Suchergebnisse - "Stockmeier, Craig A."

Astrocyte pathology in major depressive disorder: insights from human postmortem brain tissue von Rajkowska, Grazyna, Stockmeier, Craig A

“… The present paper reviews astrocyte pathology in major depressive disorder (MDD) and proposes that reductions in astrocytes and related markers are key …”
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Decreased expression of synapse-related genes and loss of synapses in major depressive disorder von Kang, Hyo Jung, Voleti, Bhavya, Hajszan, Tibor, Rajkowska, Grazyna, Stockmeier, Craig A, Licznerski, Pawel, Lepack, Ashley, Majik, Mahesh S, Jeong, Lak Shin, Banasr, Mounira, Son, Hyeon, Duman, Ronald S

“… Ronald Duman and colleagues report that synapse number is reduced in subjects with major depressive disorder. This is associated with decreased expression of …”
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Coverage of Blood Vessels by Astrocytic Endfeet Is Reduced in Major Depressive Disorder von Rajkowska, Grazyna, Hughes, Jonathan, Stockmeier, Craig A., Javier Miguel-Hidalgo, Jose, Maciag, Dorota

“… Depression and cerebrovascular disease influence each other, according to clinical studies. Despite this evidence, no studies have investigated the …”
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Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression von Feyissa, Anteneh M., Chandran, Agata, Stockmeier, Craig A., Karolewicz, Beata

“… Recent neuroimaging and postmortem studies have demonstrated abnormalities in glutamatergic transmission in major depression. Glutamate NMDA (N-methyl- …”
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A negative regulator of MAP kinase causes depressive behavior von Duric, Vanja, Banasr, Mounira, Licznerski, Pawel, Schmidt, Heath D, Stockmeier, Craig A, Simen, Arthur A, Newton, Samuel S, Duman, Ronald S

“… Gene expression changes that occur in the brains of people with depression could lead to the development of new therapies. Now, Ronald Duman and his colleagues …”
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Evaluation of chromatin accessibility in prefrontal cortex of individuals with schizophrenia von Bryois, Julien, Garrett, Melanie E., Song, Lingyun, Safi, Alexias, Giusti-Rodriguez, Paola, Johnson, Graham D., Shieh, Annie W., Buil, Alfonso, Fullard, John F., Roussos, Panos, Sklar, Pamela, Akbarian, Schahram, Haroutunian, Vahram, Stockmeier, Craig A., Wray, Gregory A., White, Kevin P., Liu, Chunyu, Reddy, Timothy E., Ashley-Koch, Allison, Sullivan, Patrick F., Crawford, Gregory E.

“… Schizophrenia genome-wide association studies have identified >150 regions of the genome associated with disease risk, yet there is little evidence that coding …”
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The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder von Jernigan, Courtney S., Goswami, Dharmendra B., Austin, Mark C., Iyo, Abiye H., Chandran, Agata, Stockmeier, Craig A., Karolewicz, Beata

“… Recent studies demonstrate that rapid antidepressant response to ketamine is mediated by activation of the mammalian target of rapamycin (mTOR) signaling …”
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Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjects von Duric, Vanja, Banasr, Mounira, Stockmeier, Craig A., Simen, Arthur A., Newton, Samuel S., Overholser, James C., Jurjus, George J., Dieter, Lesa, Duman, Ronald S.

“… Major depressive disorder (MDD) has been linked to changes in function and activity of the hippocampus, one of the central limbic regions involved in …”
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Reduced metabotropic glutamate receptor 5 density in major depression determined by [(11)C]ABP688 PET and postmortem study von Deschwanden, Alexandra, Karolewicz, Beata, Feyissa, Anteneh M, Treyer, Valerie, Ametamey, Simon M, Johayem, Anass, Burger, Cyrill, Auberson, Yves P, Sovago, Judit, Stockmeier, Craig A, Buck, Alfred, Hasler, Gregor

“… Clinical and preclinical evidence suggests a hyperactive glutamatergic system in clinical depression. Recently, the metabotropic glutamate receptor 5 (mGluR5) …”
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Astrocyte pathology in the ventral prefrontal white matter in depression von Rajkowska, Grazyna, Legutko, Beata, Moulana, Mohadetheh, Syed, Maryam, Romero, Damian G., Stockmeier, Craig A., Miguel-Hidalgo, Jose Javier

“… Astrocyte functions in white matter are less well understood than in gray matter. Our recent study of white matter in ventral prefrontal cortex (vPFC) revealed …”
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Reduced Density of Calbindin Immunoreactive GABAergic Neurons in the Occipital Cortex in Major Depression: Relevance to Neuroimaging Studies von Maciag, Dorota, Hughes, Jonathan, O'Dwyer, Gillian, Pride, Yilianys, Stockmeier, Craig A., Sanacora, Gerard, Rajkowska, Grazyna

“… Several lines of evidence suggest dysfunction of the γ-aminobutyric acid (GABA)ergic system in major depressive disorder. Neuroimaging studies report reduced …”
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Involvement of serotonin in depression: evidence from postmortem and imaging studies of serotonin receptors and the serotonin transporter von Stockmeier, Craig A.

