Suchergebnisse - "Sheldon, Helen"

Single cell RNA‐sequencing: A powerful yet still challenging technology to study cellular heterogeneity von Ke, May, Elshenawy, Badran, Sheldon, Helen, Arora, Anjali, Buffa, Francesca M

“… Almost all biomedical research to date has relied upon mean measurements from cell populations, however it is well established that what it is observed at this …”
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Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer von Morotti, Matteo, Bridges, Esther, Valli, Alessandro, Choudhry, Hani, Sheldon, Helen, Wigfield, Simon, Gray, Nicki, Zois, Christos E, Grimm, Fiona, Jones, Dylan, Teoh, Eugene J, Cheng, Wei-Chen, Lord, Simon, Anastasiou, Dimitrios, Haider, Syed, McIntyre, Alan, Goberdhan, Deborah C I, Buffa, Francesca, Harris, Adrian L

“… Tumor hypoxia is associated with poor patient outcomes in estrogen receptor-α-positive (ERα ) breast cancer. Hypoxia is known to affect tumor growth by …”
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Glutamine deprivation alters the origin and function of cancer cell exosomes von Fan, Shih‐Jung, Kroeger, Benjamin, Marie, Pauline P, Bridges, Esther M, Mason, John D, McCormick, Kristie, Zois, Christos E, Sheldon, Helen, Khalid Alham, Nasullah, Johnson, Errin, Ellis, Matthew, Stefana, Maria Irina, Mendes, Cláudia C, Wainwright, Stephen Mark, Cunningham, Christopher, Hamdy, Freddie C, Morris, John F, Harris, Adrian L, Wilson, Clive, Goberdhan, Deborah CI

“… Exosomes are secreted extracellular vesicles carrying diverse molecular cargos, which can modulate recipient cell behaviour. They are thought to derive from …”
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microRNA-associated progression pathways and potential therapeutic targets identified by integrated mRNA and microRNA expression profiling in breast cancer von Buffa, Francesca M, Camps, Carme, Winchester, Laura, Snell, Cameron E, Gee, Harriet E, Sheldon, Helen, Taylor, Marian, Harris, Adrian L, Ragoussis, Jiannis

“… microRNA expression profiling plays an emerging role in cancer classification and identification of therapeutic strategies. In this study, we have evaluated …”
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Recurrent PTPRB and PLCG1 mutations in angiosarcoma von Behjati, Sam, Tarpey, Patrick S, Sheldon, Helen, Martincorena, Inigo, Van Loo, Peter, Gundem, Gunes, Wedge, David C, Ramakrishna, Manasa, Cooke, Susanna L, Pillay, Nischalan, Vollan, Hans Kristian M, Papaemmanuil, Elli, Koss, Hans, Bunney, Tom D, Hardy, Claire, Joseph, Olivia R, Martin, Sancha, Mudie, Laura, Butler, Adam, Teague, Jon W, Patil, Meena, Steers, Graham, Cao, Yu, Gumbs, Curtis, Ingram, Davis, Lazar, Alexander J, Little, Latasha, Mahadeshwar, Harshad, Protopopov, Alexei, Al Sannaa, Ghadah A, Seth, Sahil, Song, Xingzhi, Tang, Jiabin, Zhang, Jianhua, Ravi, Vinod, Torres, Keila E, Khatri, Bhavisha, Halai, Dina, Roxanis, Ioannis, Baumhoer, Daniel, Tirabosco, Roberto, Amary, M Fernanda, Boshoff, Chris, McDermott, Ultan, Katan, Matilda, Stratton, Michael R, Futreal, P Andrew, Flanagan, Adrienne M, Harris, Adrian, Campbell, Peter J

“… Peter Campbell and colleagues identify PLCG1 and PTPRB as new driver genes for angiosarcoma through whole-exome sequencing of tumor samples. They find somatic …”
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hsa-miR-210 Is induced by hypoxia and is an independent prognostic factor in breast cancer von Camps, Carme, Buffa, Francesca M, Colella, Stefano, Moore, John, Sotiriou, Christos, Sheldon, Helen, Harris, Adrian L, Gleadle, Jonathan M, Ragoussis, Jiannis

“… MicroRNA (miRNA) expression alterations have been described in cancer. Many cancers are characterized by areas of hypoxia, enhanced hypoxia-inducible factor …”
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The role of the dementia specialist nurse in acute care: a scoping review von Griffiths, Peter, Bridges, Jackie, Sheldon, Helen, Thompson, Rachel

“… Aims and objectives To identify the potential benefits of dementia specialist nursing and to inform the implementation of roles to support people with dementia …”
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DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo von Li, Ji-Liang, Sainson, Richard C A, Oon, Chern Ein, Turley, Helen, Leek, Russell, Sheldon, Helen, Bridges, Esther, Shi, Wen, Snell, Cameron, Bowden, Emma T, Wu, Herren, Chowdhury, Partha S, Russell, Angela J, Montgomery, Craig P, Poulsom, Richard, Harris, Adrian L

“… Resistance to VEGF inhibitors is emerging as a major clinical problem. Notch signaling has been implicated in tumor angiogenesis. Therefore, to investigate …”
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Elevated expression of the adhesion GPCR ADGRL4/ELTD1 promotes endothelial sprouting angiogenesis without activating canonical GPCR signalling von Favara, David M., Liebscher, Ines, Jazayeri, Ali, Nambiar, Madhulika, Sheldon, Helen, Banham, Alison H., Harris, Adrian L.

