Suchergebnisse - "Sharpe, Arlene H"

The diverse functions of the PD1 inhibitory pathway von Sharpe, Arlene H, Pauken, Kristen E

“… T cell activation is a highly regulated process involving peptide-MHC engagement of the T cell receptor and positive costimulatory signals. Upon activation, …”
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ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity von Maazi, Hadi, Patel, Nisheel, Sankaranarayanan, Ishwarya, Suzuki, Yuzo, Rigas, Diamanda, Soroosh, Pejman, Freeman, Gordon J, Sharpe, Arlene H, Akbari, Omid

“… Allergic asthma is caused by Th2-cell-type cytokines in response to allergen exposure. Type 2 innate lymphoid cells (ILC2s) are a newly identified subset of …”
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Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family von Schildberg, Frank A, Klein, Sarah R, Freeman, Gordon J, Sharpe, Arlene H

“… Immune responses need to be controlled for optimal protective immunity and tolerance. Coinhibitory pathways in the B7-CD28 family provide critical inhibitory …”
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Coinhibitory Pathways in Immunotherapy for Cancer von Baumeister, Susanne H, Freeman, Gordon J, Dranoff, Glenn, Sharpe, Arlene H

“… The immune system is capable of recognizing tumors and eliminates many early malignant cells. However, tumors evolve to evade immune attack, and the tumor …”
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Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses von Joller, Nicole, Lozano, Ester, Burkett, Patrick R, Patel, Bonny, Xiao, Sheng, Zhu, Chen, Xia, Junrong, Tan, Tze G, Sefik, Esen, Yajnik, Vijay, Sharpe, Arlene H, Quintana, Francisco J, Mathis, Diane, Benoist, Christophe, Hafler, David A, Kuchroo, Vijay K

“… Foxp3(+) T regulatory (Treg) cells regulate immune responses and maintain self-tolerance. Recent work shows that Treg cells are comprised of many …”
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Immune checkpoint inhibitor–associated myocarditis: manifestations and mechanisms von Moslehi, Javid, Lichtman, Andrew H., Sharpe, Arlene H., Galluzzi, Lorenzo, Kitsis, Richard N.

“… Immune checkpoint inhibitors (ICIs) have transformed the treatment of various cancers, including malignancies once considered untreatable. These agents, …”
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Adverse Events Following Cancer Immunotherapy: Obstacles and Opportunities von Pauken, Kristen E., Dougan, Michael, Rose, Noel R., Lichtman, Andrew H., Sharpe, Arlene H.

“… Oncology has recently undergone a revolutionary change with widespread adoption of immunotherapy for many cancers. Immunotherapy using monoclonal antibodies …”
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The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells von Sage, Peter T, Paterson, Alison M, Lovitch, Scott B, Sharpe, Arlene H

“… The receptor CTLA-4 has been implicated in controlling B cell responses, but the mechanisms by which CTLA-4 regulates antibody production are not known. Here …”
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PD-1 pathway in tolerance and autoimmunity von Francisco, Loise M, Sage, Peter T, Sharpe, Arlene H

“… Regulatory T cells (Tregs) and the PD-1: PD-ligand (PD-L) pathway are both critical to terminating immune responses. Elimination of either can result in the …”
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Emerging concepts in PD-1 checkpoint biology von Pauken, Kristen E., Torchia, James A., Chaudhri, Apoorvi, Sharpe, Arlene H., Freeman, Gordon J.

“… •The PD-1 pathway plays multifaceted roles in regulating immune responses.•PD-1 can modulate effector and memory T cells, Treg cells, NK cells, and ILCs.•PD-1 …”
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Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway von Evavold, Charles L, Hafner-Bratkovič, Iva, Devant, Pascal, D'Andrea, Jasmin M, Ngwa, Elsy M, Boršić, Elvira, Doench, John G, LaFleur, Martin W, Sharpe, Arlene H, Thiagarajah, Jay R, Kagan, Jonathan C

“… The process of pyroptosis is mediated by inflammasomes and a downstream effector known as gasdermin D (GSDMD). Upon cleavage by inflammasome-associated …”
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Roles of CD48 in regulating immunity and tolerance von McArdel, Shannon L., Terhorst, Cox, Sharpe, Arlene H.

“… CD48, a member of the signaling lymphocyte activation molecule family, participates in adhesion and activation of immune cells. Although constitutively …”
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Targeting PD-L2–RGMb overcomes microbiome-related immunotherapy resistance von Park, Joon Seok, Gazzaniga, Francesca S., Wu, Meng, Luthens, Amalia K., Gillis, Jacob, Zheng, Wen, LaFleur, Martin W., Johnson, Sarah B., Morad, Golnaz, Park, Elizabeth M., Zhou, Yifan, Watowich, Stephanie S., Wargo, Jennifer A., Freeman, Gordon J., Kasper, Dennis L., Sharpe, Arlene H.

