Výsledky vyhľadávania - "Smith, Albert V"

Heterogeneity in White Blood Cells Has Potential to Confound DNA Methylation Measurements Autor Adalsteinsson, Bjorn T., Gudnason, Haukur, Aspelund, Thor, Harris, Tamara B., Launer, Lenore J., Eiriksdottir, Gudny, Smith, Albert V., Gudnason, Vilmundur

“…Epigenetic studies are commonly conducted on DNA from tissue samples. However, tissues are ensembles of cells that may each have their own epigenetic profile,…”
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Tutorial: a statistical genetics guide to identifying HLA alleles driving complex disease Autor Sakaue, Saori, Gurajala, Saisriram, Curtis, Michelle, Luo, Yang, Choi, Wanson, Ishigaki, Kazuyoshi, Kang, Joyce B., Rumker, Laurie, Deutsch, Aaron J., Schönherr, Sebastian, Forer, Lukas, LeFaive, Jonathon, Fuchsberger, Christian, Han, Buhm, Lenz, Tobias L., de Bakker, Paul I. W., Okada, Yukinori, Smith, Albert V., Raychaudhuri, Soumya

“…The human leukocyte antigen (HLA) locus is associated with more complex diseases than any other locus in the human genome. In many diseases, HLA explains more…”
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FixItFelix: improving genomic analysis by fixing reference errors Autor Behera, Sairam, LeFaive, Jonathon, Orchard, Peter, Mahmoud, Medhat, Paulin, Luis F., Farek, Jesse, Soto, Daniela C., Parker, Stephen C. J., Smith, Albert V., Dennis, Megan Y., Zook, Justin M., Sedlazeck, Fritz J.

“…The current version of the human reference genome, GRCh38, contains a number of errors including 1.2 Mbp of falsely duplicated and 8.04 Mbp of collapsed…”
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Meta-analysis of genome-wide association data identifies two loci influencing age at menarche Autor Perry, John R B, Stolk, Lisette, Franceschini, Nora, Lunetta, Kathryn L, Zhai, Guangju, McArdle, Patrick F, Smith, Albert V, Aspelund, Thor, Bandinelli, Stefania, Boerwinkle, Eric, Cherkas, Lynn, Eiriksdottir, Gudny, Estrada, Karol, Ferrucci, Luigi, Folsom, Aaron R, Garcia, Melissa, Gudnason, Vilmundur, Hofman, Albert, Karasik, David, Kiel, Douglas P, Launer, Lenore J, van Meurs, Joyce, Nalls, Michael A, Rivadeneira, Fernando, Shuldiner, Alan R, Singleton, Andrew, Soranzo, Nicole, Tanaka, Toshiko, Visser, Jenny A, Weedon, Michael N, Wilson, Scott G, Zhuang, Vivian, Streeten, Elizabeth A, Harris, Tamara B, Murray, Anna, Spector, Tim D, Demerath, Ellen W, Uitterlinden, André G, Murabito, Joanne M

“…André Uitterlinden and colleagues report loci at 9q31.2 and LIN28B associated with age at menarche from a meta-analysis of genome-wide association studies…”
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Association of Triglyceride-Related Genetic Variants With Mitral Annular Calcification Autor Afshar, Mehdi, Luk, Kevin, Do, Ron, Dufresne, Line, Owens, David S, Harris, Tamara B, Peloso, Gina M, Kerr, Kathleen F, Wong, Quenna, Smith, Albert V, Budoff, Mathew J, Rotter, Jerome I, Cupples, L Adrienne, Rich, Stephen S, Engert, James C, Gudnason, Vilmundur, O'Donnell, Christopher J, Post, Wendy S, Thanassoulis, George

