Výsledky vyhľadávania - "Sethna, Zachary"

Neoantigen quality predicts immunoediting in survivors of pancreatic cancer Autor Łuksza, Marta, Sethna, Zachary M., Rojas, Luis A., Lihm, Jayon, Bravi, Barbara, Elhanati, Yuval, Soares, Kevin, Amisaki, Masataka, Dobrin, Anton, Hoyos, David, Guasp, Pablo, Zebboudj, Abderezak, Yu, Rebecca, Chandra, Adrienne Kaya, Waters, Theresa, Odgerel, Zagaa, Leung, Joanne, Kappagantula, Rajya, Makohon-Moore, Alvin, Johns, Amber, Gill, Anthony, Gigoux, Mathieu, Wolchok, Jedd, Merghoub, Taha, Sadelain, Michel, Patterson, Erin, Monasson, Remi, Mora, Thierry, Walczak, Aleksandra M., Cocco, Simona, Iacobuzio-Donahue, Christine, Greenbaum, Benjamin D., Balachandran, Vinod P.

“…Cancer immunoediting 1 is a hallmark of cancer 2 that predicts that lymphocytes kill more immunogenic cancer cells to cause less immunogenic clones to dominate…”
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ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity Autor Moral, John Alec, Leung, Joanne, Rojas, Luis A., Ruan, Jennifer, Zhao, Julia, Sethna, Zachary, Ramnarain, Anita, Gasmi, Billel, Gururajan, Murali, Redmond, David, Askan, Gokce, Bhanot, Umesh, Elyada, Ela, Park, Youngkyu, Tuveson, David A., Gönen, Mithat, Leach, Steven D., Wolchok, Jedd D., DeMatteo, Ronald P., Merghoub, Taha, Balachandran, Vinod P.

“…Group 2 innate lymphoid cells (ILC2s) regulate inflammation and immunity in mammalian tissues 1 , 2 . Although ILC2s are found in cancers of these tissues 3 ,…”
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Inferring processes underlying B-cell repertoire diversity Autor Elhanati, Yuval, Sethna, Zachary, Marcou, Quentin, Callan, Jr, Curtis G, Mora, Thierry, Walczak, Aleksandra M

“…We quantify the VDJ recombination and somatic hypermutation processes in human B cells using probabilistic inference methods on high-throughput DNA sequence…”
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Population variability in the generation and selection of T-cell repertoires Autor Sethna, Zachary, Isacchini, Giulio, Dupic, Thomas, Mora, Thierry, Walczak, Aleksandra M., Elhanati, Yuval

“…The diversity of T-cell receptor (TCR) repertoires is achieved by a combination of two intrinsically stochastic steps: random receptor generation by VDJ…”
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IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer Autor Amisaki, Masataka, Zebboudj, Abderezak, Yano, Hiroshi, Zhang, Siqi Linsey, Payne, George, Chandra, Adrienne Kaya, Yu, Rebecca, Guasp, Pablo, Sethna, Zachary M., Ohmoto, Akihiro, Rojas, Luis A., Cheng, Charlotte, Waters, Theresa, Solovyov, Alexander, Martis, Stephen, Doane, Ashley S., Reiche, Charlotte, Bruno, Emmanuel M., Milighetti, Martina, Soares, Kevin, Odgerel, Zagaa, Moral, John Alec, Zhao, Julia N., Gönen, Mithat, Gardner, Rui, Tumanov, Alexei V., Khan, Abdul G., Vergnolle, Olivia, Nyakatura, Elisabeth K., Lorenz, Ivo C., Baca, Manuel, Patterson, Erin, Greenbaum, Benjamin, Artis, David, Merghoub, Taha, Balachandran, Vinod P.

“…Tertiary lymphoid structures (TLSs) are de novo ectopic lymphoid aggregates that regulate immunity in chronically inflamed tissues, including tumours. Although…”
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Identification of transcriptional programs using dense vector representations defined by mutual information with GeneVector Autor Ceglia, Nicholas, Sethna, Zachary, Freeman, Samuel S., Uhlitz, Florian, Bojilova, Viktoria, Rusk, Nicole, Burman, Bharat, Chow, Andrew, Salehi, Sohrab, Kabeer, Farhia, Aparicio, Samuel, Greenbaum, Benjamin D., Shah, Sohrab P., McPherson, Andrew

“…Deciphering individual cell phenotypes from cell-specific transcriptional processes requires high dimensional single cell RNA sequencing. However, current…”
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Accelerating multidimensional NMR and MRI experiments using iterated maps Autor Frey, Merideth A., Sethna, Zachary M., Manley, Gregory A., Sengupta, Suvrajit, Zilm, Kurt W., Loria, J. Patrick, Barrett, Sean E.

