Výsledky vyhľadávania - "Sopp, Paul"

Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia Autor Giustacchini, Alice, Thongjuea, Supat, Barkas, Nikolaos, Woll, Petter S, Povinelli, Benjamin J, Booth, Christopher A G, Sopp, Paul, Norfo, Ruggiero, Rodriguez-Meira, Alba, Ashley, Neil, Jamieson, Lauren, Vyas, Paresh, Anderson, Kristina, Segerstolpe, Åsa, Qian, Hong, Olsson-Strömberg, Ulla, Mustjoki, Satu, Sandberg, Rickard, Jacobsen, Sten Eirik W, Mead, Adam J

“…Applying a new, more sensitive single-cell transcriptomics method to diagnosis, remission and progression samples from patients with chronic myeloid leukemia…”
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Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia Autor Mettananda, Sachith, Fisher, Chris A., Hay, Deborah, Badat, Mohsin, Quek, Lynn, Clark, Kevin, Hublitz, Philip, Downes, Damien, Kerry, Jon, Gosden, Matthew, Telenius, Jelena, Sloane-Stanley, Jackie A., Faustino, Paula, Coelho, Andreia, Doondeea, Jessica, Usukhbayar, Batchimeg, Sopp, Paul, Sharpe, Jacqueline A., Hughes, Jim R., Vyas, Paresh, Gibbons, Richard J., Higgs, Douglas R.

“…β-Thalassemia is one of the most common inherited anemias, with no effective cure for most patients. The pathophysiology reflects an imbalance between α- and…”
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Assessing similarity to primary tissue and cortical layer identity in induced pluripotent stem cell-derived cortical neurons through single-cell transcriptomics Autor Handel, Adam E, Chintawar, Satyan, Lalic, Tatjana, Whiteley, Emma, Vowles, Jane, Giustacchini, Alice, Argoud, Karene, Sopp, Paul, Nakanishi, Mahito, Bowden, Rory, Cowley, Sally, Newey, Sarah, Akerman, Colin, Ponting, Chris P, Cader, M Zameel

“…Induced pluripotent stem cell (iPSC)-derived cortical neurons potentially present a powerful new model to understand corticogenesis and neurological disease…”
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Phenotypic characterisation of bovine alveolar macrophages reveals two major subsets with differential expression of CD163 Autor Randall, Emily M., Sopp, Paul, Raper, Anna, Dry, Inga, Burdon, Tom, Hope, Jayne C., Waddell, Lindsey A.

“…Bovine alveolar macrophages (AMs) defend the lungs against pathogens such as Mycobacterium bovis ( M. bovis) , the causative agent of bovine tuberculosis…”
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Long-persisting SARS-CoV-2 spike-specific CD4+ T cells associated with mild disease and increased cytotoxicity post COVID-19 Autor Liu, Guihai, Antoun, Elie, Fries, Anastasia, Yao, Xuan, Yin, Zixi, Dong, Danning, Wang, Wenbo, Wing, Peter A. C., Dejnirattisa, Wanwisa, Supasa, Piyada, Liu, Chang, Rostron, Timothy, Waugh, Craig, Clark, Kevin, Sopp, Paul, Fry, Jeremy W., Vendrell, Iolanda, McKeating, Jane A., Mongkolsapaya, Juthathip, Screaton, Gavin R., Kessler, Benedikt M., Fisher, Roman, Ogg, Graham, Mentzer, Alexander J., Knight, Julian C., Peng, Yanchun, Dong, Tao

“…The recent COVID-19 pandemic left behind the lingering question as whether new variants of concern might cause further waves of infection. Thus, it is…”
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SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells Autor Chagraoui, Hedia, Kristiansen, Maiken S., Ruiz, Juan Pablo, Serra-Barros, Ana, Richter, Johanna, Hall-Ponselé, Elisa, Gray, Nicki, Waithe, Dominic, Clark, Kevin, Hublitz, Philip, Repapi, Emmanouela, Otto, Georg, Sopp, Paul, Taylor, Stephen, Thongjuea, Supat, Vyas, Paresh, Porcher, Catherine

“…During development, it is unclear if lineage-fated cells derive from multilineage-primed progenitors and whether active mechanisms operate to restrict cell…”
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A Comprehensive Analysis of Key Immune Checkpoint Receptors on Tumor-Infiltrating T Cells From Multiple Types of Cancer Autor Li, Xi, Wang, Rouzheng, Fan, Peiwen, Yao, Xuan, Qin, Ling, Peng, Yanchun, Ma, Miaomiao, Asley, Neil, Chang, Xuimei, Feng, Yaning, Hu, Yunhui, Zhang, Yonghong, Li, Chris, Fanning, Gregory, Jones, Stephanie, Verrill, Clare, Maldonado-Perez, David, Sopp, Paul, Waugh, Craig, Taylor, Stephen, Mcgowan, Simon, Cerundolo, Vincenzo, Conlon, Christopher, McMichael, Andrew, Lu, Shichun, Wang, Xiyan, Li, Ning, Dong, Tao

