Search Results - "Shuttleworth, G"

MiR-126-3p Is Dynamically Regulated in Endothelial-to-Mesenchymal Transition during Fibrosis by Jordan, Nina P., Tingle, Samuel J., Shuttleworth, Victoria G., Cooke, Katie, Redgrave, Rachael E., Singh, Esha, Glover, Emily K., Ahmad Tajuddin, Hafiza B., Kirby, John A., Arthur, Helen M., Ward, Chris, Sheerin, Neil S., Ali, Simi

“…In fibrotic diseases, myofibroblasts derive from a range of cell types including endothelial-to-mesenchymal transition (EndMT). Increasing evidence suggests…”
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A novel method for real-time analysis of the complement C3b:FH:FI complex reveals dominant negative CFI variants in age-related macular degeneration by Hallam, Thomas M., Cox, Thomas E., Smith-Jackson, Kate, Brocklebank, Vicky, Baral, April J., Tzoumas, Nikolaos, Steel, David H., Wong, Edwin K. S., Shuttleworth, Victoria G., Lotery, Andrew J., Harris, Claire L., Marchbank, Kevin J., Kavanagh, David

“…Age-related macular degeneration (AMD) is linked to 2 main disparate genetic pathways: a chromosome 10 risk locus and the alternative pathway (AP) of…”
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A Parameter Representing Missing Charge Should Be Considered when Calibrating Action Potential Models by Barral, Yann-Stanislas H. M., Shuttleworth, Joseph G., Clerx, Michael, Whittaker, Dominic G., Wang, Ken, Polonchuk, Liudmila, Gavaghan, David J., Mirams, Gary R.

“…Computational models of the electrical potential across a cell membrane are longstanding and vital tools in electrophysiology research and applications. These…”
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Functional Characterization of Rare Genetic Variants in the N-Terminus of Complement Factor H in aHUS, C3G, and AMD by Wong, Edwin K. S., Hallam, Thomas M., Brocklebank, Vicky, Walsh, Patrick R., Smith-Jackson, Kate, Shuttleworth, Victoria G., Cox, Thomas E., Anderson, Holly E., Barlow, Paul Nigel, Marchbank, Kevin James, Harris, Claire L., Kavanagh, David

“…Membranoproliferative glomerulonephritis (MPGN), C3 glomerulopathy (C3G), atypical haemolytic uraemic syndrome (aHUS) and age-related macular degeneration…”
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Identification of the c(10×6)-CN/Cu(001) surface structure by Shuttleworth, I.G.

“…•The saturated c(10×6)-CN/Cu(001) surface structure has been identified using DFT.•The optimal sequence of surface structures is seen not to contain a…”
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Patulous nasolacrimal duct with air reflux: a complication of submucosal diathermy of the inferior turbinate by Puttasiddaiah, P M, Whittet, C R, Shuttleworth, G N

“…Submucosal diathermy to the inferior turbinate is a widely practised procedure to improve the nasal airway when nasal obstruction is due to hypertrophy of the…”
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Insertion of a Lester Jones canalicular bypass tube: a simple, quick and convenient approach by Evans, LM, Shuttleworth, G, Whittet, H

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Band structure analysis of (1×2)-H/Pd(110)-pr by Shuttleworth, I.G.

“…A novel method of band structure analysis based on the atomic orbital (AO) coefficients in LCAO-DFT has been applied to the (1×2)-H/Pd(110)-pr system. The…”
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Troubled Geographies: A Spatial History of Religion and Society in Ireland by Gregory, Ian N, Cunningham, Niall A, Lloyd, C. D, Shuttleworth, Ian G, Ell, Paul S

“…Ireland's landscape is marked by fault lines of religious, ethnic, and political identity that have shaped its troubled history. Troubled Geographies maps this…”
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Exploring the implications of changing census output geographies for the measurement of residential segregation: the example of Northern Ireland 1991-2001 by Shuttleworth, I. G., Lloyd, C. D., Martin, D. J.

“…One problem in analysing social and demographic change through time by using census data arises from differences in the size and shape of the geographical…”
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Controlled FCC/on-top binding of H/Pt(111) using surface stress by Shuttleworth, I.G.

“…[Display omitted] •The preferred binding position of H/Pt(111) changes from on-top to FCC as the surface goes approximately from compressive to tensile…”
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Ocular air gun injuries: a one-year surveillance study in the UK and Eire (BOSU). 2001–2002 by Shuttleworth, G N, Galloway, P, Sparrow, J M, Lane, C

“…Aims The vulnerability of the eye means that ocular air gun injuries figure prominently in the medical literature. This Study reports the results of the first…”
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Evaluating the predictive accuracy of ion-channel models using data from multiple experimental designs by Shuttleworth, Joseph G, Lei, Chon Lok, Windley, Monique J, Hill, Adam P, Preston, Simon P, Mirams, Gary R

“…Mathematical models are increasingly being relied upon to provide quantitatively accurate predictions of cardiac electrophysiology. Many such models concern…”
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Rare Genetic Variants in Complement Factor I Lead to Low FI Plasma Levels Resulting in Increased Risk of Age-Related Macular Degeneration by Hallam, Thomas M., Marchbank, Kevin J., Harris, Claire L., Osmond, Clive, Shuttleworth, Victoria G., Griffiths, Helen, Cree, Angela J., Kavanagh, David, Lotery, Andrew J.

“…Rare genetic variants in complement factor I (CFI) that cause low systemic levels of the protein (FI) have been reported as a strong risk factor for advanced…”
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Empirical Quantification of Predictive Uncertainty Due to Model Discrepancy by Training with an Ensemble of Experimental Designs: An Application to Ion Channel Kinetics by Shuttleworth, Joseph G., Lei, Chon Lok, Whittaker, Dominic G., Windley, Monique J., Hill, Adam P., Preston, Simon P., Mirams, Gary R.

“…When using mathematical models to make quantitative predictions for clinical or industrial use, it is important that predictions come with a reliable estimate…”
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Investigations of the CN/Cu(1 1 1) system using density functional theory by Shuttleworth, I.G.

“…The geometry, CN–CN interaction and surface bond strength and structure of the CN–Cu(1 1 1) system has been investigated using LCAO-DFT. The lowest energy…”
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Do patients with age related maculopathy and cataract benefit from cataract surgery? by Shuttleworth, G N, Luhishi, E A, Harrad, R A

“…AIMS To assess the benefits of cataract extraction in patients with age related maculopathy (ARM). METHODS 1073 randomly selected cataract operations were…”
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Ion channel model reduction using manifold boundaries by Whittaker, Dominic G, Wang, Jiahui, Shuttleworth, Joseph G, Venkateshappa, Ravichandra, Kemp, Jacob M, Claydon, Thomas W, Mirams, Gary R

“…Mathematical models of voltage-gated ion channels are used in basic research, industrial and clinical settings. These models range in complexity, but typically…”
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Using many different voltage protocols to characterise discrepancy in mathematical ion channel models by Shuttleworth, Joseph G, Lok Lei, Chon, Windley, Monique, Hill, Adam P, Perry, Matthew D, Preston, Simon, Mirams, Gary R

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Late reactivation of thyroid associated ophthalmopathy causing optic neuropathy by Bunting, H, Creten, O, Muhtaseb, M, Shuttleworth, G

“…We describe a case of thyroid associated ophthalmopathy complicated by optic neuropathy presenting 18 years after the diagnosis of dysthyroidism, due to late…”
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