Výsledky vyhľadávania - "Spraggins, Jeffrey M"

Protein identification strategies in MALDI imaging mass spectrometry: a brief review Autor Ryan, Daniel J, Spraggins, Jeffrey M, Caprioli, Richard M

“…[Display omitted] Matrix assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a powerful technology used to investigate the spatial…”
Získať plný text

Spatial mapping of protein composition and tissue organization: a primer for multiplexed antibody-based imaging Autor Hickey, John W., Neumann, Elizabeth K., Radtke, Andrea J., Camarillo, Jeannie M., Beuschel, Rebecca T., Albanese, Alexandre, McDonough, Elizabeth, Hatler, Julia, Wiblin, Anne E., Fisher, Jeremy, Croteau, Josh, Small, Eliza C., Sood, Anup, Caprioli, Richard M., Angelo, R. Michael, Nolan, Garry P., Chung, Kwanghun, Hewitt, Stephen M., Germain, Ronald N., Spraggins, Jeffrey M., Lundberg, Emma, Snyder, Michael P., Kelleher, Neil L., Saka, Sinem K.

“…Tissues and organs are composed of distinct cell types that must operate in concert to perform physiological functions. Efforts to create high-dimensional…”
Získať plný text

Spatial Metabolomics of the Human Kidney using MALDI Trapped Ion Mobility Imaging Mass Spectrometry Autor Neumann, Elizabeth K, Migas, Lukasz G, Allen, Jamie L, Caprioli, Richard M, Van de Plas, Raf, Spraggins, Jeffrey M

“…Low molecular weight metabolites are essential for defining the molecular phenotypes of cells. However, spatial metabolomics tools often lack the sensitivity,…”
Zistit podrobnosti o prístupe

Resolving the Complexity of Spatial Lipidomics Using MALDI TIMS Imaging Mass Spectrometry Autor Djambazova, Katerina V, Klein, Dustin R, Migas, Lukasz G, Neumann, Elizabeth K, Rivera, Emilio S, Van de Plas, Raf, Caprioli, Richard M, Spraggins, Jeffrey M

“…Lipids are a structurally diverse class of molecules with important biological functions including cellular signaling and energy storage. Matrix-assisted laser…”
Zistit podrobnosti o prístupe

Microscopy-Directed Imaging Mass Spectrometry for Rapid High Spatial Resolution Molecular Imaging of Glomeruli Autor Esselman, Allison B, Patterson, Nathan Heath, Migas, Lukasz G, Dufresne, Martin, Djambazova, Katerina V, Colley, Madeline E, Van de Plas, Raf, Spraggins, Jeffrey M

“…The glomerulus is a multicellular functional tissue unit (FTU) of the nephron that is responsible for blood filtration. Each glomerulus contains multiple…”
Zistit podrobnosti o prístupe

High Spatial Resolution MALDI Imaging Mass Spectrometry of Fresh-Frozen Bone Autor Good, Christopher J, Neumann, Elizabeth K, Butrico, Casey E, Cassat, James E, Caprioli, Richard M, Spraggins, Jeffrey M

“…Bone and bone marrow are vital to mammalian structure, movement, and immunity. These tissues are also commonly subjected to molecular alterations giving rise…”
Zistit podrobnosti o prístupe

Enhanced sensitivity for high spatial resolution lipid analysis by negative ion mode matrix assisted laser desorption ionization imaging mass spectrometry Autor Angel, Peggi M, Spraggins, Jeffrey M, Baldwin, H Scott, Caprioli, Richard

“…We have achieved enhanced lipid imaging to a ~10 μm spatial resolution using negative ion mode matrix assisted laser desorption ionization (MALDI) imaging mass…”
Zistit podrobnosti o prístupe

Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis Autor Weiss, Andy, Murdoch, Caitlin C, Edmonds, Katherine A, Jordan, Matthew R, Monteith, Andrew J, Perera, Yasiru R, Rodríguez Nassif, Aslin M, Petoletti, Amber M, Beavers, William N, Munneke, Matthew J, Drury, Sydney L, Krystofiak, Evan S, Thalluri, Kishore, Wu, Hongwei, Kruse, Angela R S, DiMarchi, Richard D, Caprioli, Richard M, Spraggins, Jeffrey M, Chazin, Walter J, Giedroc, David P, Skaar, Eric P

“…Zinc (Zn) is an essential micronutrient and cofactor for up to 10% of proteins in living organisms. During Zn limitation, specialized enzymes called…”
Zistit podrobnosti o prístupe

High-Speed MALDI-TOF Imaging Mass Spectrometry: Rapid Ion Image Acquisition and Considerations for Next Generation Instrumentation Autor Spraggins, Jeffrey M., Caprioli, Richard M.

