Výsledky vyhľadávania - "Serresi, Michela"

Dendrimer internalization and intracellular trafficking in living cells Autor Albertazzi, Lorenzo, Serresi, Michela, Albanese, Alberto, Beltram, Fabio

“…The ability of dendrimers to cross cell membranes is of much interest for their application in drug and gene delivery. Recent studies demonstrate that…”
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HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness Autor Ho, Jessica SY, Di Tullio, Federico, Schwarz, Megan, Low, Diana, Incarnato, Danny, Gay, Florence, Tabaglio, Tommaso, Zhang, JingXian, Wollmann, Heike, Chen, Leilei, An, Omer, Chan, Tim Hon Man, Hall Hickman, Alexander, Zheng, Simin, Roudko, Vladimir, Chen, Sujun, Karz, Alcida, Ahmed, Musaddeque, He, Housheng Hansen, Greenbaum, Benjamin D, Oliviero, Salvatore, Serresi, Michela, Gargiulo, Gaetano, Mann, Karen M, Hernando, Eva, Mulholland, David, Marazzi, Ivan, Wee, Dave Keng Boon, Guccione, Ernesto

“…High spliceosome activity is a dependency for cancer cells, making them more vulnerable to perturbation of the splicing machinery compared to normal cells. To…”
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Logical design of synthetic cis-regulatory DNA for genetic tracing of cell identities and state changes Autor Company, Carlos, Schmitt, Matthias Jürgen, Dramaretska, Yuliia, Serresi, Michela, Kertalli, Sonia, Jiang, Ben, Yin, Jiang-An, Aguzzi, Adriano, Barozzi, Iros, Gargiulo, Gaetano

“…Descriptive data are rapidly expanding in biomedical research. Instead, functional validation methods with sufficient complexity remain underdeveloped…”
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Neuronal polarity selection by topography-induced focal adhesion control Autor Ferrari, Aldo, Cecchini, Marco, Serresi, Michela, Faraci, Paolo, Pisignano, Dario, Beltram, Fabio

“…Interaction between differentiating neurons and the extracellular environment guides the establishment of cell polarity during nervous system development…”
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Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells Autor Lancini, Cesare, van den Berk, Paul C M, Vissers, Joseph H A, Gargiulo, Gaetano, Song, Ji-Ying, Hulsman, Danielle, Serresi, Michela, Tanger, Ellen, Blom, Marleen, Vens, Conchita, van Lohuizen, Maarten, Jacobs, Heinz, Citterio, Elisabetta

“…Histone ubiquitination at DNA breaks is required for activation of the DNA damage response (DDR) and DNA repair. How the dynamic removal of this modification…”
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Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis Autor Pece, Salvatore, Serresi, Michela, Santolini, Elisa, Capra, Maria, Hulleman, Esther, Galimberti, Viviana, Zurrida, Stefano, Maisonneuve, Patrick, Viale, Giuseppe, Di Fiore, Pier Paolo

“…The biological antagonism between Notch and Numb controls the proliferative/differentiative balance in development and homeostasis. Although altered Notch…”
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Raman study of chromophore states in photochromic fluorescent proteins Autor Luin, Stefano, Voliani, Valerio, Lanza, Giacomo, Bizzarri, Ranieri, Amat, Pietro, Tozzini, Valentina, Serresi, Michela, Beltram, Fabio

“…The photophysical mechanism underlying the photochromic behavior of green fluorescent protein (GFP) mutants is investigated by means of preresonant Raman…”
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Viral density and virus-to-bacterium ratio in deep-sea sediments of the Eastern Mediterranean Autor Danovaro, R, Serresi, M

“…Viruses are now recognized as a key component in pelagic systems, but their role in marine sediment has yet to be assessed. In this study bacterial and viral…”
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Cell States in Cancer: Drivers, Passengers, and Trailers Autor Gargiulo, Gaetano, Serresi, Michela, Marine, Jean-Christophe

“…Cancer is traditionally perceived through a genetic lens, with therapeutic strategies targeting oncogenic driver mutations. We advocate an overarching…”
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Green fluorescent protein based pH indicators for in vivo use: a review Autor Bizzarri, Ranieri, Serresi, Michela, Luin, Stefano, Beltram, Fabio

“…Green fluorescent protein (GFP) and its variants have been used as fluorescent reporters in a variety of applications for monitoring dynamic processes in cells…”
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Phenotypic Mapping of Pathologic Cross-Talk between Glioblastoma and Innate Immune Cells by Synthetic Genetic Tracing Autor Schmitt, Matthias Jürgen, Company, Carlos, Dramaretska, Yuliia, Barozzi, Iros, Göhrig, Andreas, Kertalli, Sonia, Großmann, Melanie, Naumann, Heike, Sanchez-Bailon, Maria Pilar, Hulsman, Danielle, Glass, Rainer, Squatrito, Massimo, Serresi, Michela, Gargiulo, Gaetano