“…Cancer patients often display dysfunctional antitumor T-cell responses. Because noteworthy benefits of immune checkpoint pathway blockade, such as programmed…”
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Evaluation of T cell responses to naturally processed variant SARS-CoV-2 spike antigens in individuals following infection or vaccination Autor Yin, Zixi, Chen, Ji-Li, Lu, Yongxu, Wang, Beibei, Godfrey, Leila, Mentzer, Alexander J., Yao, Xuan, Liu, Guihai, Wellington, Dannielle, Zhao, Yiqi, Wing, Peter A.C., Dejnirattisa, Wanwisa, Supasa, Piyada, Liu, Chang, Hublitz, Philip, Beveridge, Ryan, Waugh, Craig, Clark, Sally-Ann, Clark, Kevin, Sopp, Paul, Rostron, Timothy, Mongkolsapaya, Juthathip, Screaton, Gavin R., Ogg, Graham, Ewer, Katie, Pollard, Andrew J., Gilbert, Sarah, Knight, Julian C., Lambe, Teresa, Smith, Geoffrey L., Dong, Tao, Peng, Yanchun

“…Most existing studies characterizing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cell responses are peptide based. This does not…”
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Tumor-specific CD8 T cell characterization in HR+ breast cancer reveals an impaired antitumoral response in patients with lymph node metastasis Autor Pinho, Mariana Pereira, Antoun, Elie, Sandhar, Balraj, Shu, Ting, Gao, Fei, Yang, Xiaobao, Bates, Adam, Cerundolo, Lucia, Hamid, Megat H.B.A., Maldonado-Perez, David, Teague, Renuka, Warner, Eve, Winter, Lucinda, Alham, Nasullah Khalid, Verrill, Clare, Lord, Simon R., Rostron, Timothy, Clark, Sally-Ann, Waugh, Craig, Sopp, Paul, Conlon, Chris, Fernandes, Ricardo A., Harris, Adrian L., Peng, Yanchun, Adwani, Asha, Dong, Tao

“…Most breast cancers express the estrogen receptor (ER), but the immune response of hormone receptor-positive (HR+) breast cancer remains poorly characterized…”
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Natural killer cell number and phenotype in bovine peripheral blood is influenced by age Autor Graham, Elizabeth M., Thom, Michelle L., Howard, Chris J., Boysen, Preben, Storset, Anne K., Sopp, Paul, Hope, Jayne C.

“…Natural killer (NK) cells are critical to the innate defence against intracellular infection. High NK cell frequencies have been detected in human neonates,…”
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Summary of the animal homologue section of HLDA8 Autor Saalmüller, Armin, Lunney, Joan K., Daubenberger, Claudia, Davis, William, Fischer, Uwe, Göbel, Thomas W., Griebel, Phil, Hollemweguer, Enoc, Lasco, Todd, Meister, Richard, Schuberth, Hans-Joachim, Sestak, Karol, Sopp, Paul, Steinbach, Falko, Xiao-Wei, Wu, Aasted, Bent

“…Development of reagents against leukocyte differentiation antigens in veterinary immunology is slower compared to humans and mice. Cross-reactivity studies…”
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NK-like CD8+ cells in immunologically naïve neonatal calves that respond to dendritic cells infected with Mycobacterium bovis BCG Autor Hope, Jayne C., Sopp, Paul, Howard, Chris J.

“…Pre‐exposure to environmental mycobacteria and induction of an inappropriately biased immune response may be major factors affecting the efficacy of BCG;…”
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Differences in the induction of CD8+ T cell responses by subpopulations of dendritic cells from afferent lymph are related to IL-1α secretion Autor Hope, Jayne C., Sopp, Paul, Collins, Robert A, Howard, Chris J.

“…The major subset of dendritic cells (DC) from bovine afferent lymph expresses the SIRPα MyD‐1 antigen, but not CD11a or the antigen recognized by mAb CC81, and…”
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GTAC enables parallel genotyping of multiple genomic loci with chromatin accessibility profiling in single cells Autor Turkalj, Sven, Jakobsen, Niels Asger, Groom, Angus, Metzner, Marlen, Riva, Simone G, Gür, E Ravza, Usukhbayar, Batchimeg, Salazar, Mirian Angulo, Hentges, Lance D, Mickute, Gerda, Clark, Kevin, Sopp, Paul, Davies, James O J, Hughes, Jim R, Vyas, Paresh

“…Understanding clonal evolution and cancer development requires experimental approaches for characterizing the consequences of somatic mutations on gene…”
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T cell memory response to MPXV infection exhibits greater effector function and migratory potential compared to MVA-BN vaccination Autor Chen, Ji-Li, Wang, Beibei, Lu, Yongxu, Antoun, Elie, Bird, Olivia, Drennan, Philip G., Yin, Zixi, Liu, Guihai, Yao, Xuan, Pidoux, Maya, Bates, Adam, Jayathilaka, Deshni, Wang, Junyuan, Angus, Brian, Beer, Sally, Espinosa, Alexis, Baillie, J. Kenneth, Semple, Malcolm G., Rostron, Timothy, Waugh, Craig, Sopp, Paul, Knight, Julian C., Fullerton, James N., Coles, Mark, Smith, Geoffrey L., Mentzer, Alexander J., Peng, Yanchun, Dong, Tao