“…A prototype matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometer has been used for high-speed ion image acquisition. The…”
Získať plný text

MALDI imaging of lipid biochemistry in tissues by mass spectrometry Autor Berry, Karin A Zemski, Hankin, Joseph A, Barkley, Robert M, Spraggins, Jeffrey M, Caprioli, Richard M, Murphy, Robert C

Zistit podrobnosti o prístupe

Use of Single-Cell -Omic Technologies to Study the Gastrointestinal Tract and Diseases, From Single Cell Identities to Patient Features Autor Islam, Mirazul, Chen, Bob, Spraggins, Jeffrey M, Kelly, Ryan T, Lau, Ken S

“…Single cells are the building blocks of tissue systems that determine organ phenotypes, behaviors, and functions. Understanding the differences between cell…”
Zistit podrobnosti o prístupe

Uncovering Molecular Heterogeneity in the Kidney With Spatially Targeted Mass Spectrometry Autor Kruse, Angela R. S., Spraggins, Jeffrey M.

“…The kidney functions through the coordination of approximately one million multifunctional nephrons in 3-dimensional space. Molecular understanding of the…”
Získať plný text

Diabetic nephropathy induces alterations in the glomerular and tubule lipid profiles Autor Grove, Kerri J, Voziyan, Paul A, Spraggins, Jeffrey M, Wang, Suwan, Paueksakon, Paisit, Harris, Raymond C, Hudson, Billy G, Caprioli, Richard M

“…Diabetic nephropathy (DN) is a major life-threatening complication of diabetes. Renal lesions affect glomeruli and tubules, but the pathogenesis is not…”
Zistit podrobnosti o prístupe

Enhanced Ion Transmission Efficiency up to m/ z 24 000 for MALDI Protein Imaging Mass Spectrometry Autor Prentice, Boone M, Ryan, Daniel J, Van de Plas, Raf, Caprioli, Richard M, Spraggins, Jeffrey M

“…The molecular identification of species of interest is an important part of an imaging mass spectrometry (IMS) experiment. The high resolution accurate mass…”
Zistit podrobnosti o prístupe

Spatial patterns of hepatocyte glucose flux revealed by stable isotope tracing and multi-scale microscopy Autor Habashy, Aliyah, Acree, Christopher, Kim, Keun-Young, Zahraei, Ali, Dufresne, Martin, Phan, Sebastien, Cutler, Melanie, Patterson, Emilee, Mulligan, Alexandra G., Burkewitz, Kristopher, Flynn, Charles Robert, Lantier, Louise, Deerinck, Thomas, McGuinness, Owen P., Spraggins, Jeffrey M., Ellisman, Mark H., Arrojo e Drigo, Rafael

“…Metabolic homeostasis requires engagement of catabolic and anabolic pathways consuming nutrients that generate and consume energy and biomass. Our current…”
Získať plný text

Untangling Alzheimer’s disease with spatial multi-omics: a brief review Autor Marshall, Cody R., Farrow, Melissa A., Djambazova, Katerina V., Spraggins, Jeffrey M.

“…Alzheimer’s disease (AD) is the most common form of neurological dementia, specified by extracellular β-amyloid plaque deposition, neurofibrillary tangles, and…”
Získať plný text

Connecting imaging mass spectrometry and magnetic resonance imaging-based anatomical atlases for automated anatomical interpretation and differential analysis Autor Verbeeck, Nico, Spraggins, Jeffrey M., Murphy, Monika J.M., Wang, Hui-dong, Deutch, Ariel Y., Caprioli, Richard M., Van de Plas, Raf

“…Imaging mass spectrometry (IMS) is a molecular imaging technology that can measure thousands of biomolecules concurrently without prior tagging, making it…”
Získať plný text

A derivatization and validation strategy for determining the spatial localization of endogenous amine metabolites in tissues using MALDI imaging mass spectrometry Autor Manier, M. Lisa, Spraggins, Jeffrey M., Reyzer, Michelle L., Norris, Jeremy L., Caprioli, Richard M.

“…Imaging mass spectrometry (IMS) studies increasingly focus on endogenous small molecular weight metabolites and consequently bring special analytical…”
Získať plný text

Protein identification in imaging mass spectrometry through spatially targeted liquid micro‐extractions Autor Ryan, Daniel J., Nei, David, Prentice, Boone M., Rose, Kristie L., Caprioli, Richard M., Spraggins, Jeffrey M.

“…Rationale Liquid extraction surface analysis (LESA) can be used to generate spatially directed protein identifications in an imaging mass spectrometry (IMS)…”
Získať plný text

Segmentation of human functional tissue units in support of a Human Reference Atlas Autor Jain, Yashvardhan, Godwin, Leah L., Ju, Yingnan, Sood, Naveksha, Quardokus, Ellen M., Bueckle, Andreas, Longacre, Teri, Horning, Aaron, Lin, Yiing, Esplin, Edward D., Hickey, John W., Snyder, Michael P., Patterson, Nathan Heath, Spraggins, Jeffrey M., Börner, Katy

“…The Human BioMolecular Atlas Program (HuBMAP) aims to compile a Human Reference Atlas (HRA) for the healthy adult body at the cellular level. Functional tissue…”
Získať plný text