padmanabhan, Sandosh, Melander, Olle, Johnson, Toby, Di Blasio, Anna Maria, Lee, Wai K., Gentilini, Davide, Hastie, Claire E., Menni, Cristina, Monti, Maria Cristina, Delles, Christian, Laing, Stewart, Corso, Barbara, Navis, Gerjan, Kwakernaak, Arjan J., van der Harst, Pim, Bochud, Murielle, Maillard, Marc, Burnier, Michel, Hedner, Thomas, Kjeldsen, Sverre, Wahlstrand, Björn, Sjögren, Marketa, Fava, Cristiano, Montagnana, Martina, Danese, Elisa, Torffvit, Ole, Hedblad, Bo, Snieder, Harold, Connell, John M. C., Brown, Morris, Samani, Nilesh J., Farrall, Martin, Cesana, Giancarlo, Mancia, Giuseppe, Signorini, Stefano, Grassi, Guido, Eyheramendy, Susana, Wichmann, H. Erich, Laan, Maris, Strachan, David P., Sever, Peter, Shields, Denis Colm, Stanton, Alice, Vollenweider, Peter, Teumer, Alexander, Völzke, Henry, Rettig, Rainer, Newton-Cheh, Christopher, Arora, Pankaj, Zhang, Feng, Soranzo, Nicole, Spector, Timothy D., Lucas, Gavin, Kathiresan, Sekar, Siscovick, David S., Luan, Jian'an, Loos, Ruth J. F., Wareham, Nicholas J., Penninx, Brenda W., Nolte, Ilja M., McBride, Martin, Miller, William H., Nicklin, Stuart A., Baker, Andrew H., Graham, Delyth, McDonald, Robert A., Pell, Jill P., Sattar, Naveed, Welsh, Paul, Munroe, Patricia, Caulfield, Mark J., Zanchetti, Alberto, Dominiczak, Anna F.

“… Hypertension is a heritable and major contributor to the global burden of disease. The sum of rare and common genetic variants robustly identified so far …”
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A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study von Granada, Mark, Wilk, Jemma B., Tuzova, Marina, Strachan, David P., Weidinger, Stephan, Albrecht, Eva, Gieger, Christian, Heinrich, Joachim, Himes, Blanca E., Hunninghake, Gary M., Celedón, Juan C., Weiss, Scott T., Cruikshank, William W., Farrer, Lindsay A., Center, David M., O'Connor, George T.

“… Atopy and plasma IgE concentration are genetically complex traits, and the specific genetic risk factors that lead to IgE dysregulation and clinical atopy are …”
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Genome-wide Analysis of Body Proportion Classifies Height-Associated Variants by Mechanism of Action and Implicates Genes Important for Skeletal Development von Chan, Yingleong, Salem, Rany M, Hsu, Yu-Han H, McMahon, George, Pers, Tune H, Vedantam, Sailaja, Esko, Tonu, Guo, Michael H, Lim, Elaine T, Franke, Lude, Smith, George Davey, Strachan, David P, Hirschhorn, Joel N

“… Human height is a composite measurement, reflecting the sum of leg, spine, and head lengths. Many common variants influence total height, but the effects of …”
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Gut microbiota and development of atopic eczema in 3 European birth cohorts von Adlerberth, Ingegerd, Strachan, David P., Matricardi, Paolo M., Ahrné, Siv, Orfei, Lia, Åberg, Nils, Perkin, Michael R., Tripodi, Salvatore, Hesselmar, Bill, Saalman, Robert, Coates, Anthony R., Bonanno, Carmen L., Panetta, Valentina, Wold, Agnes E.

“… Stimulation of the immune system by gut microbes might prevent allergy development. The present study examined the hypothesis that sensitization to food …”
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GWAS on retinal vasculometry phenotypes von Jiang, Xiaofan, Hysi, Pirro G., Khawaja, Anthony P., Mahroo, Omar A., Xu, Zihe, Hammond, Christopher J., Foster, Paul J., Welikala, Roshan A., Barman, Sarah A., Whincup, Peter H., Rudnicka, Alicja R., Owen, Christopher G., Strachan, David P.

“… The eye is the window through which light is transmitted and visual sensory signalling originates. It is also a window through which elements of the …”
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A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order von Ramasamy, Adaikalavan, Curjuric, Ivan, Coin, Lachlan J., Kumar, Ashish, McArdle, Wendy L., Imboden, Medea, Leynaert, Benedicte, Kogevinas, Manolis, Schmid-Grendelmeier, Peter, Pekkanen, Juha, Wjst, Matthias, Bircher, Andreas J., Sovio, Ulla, Rochat, Thierry, Hartikainen, Anna-Liisa, Balding, David J., Jarvelin, Marjo-Riitta, Probst-Hensch, Nicole, Strachan, David P., Jarvis, Deborah L.

“… Hay fever or seasonal allergic rhinitis (AR) is a chronic disorder associated with IgE sensitization to grass. The underlying genetic variants have not been …”
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Shared genetic variants suggest common pathways in allergy and autoimmune diseases von Kreiner, Eskil, Waage, Johannes, Standl, Marie, Brix, Susanne, Pers, Tune H., Couto Alves, Alexessander, Warrington, Nicole M., Tiesler, Carla M.T., Fuertes, Elaine, Franke, Lude, Hirschhorn, Joel N., James, Alan, Simpson, Angela, Tung, Joyce Y., Koppelman, Gerard H., Postma, Dirkje S., Pennell, Craig E., Jarvelin, Marjo-Riitta, Custovic, Adnan, Timpson, Nicholas, Ferreira, Manuel A., Strachan, David P., Henderson, John, Hinds, David, Bisgaard, Hans, Bønnelykke, Klaus

“… The relationship between allergy and autoimmune disorders is complex and poorly understood. We sought to investigate commonalities in genetic loci and pathways …”
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Does outdoor air pollution induce new cases of asthma? Biological plausibility and evidence; a review von GOWERS, ALISON M., CULLINAN, PAUL, AYRES, JON G., ANDERSON, H. ROSS, STRACHAN, DAVID P., HOLGATE, STEPHEN T., MILLS, INGA C., MAYNARD, ROBERT L.

“… ABSTRACT It is widely accepted that air pollution can exacerbate asthma in those who already have the condition. What is less clear is whether air pollution …”
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Overweight/Obesity and Respiratory and Allergic Disease in Children: International Study of Asthma and Allergies in Childhood (ISAAC) Phase Two von Weinmayr, Gudrun, Forastiere, Francesco, Büchele, Gisela, Jaensch, Andrea, Strachan, David P., Nagel, Gabriele

“… Childhood obesity and asthma are increasing worldwide. A possible link between the two conditions has been postulated. Cross-sectional studies of stratified …”
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Potential asthma risk factors do not account for global asthma symptom prevalence patterns and time trends in children and adolescents von Rutter, Charlotte E., Silverwood, Richard J., Pearce, Neil, Strachan, David P.

“… The International Study of Asthma and Allergies in Childhood (ISAAC) and the Global Asthma Network (GAN) conducted a series of global asthma prevalence …”
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