“…In 2022, a global mpox outbreak occurred, and remains a concern today. The T cell memory response to MPXV (monkeypox virus) infection has not been fully…”
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Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity Autor Hamid, Megat H. B. A., Cespedes, Pablo F., Jin, Chen, Chen, Ji-Li, Gileadi, Uzi, Antoun, Elie, Liang, Zhu, Gao, Fei, Teague, Renuka, Manoharan, Nikita, Maldonado-Perez, David, Khalid-Alham, Nasullah, Cerundolo, Lucia, Ciaoca, Raul, Hester, Svenja S., Pinto-Fernández, Adán, Draganov, Simeon D., Vendrell, Iolanda, Liu, Guihai, Yao, Xuan, Kvalvaag, Audun, Dominey-Foy, Delaney C. C., Nanayakkara, Charunya, Kanellakis, Nikolaos, Chen, Yi-Ling, Waugh, Craig, Clark, Sally-Ann, Clark, Kevin, Sopp, Paul, Rahman, Najib M., Verrill, Clare, Kessler, Benedikt M., Ogg, Graham, Fernandes, Ricardo A., Fisher, Roman, Peng, Yanchun, Dustin, Michael L., Dong, Tao

“…Cancer remains one of the leading causes of mortality worldwide, leading to increased interest in utilizing immunotherapy strategies for better cancer…”
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A toolbox facilitating stable transfection of Eimeria species Autor Clark, Julie D., Billington, Karen, Bumstead, Janene M., Oakes, Richard D., Soon, Puay Eng, Sopp, Paul, Tomley, Fiona M., Blake, Damer P.

“…Stable transfection of Eimeria species has been difficult to achieve because of the obligate requirement for in vivo amplification and selection of the…”
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Subset-Specific Expression of Toll-Like Receptors by Bovine Afferent Lymph Dendritic Cells Autor Werling, Dirk, Hope, Jayne C., Siddiqui, Nazneen, Widdison, Stephanie, Russell, Chris, Sopp, Paul, Coffey, Tracey J.

“…Within the ruminant system, several possibilities exist to generate dendritic cells migrating out from the tissue into the regional draining lymph nodes as…”
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Workshop cluster 1+γδ T‐cell receptor+ T cells from calves express high levels of interferon‐γ in response to stimulation with interleukin‐12 and ‐18 Autor Price, Sally J., Sopp, Paul, Howard, Christopher J., Hope, Jayne C.

“…Summary γδ T‐cell receptor+ T lymphocytes are an important element of the innate immune system. Early production of interferon (IFN)‐γ by γδ T cells may have a…”
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An immunodominant NP 105-113 -B07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease Autor Peng, Yanchun, Felce, Suet Ling, Dong, Danning, Penkava, Frank, Mentzer, Alexander J, Yao, Xuan, Liu, Guihai, Yin, Zixi, Chen, Ji-Li, Lu, Yongxu, Wellington, Dannielle, Wing, Peter A C, Dominey-Foy, Delaney C C, Jin, Chen, Wang, Wenbo, Hamid, Megat Abd, Fernandes, Ricardo A, Wang, Beibei, Fries, Anastasia, Zhuang, Xiaodong, Ashley, Neil, Rostron, Timothy, Waugh, Craig, Sopp, Paul, Hublitz, Philip, Beveridge, Ryan, Tan, Tiong Kit, Dold, Christina, Kwok, Andrew J, Rich-Griffin, Charlotte, Dejnirattisa, Wanwisa, Liu, Chang, Kurupati, Prathiba, Nassiri, Isar, Watson, Robert A, Tong, Orion, Taylor, Chelsea A, Kumar Sharma, Piyush, Sun, Bo, Curion, Fabiola, Revale, Santiago, Garner, Lucy C, Jansen, Kathrin, Ferreira, Ricardo C, Attar, Moustafa, Fry, Jeremy W, Russell, Rebecca A, Stauss, Hans J, James, William, Townsend, Alain, Ho, Ling-Pei, Klenerman, Paul, Mongkolsapaya, Juthathip, Screaton, Gavin R, Dendrou, Calliope, Sansom, Stephen N, Bashford-Rogers, Rachael, Chain, Benny, Smith, Geoffrey L, McKeating, Jane A, Fairfax, Benjamin P, Bowness, Paul, McMichael, Andrew J, Ogg, Graham, Knight, Julian C, Dong, Tao

“…NP -B*07:02-specific CD8 T cell responses are considered among the most dominant in SARS-CoV-2-infected individuals. We found strong association of this…”
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