“…[Display omitted] •An iterated maps algorithm is applied to sparsely-sampled time domain data.•Used to reconstruct spectra from noisy 2D NMR and 3D MRI of…”
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OLGA: fast computation of generation probabilities of B- and T-cell receptor amino acid sequences and motifs Autor Sethna, Zachary, Elhanati, Yuval, Callan, Curtis G, Walczak, Aleksandra M, Mora, Thierry

“…High-throughput sequencing of large immune repertoires has enabled the development of methods to predict the probability of generation by V(D)J recombination…”
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RNA vaccines for cancer: Principles to practice Autor Guasp, Pablo, Reiche, Charlotte, Sethna, Zachary, Balachandran, Vinod P

“…Vaccines are the most impactful medicines to improve health. Though potent against pathogens, vaccines for cancer remain an unfulfilled promise. However,…”
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Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer Autor Rojas, Luis A., Sethna, Zachary, Soares, Kevin C., Olcese, Cristina, Pang, Nan, Patterson, Erin, Lihm, Jayon, Ceglia, Nicholas, Guasp, Pablo, Chu, Alexander, Yu, Rebecca, Chandra, Adrienne Kaya, Waters, Theresa, Ruan, Jennifer, Amisaki, Masataka, Zebboudj, Abderezak, Odgerel, Zagaa, Payne, George, Derhovanessian, Evelyna, Müller, Felicitas, Rhee, Ina, Yadav, Mahesh, Dobrin, Anton, Sadelain, Michel, Łuksza, Marta, Cohen, Noah, Tang, Laura, Basturk, Olca, Gönen, Mithat, Katz, Seth, Do, Richard Kinh, Epstein, Andrew S., Momtaz, Parisa, Park, Wungki, Sugarman, Ryan, Varghese, Anna M., Won, Elizabeth, Desai, Avni, Wei, Alice C., D’Angelica, Michael I., Kingham, T. Peter, Mellman, Ira, Merghoub, Taha, Wolchok, Jedd D., Sahin, Ugur, Türeci, Özlem, Greenbaum, Benjamin D., Jarnagin, William R., Drebin, Jeffrey, O’Reilly, Eileen M., Balachandran, Vinod P.

“…Pancreatic ductal adenocarcinoma (PDAC) is lethal in 88% of patients 1 , yet harbours mutation-derived T cell neoantigens that are suitable for vaccines 2 , 3…”
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Predicting the spectrum of TCR repertoire sharing with a data‐driven model of recombination Autor Elhanati, Yuval, Sethna, Zachary, Callan, Curtis G., Mora, Thierry, Walczak, Aleksandra M.

“…Summary Despite the extreme diversity of T‐cell repertoires, many identical T‐cell receptor (TCR) sequences are found in a large number of individual mice and…”
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RNA neoantigen vaccines prime long-lived CD8+ T cells in pancreatic cancer Autor Sethna, Zachary, Guasp, Pablo, Reiche, Charlotte, Milighetti, Martina, Ceglia, Nicholas, Patterson, Erin, Lihm, Jayon, Payne, George, Lyudovyk, Olga, Rojas, Luis A., Pang, Nan, Ohmoto, Akihiro, Amisaki, Masataka, Zebboudj, Abderezak, Odgerel, Zagaa, Bruno, Emmanuel M., Zhang, Siqi Linsey, Cheng, Charlotte, Elhanati, Yuval, Derhovanessian, Evelyna, Manning, Luisa, Müller, Felicitas, Rhee, Ina, Yadav, Mahesh, Merghoub, Taha, Wolchok, Jedd D., Basturk, Olca, Gönen, Mithat, Epstein, Andrew S., Momtaz, Parisa, Park, Wungki, Sugarman, Ryan, Varghese, Anna M., Won, Elizabeth, Desai, Avni, Wei, Alice C., D’Angelica, Michael I., Kingham, T. Peter, Soares, Kevin C., Jarnagin, William R., Drebin, Jeffrey, O’Reilly, Eileen M., Mellman, Ira, Sahin, Ugur, Türeci, Özlem, Greenbaum, Benjamin D., Balachandran, Vinod P.

