Suchergebnisse - "Shah, Samah"

A proteomic atlas of senescence-associated secretomes for aging biomarker development von Basisty, Nathan, Kale, Abhijit, Jeon, Ok Hee, Kuehnemann, Chisaka, Payne, Therese, Rao, Chirag, Holtz, Anja, Shah, Samah, Sharma, Vagisha, Ferrucci, Luigi, Campisi, Judith, Schilling, Birgit

“… The senescence-associated secretory phenotype (SASP) has recently emerged as a driver of and promising therapeutic target for multiple age-related conditions, …”
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Coenzyme A binding sites induce proximal acylation across protein families von Carrico, Chris, Cruz, Andrew, Walter, Marius, Meyer, Jesse, Wehrfritz, Cameron, Shah, Samah, Wei, Lei, Schilling, Birgit, Verdin, Eric

“… Lysine Nɛ-acylations, such as acetylation or succinylation, are post-translational modifications that regulate protein function. In mitochondria, lysine …”
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Dietary dicarboxylic acids provide a nonstorable alternative fat source that protects mice against obesity von Goetzman, Eric S., Zhang, Bob B., Zhang, Yuxun, Bharathi, Sivakama S., Bons, Joanna, Rose, Jacob, Shah, Samah, Solo, Keaton J., Schmidt, Alexandra V., Richert, Adam C., Mullett, Steven J., Gelhaus, Stacy L., Rao, Krithika S., Shiva, Sruti S., Pfister, Katherine E., Silva Barbosa, Anne, Sims-Lucas, Sunder, Dobrowolski, Steven F., Schilling, Birgit

“… Dicarboxylic fatty acids are generated in the liver and kidney in a minor pathway called fatty acid ω-oxidation. The effects of consuming dicarboxylic fatty …”
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SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein von Walter, Marius, Chen, Irene P., Vallejo-Gracia, Albert, Kim, Ik-Jung, Bielska, Olga, Lam, Victor L., Hayashi, Jennifer M., Cruz, Andrew, Shah, Samah, Soveg, Frank W., Gross, John D., Krogan, Nevan J., Jerome, Keith R., Schilling, Birgit, Ott, Melanie, Verdin, Eric

“… SARS-CoV-2 non-structural protein Nsp14 is a highly conserved enzyme necessary for viral replication. Nsp14 forms a stable complex with non-structural protein …”
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KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss von Kauwe, Grant, Pareja-Navarro, Kristeen A., Yao, Lei, Chen, Jackson H., Wong, Ivy, Saloner, Rowan, Cifuentes, Helen, Nana, Alissa L., Shah, Samah, Li, Yaqiao, Le, David, Spina, Salvatore, Grinberg, Lea T., Seeley, William W., Kramer, Joel H., Sacktor, Todd C., Schilling, Birgit, Gan, Li, Casaletto, Kaitlin B., Tracy, Tara E.

“… Synaptic plasticity is obstructed by pathogenic tau in the brain, representing a key mechanism that underlies memory loss in Alzheimer's disease (AD) and …”
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Proteomic analysis of X-linked dystonia parkinsonism disease striatal neurons reveals altered RNA metabolism and splicing von Tshilenge, Kizito-Tshitoko, Bons, Joanna, Aguirre, Carlos Galicia, Geronimo-Olvera, Cristian, Shah, Samah, Rose, Jacob, Gerencser, Akos A., Mak, Sally K., Ehrlich, Michelle E., Bragg, D. Cristopher, Schilling, Birgit, Ellerby, Lisa M.

“… X-linked dystonia-parkinsonism (XDP) is a rare neurodegenerative disease endemic to the Philippines. The genetic cause for XDP is an insertion of a …”
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A novel splice variant of Elp3/Kat9 regulates mitochondrial tRNA modification and function von Boutoual, Rachid, Jo, Hyunsun, Heckenbach, Indra, Tiwari, Ritesh, Kasler, Herbert, Lerner, Chad A., Shah, Samah, Schilling, Birgit, Calvanese, Vincenzo, Rardin, Matthew J., Scheibye-Knudsen, Morten, Verdin, Eric

“… Post-translational modifications, such as lysine acetylation, regulate the activity of diverse proteins across many cellular compartments. Protein …”
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Sirtuin-5 Is Recruited to Hepatic Peroxisomes in Mice Fed Dodecanedioic Acid but Has Little Impact on the Peroxisomal Succinylome von Zhang, Yuxun, Zhang, Bob B., Bharathi, Sivakama S., Bons, Joanna, Rose, Jacob P., Shah, Samah, Dobrowolski, Steven F., Sims-Lucas, Sunder, Schilling, Birgit, Goetzman, Eric S.

