Suchergebnisse - "Sharov, Alexei A"

Atlas of regulated target genes of transcription factors (ART-TF) in human ES cells von Sharov, Alexei A., Nakatake, Yuhki, Wang, Weidong

“… Background Transcription factors (TFs) play central roles in maintaining “stemness” of embryonic stem (ES) cells and their differentiation into several …”
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Totipotent Embryonic Stem Cells Arise in Ground-State Culture Conditions von Morgani, Sophie M., Canham, Maurice A., Nichols, Jennifer, Sharov, Alexei A., Migueles, Rosa Portero, Ko, Minoru S.H., Brickman, Joshua M.

“… Embryonic stem cells (ESCs) are derived from mammalian embryos during the transition from totipotency, when individual blastomeres can make all lineages, to …”
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Functional Heterogeneity of Embryonic Stem Cells Revealed through Translational Amplification of an Early Endodermal Transcript von Canham, Maurice A., Sharov, Alexei A., Ko, Minoru S. H., Brickman, Joshua M.

“… ES cells are defined as self-renewing, pluripotent cell lines derived from early embryos. Cultures of ES cells are also characterized by the expression of …”
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Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells von Masui, Shinji, Nakatake, Yuhki, Toyooka, Yayoi, Shimosato, Daisuke, Yagi, Rika, Takahashi, Kazue, Okochi, Hitoshi, Okuda, Akihiko, Matoba, Ryo, Sharov, Alexei A., Ko, Minoru S. H., Niwa, Hitoshi

“… The pluripotency of embryonic stem (ES) cells is thought to be maintained by a few key transcription factors, including Oct3/4 and Sox2. The function of Oct3/4 …”
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ExAtlas: An interactive online tool for meta-analysis of gene expression data von Sharov, Alexei A, Schlessinger, David, Ko, Minoru S H

“… We have developed ExAtlas, an on-line software tool for meta-analysis and visualization of gene expression data. In contrast to existing software tools, …”
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A conserved Oct4/POUV-dependent network links adhesion and migration to progenitor maintenance von Livigni, Alessandra, Peradziryi, Hanna, Sharov, Alexei A, Chia, Gloryn, Hammachi, Fella, Migueles, Rosa Portero, Sukparangsi, Woranop, Pernagallo, Salvatore, Bradley, Mark, Nichols, Jennifer, Ko, Minoru S H, Brickman, Joshua M

“… The class V POU domain transcription factor Oct4 (Pou5f1) is a pivotal regulator of embryonic stem cell (ESC) self-renewal and reprogramming of somatic cells …”
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Dynamics of global gene expression changes during mouse preimplantation development von Hamatani, Toshio, Carter, Mark G, Sharov, Alexei A, Ko, Minoru S H

“… Understanding preimplantation development is important both for basic reproductive biology and for practical applications including regenerative medicine and …”
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Transient bursts of Zscan4 expression are accompanied by the rapid derepression of heterochromatin in mouse embryonic stem cells von Akiyama, Tomohiko, Xin, Li, Oda, Mayumi, Sharov, Alexei A., Amano, Misa, Piao, Yulan, Cadet, J. Scotty, Dudekula, Dawood B., Qian, Yong, Wang, Weidong, Ko, Shigeru B. H., Ko, Minoru S. H.

“… Mouse embryonic stem cells (mESCs) have a remarkable capacity to maintain normal genome stability and karyotype in culture. We previously showed that …”
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Dissecting Oct3/4-Regulated Gene Networks in Embryonic Stem Cells by Expression Profiling von Matoba, Ryo, Niwa, Hitoshi, Masui, Shinji, Ohtsuka, Satoshi, Carter, Mark G., Sharov, Alexei A., Ko, Minoru S.H.

“… POU transcription factor Pou5f1 (Oct3/4) is required to maintain ES cells in an undifferentiated state. Here we show that global expression profiling of …”
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Identification of Transcription Factors for Lineage-Specific ESC Differentiation von Yamamizu, Kohei, Piao, Yulan, Sharov, Alexei A., Zsiros, Veronika, Yu, Hong, Nakazawa, Kazu, Schlessinger, David, Ko, Minoru S.H.

“… A network of transcription factors (TFs) determines cell identity, but identity can be altered by overexpressing a combination of TFs. However, choosing and …”
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Generation and Profiling of 2,135 Human ESC Lines for the Systematic Analyses of Cell States Perturbed by Inducing Single Transcription Factors von Nakatake, Yuhki, Ko, Shigeru B.H., Sharov, Alexei A., Wakabayashi, Shunichi, Murakami, Miyako, Sakota, Miki, Chikazawa, Nana, Ookura, Chiaki, Sato, Saeko, Ito, Noriko, Ishikawa-Hirayama, Madoka, Mak, Siu Shan, Jakt, Lars Martin, Ueno, Tomoo, Hiratsuka, Ken, Matsushita, Misako, Goparaju, Sravan Kumar, Akiyama, Tomohiko, Ishiguro, Kei-ichiro, Oda, Mayumi, Gouda, Norio, Umezawa, Akihiro, Akutsu, Hidenori, Nishimura, Kunihiro, Matoba, Ryo, Ohara, Osamu, Ko, Minoru S.H.

