Výsledky vyhľadávania - "Spears, Melissa"

Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial Autor James, Nicholas D, Sydes, Matthew R, Clarke, Noel W, Mason, Malcolm D, Dearnaley, David P, Spears, Melissa R, Ritchie, Alastair W S, Parker, Christopher C, Russell, J Martin, Attard, Gerhardt, de Bono, Johann, Cross, William, Jones, Rob J, Thalmann, George, Amos, Claire, Matheson, David, Millman, Robin, Alzouebi, Mymoona, Beesley, Sharon, Birtle, Alison J, Brock, Susannah, Cathomas, Richard, Chakraborti, Prabir, Chowdhury, Simon, Cook, Audrey, Elliott, Tony, Gale, Joanna, Gibbs, Stephanie, Graham, John D, Hetherington, John, Hughes, Robert, Laing, Robert, McKinna, Fiona, McLaren, Duncan B, O'Sullivan, Joe M, Parikh, Omi, Peedell, Clive, Protheroe, Andrew, Robinson, Angus J, Srihari, Narayanan, Srinivasan, Rajaguru, Staffurth, John, Sundar, Santhanam, Tolan, Shaun, Tsang, David, Wagstaff, John, Parmar, Mahesh K B

“…Long-term hormone therapy has been the standard of care for advanced prostate cancer since the 1940s. STAMPEDE is a randomised controlled trial using a…”
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Survival with Newly Diagnosed Metastatic Prostate Cancer in the “Docetaxel Era”: Data from 917 Patients in the Control Arm of the STAMPEDE Trial (MRC PR08, CRUK/06/019) Autor James, Nicholas David, Spears, Melissa R., Clarke, Noel W., Dearnaley, David P., De Bono, Johann S., Gale, Joanna, Hetherington, John, Hoskin, Peter J., Jones, Robert J., Laing, Robert, Lester, Jason F., McLaren, Duncan, Parker, Christopher C., Parmar, Mahesh K.B., Ritchie, Alastair W.S., Russell, J. Martin, Strebel, Räto T., Thalmann, George N., Mason, Malcolm D., Sydes, Matthew R.

“…Prostate cancer (PCa) is the second most common disease among men worldwide. It is important to know survival outcomes and prognostic factors for this disease…”
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Adding abiraterone to androgen deprivation therapy in men with metastatic hormone-sensitive prostate cancer: A systematic review and meta-analysis Autor Rydzewska, Larysa H.M., Burdett, Sarah, Vale, Claire L., Clarke, Noel W., Fizazi, Karim, Kheoh, Thian, Mason, Malcolm D., Miladinovic, Branko, James, Nicholas D., Parmar, Mahesh K.B., Spears, Melissa R., Sweeney, Christopher J., Sydes, Matthew R., Tran, NamPhuong, Tierney, Jayne F.

“…There is a need to synthesise the results of numerous randomised controlled trials evaluating the addition of therapies to androgen deprivation therapy (ADT)…”
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Adding Celecoxib With or Without Zoledronic Acid for Hormone-Naïve Prostate Cancer: Long-Term Survival Results From an Adaptive, Multiarm, Multistage, Platform, Randomized Controlled Trial Autor Mason, Malcolm D, Clarke, Noel W, James, Nicholas D, Dearnaley, David P, Spears, Melissa R, Ritchie, Alastair W S, Attard, Gerhardt, Cross, William, Jones, Rob J, Parker, Christopher C, Russell, J Martin, Thalmann, George N, Schiavone, Francesca, Cassoly, Estelle, Matheson, David, Millman, Robin, Rentsch, Cyrill A, Barber, Jim, Gilson, Clare, Ibrahim, Azman, Logue, John, Lydon, Anna, Nikapota, Ashok D, O'Sullivan, Joe M, Porfiri, Emilio, Protheroe, Andrew, Srihari, Narayanan Nair, Tsang, David, Wagstaff, John, Wallace, Jan, Walmsley, Catherine, Parmar, Mahesh K B, Sydes, Matthew R

“…Purpose Systemic Therapy for Advanced or Metastatic Prostate Cancer: Evaluation of Drug Efficacy is a randomized controlled trial using a multiarm, multistage,…”
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Failure-Free Survival and Radiotherapy in Patients With Newly Diagnosed Nonmetastatic Prostate Cancer: Data From Patients in the Control Arm of the STAMPEDE Trial Autor James, Nicholas D, Spears, Melissa R, Clarke, Noel W, Dearnaley, David P, Mason, Malcolm D, Parker, Christopher C, Ritchie, Alastair W S, Russell, J Martin, Schiavone, Francesca, Attard, Gerhardt, de Bono, Johann S, Birtle, Alison, Engeler, Daniel S, Elliott, Tony, Matheson, David, O'Sullivan, Joe, Pudney, Delia, Srihari, Narayanan, Wallace, Jan, Barber, Jim, Syndikus, Isabel, Parmar, Mahesh K B, Sydes, Matthew R

