Suchergebnisse - "Snyder, Michael P"

High-throughput sequencing technologies von Reuter, Jason A, Spacek, Damek V, Snyder, Michael P

“… The human genome sequence has profoundly altered our understanding of biology, human diversity, and disease. The path from the first draft sequence to our …”
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Digital Health: Tracking Physiomes and Activity Using Wearable Biosensors Reveals Useful Health-Related Information von Li, Xiao, Dunn, Jessilyn, Salins, Denis, Zhou, Gao, Zhou, Wenyu, Schüssler-Fiorenza Rose, Sophia Miryam, Perelman, Dalia, Colbert, Elizabeth, Runge, Ryan, Rego, Shannon, Sonecha, Ria, Datta, Somalee, McLaughlin, Tracey, Snyder, Michael P.

“… A new wave of portable biosensors allows frequent measurement of health-related physiology. We investigated the use of these devices to monitor human …”
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Nonlinear dynamics of multi-omics profiles during human aging von Shen, Xiaotao, Wang, Chuchu, Zhou, Xin, Zhou, Wenyu, Hornburg, Daniel, Wu, Si, Snyder, Michael P.

“… Aging is a complex process associated with nearly all diseases. Understanding the molecular changes underlying aging and identifying therapeutic targets for …”
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The Integrative Human Microbiome Project von Proctor, Lita M., Creasy, Heather H., Fettweis, Jennifer M., Lloyd-Price, Jason, Mahurkar, Anup, Zhou, Wenyu, Buck, Gregory A., Snyder, Michael P., Strauss, Jerome F., Weinstock, George M., White, Owen, Huttenhower, Curtis

“… The NIH Human Microbiome Project (HMP) has been carried out over ten years and two phases to provide resources, methods, and discoveries that link interactions …”
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Biomarkers of aging for the identification and evaluation of longevity interventions von Moqri, Mahdi, Herzog, Chiara, Poganik, Jesse R, Justice, Jamie, Belsky, Daniel W, Higgins-Chen, Albert, Moskalev, Alexey, Fuellen, Georg, Cohen, Alan A, Bautmans, Ivan, Widschwendter, Martin, Ding, Jingzhong, Fleming, Alexander, Mannick, Joan, Han, Jing-Dong Jackie, Zhavoronkov, Alex, Barzilai, Nir, Kaeberlein, Matt, Cummings, Steven, Kennedy, Brian K, Ferrucci, Luigi, Horvath, Steve, Verdin, Eric, Maier, Andrea B, Snyder, Michael P, Sebastiano, Vittorio, Gladyshev, Vadim N

“… With the rapid expansion of aging biology research, the identification and evaluation of longevity interventions in humans have become key goals of this field …”
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Widespread contribution of transposable elements to the innovation of gene regulatory networks von Sundaram, Vasavi, Cheng, Yong, Ma, Zhihai, Li, Daofeng, Xing, Xiaoyun, Edge, Peter, Snyder, Michael P, Wang, Ting

“… Transposable elements (TEs) have been shown to contain functional binding sites for certain transcription factors (TFs). However, the extent to which TEs …”
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High‐throughput sequencing for biology and medicine von Soon, Wendy Weijia, Hariharan, Manoj, Snyder, Michael P

“… Advances in genome sequencing have progressed at a rapid pace, with increased throughput accompanied by plunging costs. But these advances go far beyond faster …”
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Defining a personal, allele-specific, and single-molecule long-read transcriptome von Tilgner, Hagen, Grubert, Fabian, Sharon, Donald, Snyder, Michael P

“… Personal transcriptomes in which all of an individual's genetic variants (e.g., single nucleotide variants) and transcript isoforms (transcription start sites, …”
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COVID-19-Induced New-Onset Diabetes: Trends and Technologies von Metwally, Ahmed A, Mehta, Pranav, Johnson, Brian S, Nagarjuna, Anvith, Snyder, Michael P

“… The coronavirus disease 2019 (COVID-19) global pandemic continues to spread worldwide with approximately 216 million confirmed cases and 4.49 million deaths to …”
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Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution von Corces, M Ryan, Buenrostro, Jason D, Wu, Beijing, Greenside, Peyton G, Chan, Steven M, Koenig, Julie L, Snyder, Michael P, Pritchard, Jonathan K, Kundaje, Anshul, Greenleaf, William J, Majeti, Ravindra, Chang, Howard Y

“… Howard Chang, Ravindra Majeti and colleagues define the chromatin accessibility and transcriptional landscapes in 13 human primary blood cell types and in …”
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Circular DNA elements of chromosomal origin are common in healthy human somatic tissue von Møller, Henrik Devitt, Mohiyuddin, Marghoob, Prada-Luengo, Iñigo, Sailani, M. Reza, Halling, Jens Frey, Plomgaard, Peter, Maretty, Lasse, Hansen, Anders Johannes, Snyder, Michael P., Pilegaard, Henriette, Lam, Hugo Y. K., Regenberg, Birgitte