“…Mitral annular calcium (MAC), commonly identified by cardiac imaging, is associated with cardiovascular events and predisposes to the development of clinically…”
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A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium Autor Newman, Anne B, Walter, Stefan, Lunetta, Kathryn L, Garcia, Melissa E, Slagboom, P Eline, Christensen, Kaare, Arnold, Alice M, Aspelund, Thor, Aulchenko, Yurii S, Benjamin, Emelia J, Christiansen, Lene, D'Agostino, Sr, Ralph B, Fitzpatrick, Annette L, Franceschini, Nora, Glazer, Nicole L, Gudnason, Vilmundur, Hofman, Albert, Kaplan, Robert, Karasik, David, Kelly-Hayes, Margaret, Kiel, Douglas P, Launer, Lenore J, Marciante, Kristin D, Massaro, Joseph M, Miljkovic, Iva, Nalls, Michael A, Hernandez, Dena, Psaty, Bruce M, Rivadeneira, Fernando, Rotter, Jerome, Seshadri, Sudha, Smith, Albert V, Taylor, Kent D, Tiemeier, Henning, Uh, Hae-Won, Uitterlinden, André G, Vaupel, James W, Walston, Jeremy, Westendorp, Rudi G J, Harris, Tamara B, Lumley, Thomas, van Duijn, Cornelia M, Murabito, Joanne M

“…Genome-wide association studies (GWAS) may yield insights into longevity. We performed a meta-analysis of GWAS in Caucasians from four prospective cohort…”
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Association of Lipid-Related Genetic Variants with the Incidence of Atrial Fibrillation: The AFGen Consortium Autor Norby, Faye L., Eryd, Samuel Adamsson, Niemeijer, Maartje N., Rose, Lynda M., Smith, Albert V., Yin, Xiaoyan, Agarwal, Sunil K., Arking, Dan E., Chasman, Daniel L., Chen, Lin Y., Eijgelsheim, Mark, Engström, Gunnar, Franco, Oscar H., Heeringa, Jan, Hindy, George, Hofman, Albert, Lutsey, Pamela L., Magnani, Jared W., McManus, David D., Orho-Melander, Marju, Pankow, James S., Rukh, Gull, Schulz, Christina-Alexandra, Uitterlinden, André G., Albert, Christine M., Benjamin, Emelia J., Gudnason, Vilmundur, Smith, J. Gustav, Stricker, Bruno H. C., Alonso, Alvaro

“…Several studies have shown associations between blood lipid levels and the risk of atrial fibrillation (AF). To test the potential effect of blood lipids with…”
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GAWMerge expands GWAS sample size and diversity by combining array-based genotyping and whole-genome sequencing Autor Mathur, Ravi, Fang, Fang, Gaddis, Nathan, Hancock, Dana B., Cho, Michael H., Hokanson, John E., Bierut, Laura J., Lutz, Sharon M., Young, Kendra, Smith, Albert V., Silverman, Edwin K., Page, Grier P., Johnson, Eric O.

“…Genome-wide association studies (GWAS) have made impactful discoveries for complex diseases, often by amassing very large sample sizes. Yet, GWAS of many…”
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Accounting for population structure in genetic studies of cystic fibrosis Autor Kingston, Hanley, Stilp, Adrienne M., Gordon, William, Broome, Jai, Gogarten, Stephanie M., Ling, Hua, Barnard, John, Dugan-Perez, Shannon, Ellinor, Patrick T., Gabriel, Stacey, Germer, Soren, Gibbs, Richard A., Gupta, Namrata, Rice, Kenneth, Smith, Albert V., Zody, Michael C., Blackman, Scott M., Cutting, Garry, Knowles, Michael R., Zhou, Yi-Hui, Rosenfeld, Margaret, Gibson, Ronald L., Bamshad, Michael, Fohner, Alison, Blue, Elizabeth E.

“…CFTR F508del (c.1521_1523delCTT, p.Phe508delPhe) is the most common pathogenic allele underlying cystic fibrosis (CF), and its frequency varies in a geographic…”
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Assessing population differentiation and isolation from single-nucleotide polymorphism data Autor Nicholson, George, Smith, Albert V., Jónsson, Frosti, Gústafsson, Ómar, Stefánsson, Kári, Donnelly, Peter

“…We introduce a new, hierarchical, model for single-nucleotide polymorphism allele frequencies in a structured population, which is naturally fitted via Markov…”
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Sparse allele vectors and the savvy software suite Autor LeFaive, Jonathon, Smith, Albert V, Kang, Hyun Min, Abecasis, Gonçalo

