Search Results - "Signal Transduction - drug effects"

Therapeutic targeting of acute myeloid leukemia stem cells by Pollyea, Daniel A, Jordan, Craig T

“…) and other forms of cancer. The nature and existence of tumor-initiating cells for leukemia and other malignancies have long been the subject of intense and rigorous study…”
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Combined antiangiogenic and anti-PD-L1 therapy stimulates tumor immunity through HEV formation by Allen, Elizabeth, Jabouille, Arnaud, Rivera, Lee B, Lodewijckx, Inge, Missiaen, Rindert, Steri, Veronica, Feyen, Kevin, Tawney, Jaime, Hanahan, Douglas, Michael, Iacovos P, Bergers, Gabriele

“…Inhibitors of VEGF (vascular endothelial growth factor)/VEGFR2 (vascular endothelial growth factor receptor 2) are commonly used in the clinic, but their…”
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Molecular adaptations of the blood-brain barrier promote stress resilience vs. depression by Dudek, Katarzyna A, Dion-Albert, Laurence, Lebel, Manon, LeClair, Katherine, Labrecque, Simon, Tuck, Ellen, Ferrer Perez, Carmen, Golden, Sam A, Tamminga, Carol, Turecki, Gustavo, Mechawar, Naguib, Russo, Scott J, Menard, Caroline

“…Preclinical and clinical studies suggest that inflammation and vascular dysfunction contribute to the pathogenesis of major depressive disorder (MDD). Chronic…”
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The chemistry and biological activities of N-acetylcysteine by Samuni, Yuval, Goldstein, Sara, Dean, Olivia M., Berk, Michael

“…N-acetylcysteine (NAC) has been in clinical practice for several decades. It has been used as a mucolytic agent and for the treatment of numerous disorders…”
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Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects by Boscolo, Elisa, Limaye, Nisha, Huang, Lan, Kang, Kyu-Tae, Soblet, Julie, Uebelhoer, Melanie, Mendola, Antonella, Natynki, Marjut, Seront, Emmanuel, Dupont, Sophie, Hammer, Jennifer, Legrand, Catherine, Brugnara, Carlo, Eklund, Lauri, Vikkula, Miikka, Bischoff, Joyce, Boon, Laurence M.

“…Venous malformations (VMs) are composed of ectatic veins with scarce smooth muscle cell coverage. Activating mutations in the endothelial cell tyrosine kinase…”
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The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity by Broeders, Evie P M, Nascimento, Emmani B M, Havekes, Bas, Brans, Boudewijn, Roumans, Kay H M, Tailleux, Anne, Schaart, Gert, Kouach, Mostafa, Charton, Julie, Deprez, Benoit, Bouvy, Nicole D, Mottaghy, Felix, Staels, Bart, van Marken Lichtenbelt, Wouter D, Schrauwen, Patrick

“…) on human BAT activity. Treatment of 12 healthy female subjects with CDCA for 2 days resulted in increased BAT activity…”
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Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism by Zheng, Xiaojiao, Chen, Tianlu, Jiang, Runqiu, Zhao, Aihua, Wu, Qing, Kuang, Junliang, Sun, Dongnan, Ren, Zhenxing, Li, Mengci, Zhao, Mingliang, Wang, Shouli, Bao, Yuqian, Li, Huating, Hu, Cheng, Dong, Bing, Li, Defa, Wu, Jiayu, Xia, Jialin, Wang, Xuemei, Lan, Ke, Rajani, Cynthia, Xie, Guoxiang, Lu, Aiping, Jia, Weiping, Jiang, Changtao, Jia, Wei

“…Hyocholic acid (HCA) and its derivatives are found in trace amounts in human blood but constitute approximately 76% of the bile acid (BA) pool in pigs, a…”
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Phase I, Randomized, Double-blind, Placebo-controlled, Single-dose, and Multiple-dose Studies of Erenumab in Healthy Subjects and Patients With Migraine by de Hoon, Jan, Van Hecken, Anne, Vandermeulen, Corinne, Yan, Lucy, Smith, Brian, Chen, Jiyun Sunny, Bautista, Edgar, Hamilton, Lisa, Waksman, Javier, Vu, Thuy, Vargas, Gabriel

“…), and pharmacodynamics of single and multiple administrations of erenumab in healthy subjects and patients with migraine…”
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Targeting B cell receptor signaling with ibrutinib in diffuse large B cell lymphoma by Wilson, Wyndham H, Young, Ryan M, Schmitz, Roland, Yang, Yandan, Pittaluga, Stefania, Wright, George, Lih, Chih-Jian, Williams, P Mickey, Shaffer, Arthur L, Gerecitano, John, de Vos, Sven, Goy, Andre, Kenkre, Vaishalee P, Barr, Paul M, Blum, Kristie A, Shustov, Andrei, Advani, Ranjana, Fowler, Nathan H, Vose, Julie M, Elstrom, Rebecca L, Habermann, Thomas M, Barrientos, Jacqueline C, McGreivy, Jesse, Fardis, Maria, Chang, Betty Y, Clow, Fong, Munneke, Brian, Moussa, Davina, Beaupre, Darrin M, Staudt, Louis M

“… In a phase 1/2 clinical trial that involved 80 subjects with relapsed or refractory DLBCL, ibrutinib produced complete or partial responses in 37% (14/38…”
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SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function by Price, Nathan L, Gomes, Ana P, Ling, Alvin J Y, Duarte, Filipe V, Martin-Montalvo, Alejandro, North, Brian J, Agarwal, Beamon, Ye, Lan, Ramadori, Giorgio, Teodoro, Joao S, Hubbard, Basil P, Varela, Ana T, Davis, James G, Varamini, Behzad, Hafner, Angela, Moaddel, Ruin, Rolo, Anabela P, Coppari, Roberto, Palmeira, Carlos M, de Cabo, Rafael, Baur, Joseph A, Sinclair, David A