“…The natural history of patients with newly diagnosed high-risk nonmetastatic (M0) prostate cancer receiving hormone therapy (HT) either alone or with…”
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Testing many treatments within a single protocol over 10 years at MRC Clinical Trials Unit at UCL: Multi-arm, multi-stage platform, umbrella and basket protocols Autor Parmar, Mahesh Kb, Sydes, Matthew R, Cafferty, Fay H, Choodari-Oskooei, Babak, Langley, Ruth E, Brown, Louise, Phillips, Patrick Pj, Spears, Melissa R, Rowley, Sam, Kaplan, Richard, James, Nicholas D, Maughan, Timothy, Paton, Nicholas, Royston, Patrick J

“…There is real need to change how we do some of our clinical trials, as currently the testing and development process is too slow, too costly and too…”
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Service use in adolescents at risk of depression and self-harm: prospective longitudinal study Autor Sayal, Kapil, Yates, Nichola, Spears, Melissa, Stallard, Paul

“…Purpose Although depression and self-harm are common mental health problems in adolescents, there are barriers to accessing help. Using a community-based…”
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Combining Enzalutamide with Abiraterone, Prednisone, and Androgen Deprivation Therapy in the STAMPEDE Trial Autor Attard, Gerhardt, Sydes, Matthew R., Mason, Malcolm D., Clarke, Noel W., Aebersold, Daniel, de Bono, Johann S., Dearnaley, David P., Parker, Chris C., Ritchie, Alastair W.S., Russell, J. Martin, Thalmann, George, Cassoly, Estelle, Millman, Robin, Matheson, David, Schiavone, Francesca, Spears, Melissa R., Parmar, Mahesh K.B., James, Nicholas D.

“…There are compelling reasons to study the addition of both enzalutamide and abiraterone, in combination, to standard-of-care for hormone-naïve prostate cancer…”
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Could a brief assessment of negative emotions and self-esteem identify adolescents at current and future risk of self-harm in the community? A prospective cohort analysis Autor Phillips, Rhiannon, Spears, Melissa R, Montgomery, Alan A, Millings, Abigail, Sayal, Kapil, Stallard, Paul

“…Background Self-harm is common in adolescents, but it is often unreported and undetected. Available screening tools typically ask directly about self-harm and…”
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The relative importance of central and brachial blood pressure in predicting cardiovascular events: an individual participant meta-analysis of prospective observational data from 22,433 subjects Autor McEniery, Carmel, Ben-Shlomo, Yoav, May, Margaret, Spears, Melissa, Brumback, Lyndia, Cameron, James, Chen, Chen-Huan, Chirinos, Julio, Czarnecka, Danuta, Dart, Anthony, Devereux, Richard, Dhaun, Neeraj, Duprez, Daniel, Hwang, Shih-Jen, Jacobs, David, Jankowski, Piotr, Janner, Julie, Lacy, Peter, Mitchell, Gary, Pini, Riccardo

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2.1 THE RELATIVE IMPORTANCE OF CENTRAL AND BRACHIAL BLOOD PRESSURE IN PREDICTING CARDIOVASCULAR EVENTS: AN INDIVIDUAL PARTICIPANT META-ANALYSIS OF PROSPECTIVE OBSERVATIONAL DATA FROM 22,433 SUBJECTS Autor McEniery, Carmel, Ben-Shlomo, Yoav, May, Margaret, Spears, Melissa, Brumback, Lyndia, Cameron, James, Chen, Chen-Huan, Chirinos, Julio, Czarnecka, Danuta, Dart, Anthony, Devereux, Richard, Dhaun, Neeraj, Duprez, Daniel, Hwang, Shih-Jen, Jacobs, David, Jankowski, Piotr, Janner, Julie, Lacy, Peter, Mitchell, Gary, Pini, Riccardo

“…Systolic blood pressure (SBP) differs between the brachial artery and aorta. Prospective data suggest that central pressure predicts future cardiovascular…”
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School connectedness, peer attachment, and self-esteem as predictors of adolescent depression Autor Millings, Abigail, Buck, Rhiannon, Montgomery, Alan, Spears, Melissa, Stallard, Paul