“…Abstract Summary The sparse allele vectors file format is an efficient storage format for large-scale DNA variation data and is designed for high throughput…”
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Association of Genetic Variants with Postsurgical Pain: A Systematic Review and Meta-analyses Autor Frangakis, Stephan G, MacEachern, Mark, Akbar, T Adam, Bolton, Christian, Lin, Victor, Smith, Albert V, Brummett, Chad M, Bicket, Mark C

“…Postsurgical pain is a key component of surgical recovery. However, the genetic drivers of postsurgical pain remain unclear. A broad review and meta-analyses…”
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A meta-analysis of genome-wide association studies identifies multiple longevity genes Autor Deelen, Joris, Evans, Daniel S., Arking, Dan E., Tesi, Niccolò, Nygaard, Marianne, Liu, Xiaomin, Wojczynski, Mary K., Biggs, Mary L., van der Spek, Ashley, Atzmon, Gil, Ware, Erin B., Sarnowski, Chloé, Smith, Albert V., Seppälä, Ilkka, Cordell, Heather J., Dose, Janina, Amin, Najaf, Arnold, Alice M., Ayers, Kristin L., Barzilai, Nir, Becker, Elizabeth J., Beekman, Marian, Blanché, Hélène, Christensen, Kaare, Christiansen, Lene, Collerton, Joanna C., Cubaynes, Sarah, Cummings, Steven R., Davies, Karen, Debrabant, Birgit, Deleuze, Jean-François, Duncan, Rachel, Faul, Jessica D., Franceschi, Claudio, Galan, Pilar, Gudnason, Vilmundur, Harris, Tamara B., Huisman, Martijn, Hurme, Mikko A., Jagger, Carol, Jansen, Iris, Jylhä, Marja, Kähönen, Mika, Karasik, David, Kardia, Sharon L. R., Kingston, Andrew, Kirkwood, Thomas B. L., Launer, Lenore J., Lehtimäki, Terho, Lieb, Wolfgang, Lyytikäinen, Leo-Pekka, Martin-Ruiz, Carmen, Min, Junxia, Nebel, Almut, Newman, Anne B., Nie, Chao, Nohr, Ellen A., Orwoll, Eric S., Perls, Thomas T., Province, Michael A., Psaty, Bruce M., Raitakari, Olli T., Reinders, Marcel J. T., Robine, Jean-Marie, Rotter, Jerome I., Sebastiani, Paola, Smith, Jennifer, Sørensen, Thorkild I. A., Taylor, Kent D., Uitterlinden, André G., van der Flier, Wiesje, van der Lee, Sven J., van Duijn, Cornelia M., van Heemst, Diana, Vaupel, James W., Weir, David, Ye, Kenny, Zeng, Yi, Zheng, Wanlin, Holstege, Henne, Kiel, Douglas P., Lunetta, Kathryn L., Slagboom, P. Eline, Murabito, Joanne M.