“…A fundamental challenge for cancer vaccines is to generate long-lived functional T cells that are specific for tumour antigens. Here we find that mRNA–lipoplex…”
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Fundamental immune–oncogenicity trade-offs define driver mutation fitness Autor Hoyos, David, Zappasodi, Roberta, Schulze, Isabell, Sethna, Zachary, de Andrade, Kelvin César, Bajorin, Dean F., Bandlamudi, Chaitanya, Callahan, Margaret K., Funt, Samuel A., Hadrup, Sine R., Holm, Jeppe S., Rosenberg, Jonathan E., Shah, Sohrab P., Vázquez-García, Ignacio, Weigelt, Britta, Wu, Michelle, Zamarin, Dmitriy, Campitelli, Laura F., Osborne, Edward J., Klinger, Mark, Robins, Harlan S., Khincha, Payal P., Savage, Sharon A., Balachandran, Vinod P., Wolchok, Jedd D., Hellmann, Matthew D., Merghoub, Taha, Levine, Arnold J., Łuksza, Marta, Greenbaum, Benjamin D.

“…Missense driver mutations in cancer are concentrated in a few hotspots 1 . Various mechanisms have been proposed to explain this skew, including biased…”
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Population variability in the generation and thymic selection of T-cell repertoires Autor Sethna, Zachary, Isacchini, Giulio, Dupic, Thomas, Mora, Thierry, Walczak, Aleksandra, Elhanati, Yuval

“…The diversity of T-cell receptor (TCR) repertoires is achieved by a combination of two intrinsically stochastic steps: random receptor generation by VDJ…”
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Insights into immune system development and function from mouse T-cell repertoires Autor Sethna, Zachary, Elhanati, Yuval, Dudgeon, Crissy S, Callan, Jr, Curtis G, Levine, Arnold J, Mora, Thierry, Walczak, Aleksandra M

“…The ability of the adaptive immune system to respond to arbitrary pathogens stems from the broad diversity of immune cell surface receptors. This diversity…”
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TCRi: Information theoretic metrics for single cell RNA and TCR sequencing in cancer Autor Ceglia, Nicholas, Sethna, Zachary M, Elhanati, Yuval, Burman, Bharat, Chow, Andrew, Zamarin, Dmitriy, Dewolf, Susan, Shahid, Sanam, Bojilova, Viktoria, Rusk, Nicole, Balachandran, Vinod P, Mcpherson, Andrew, Shah, Sohrab P, Greenbaum, Benjamin D

“…Single-cell T cell repertoire sequencing can pair both T cell receptor (TCR) and gene expression sequence data, providing an enriched view of T cell behavior…”
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Author Correction: Fundamental immune–oncogenicity trade-offs define driver mutation fitness Autor Hoyos, David, Zappasodi, Roberta, Schulze, Isabell, Sethna, Zachary, de Andrade, Kelvin César, Bajorin, Dean F., Bandlamudi, Chaitanya, Callahan, Margaret K., Funt, Samuel A., Hadrup, Sine R., Holm, Jeppe S., Rosenberg, Jonathan E., Shah, Sohrab P., Vázquez-García, Ignacio, Weigelt, Britta, Wu, Michelle, Zamarin, Dmitriy, Campitelli, Laura F., Osborne, Edward J., Klinger, Mark, Robins, Harlan S., Khincha, Payal P., Savage, Sharon A., Balachandran, Vinod P., Wolchok, Jedd D., Hellmann, Matthew D., Merghoub, Taha, Levine, Arnold J., Łuksza, Marta, Greenbaum, Benjamin D.

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Generative models of T-cell receptor sequences Autor Isacchini, Giulio, Sethna, Zachary, Elhanati, Yuval, Nourmohammad, Armita, Walczak, Aleksandra M, Mora, Thierry

“…T-cell receptors (TCR) are key proteins of the adaptive immune system, generated randomly in each individual, whose diversity underlies our ability to…”
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Probability, Entropy, and Adaptive Immune System Repertoires Autor Sethna, Zachary Michael

“…The adaptive immune system, composed of white blood cells called lymphocytes (B and T cells) that circulate in the lymph and blood, is a precision tool that…”
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On generative models of T-cell receptor sequences Autor Isacchini, Giulio, Sethna, Zachary, Elhanati, Yuval, Nourmohammad, Armita, Walczak, Aleksandra M, Mora, Thierry

“…T-cell receptors (TCR) are key proteins of the adaptive immune system, generated randomly in each individual, whose diversity underlies our ability to…”
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