Search Results - "Skidmore, Mark A."

Unfractionated heparin inhibits live wild type SARS‐CoV‐2 cell infectivity at therapeutically relevant concentrations by Tree, Julia A., Turnbull, Jeremy E., Buttigieg, Karen R., Elmore, Michael J., Coombes, Naomi, Hogwood, John, Mycroft‐West, Courtney J., Lima, Marcelo A., Skidmore, Mark A., Karlsson, Richard, Chen, Yen‐Hsi, Yang, Zhang, Spalluto, Cosma Mirella, Staples, Karl J., Yates, Edwin A., Gray, Elaine, Singh, Dave, Wilkinson, Tom, Page, Clive P., Carroll, Miles W.

“…Background and Purpose Currently, there are no licensed vaccines and limited antivirals for the treatment of COVID‐19. Heparin (delivered systemically) is…”
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Structural and mechanistic characterization of bifunctional heparan sulfate N-deacetylase-N-sulfotransferase 1 by Mycroft-West, Courtney J., Abdelkarim, Sahar, Duyvesteyn, Helen M. E., Gandhi, Neha S., Skidmore, Mark A., Owens, Raymond J., Wu, Liang

“…Heparan sulfate (HS) polysaccharides are major constituents of the extracellular matrix, which are involved in myriad structural and signaling processes…”
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The Hyperlipidaemic Drug Fenofibrate Significantly Reduces Infection by SARS-CoV-2 in Cell Culture Models by Davies, Scott P., Mycroft-West, Courtney J., Pagani, Isabel, Hill, Harriet J., Chen, Yen-Hsi, Karlsson, Richard, Bagdonaite, Ieva, Guimond, Scott E., Stamataki, Zania, De Lima, Marcelo Andrade, Turnbull, Jeremy E., Yang, Zhang, Vicenzi, Elisa, Skidmore, Mark A., Khanim, Farhat L., Richardson, Alan

“…The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has caused a significant number of fatalities and worldwide disruption. To identify…”
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Subverting the mechanisms of cell death: flavivirus manipulation of host cell responses to infection by Vicenzi, Elisa, Pagani, Isabel, Ghezzi, Silvia, Taylor, Sarah L, Rudd, Timothy R, Lima, Marcelo A, Skidmore, Mark A, Yates, Edwin A

“…Viruses exploit host metabolic and defence machinery for their own replication. The flaviviruses, which include Dengue (DENV), Yellow Fever (YFV), Japanese…”
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Glycosaminoglycans from Litopenaeus vannamei Inhibit the Alzheimer’s Disease β Secretase, BACE1 by Mycroft-West, Courtney J., Devlin, Anthony J., Cooper, Lynsay C., Guimond, Scott E., Procter, Patricia, Guerrini, Marco, Miller, Gavin J., Fernig, David G., Yates, Edwin A., Lima, Marcelo A., Skidmore, Mark A.

“…Only palliative therapeutic options exist for the treatment of Alzheimer’s Disease; no new successful drug candidates have been developed in over 15 years. The…”
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A semi-synthetic glycosaminoglycan analogue inhibits and reverses Plasmodium falciparum cytoadherence by Skidmore, Mark A., Mustaffa, Khairul Mohd Fadzli, Cooper, Lynsay C., Guimond, Scott E., Yates, Edwin A., Craig, Alister G.

“…A feature of mature Plasmodium falciparum parasitized red blood cells is their ability to bind surface molecules of the microvascular endothelium via the…”
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Evidence of a putative glycosaminoglycan binding site on the glycosylated SARS-CoV-2 spike protein N-terminal domain by Schuurs, Zachariah P., Hammond, Edward, Elli, Stefano, Rudd, Timothy R., Mycroft-West, Courtney J., Lima, Marcelo A., Skidmore, Mark A., Karlsson, Richard, Chen, Yen-Hsi, Bagdonaite, Ieva, Yang, Zhang, Ahmed, Yassir A., Richard, Derek J., Turnbull, Jeremy, Ferro, Vito, Coombe, Deirdre R., Gandhi, Neha S.

“…[Display omitted] •Co-solvent MD simulation identified a putative glycosaminoglycan binding site.•Novel binding site identified at R246 and the mutated S247R…”
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A Glycosaminoglycan Extract from Portunus pelagicus Inhibits BACE1, the β Secretase Implicated in Alzheimer’s Disease by Mycroft-West, Courtney J., Cooper, Lynsay C., Devlin, Anthony J., Procter, Patricia, Guimond, Scott E., Guerrini, Marco, Fernig, David G., Lima, Marcelo A., Yates, Edwin A., Skidmore, Mark A.