“… Lysine succinylation, and its reversal by sirtuin-5 (SIRT5), is known to modulate mitochondrial fatty acid β-oxidation (FAO). We recently showed that feeding …”
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MicroRNA sequence codes for small extracellular vesicle release and cellular retention von Garcia-Martin, Ruben, Wang, Guoxiao, Brandão, Bruna B., Zanotto, Tamires M., Shah, Samah, Kumar Patel, Sandip, Schilling, Birgit, Kahn, C. Ronald

“… Exosomes and other small extracellular vesicles (sEVs) provide a unique mode of cell-to-cell communication in which microRNAs (miRNAs) produced and released …”
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Emerging mass spectrometry-based proteomics methodologies for novel biomedical applications von Pino, Lindsay K, Rose, Jacob, O'Broin, Amy, Shah, Samah, Schilling, Birgit

“… Research into the basic biology of human health and disease, as well as translational human research and clinical applications, all benefit from the growing …”
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Dietary dicarboxylic acids provide a nonstorable alternative fat source that protects mice against obesity von Goetzman, Eric S, Zhang, Bob B, Zhang, Yuxun, Bharathi, Sivakama S, Bons, Joanna, Rose, Jacob, Shah, Samah, Solo, Keaton J, Schmidt, Alexandra V, Richert, Adam C, Mullett, Steven J, Geibaus, Stacy L, Rao, Krithika S, Shiva, Srūti S, Pfister, Katherine E, Barbosa, Anne Silva, Sims-Lucas, Sunder, Dobrowolski, Steven F, Schilling, Birgit

“… Dicarboxylic fatty acids are generated in the liver and kidney in a minor pathway called fatty acid co-oxidation. The effects of consuming dicarboxylic fatty …”
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β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain von Madhavan, Sidharth S, Roa Diaz, Stephanie, Peralta, Sawyer, Nomura, Mitsunori, King, Christina D, Ceyhan, Kaya E, Lin, Anwen, Bhaumik, Dipa, Foulger, Anna C, Shah, Samah, Blade, Thanh, Gray, Wyatt, Chamoli, Manish, Eap, Brenda, Panda, Oishika, Diaz, Diego, Garcia, Thelma Y, Stubbs, Brianna J, Ulrich, Scott M, Lithgow, Gordon J, Schilling, Birgit, Verdin, Eric, Chaudhuri, Asish R, Newman, John C

“… Loss of proteostasis is a hallmark of aging and Alzheimer disease (AD). We identify β-hydroxybutyrate (βHB), a ketone body, as a regulator of protein …”
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Data‐independent acquisition and quantification of extracellular matrix from human lung in chronic inflammation‐associated carcinomas von Bons, Joanna, Pan, Deng, Shah, Samah, Bai, Rosemary, Chen‐Tanyolac, Chira, Wang, Xianhong, Elliott, Daffolyn R. Fels, Urisman, Anatoly, O'Broin, Amy, Basisty, Nathan, Rose, Jacob, Sangwan, Veena, Camilleri‐Broët, Sophie, Tankel, James, Gascard, Philippe, Ferri, Lorenzo, Tlsty, Thea D., Schilling, Birgit

“… Early events associated with chronic inflammation and cancer involve significant remodeling of the extracellular matrix (ECM), which greatly affects its …”
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TurnoveR: A Skyline External Tool for Analysis of Protein Turnover in Metabolic Labeling Studies von Basisty, Nathan, Shulman, Nicholas, Wehrfritz, Cameron, Marsh, Alexandra N, Shah, Samah, Rose, Jacob, Ebert, Scott, Miller, Matthew, Dai, Dao-Fu, Rabinovitch, Peter S, Adams, Christopher M, MacCoss, Michael J, MacLean, Brendan, Schilling, Birgit

