Výsledky vyhľadávania - "Sotgia, Federica"

Bedaquiline, an FDA-approved drug, inhibits mitochondrial ATP production and metastasis in vivo, by targeting the gamma subunit (ATP5F1C) of the ATP synthase Autor Fiorillo, Marco, Scatena, Cristian, Naccarato, Antonio Giuseppe, Sotgia, Federica, Lisanti, Michael P

“…Here, we provide evidence that high ATP production by the mitochondrial ATP-synthase is a new therapeutic target for anticancer therapy, especially for…”
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Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth Autor Martinez-Outschoorn, Ubaldo E., Lisanti, Michael P., Sotgia, Federica

“…Fibroblasts are the most abundant “non-cancerous” cells in tumors. However, it remains largely unknown how these cancer-associated fibroblasts (CAFs) promote…”
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Cancer metabolism: a therapeutic perspective Autor Martinez-Outschoorn, Ubaldo E., Peiris-Pagés, Maria, Pestell, Richard G., Sotgia, Federica, Lisanti, Michael P.

“…Key Points The metabolic ecology of tumours enables component cells to generate ATP, maintain redox balance, and undertake biosynthesis, which in turn support…”
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Tumor microenvironment and metabolic synergy in breast cancers: critical importance of mitochondrial fuels and function Autor Martinez-Outschoorn, Ubaldo, Sotgia, Federica, Lisanti, Michael P

“…Metabolic synergy or metabolic coupling between glycolytic stromal cells (Warburg effect) and oxidative cancer cells occurs in human breast cancers and…”
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High ATP Production Fuels Cancer Drug Resistance and Metastasis: Implications for Mitochondrial ATP Depletion Therapy Autor Fiorillo, Marco, Ózsvári, Béla, Sotgia, Federica, Lisanti, Michael P.

“…Recently, we presented evidence that high mitochondrial ATP production is a new therapeutic target for cancer treatment. Using ATP as a biomarker, we isolated…”
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Doxycycline, Azithromycin and Vitamin C (DAV): A potent combination therapy for targeting mitochondria and eradicating cancer stem cells (CSCs) Autor Fiorillo, Marco, Tóth, Fanni, Sotgia, Federica, Lisanti, Michael P

“…Here, we devised a new strategy for eradicating cancer stem cells (CSCs), via a "synthetic-metabolic" approach, involving two FDA-approved antibiotics and a…”
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Mitochondrial biomarkers predict tumor progression and poor overall survival in gastric cancers: Companion diagnostics for personalized medicine Autor Sotgia, Federica, Lisanti, Michael P

“…Here, we employed a bioinformatics approach to identify novel molecular determinants to predict tumor progression and overall survival in gastric cancer…”
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“Energetic” Cancer Stem Cells (e-CSCs): A New Hyper-Metabolic and Proliferative Tumor Cell Phenotype, Driven by Mitochondrial Energy Autor Fiorillo, Marco, Sotgia, Federica, Lisanti, Michael P.

“…Here, we provide the necessary evidence that mitochondrial metabolism drives the anchorage-independent proliferation of CSCs. Two human breast cancer cell…”
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Repurposing atovaquone: targeting mitochondrial complex III and OXPHOS to eradicate cancer stem cells Autor Fiorillo, Marco, Lamb, Rebecca, Tanowitz, Herbert B, Mutti, Luciano, Krstic-Demonacos, Marija, Cappello, Anna Rita, Martinez-Outschoorn, Ubaldo E, Sotgia, Federica, Lisanti, Michael P

“…Atovaquone is an FDA-approved anti-malarial drug, which first became clinically available in the year 2000. Currently, its main usage is for the treatment of…”
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Mitochondria as new therapeutic targets for eradicating cancer stem cells: Quantitative proteomics and functional validation via MCT1/2 inhibition Autor Lamb, Rebecca, Harrison, Hannah, Hulit, James, Smith, Duncan L, Lisanti, Michael P, Sotgia, Federica

“…Here, we used quantitative proteomics analysis to identify novel therapeutic targets in cancer stem cells and/or progenitor cells. For this purpose,…”
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Mitochondrial oxidative stress drives tumor progression and metastasis: should we use antioxidants as a key component of cancer treatment and prevention? Autor Sotgia, Federica, Martinez-Outschoorn, Ubaldo E, Lisanti, Michael P

“…The functional role of oxidative stress in cancer pathogenesis has long been a hotly debated topic. A study published this month in BMC Cancer by Goh et al. ,…”
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Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: Connecting TGF-β signaling with "Warburg-like" cancer metabolism and L-lactate production Autor Guido, Carmela, Whitaker-Menezes, Diana, Capparelli, Claudia, Balliet, Renee, Lin, Zhao, Pestell, Richard G., Howell, Anthony, Aquila, Saveria, Andò, Sebastiano, Martinez-Outschoorn, Ubaldo, Sotgia, Federica, Lisanti, Michael P.