“…Resveratrol induces mitochondrial biogenesis and protects against metabolic decline, but whether SIRT1 mediates these benefits is the subject of debate…”
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Metformin Alters Human Host Responses to Mycobacterium tuberculosis in Healthy Subjects by Lachmandas, Ekta, Eckold, Clare, Böhme, Julia, Koeken, Valerie A C M, Marzuki, Mardiana Binte, Blok, Bastiaan, Arts, Rob J W, Chen, Jinmiao, Teng, Karen W W, Ratter, Jacqueline, Smolders, Elise J, Van den Heuvel, Corina, Stienstra, Rinke, Dockrell, Hazel M, Newell, Evan, Netea, Mihai G, Singhal, Amit, Cliff, Jacqueline M, Van Crevel, Reinout

“…Abstract Background Metformin, the most widely administered diabetes drug, has been proposed as a candidate adjunctive host-directed therapy for tuberculosis,…”
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Diabetic cardiomyopathy: Mechanisms and new treatment strategies targeting antioxidant signaling pathways by Huynh, Karina, Bernardo, Bianca C., McMullen, Julie R., Ritchie, Rebecca H.

“… Both experimental and clinical evidence suggest that diabetic subjects are predisposed to a distinct cardiomyopathy, independent of concomitant macro- and microvascular disorders…”
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Proton and calcium pumping P-type ATPases and their regulation of plant responses to the environment by Fuglsang, Anja T, Palmgren, Michael

“…+, respectively, they are also subject to exquisite regulation in response to biotic and abiotic events in the environment…”
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Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice by Gomez, Delphine, Baylis, Richard A., Durgin, Brittany G., Newman, Alexandra A. C., Alencar, Gabriel F., Mahan, Sidney, St. Hilaire, Cynthia, Müller, Werner, Waisman, Ari, Francis, Sheila E., Pinteaux, Emmanuel, Randolph, Gwendalyn J., Gram, Hermann, Owens, Gary K.

“…) trial, in which post-myocardial infarction subjects were treated with an IL-1β antibody. Here, we performed intervention studies in which smooth muscle cell…”
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Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma by Simpson, Tyler R, Li, Fubin, Montalvo-Ortiz, Welby, Sepulveda, Manuel A, Bergerhoff, Katharina, Arce, Frederick, Roddie, Claire, Henry, Jake Y, Yagita, Hideo, Wolchok, Jedd D, Peggs, Karl S, Ravetch, Jeffrey V, Allison, James P, Quezada, Sergio A

“… Although subject to debate, current models favor a mechanism of activity involving blockade of the inhibitory activity of CTLA-4 on both effector (T eff) and regulatory (T reg…”
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Steroid resistance of airway type 2 innate lymphoid cells from patients with severe asthma: The role of thymic stromal lymphopoietin by Liu, Sucai, Verma, Mukesh, Michalec, Lidia, Liu, Weimin, Sripada, Anand, Rollins, Donald, Good, James, Ito, Yoko, Chu, HongWei, Gorska, Magdalena M., Martin, Richard J., Alam, Rafeul

“… We studied human blood and lung ILC2s from asthmatic patients and control subjects using flow cytometry and ELISA…”
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Autophagy and mitophagy in the context of doxorubicin-induced cardiotoxicity by Koleini, Navid, Kardami, Elissavet

“… Autophagy, regarded generally as a protective mechanism that maintains cell viability by recycling unwanted and damaged cellular constituents, is nevertheless subject to dysregulation having…”
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Metformin alleviates hyperglycemia-induced endothelial impairment by downregulating autophagy via the Hedgehog pathway by Niu, Chao, Chen, Zhiwei, Kim, Kyoung Tae, Sun, Jia, Xue, Mei, Chen, Gen, Li, Santie, Shen, Yingjie, Zhu, Zhongxin, Wang, Xu, Liang, Jiaojiao, Jiang, Chao, Cong, Weitao, Jin, Litai, Li, Xiaokun

“…Studies regarding macroautophagic/autophagic regulation in endothelial cells (ECs) under diabetic conditions are very limited. Clinical evidence establishes an…”
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Cardiovascular disease and cancer: Evidence for shared disease pathways and pharmacologic prevention by Masoudkabir, Farzad, Sarrafzadegan, Nizal, Gotay, Carolyn, Ignaszewski, Andrew, Krahn, Andrew D., Davis, Margot K., Franco, Christopher, Mani, Arya

“…Cardiovascular disease (CVD) and cancer are leading causes of mortality and morbidity worldwide. Strategies to improve their treatment and prevention are…”
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Structural insight into allosteric modulation of protease-activated receptor 2 by Cheng, Robert K. Y., Fiez-Vandal, Cédric, Schlenker, Oliver, Edman, Karl, Aggeler, Birte, Brown, Dean G., Brown, Giles A., Cooke, Robert M., Dumelin, Christoph E., Doré, Andrew S., Geschwindner, Stefan, Grebner, Christoph, Hermansson, Nils-Olov, Jazayeri, Ali, Johansson, Patrik, Leong, Louis, Prihandoko, Rudi, Rappas, Mathieu, Soutter, Holly, Snijder, Arjan, Sundström, Linda, Tehan, Benjamin, Thornton, Peter, Troast, Dawn, Wiggin, Giselle, Zhukov, Andrei, Marshall, Fiona H., Dekker, Niek

“…Crystal structures of protease-activated receptor 2 (PAR2) in complex with two different antagonist ligands and with a blocking antibody reveal binding sites…”
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