“… In spite of its central role in biology and disease, protein turnover is a largely understudied aspect of most proteomic studies due to the complexity of …”
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Simultaneous Affinity Enrichment of Two Post-Translational Modifications for Quantification and Site Localization von Xie, Xueshu, Shah, Samah, Holtz, Anja, Rose, Jacob, Basisty, Nathan, Schilling, Birgit

“… Studying multiple post-translational modifications (PTMs) of proteins is a crucial step to understand PTM crosstalk and gain more holistic insights into …”
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Concerted changes in Epithelium and Stroma: a multi-scale, multi-omics analysis of progression from Barrett's Esophagus to adenocarcinoma von Strasser, Michael K, Gibbs, David L, Gascard, Philippe, Bons, Joanna, Hickey, John W, Pan, Deng, Caruso, Joseph A, Wang, Xianhong, Chen-Tanyolac, Chira, Bai, Rosemary, Schürch, Christian M, Tan, Yuqi, Black, Sarah, Chu, Pauline, Ozkan, Alican, Basisty, Nathan, Sangwan, Veena, Rose, Jacob, Shah, Samah, Burton, Jordan B, Camilleri-Broet, Sophie, Fiset, Pierre Olivier, Bertos, Nicholas, Berube, Julie, Djambazian, Haig, Li, Rui, Oikonomopoulos, Spyridon, Elliott, Daffolyn Rachael Fels, Vernovsky, Sarah, Shimshoni, Elee, Collyar, Deborah, Russell, Ann, Ragoussis, Jiannis, Stachler, Matthew D, Goldenring, James R, McDonald, Stuart A C, Ingber, Donald E, Schilling, Birgit, Nolan, Garry P, Tlsty, Thea D, Huang, Sui, Ferri, Lorenzo E

“… Esophageal adenocarcinoma arises from Barrett's esophagus, a metaplastic condition. Multi-omics profiling, integrating single-cell transcriptomics, …”
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Simultaneous Affinity Enrichment of Two Post-Translational Modifications for Quantification and Site Localization von Xie, Xueshu, Shah, Samah, Holtz, Anja, Rose, Jacob, Basisty, Nathan, Schilling, Birgit

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Extracellular Matrix Orchestration of Tissue Remodeling in the Chronically Inflamed Mouse Colon von Moutin, Elisa B., Bons, Joanna, Giavara, Giada, Lourenco, Filipe, Pan, Deng, Burton, Jordan B., Shah, Samah, Colombé, Mathilde, Gascard, Philippe, Tlsty, Thea, Schilling, Birgit, Winton, Douglas J.

“… Chronic inflammatory illnesses are debilitating and recurrent conditions associated with significant comorbidities, including an increased risk of developing …”
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Ketogenic diet administration later in life improves memory by modifying the synaptic cortical proteome via the PKA signaling pathway in aging mice von Acuña-Catalán, Diego, Shah, Samah, Wehrfritz, Cameron, Nomura, Mitsunori, Acevedo, Alejandro, Olmos, Cristina, Quiroz, Gabriel, Huerta, Hernán, Bons, Joanna, Ampuero, Estibaliz, Wyneken, Ursula, Sanhueza, Magdalena, Arancibia, Felipe, Contreras, Darwin, Cárdenas, Julio César, Morales, Bernardo, Schilling, Birgit, Newman, John C., González-Billault, Christian

“… Aging compromises brain function leading to cognitive decline. A cyclic ketogenic diet (KD) improves memory in aged mice after long-term administration; …”
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Extracellular Matrix Orchestration of Tissue Remodeling in the Chronically Inflamed Mouse ColonSummary von Elisa B. Moutin, Joanna Bons, Giada Giavara, Filipe Lourenco, Deng Pan, Jordan B. Burton, Samah Shah, Mathilde Colombé, Philippe Gascard, Thea Tlsty, Birgit Schilling, Douglas J. Winton

“… Background & Aims: Chronic inflammatory illnesses are debilitating and recurrent conditions associated with significant comorbidities, including an increased …”
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