“…Therapeutic options for Alzheimer’s disease, the most common form of dementia, are currently restricted to palliative treatments. The glycosaminoglycan…”
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Disaccharide compositional analysis of heparan sulfate and heparin polysaccharides using UV or high-sensitivity fluorescence (BODIPY) detection by Skidmore, Mark A, Guimond, Scott E, Dumax-Vorzet, Audrey F, Yates, Edwin A, Turnbull, Jeremy E

“…One of the first steps in characterizing heparan sulfate (HS) and its close relative heparin is to conduct disaccharide composition analysis. This provides an…”
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Molecular Changes in Dengue Envelope Protein Domain III upon Interaction with Glycosaminoglycans by Hyatt, James G., Prévost, Sylvain, Devos, Juliette M., Mycroft-West, Courtney J., Skidmore, Mark A., Winter, Anja

“…Dengue fever is a rapidly emerging vector-borne viral disease with a growing global burden of approximately 390 million new infections per annum. The Dengue…”
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Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin by Mycroft-West, Courtney J., Su, Dunhao, Pagani, Isabel, Rudd, Timothy R., Elli, Stefano, Gandhi, Neha S., Guimond, Scott E., Miller, Gavin J., Meneghetti, Maria C. Z., Nader, Helena B., Li, Yong, Nunes, Quentin M., Procter, Patricia, Mancini, Nicasio, Clementi, Massimo, Bisio, Antonella, Forsyth, Nicholas R., Ferro, Vito, Turnbull, Jeremy E., Guerrini, Marco, Fernig, David G., Vicenzi, Elisa, Yates, Edwin A., Lima, Marcelo A., Skidmore, Mark A.

“…Abstract The dependence of development and homeostasis in animals on the interaction of hundreds of extracellular regulatory proteins with the peri- and…”
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Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells by Ghezzi, Silvia, Cooper, Lynsay, Rubio, Alicia, Pagani, Isabel, Capobianchi, Maria Rosaria, Ippolito, Giuseppe, Pelletier, Julien, Meneghetti, Maria Cecilia Z., Lima, Marcelo A., Skidmore, Mark A., Broccoli, Vania, Yates, Edwin A., Vicenzi, Elisa

“…The recent Zika virus (ZIKV) outbreak, which mainly affected Brazil and neighbouring states, demonstrated the paucity of information concerning the…”
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The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids by Rudd, Timothy R, Skidmore, Mark A, Guimond, Scott E, Holman, Joseph, Turnbull, Jeremy E, Lauder, Robert M, Fernig, David G, Yates, Edwin A

“…The ultraviolet circular dichroism (CD) spectra of commercial low-molecular-weight heparins, heparinoids and other anticoagulant preparations have been…”
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Marine glycosaminoglycan-like carbohydrates as potential drug candidates for infectious disease by Mycroft-West, Courtney J, Yates, Edwin A, Skidmore, Mark A

“…Glycosaminoglycans (GAGs), present in the extracellular matrix, are exploited by numerous, distinct microbes for cellular attachment, adhesion, invasion and…”
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Evidence for Multiple Binding Modes in the Initial Contact Between SARS‐CoV‐2 Spike S1 Protein and Cell Surface Glycans by Parafioriti, Michela, Ni, Minghong, Petitou, Maurice, Mycroft‐West, Courtney J., Rudd, Timothy R., Gandhi, Neha S., Ferro, Vito, Turnbull, Jeremy E., Lima, Marcelo A., Skidmore, Mark A., Fernig, David G., Yates, Edwin A., Bisio, Antonella, Guerrini, Marco, Elli, Stefano

“…Infection of host cells by SARS‐CoV‐2 begins with recognition by the virus S (spike) protein of cell surface heparan sulfate (HS), tethering the virus to the…”
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The role of heparan sulfate in host macrophage infection by Leishmania species by Maciej-Hulme, Marissa L, Skidmore, Mark A, Price, Helen P

“…The leishmaniases are a group of neglected tropical diseases caused by parasites from the genus. More than 20 species are responsible for human disease,…”
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The Activities of Heparan Sulfate and its Analogue Heparin are Dictated by Biosynthesis, Sequence, and Conformation by Skidmore, Mark A., Guimond, Scott E., Rudd, Tim R., Fernig, David G., Turnbull, Jeremy E., Yates, Edwin A.

“…The glycosaminoglycan heparan sulfate (HS), is expressed on the surface of virtually all mammalian cells and is implicated in many crucial biological…”
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Cover Feature: Harnessing a Biocatalyst to Bioremediate the Purification of Alkylglycosides (ChemBioChem 1/2024) by Wahart, Alice J. C., Dolan, Jonathan P., Anderson, Simon D., Cheallaigh, Aisling Ní, Staniland, Jessica, Lima, Marcelo A., Skidmore, Mark A., Miller, Gavin J., Cosgrove, Sebastian C.

“…Wahart et al. demonstrate the use of an immobilised oxidase enzyme coupled to an extractive amino resin for the bioremediation of a common industrial…”
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Harnessing a Biocatalyst to Bioremediate the Purification of Alkylglycosides by Wahart, Alice J. C., Dolan, Jonathan P., Anderson, Simon D., Cheallaigh, Aisling Ní, Staniland, Jessica, Lima, Marcelo A., Skidmore, Mark A., Miller, Gavin J., Cosgrove, Sebastian C.

“…As the world moves towards net‐zero carbon emissions, the development of sustainable chemical manufacturing processes is essential. Within manufacturing,…”
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A sulphated glycosaminoglycan extract from Placopecten magellanicus inhibits the Alzheimer's disease β-site amyloid precursor protein cleaving enzyme 1 (BACE-1) by Mycroft-West, Courtney J., Devlin, Anthony J., Cooper, Lynsay C., Guimond, Scott E., Procter, Patricia, Miller, Gavin J., Guerrini, Marco, Fernig, David G., Yates, Edwin A., Lima, Marcelo A., Skidmore, Mark A.

“…The clinically important anticoagulant heparin, a member of the glycosaminoglycan family of carbohydrates that is extracted predominantly from porcine and…”
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