“…Recent literature suggests that school connectedness (SC) may be a key determinant of adolescent mental health. Specifically, SC has been found to have a…”
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Abiraterone for Prostate Cancer Not Previously Treated with Hormone Therapy Autor James, Nicholas D, de Bono, Johann S, Spears, Melissa R, Clarke, Noel W, Mason, Malcolm D, Dearnaley, David P, Ritchie, Alastair W.S, Amos, Claire L, Gilson, Clare, Jones, Rob J, Matheson, David, Millman, Robin, Attard, Gerhardt, Chowdhury, Simon, Cross, William R, Gillessen, Silke, Parker, Christopher C, Russell, J. Martin, Berthold, Dominik R, Brawley, Chris, Adab, Fawzi, Aung, San, Birtle, Alison J, Bowen, Jo, Brock, Susannah, Chakraborti, Prabir, Ferguson, Catherine, Gale, Joanna, Gray, Emma, Hingorani, Mohan, Hoskin, Peter J, Lester, Jason F, Malik, Zafar I, McKinna, Fiona, McPhail, Neil, Money-Kyrle, Julian, O’Sullivan, Joe, Parikh, Omi, Protheroe, Andrew, Robinson, Angus, Srihari, Narayanan N, Thomas, Carys, Wagstaff, John, Wylie, James, Zarkar, Anjali, Parmar, Mahesh K.B, Sydes, Matthew R

“…The addition of abiraterone and prednisolone to standard androgen-deprivation therapy as the first treatment for patients with locally advanced or metastatic…”
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Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects Autor Ben-Shlomo, Yoav, Spears, Melissa, Boustred, Chris, May, Margaret, Anderson, Simon G, Benjamin, Emelia J, Boutouyrie, Pierre, Cameron, James, Chen, Chen-Huan, Cruickshank, J Kennedy, Hwang, Shih-Jen, Lakatta, Edward G, Laurent, Stephane, Maldonado, João, Mitchell, Gary F, Najjar, Samer S, Newman, Anne B, Ohishi, Mitsuru, Pannier, Bruno, Pereira, Telmo, Vasan, Ramachandran S, Shokawa, Tomoki, Sutton-Tyrell, Kim, Verbeke, Francis, Wang, Kang-Ling, Webb, David J, Willum Hansen, Tine, Zoungas, Sophia, McEniery, Carmel M, Cockcroft, John R, Wilkinson, Ian B

“…The goal of this study was to determine whether aortic pulse wave velocity (aPWV) improves prediction of cardiovascular disease (CVD) events beyond…”
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Self-harm in young adolescents (12–16 years): onset and short-term continuation in a community sample Autor Stallard, Paul, Spears, Melissa, Montgomery, Alan A, Phillips, Rhiannon, Sayal, Kapil

“…Background To investigate the prevalence of self-harm in young adolescents and factors associated with onset and continuity over a one year period. Method…”
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Self-management of fatigue in rheumatoid arthritis: a randomised controlled trial of group cognitive-behavioural therapy Autor Hewlett, Sarah, Ambler, Nick, Almeida, Celia, Cliss, Alena, Hammond, Alison, Kitchen, Karen, Knops, Bev, Pope, Denise, Spears, Melissa, Swinkels, Annette, Pollock, Jon

“…Objectives To investigate the effect of group cognitive behavioural therapy (CBT) for fatigue self-management, compared with groups receiving fatigue…”
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School intervention to improve mental health of students in Santiago, Chile: a randomized clinical trial Autor Araya, Ricardo, Fritsch, Rosemarie, Spears, Melissa, Rojas, Graciela, Martinez, Vania, Barroilhet, Sergio, Vöhringer, Paul, Gunnell, David, Stallard, Paul, Guajardo, Viviana, Gaete, Jorge, Noble, Sian, Montgomery, Alan A

“…Depression can have devastating effects unless prevented or treated early and effectively. Schools offer an excellent opportunity to intervene with adolescents…”
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Factors associated with the development of self-harm amongst a socio-economically deprived cohort of adolescents in Santiago, Chile Autor Spears, Melissa, Montgomery, Alan A., Gunnell, David, Araya, Ricardo

“…Purpose Studies carried out in the West indicate that the incidence of self-harm (SH) is particularly high amongst adolescents, but few studies have…”
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Abiraterone in Metastatic Prostate Cancer Autor de Bono, Johann, Eisenberger, Mario, Sartor, Oliver, Tannock, Ian F, Ismaili, Nabil, Guessous, Fadila, James, Nicholas D, Spears, Melissa R, Sydes, Matthew R, Fizazi, Karim, Chi, Kim N

“…To the Editor: Fizazi et al. (July 27 issue) 1 report on the LATITUDE trial, and in the same issue, James et al. 2 report on the Systemic Therapy in Advancing…”
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Cost-effectiveness of classroom-based cognitive behaviour therapy in reducing symptoms of depression in adolescents: a trial-based analysis Autor Anderson, Rob, Ukoumunne, Obioha C., Sayal, Kapil, Phillips, Rhiannon, Taylor, John A., Spears, Melissa, Araya, Ricardo, Lewis, Glyn, Millings, Abigail, Montgomery, Alan A., Stallard, Paul

“…Background A substantial minority of adolescents suffer from depression and it is associated with increased risk of suicide, social and educational impairment,…”
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