“… ADGRL4/ELTD1 is an orphan adhesion GPCR (aGPCR) expressed in endothelial cells that regulates tumour angiogenesis. The majority of aGPCRs are orphan receptors …”
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Galectin-3 acts as an angiogenic switch to induce tumor angiogenesis via Jagged-1/Notch activation von Dos Santos, Sofia Nascimento, Sheldon, Helen, Pereira, Jonathas Xavier, Paluch, Christopher, Bridges, Esther M, El-Cheikh, Márcia Curry, Harris, Adrian L, Bernardes, Emerson Soares

“… Angiogenesis is a coordinated process tightly regulated by the balance between Delta-like-4 (DLL4) and Jagged-1 (JAG1) in endothelial cells. Here we show that …”
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RHOQ is induced by DLL4 and regulates angiogenesis by determining the intracellular route of the Notch intracellular domain von Bridges, Esther, Sheldon, Helen, Kleibeuker, Esther, Ramberger, Evelyn, Zois, Christos, Barnard, Alun, Harjes, Ulrike, Li, Ji-Liang, Masiero, Massimo, MacLaren, Robert, Harris, Adrian

“… Angiogenesis, the formation of new blood vessels by endothelial cells, is a finely tuned process relying on the balance between promoting and repressing …”
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A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis von Kerr, Georgina, Sheldon, Helen, Chaikuad, Apirat, Alfano, Ivan, von Delft, Frank, Bullock, Alex N., Harris, Adrian L.

“… Activin receptor-like kinase 1 (ALK1, encoded by the gene ACVRL1 ) is a type I BMP/TGF-β receptor that mediates signalling in endothelial cells via …”
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Investigations on Zinc Isotope Fractionation in Breast Cancer Tissue Using in vitro Cell Culture Uptake-Efflux Experiments von Schilling, Kathrin, Harris, Adrian L., Halliday, Alex N., Schofield, Christopher J., Sheldon, Helen, Haider, Syed, Larner, Fiona

“… Zinc (Zn) accumulates in breast cancer tumors compared to adjacent healthy tissue. Clinical samples of breast cancer tissue show light Zn isotopic compositions …”
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Phase I/II trial of bevacizumab and radiotherapy for locally advanced inoperable colorectal cancer: vasculature-independent radiosensitizing effect of bevacizumab von Koukourakis, Michael I, Giatromanolaki, Alexandra, Sheldon, Helen, Buffa, Francesca M, Kouklakis, George, Ragoussis, Ioannis, Sivridis, Efthimios, Harris, Adrian L

“… Anti-vascular endothelial growth factor therapy enhances the activity of radiotherapy in experimental models, and bevacizumab has therapeutic activity in …”
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ELTD1 is present in extracellular vesicles derived from endothelial cells as a cleaved extracellular domain which induces in vivo angiogenesis von Sheldon, Helen, Zhang, Wei, Bridges, Esther, Ang, Koon Hwee, Lin, Salwa, Masiero, Massimo, Li, Demin, Handford, Penny A., Whiteman, Pat, Fischer, Roman, Buffa, Francesca, Vatish, Manu, Banham, Alison H., Harris, Adrian L.

“… ELTD1/ADGRL4 is an adhesion GPCR with an important role in angiogenesis. We recently identified a role for ELTD1 in wound repair and inflammation. Activation …”
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Copper chelator ATN-224 inhibits endothelial function by multiple mechanisms von Lowndes, Sarah A., Sheldon, Helen V., Cai, Shijie, Taylor, Jennifer M., Harris, Adrian L.

“… Copper is required for the proliferation of endothelial cells and copper-lowering therapy reduces tumour growth in animal models. It has been reported that …”
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Providing easier access to community‐based healthcare for people with joint pain: Experiences of delivering ESCAPE‐pain in community venues by exercise professionals von Hurley, Michael, Sheldon, Helen, Connolly, Margaret, Carter, Andrea, Hallett, Rachel

“… Background Joint pain adversely impacts the physical, mental, socioeconomic and emotional wellbeing of many millions of people. Enabling Self‐management and …”
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New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes von Sheldon, Helen, Heikamp, Emily, Turley, Helen, Dragovic, Rebecca, Thomas, Peter, Oon, Chern Ein, Leek, Russell, Edelmann, Mariola, Kessler, Benedikt, Sainson, Richard C A, Sargent, Ian, Li, Ji-Liang, Harris, Adrian L

“… Notch signaling is an evolutionary conserved pathway that is mediated by cell-cell contact. It is involved in a variety of developmental processes and has an …”
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Remote monitoring of patients with rheumatoid arthritis in a low disease activity state: a mixed methods evaluation across six hospitals in London, UK von Watson, Kathryn, Sheldon, Helen, Pallari, Elena, Arumalla, Nikita, Olive, Rachel R, Boiko, Olga, Aznar, Camille, Adams, Emma-Jayne, Bosworth, Ailsa, Demetriou, Len, Martin, Melanie, Palmer, Mary-Ann, Sinclair, Polly, Smith, Emily J, Sevdalis, Nick, Walker, Andrew, Garrood, Toby

“… Objectives This study evaluated the scale-up of a remote monitoring service, capturing monthly Rheumatoid Arthritis Impact of Disease scores and …”
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ELTD1 Activation Induces an Endothelial-EMT Transition to a Myofibroblast Phenotype von Sheldon, Helen, Alexander, John, Bridges, Esther, Moreira, Lucia, Reilly, Svetlana, Ang, Koon Hwee, Wang, Dian, Lin, Salwa, Haider, Syed, Banham, Alison H., Harris, Adrian L.

“… ELTD1 is expressed in endothelial and vascular smooth muscle cells and has a role in angiogenesis. It has been classified as an adhesion GPCR, but as yet, no …”
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