“… The human genome is generally organized into stable chromosomes, and only tumor cells are known to accumulate kilobase (kb)-sized extrachromosomal circular DNA …”
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Altered Cardiac Energetics and Mitochondrial Dysfunction in Hypertrophic Cardiomyopathy von Ranjbarvaziri, Sara, Kooiker, Kristina B, Ellenberger, Mathew, Fajardo, Giovanni, Zhao, Mingming, Vander Roest, Alison Schroer, Woldeyes, Rahel A, Koyano, Tiffany T, Fong, Robyn, Ma, Ning, Tian, Lei, Traber, Gavin M, Chan, Frandics, Perrino, John, Reddy, Sushma, Chiu, Wah, Wu, Joseph C, Woo, Joseph Y, Ruppel, Kathleen M, Spudich, James A, Snyder, Michael P, Contrepois, Kévin, Bernstein, Daniel

“… Hypertrophic cardiomyopathy (HCM) is a complex disease partly explained by the effects of individual gene variants on sarcomeric protein biomechanics. At the …”
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H3K4me3 breadth is linked to cell identity and transcriptional consistency von Benayoun, Bérénice A, Pollina, Elizabeth A, Ucar, Duygu, Mahmoudi, Salah, Karra, Kalpana, Wong, Edith D, Devarajan, Keerthana, Daugherty, Aaron C, Kundaje, Anshul B, Mancini, Elena, Hitz, Benjamin C, Gupta, Rakhi, Rando, Thomas A, Baker, Julie C, Snyder, Michael P, Cherry, J Michael, Brunet, Anne

“… Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to mark the transcription start sites of active genes. Here, we show that …”
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TidyMass an object-oriented reproducible analysis framework for LC–MS data von Shen, Xiaotao, Yan, Hong, Wang, Chuchu, Gao, Peng, Johnson, Caroline H., Snyder, Michael P.

“… Reproducibility, traceability, and transparency have been long-standing issues for metabolomics data analysis. Multiple tools have been developed, but …”
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Leveraging physiology and artificial intelligence to deliver advancements in health care von Zhang, Angela, Wu, Zhenqin, Wu, Eric, Wu, Matthew, Snyder, Michael P, Zou, James, Wu, Joseph C

“… Artificial intelligence in health care has experienced remarkable innovation and progress in the last decade. Significant advancements can be attributed to the …”
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Landscape and variation of RNA secondary structure across the human transcriptome von Wan, Yue, Qu, Kun, Zhang, Qiangfeng Cliff, Flynn, Ryan A., Manor, Ohad, Ouyang, Zhengqing, Zhang, Jiajing, Spitale, Robert C., Snyder, Michael P., Segal, Eran, Chang, Howard Y.

“… An RNA secondary structure (RSS) map of coding and noncoding RNA from a human family (two parents and their child) is produced; this reveals that approximately …”
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Static and Dynamic DNA Loops form AP-1-Bound Activation Hubs during Macrophage Development von Phanstiel, Douglas H, Van Bortle, Kevin, Spacek, Damek, Hess, Gaelen T, Shamim, Muhammad Saad, Machol, Ido, Love, Michael I, Aiden, Erez Lieberman, Bassik, Michael C, Snyder, Michael P

“… The three-dimensional arrangement of the human genome comprises a complex network of structural and regulatory chromatin loops important for coordinating …”
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Gaining comprehensive biological insight into the transcriptome by performing a broad-spectrum RNA-seq analysis von Sahraeian, Sayed Mohammad Ebrahim, Mohiyuddin, Marghoob, Sebra, Robert, Tilgner, Hagen, Afshar, Pegah T., Au, Kin Fai, Bani Asadi, Narges, Gerstein, Mark B., Wong, Wing Hung, Snyder, Michael P., Schadt, Eric, Lam, Hugo Y. K.

“… RNA-sequencing (RNA-seq) is an essential technique for transcriptome studies, hundreds of analysis tools have been developed since it was debuted. Although …”
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The gut microbiome: a key player in the complexity of amyotrophic lateral sclerosis (ALS) von Boddy, Sarah L., Giovannelli, Ilaria, Sassani, Matilde, Cooper-Knock, Johnathan, Snyder, Michael P., Segal, Eran, Elinav, Eran, Barker, Lynne A., Shaw, Pamela J., McDermott, Christopher J.

“… Background Much progress has been made in mapping genetic abnormalities linked to amyotrophic lateral sclerosis (ALS), but the majority of cases still present …”
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Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens von Morgens, David W., Wainberg, Michael, Boyle, Evan A., Ursu, Oana, Araya, Carlos L., Tsui, C. Kimberly, Haney, Michael S., Hess, Gaelen T., Han, Kyuho, Jeng, Edwin E., Li, Amy, Snyder, Michael P., Greenleaf, William J., Kundaje, Anshul, Bassik, Michael C.

“… CRISPR-Cas9 screens are powerful tools for high-throughput interrogation of genome function, but can be confounded by nuclease-induced toxicity at both on- and …”
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