“… Definitive conclusions on the role of serotonin receptors and transporter in suicide and depression have been elusive in studies of postmortem brain tissue. A …”
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Extracellular matrix abnormalities in the hippocampus of subjects with substance use disorder von Valeri, Jake, Stiplosek, Charlotte, O’Donovan, Sinead M., Sinclair, David, Grant, Kathleen A., Bollavarapu, Ratna, Platt, Donna M., Stockmeier, Craig A., Gisabella, Barbara, Pantazopoulos, Harry

“… Contextual triggers are significant factors contributing to relapse in substance use disorders (SUD). Emerging evidence points to a critical role of …”
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Elevated gene expression of glutamate receptors in noradrenergic neurons from the locus coeruleus in major depression von Chandley, Michelle J., Szebeni, Attila, Szebeni, Katalin, Crawford, Jessica D., Stockmeier, Craig A., Turecki, Gustavo, Kostrzewa, Richard M., Ordway, Gregory A.

“… Glutamate receptors are promising drug targets for the treatment of urgent suicide ideation and chronic major depressive disorder (MDD) that may lead to …”
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SELENBP1 overexpression in the prefrontal cortex underlies negative symptoms of schizophrenia von Kim, Soojin, Kim, Seong-Wook, Bui, Mai Anh Thi, Kim, Yeji, Kim, Minsoo, Park, Jung-Cheol, Kim, Nam-Heon, Pyeon, Gyeong Hee, Jo, Yong Sang, Jang, Jaewon, Koh, Hae-Young, Jeong, Chae-Hong, Kang, Moonkyung, Kang, Hyo Jung, Lee, Yong-Woo, Stockmeier, Craig A, Seong, Je Kyung, Woo, Dong Ho, Han, Jung-Soo, Kim, Yeon-Soo

“… The selenium-binding protein 1 (SELENBP1) has been reported to be up-regulated in the prefrontal cortex (PFC) of schizophrenia patients in postmortem reports …”
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Acute stressors and clinical characteristics differentiate death by suicide, accident, or natural causes among illicit and prescription opiate users von Athey, Alison J., Beale, Eleanor E., Overholser, James C., Stockmeier, Craig A., Bagge, Courtney L.

“… •Compared opioid users who died by natural cases, accidents, and suicide.•Substance use and suicide risk were evaluated using psychological autopsy …”
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Altered Expression of Phox2 Transcription Factors in the Locus Coeruleus in Major Depressive Disorder Mimicked by Chronic Stress and Corticosterone Treatment In Vivo and In Vitro von Fan, Yan, Chen, Ping, Raza, Muhammad U., Szebeni, Attila, Szebeni, Katalin, Ordway, Gregory A., Stockmeier, Craig A., Zhu, Meng-Yang

“… [Display omitted] •Protein levels of Phox2a, mRNA and protein levels of Phox2b were elevated in the locus coeruleus from brain donors of MDD.•CSD significantly …”
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Cellular changes in the postmortem hippocampus in major depression von Stockmeier, Craig A., Mahajan, Gouri J., Konick, Lisa C., Overholser, James C., Jurjus, George J., Meltzer, Herbert Y., Uylings, Harry B.M., Friedman, Lee, Rajkowska, Grazyna

“… Imaging studies report that hippocampal volume is decreased in major depressive disorder (MDD). A cellular basis for reduced hippocampal volume in MDD has not …”
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Gene expression deficits in pontine locus coeruleus astrocytes in men with major depressive disorder von Chandley, Michelle J., Szebeni, Katalin, Szebeni, Attila, Crawford, Jessica, Ordway, Gregory A., Stockmeier, Craig A., Miguel-Hidalgo, Jose Javier, Turecki, Gustavo

“… Norepinephrine and glutamate are among several neurotransmitters implicated in the neuropathology of major depressive disorder (MDD). Glia deficits have also …”
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Transcriptome Analysis of Post-Mortem Brain Tissue Reveals Up-Regulation of the Complement Cascade in a Subgroup of Schizophrenia Patients von Lindholm Carlström, Eva, Niazi, Adnan, Etemadikhah, Mitra, Halvardson, Jonatan, Enroth, Stefan, Stockmeier, Craig A., Rajkowska, Grazyna, Nilsson, Bo, Feuk, Lars

“… Schizophrenia is a genetically complex neuropsychiatric disorder with largely unresolved mechanisms of pathology. Identification of genes and pathways …”
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