“…We have previously shown that a loss of stromal Cav-1 is a biomarker of poor prognosis in breast cancers. Mechanistically, a loss of Cav-1 induces the…”
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Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs) Autor De Francesco, Ernestina Marianna, Bonuccelli, Gloria, Maggiolini, Marcello, Sotgia, Federica, Lisanti, Michael P

“…Here, we developed a new synthetic lethal strategy for further optimizing the eradication of cancer stem cells (CSCs). Briefly, we show that chronic treatment…”
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Ketone body utilization drives tumor growth and metastasis Autor Martinez-Outschoorn, Ubaldo E., Lin, Zhao, Whitaker-Menezes, Diana, Howell, Anthony, Sotgia, Federica, Lisanti, Michael P.

“…We have previously proposed that catabolic fibroblasts generate mitochondrial fuels (such as ketone bodies) to promote the anabolic growth of human cancer…”
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Oncogenes induce the cancer-associated fibroblast phenotype: Metabolic symbiosis and "fibroblast addiction" are new therapeutic targets for drug discovery Autor Lisanti, Michael P., Martinez-Outschoorn, Ubaldo E., Sotgia, Federica

“…Metabolic coupling, between mitochondria in cancer cells and catabolism in stromal fibroblasts, promotes tumor growth, recurrence, metastasis, and predicts…”
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Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells Autor De Luca, Arianna, Fiorillo, Marco, Peiris-Pagès, Maria, Ozsvari, Bela, Smith, Duncan L, Sanchez-Alvarez, Rosa, Martinez-Outschoorn, Ubaldo E, Cappello, Anna Rita, Pezzi, Vincenzo, Lisanti, Michael P, Sotgia, Federica

“…Here, we show that new mitochondrial biogenesis is required for the anchorage independent survival and propagation of cancer stem-like cells (CSCs). More…”
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GPER mediates the angiocrine actions induced by IGF1 through the HIF-1α/VEGF pathway in the breast tumor microenvironment Autor De Francesco, Ernestina M., Sims, Andrew H., Maggiolini, Marcello, Sotgia, Federica, Lisanti, Michael P., Clarke, Robert B.

“…Background The G protein estrogen receptor GPER/GPR30 mediates estrogen action in breast cancer cells as well as in breast cancer-associated fibroblasts…”
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Role of cholesterol in the development and progression of breast cancer Autor Llaverias, Gemma, Danilo, Christiane, Mercier, Isabelle, Daumer, Kristin, Capozza, Franco, Williams, Terence M, Sotgia, Federica, Lisanti, Michael P, Frank, Philippe G

“…Diet and obesity are important risk factors for cancer development. Many studies have suggested an important role for several dietary nutrients in the…”
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Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism Autor Bonuccelli, Gloria, Tsirigos, Aristotelis, Whitaker-Menezes, Diana, Pavlides, Stephanos, Pestell, Richard G., Chiavarina, Barbara, Frank, Philippe G., Flomenberg, Neal, Howell, Anthony, Martinez-Outschoorn, Ubaldo E., Sotgia, Federica, Lisanti, Michael P.

“…Previously, we proposed a new model for understanding the "Warburg effect" in tumor metabolism. In this scheme, cancer-associated fibroblasts undergo aerobic…”
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The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma Autor Pavlides, Stephanos, Whitaker-Menezes, Diana, Castello-Cros, Remedios, Flomenberg, Neal, Witkiewicz, Agnieszka K., Frank, Philippe G., Casimiro, Mathew C., Wang, Chenguang, Fortina, Paolo, Addya, Sankar, Pestell, Richard G., Martinez-Outschoorn, Ubaldo E., Sotgia, Federica, Lisanti, Michael P.

“…Here, we propose a new model for understanding the Warburg effect in tumor metabolism.  Our hypothesis is that epithelial cancer cells induce the Warburg…”
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