“…Glioblastoma is a lethal brain tumor that exhibits heterogeneity and resistance to therapy. Our understanding of tumor homeostasis is limited by a lack of…”
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A ligand-inducible epidermal growth factor receptor/anaplastic lymphoma kinase chimera promotes mitogenesis and transforming properties in 3T3 cells Autor Piccinini, Gina, Bacchiocchi, Roberta, Serresi, Michela, Vivani, Caterina, Rossetti, Silvia, Gennaretti, Claudia, Carbonari, Damiano, Fazioli, Francesca

“…Oncogenic rearrangements of the anaplastic lymphoma kinase (ALK) gene, encoding a receptor type tyrosine kinase, are frequently associated with anaplastic…”
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Polycomb Repressive Complex 2 Is a Barrier to KRAS-Driven Inflammation and Epithelial-Mesenchymal Transition in Non-Small-Cell Lung Cancer Autor Serresi, Michela, Gargiulo, Gaetano, Proost, Natalie, Siteur, Bjorn, Cesaroni, Matteo, Koppens, Martijn, Xie, Huafeng, Sutherland, Kate D, Hulsman, Danielle, Citterio, Elisabetta, Orkin, Stuart, Berns, Anton, van Lohuizen, Maarten

“…Polycomb repressive complexes (PRC) are frequently implicated in human cancer, acting either as oncogenes or tumor suppressors. Here, we show that PRC2 is a…”
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A novel chimeric cell-penetrating peptide with membrane-disruptive properties for efficient endosomal escape Autor Salomone, Fabrizio, Cardarelli, Francesco, Di Luca, Mariagrazia, Boccardi, Claudia, Nifosì, Riccardo, Bardi, Giuseppe, Di Bari, Lorenzo, Serresi, Michela, Beltram, Fabio

“…Efficient endocytosis into a wide range of target cells and low toxicity make the arginine-rich Tat peptide (Tat11: YGRKKRRQRRR, residues 47–57 of HIV-1 Tat…”
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In vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis Autor Gargiulo, Gaetano, Cesaroni, Matteo, Serresi, Michela, de Vries, Nienke, Hulsman, Danielle, Bruggeman, Sophia W, Lancini, Cesare, van Lohuizen, Maarten

“…In mouse and human neural progenitor and glioblastoma "stem-like" cells, we identified key targets of the Polycomb-group protein BMI1 by combining ChIP-seq…”
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Basic Science and Pathogenesis Autor Deckert, Annika, Böddrich, Annett, Diez, Lisa, Schmitt, Matthias Jürgen, Nevado, Juan Carlos Company, Beetz, Stephanie, Brusendorf, Lydia, Serresi, Michela, Wegmann, Susanne, Gargiulo, Gaetano, Wanker, Erich

“…The microtubule-associated protein tau is the most commonly misfolded protein in neurodegenerative disorders including Alzheimer's disease and other related…”
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Unraveling the interplay between tau seeding and autophagy processes Autor Deckert, Annika, Böddrich, Annett, Diez, Lisa, Schmitt, Matthias Jürgen, Nevado, Juan Carlos Company, Beetz, Stephanie, Brusendorf, Lydia, Serresi, Michela, Wegmann, Susanne, Gargiulo, Gaetano, Wanker, Erich

“…Background The microtubule‐associated protein tau is the most commonly misfolded protein in neurodegenerative disorders including Alzheimer’s disease and other…”
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Functional antagonism of chromatin modulators regulates epithelial-mesenchymal transition Autor Serresi, Michela, Kertalli, Sonia, Li, Lifei, Schmitt, Matthias Jürgen, Dramaretska, Yuliia, Wierikx, Jikke, Hulsman, Danielle, Gargiulo, Gaetano

“…Chromatin modulators with antagonistic functions on epithelial-mesenchymal interconversion regulate common pan-cancer genes. Epithelial-mesenchymal transition…”
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Ezh2 inhibition in Kras-driven lung cancer amplifies inflammation and associated vulnerabilities Autor Serresi, Michela, Siteur, Bjorn, Hulsman, Danielle, Company, Carlos, Schmitt, Matthias J, Lieftink, Cor, Morris, Ben, Cesaroni, Matteo, Proost, Natalie, Beijersbergen, Roderick L, van Lohuizen, Maarten, Gargiulo, Gaetano

“…Kras-driven non-small-cell lung cancers (NSCLCs) are a leading cause of death with limited therapeutic options. Many NSCLCs exhibit high levels of Ezh2, the…”
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In vivo shRNA screens in solid tumors Autor Gargiulo, Gaetano, Serresi, Michela, Cesaroni, Matteo, Hulsman, Danielle, van Lohuizen, Maarten

“…Gargiulo et al . describe the use of shRNA libraries for functional screens in orthotopic mouse tumor models, using glioma and lung cancer as examples…”
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