“… The gut microbiota is a crucial regulator of anti-tumour immunity during immune checkpoint inhibitor therapy. Several bacteria that promote an anti-tumour …”
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Inhibitors of the PD-1 Pathway in Tumor Therapy von LaFleur, Martin W, Muroyama, Yuki, Drake, Charles G, Sharpe, Arlene H

“… The programmed death 1 (PD-1) pathway delivers inhibitory signals that function as a brake for immune responses. This pathway limits the initiation and …”
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Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity von Ringel, Alison E, Drijvers, Jefte M, Baker, Gregory J, Catozzi, Alessia, García-Cañaveras, Juan C, Gassaway, Brandon M, Miller, Brian C, Juneja, Vikram R, Nguyen, Thao H, Joshi, Shakchhi, Yao, Cong-Hui, Yoon, Haejin, Sage, Peter T, LaFleur, Martin W, Trombley, Justin D, Jacobson, Connor A, Maliga, Zoltan, Gygi, Steven P, Sorger, Peter K, Rabinowitz, Joshua D, Sharpe, Arlene H, Haigis, Marcia C

“… Obesity is a major cancer risk factor, but how differences in systemic metabolism change the tumor microenvironment (TME) and impact anti-tumor immunity is not …”
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PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity von Helou, Doumet Georges, Shafiei-Jahani, Pedram, Lo, Richard, Howard, Emily, Hurrell, Benjamin P., Galle-Treger, Lauriane, Painter, Jacob D., Lewis, Gavin, Soroosh, Pejman, Sharpe, Arlene H., Akbari, Omid

“… Allergic asthma is a leading chronic disease associated with airway hyperreactivity (AHR). Type-2 innate lymphoid cells (ILC2s) are a potent source of T-helper …”
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CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent Lethal Disease von Sakai, Shunsuke, Kauffman, Keith D., Sallin, Michelle A., Sharpe, Arlene H., Young, Howard A., Ganusov, Vitaly V., Barber, Daniel L.

“… IFN-γ-producing CD4 T cells are required for protection against Mycobacterium tuberculosis (Mtb) infection, but the extent to which IFN-γ contributes to …”
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B-cell-specific checkpoint molecules that regulate anti-tumour immunity von Bod, Lloyd, Kye, Yoon-Chul, Shi, Jingwen, Torlai Triglia, Elena, Schnell, Alexandra, Fessler, Johannes, Ostrowski, Stephen M., Von-Franque, Max Y., Kuchroo, Juhi R., Barilla, Rocky M., Zaghouani, Sarah, Christian, Elena, Delorey, Toni Marie, Mohib, Kanishka, Xiao, Sheng, Slingerland, Nadine, Giuliano, Christopher J., Ashenberg, Orr, Li, Zhaorong, Rothstein, David M., Fisher, David E., Rozenblatt-Rosen, Orit, Sharpe, Arlene H., Quintana, Francisco J., Apetoh, Lionel, Regev, Aviv, Kuchroo, Vijay K.

“… The role of B cells in anti-tumour immunity is still debated and, accordingly, immunotherapies have focused on targeting T and natural killer cells to inhibit …”
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Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth von Kleffel, Sonja, Posch, Christian, Barthel, Steven R, Mueller, Hansgeorg, Schlapbach, Christoph, Guenova, Emmanuella, Elco, Christopher P, Lee, Nayoung, Juneja, Vikram R, Zhan, Qian, Lian, Christine G, Thomi, Rahel, Hoetzenecker, Wolfram, Cozzio, Antonio, Dummer, Reinhard, Mihm, Jr, Martin C, Flaherty, Keith T, Frank, Markus H, Murphy, George F, Sharpe, Arlene H, Kupper, Thomas S, Schatton, Tobias

“… Therapeutic antibodies targeting programmed cell death 1 (PD-1) activate tumor-specific immunity and have shown remarkable efficacy in the treatment of …”
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T Cell Activation Depends on Extracellular Alanine von Ron-Harel, Noga, Ghergurovich, Jonathan M., Notarangelo, Giulia, LaFleur, Martin W., Tsubosaka, Yoshiki, Sharpe, Arlene H., Rabinowitz, Joshua D., Haigis, Marcia C.

“… T cell stimulation is metabolically demanding. To exit quiescence, T cells rely on environmental nutrients, including glucose and the amino acids glutamine, …”
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