“… Transcription factors (TFs) play a pivotal role in determining cell states, yet our understanding of the causative relationship between TFs and cell states is …”
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BAF250B‐Associated SWI/SNF Chromatin‐Remodeling Complex Is Required to Maintain Undifferentiated Mouse Embryonic Stem Cells von Yan, Zhijiang, Wang, Zhong, Sharova, Lioudmila, Sharov, Alexei A., Ling, Chen, Piao, Yulan, Aiba, Kazuhiro, Matoba, Ryo, Wang, Weidong, Ko, Minoru S. H.

“… Whether SWI/SNF chromatin remodeling complexes play roles in embryonic stem (ES) cells remains unknown. Here we show that SWI/SNF complexes are present in …”
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Essential Role of Chromatin Remodeling Protein Bptf in Early Mouse Embryos and Embryonic Stem Cells von Landry, Joseph, Sharov, Alexei A., Piao, Yulan, Sharova, Lioudmila V., Xiao, Hua, Southon, Eileen, Matta, Jennifer, Tessarollo, Lino, Zhang, Ying E., Ko, Minoru S. H., Kuehn, Michael R., Yamaguchi, Terry P., Wu, Carl

“… We have characterized the biological functions of the chromatin remodeling protein Bptf (Bromodomain PHD-finger Transcription Factor), the largest subunit of …”
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Exhaustive Search for Over-represented DNA Sequence Motifs with CisFinder von Sharov, Alexei A., Ko, Minoru S.H.

“… We present CisFinder software, which generates a comprehensive list of motifs enriched in a set of DNA sequences and describes them with position frequency …”
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Age-associated alteration of gene expression patterns in mouse oocytes von Hamatani, Toshio, Falco, Geppino, Carter, Mark G, Akutsu, Hidenori, Stagg, Carole A, Sharov, Alexei A, Dudekula, Dawood B, VanBuren, Vincent, Ko, Minoru S H

“… Decreasing oocyte competence with maternal aging is a major factor in human infertility. To investigate the age-dependent molecular changes in a mouse model, …”
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Identification of Pou5f1, Sox2, and Nanog downstream target genes with statistical confidence by applying a novel algorithm to time course microarray and genome-wide chromatin immunoprecipitation data von Sharov, Alexei A, Masui, Shinji, Sharova, Lioudmila V, Piao, Yulan, Aiba, Kazuhiro, Matoba, Ryo, Xin, Li, Niwa, Hitoshi, Ko, Minoru SH

“… Background Target genes of a transcription factor (TF) Pou5f1 ( Oct3/4 or Oct4 ), which is essential for pluripotency maintenance and self-renewal of embryonic …”
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Functional Information: Towards Synthesis of Biosemiotics and Cybernetics von Sharov, Alexei A.

“… Biosemiotics and cybernetics are closely related, yet they are separated by the boundary between life and non-life: biosemiotics is focused on living …”
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Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors von Nishiyama, Akira, Xin, Li, Sharov, Alexei A, Thomas, Marshall, Mowrer, Gregory, Meyers, Emily, Piao, Yulan, Mehta, Samir, Yee, Sarah, Nakatake, Yuhki, Stagg, Carole, Sharova, Lioudmila, Correa-Cerro, Lina S, Bassey, Uwem, Hoang, Hien, Kim, Eugene, Tapnio, Richard, Qian, Yong, Dudekula, Dawood, Zalzman, Michal, Li, Manxiang, Falco, Geppino, Yang, Hsih-Te, Lee, Sung-Lim, Monti, Manuela, Stanghellini, Ilaria, Islam, Md Nurul, Nagaraja, Ramaiah, Goldberg, Ilya, Wang, Weidong, Longo, Dan L, Schlessinger, David, Ko, Minoru S H

“… To examine transcription factor (TF) network(s), we created mouse ESC lines, in each of which 1 of 50 TFs tagged with a FLAG moiety is inserted into a …”
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Generation and gene expression profiling of 48 transcription-factor-inducible mouse embryonic stem cell lines von Yamamizu, Kohei, Sharov, Alexei A., Piao, Yulan, Amano, Misa, Yu, Hong, Nishiyama, Akira, Dudekula, Dawood B., Schlessinger, David, Ko, Minoru S. H.

“… Mouse embryonic stem cells (ESCs) can differentiate into a wide range – and possibly all cell types in vitro , and thus provide an ideal platform to study …”
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Transcriptional Activation by Oct4 Is Sufficient for the Maintenance and Induction of Pluripotency von Hammachi, Fella, Morrison, Gillian M., Sharov, Alexei A., Livigni, Alessandra, Narayan, Santosh, Papapetrou, Eirini P., O'Malley, James, Kaji, Keisuke, Ko, Minoru S.H., Ptashne, Mark, Brickman, Joshua M.

“… Oct4 is an essential regulator of pluripotency in vivo and in vitro in embryonic stem cells, as well as a key mediator of the reprogramming of somatic cells …”
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