“…Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies of a…”
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Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals Autor Ntalla, Ioanna, Karthikeyan, Savita, Mifsud, Borbala, Kraja, Aldi T., Cartwright, James H., Hellwege, Jacklyn N., Giri, Ayush, Tragante, Vinicius, Prins, Bram P., Cabrera, Claudia P., Eales, James M., Akbarov, Artur, Bielak, Lawrence F., Brody, Jennifer A., Drenos, Fotios, Nielsen, Sune Fallgaard, Faul, Jessica D., Franceschini, Nora, Gao, He, Giulianini, Franco, Hwang, Shih-Jen, Kanoni, Stavroula, Lindström, Jaana, Luan, Jian’an, Mahajan, Anubha, Malerba, Giovanni, Perola, Markus, Richard, Melissa, Richardson, Tom G., Sepúlveda, Nuno, Thériault, Sébastien, Trompet, Stella, Varga, Tibor V., Velez Edwards, Digna R., Veronesi, Giovanni, Weiss, Stefan, Willems, Sara M., Young, Robin, Zhang, Weihua, Zhao, Wei, Evangelou, Evangelos, Aeschbacher, Stefanie, Asllanaj, Eralda, Mutsert, Renée de, Dörr, Marcus, Gaziano, J. Michael, Have, Christian T., Kajantie, Eero, Kamat, Mihir, Karpe, Fredrik, Koistinen, Heikki A., Moitry, Marie, Peters, James, Rossouw, Jacques, Sever, Peter S., Sigurdsson, Emil L., Skaaby, Tea, Sun, Yan V., Trabetti, Elisabetta, Vaartjes, Ilonca, Buring, Julie E., Chowdhury, Rajiv, Correa, Adolfo, Deary, Ian J., Deloukas, Panos, Ferrières, Jean, Fornage, Myriam, Gaunt, Tom R., Harris, Tamara B., Järvelin, Marjo-Riitta, Kooperberg, Charles, Launer, Lenore J., Majumder, Abdulla al Shafi, Laakso, Markku, Melander, Olle, Mohlke, Karen L., Orho-Melander, Marju, Palmas, Walter, Polasek, Ozren, Province, Michael A., Rolandsson, Olov, Rosendaal, Frits R., Rotter, Jerome I., Samani, Nilesh J., Soranzo, Nicole, Spector, Timothy D., Starr, John M., van der Harst, Pim, van der Meer, Peter, Verweij, Niek, Virtamo, Jarmo, Wareham, Nicholas J., Langenberg, Claudia, Liu, Chunyu, Manning, Alisa K., Morrison, Alanna C., O’Donnell, Christopher J., Saleheen, Danish, Boerwinkle, Eric, Chasman, Daniel I.

“…Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to ~1.3 million…”
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Imputation Server PGS: an automated approach to calculate polygenic risk scores on imputation servers Autor Forer, Lukas, Taliun, Daniel, LeFaive, Jonathon, Smith, Albert V, Boughton, Andrew P, Coassin, Stefan, Lamina, Claudia, Kronenberg, Florian, Fuchsberger, Christian, Schönherr, Sebastian

“…Polygenic scores (PGS) enable the prediction of genetic predisposition for a wide range of traits and diseases by calculating the weighted sum of allele…”
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The yeast Red1 protein localizes to the cores of meiotic chromosomes Autor Smith, A V, Roeder, G S

“…Mutants in the meiosis-specific RED1 gene of S. cerevisiae fail to make any synaptonemal complex (SC) or any obvious precursors to the SC. Using antibodies…”
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Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities Autor Armstrong, Nicola J, Mather, Karen A, Sargurupremraj, Muralidharan, Knol, Maria J, Malik, Rainer, Satizabal, Claudia L, Yanek, Lisa R, Wen, Wei, Gudnason, Vilmundur G, Dueker, Nicole D, Elliott, Lloyd T, Hofer, Edith, Bis, Joshua, Jahanshad, Neda, Li, Shuo, Logue, Mark A, Luciano, Michelle, Scholz, Markus, Smith, Albert V, Trompet, Stella, Vojinovic, Dina, Xia, Rui, Alfaro-Almagro, Fidel, Ames, David, Amin, Najaf, Amouyel, Philippe, Beiser, Alexa S, Brodaty, Henry, Deary, Ian J, Fennema-Notestine, Christine, Gampawar, Piyush G, Gottesman, Rebecca, Griffanti, Ludovica, Jack, Jr, Clifford R, Jenkinson, Mark, Jiang, Jiyang, Kral, Brian G, Kwok, John B, Lampe, Leonie, C M Liewald, David, Maillard, Pauline, Marchini, Jonathan, Bastin, Mark E, Mazoyer, Bernard, Pirpamer, Lukas, Rafael Romero, José, Roshchupkin, Gennady V, Schofield, Peter R, Schroeter, Matthias L, Stott, David J, Thalamuthu, Anbupalam, Trollor, Julian, Tzourio, Christophe, van der Grond, Jeroen, Vernooij, Meike W, Witte, Veronica A, Wright, Margaret J, Yang, Qiong, Morris, Zoe, Siggurdsson, Siggi, Psaty, Bruce, Villringer, Arno, Schmidt, Helena, Haberg, Asta K, van Duijn, Cornelia M, Jukema, J Wouter, Dichgans, Martin, Sacco, Ralph L, Wright, Clinton B, Kremen, William S, Becker, Lewis C, Thompson, Paul M, Mosley, Thomas H, Wardlaw, Joanna M, Ikram, M Arfan, Adams, Hieab H H, Seshadri, Sudha, Sachdev, Perminder S, Smith, Stephen M, Launer, Lenore, Longstreth, William, DeCarli, Charles, Schmidt, Reinhold, Fornage, Myriam, Debette, Stephanie, Nyquist, Paul A

“…Periventricular white matter hyperintensities (WMH; PVWMH) and deep WMH (DWMH) are regional classifications of WMH and reflect proposed differences in cause…”
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TOP-LD: A tool to explore linkage disequilibrium with TOPMed whole-genome sequence data Autor Huang, Le, Rosen, Jonathan D, Sun, Quan, Chen, Jiawen, Wheeler, Marsha M, Zhou, Ying, Min, Yuan-I, Kooperberg, Charles, Conomos, Matthew P, Stilp, Adrienne M, Rich, Stephen S, Rotter, Jerome I, Manichaikul, Ani, Loos, Ruth J F, Kenny, Eimear E, Blackwell, Thomas W, Smith, Albert V, Jun, Goo, Sedlazeck, Fritz J, Metcalf, Ginger, Boerwinkle, Eric, Raffield, Laura M, Reiner, Alex P, Auer, Paul L, Li, Yun

“…Current publicly available tools that allow rapid exploration of linkage disequilibrium (LD) between markers (e.g., HaploReg and LDlink) are based on…”
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Association of common genetic variants with brain microbleeds: A genome-wide association study Autor Knol, Maria J, Lu, Dongwei, Traylor, Matthew, Adams, Hieab H H, Romero, José Rafael J, Smith, Albert V, Fornage, Myriam, Hofer, Edith, Liu, Junfeng, Hostettler, Isabel C, Luciano, Michelle, Trompet, Stella, Giese, Anne-Katrin, Hilal, Saima, van den Akker, Erik B, Vojinovic, Dina, Li, Shuo, Sigurdsson, Sigurdur, van der Lee, Sven J, Jack, Jr, Clifford R, Wilson, Duncan, Yilmaz, Pinar, Satizabal, Claudia L, Liewald, David C M, van der Grond, Jeroen, Chen, Christopher, Saba, Yasaman, van der Lugt, Aad, Bastin, Mark E, Windham, B Gwen, Cheng, Ching Yu, Pirpamer, Lukas, Kantarci, Kejal, Himali, Jayandra J, Yang, Qiong, Morris, Zoe, Beiser, Alexa S, Tozer, Daniel J, Vernooij, Meike W, Amin, Najaf, Beekman, Marian, Koh, Jia Yu, Stott, David J, Houlden, Henry, Schmidt, Reinhold, Gottesman, Rebecca F, MacKinnon, Andrew D, DeCarli, Charles, Gudnason, Vilmundur, Deary, Ian J, van Duijn, Cornelia M, Slagboom, P Eline, Wong, Tien Yin, Rost, Natalia S, Jukema, J Wouter, Mosley, Thomas H, Werring, David J, Schmidt, Helena, Wardlaw, Joanna M, Ikram, M Arfan, Seshadri, Sudha, Launer, Lenore J, Markus, Hugh S

“…To identify common genetic variants associated with the presence of brain microbleeds (BMBs). We performed genome-wide association studies in 11…”
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Genetic Obesity and the Risk of Atrial Fibrillation: Causal Estimates from Mendelian Randomization Autor Chatterjee, Neal A, Giulianini, Franco, Geelhoed, Bastiaan, Lunetta, Kathryn L, Misialek, Jeffrey R, Niemeijer, Maartje N, Rienstra, Michiel, Rose, Lynda M, Smith, Albert V, Arking, Dan E, Ellinor, Patrick T, Heeringa, Jan, Lin, Honghuang, Lubitz, Steven A, Soliman, Elsayed Z, Verweij, Niek, Alonso, Alvaro, Benjamin, Emelia J, Gudnason, Vilmundur, Stricker, Bruno H C, Van Der Harst, Pim, Chasman, Daniel I, Albert, Christine M

“…Observational studies have identified an association between body mass index (BMI) and incident atrial fibrillation (AF). Inferring causality from…”
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