Suchergebnisse - "Sergeant, Martin J."

A genomic overview of the population structure of Salmonella von Alikhan, Nabil-Fareed, Zhou, Zhemin, Sergeant, Martin J., Achtman, Mark

“… For many decades, Salmonella enterica has been subdivided by serological properties into serovars or further subdivided for epidemiological tracing by a …”
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GrapeTree: visualization of core genomic relationships among 100,000 bacterial pathogens von Zhou, Zhemin, Alikhan, Nabil-Fareed, Sergeant, Martin J, Luhmann, Nina, Vaz, Cátia, Francisco, Alexandre P, Carriço, João André, Achtman, Mark

“… Current methods struggle to reconstruct and visualize the genomic relationships of large numbers of bacterial genomes. GrapeTree facilitates the analyses of …”
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Extensive Microbial and Functional Diversity within the Chicken Cecal Microbiome von Sergeant, Martin J., Constantinidou, Chrystala, Cogan, Tristan A., Bedford, Michael R., Penn, Charles W., Pallen, Mark J.

“… Chickens are major source of food and protein worldwide. Feed conversion and the health of chickens relies on the largely unexplored complex microbial …”
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Differences in the Faecal Microbiome in Schistosoma haematobium Infected Children vs. Uninfected Children von Kay, Gemma Louise, Millard, Andrew, Sergeant, Martin J., Midzi, Nicholas, Gwisai, Reggis, Mduluza, Takafira, Ivens, Alasdair, Nausch, Norman, Mutapi, Francisca, Pallen, Mark

“… Several infectious diseases and therapeutic interventions cause gut microbe dysbiosis and associated pathology. We characterised the gut microbiome of children …”
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High-Throughput Sequencing of 16S rRNA Gene Amplicons: Effects of Extraction Procedure, Primer Length and Annealing Temperature von Sergeant, Martin J., Constantinidou, Chrystala, Cogan, Tristan, Penn, Charles W., Pallen, Mark J.

“… The analysis of 16S-rDNA sequences to assess the bacterial community composition of a sample is a widely used technique that has increased with the advent of …”
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Culture-independent detection and characterisation of Mycobacterium tuberculosis and M. africanum in sputum samples using shotgun metagenomics on a benchtop sequencer von Doughty, Emma L., Sergeant, Martin J., Adetifa, Ifedayo, Antonio, Martin, Pallen, Mark J.

“… Tuberculosis remains a major global health problem. Laboratory diagnostic methods that allow effective, early detection of cases are central to management of …”
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Recovery of a Medieval Brucella melitensis Genome Using Shotgun Metagenomics von Kay, Gemma L., Sergeant, Martin J., Giuffra, Valentina, Bandiera, Pasquale, Milanese, Marco, Bramanti, Barbara, Bianucci, Raffaella, Pallen, Mark J.

“… Shotgun metagenomics provides a powerful assumption-free approach to the recovery of pathogen genomes from contemporary and historical material. We sequenced …”
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Multi Locus View: an extensible web-based tool for the analysis of genomic data von Sergeant, Martin J., Hughes, Jim R., Hentges, Lance, Lunter, Gerton, Downes, Damien J., Taylor, Stephen

“… Tracking and understanding data quality, analysis and reproducibility are critical concerns in the biological sciences. This is especially true in genomics …”
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Short-tailed stx phages exploit the conserved YaeT protein to disseminate Shiga toxin genes among enterobacteria von Smith, Darren L, James, Chloë E, Sergeant, Martin J, Yaxian, Yan, Saunders, Jon R, McCarthy, Alan J, Allison, Heather E

“… Infection of Escherichia coli by Shiga toxin-encoding bacteriophages (Stx phages) was the pivotal event in the evolution of the deadly Shiga toxin-encoding E …”
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LanceOtron: a deep learning peak caller for genome sequencing experiments von Hentges, Lance D, Sergeant, Martin J, Cole, Christopher B, Downes, Damien J, Hughes, Jim R, Taylor, Stephen

“… Abstract Motivation Genome sequencing experiments have revolutionized molecular biology by allowing researchers to identify important DNA-encoded elements …”
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Eighteenth-century genomes show that mixed infections were common at time of peak tuberculosis in Europe von Kay, Gemma L., Sergeant, Martin J., Zhou, Zhemin, Chan, Jacqueline Z.-M., Millard, Andrew, Quick, Joshua, Szikossy, Ildikó, Pap, Ildikó, Spigelman, Mark, Loman, Nicholas J., Achtman, Mark, Donoghue, Helen D., Pallen, Mark J.

“… Tuberculosis (TB) was once a major killer in Europe, but it is unclear how the strains and patterns of infection at ‘peak TB’ relate to what we see today. Here …”
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Pan-genome Analysis of Ancient and Modern Salmonella enterica Demonstrates Genomic Stability of the Invasive Para C Lineage for Millennia von Zhou, Zhemin, Lundstrøm, Inge, Tran-Dien, Alicia, Duchêne, Sebastián, Alikhan, Nabil-Fareed, Sergeant, Martin J, Langridge, Gemma, Fotakis, Anna K, Nair, Satheesh, Stenøien, Hans K, Hamre, Stian S, Casjens, Sherwood, Christophersen, Axel, Quince, Christopher, Thomson, Nicholas R, Weill, François-Xavier, Ho, Simon Y W, Gilbert, M Thomas P, Achtman, Mark

“… Salmonella enterica serovar Paratyphi C causes enteric (paratyphoid) fever in humans. Its presentation can range from asymptomatic infections of the blood …”
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Does abscisic acid affect strigolactone biosynthesis von López-Ráez, Juan A, Kohlen, Wouter, Charnikhova, Tatsiana, Mulder, Patrick, Undas, Anna K, Sergeant, Martin J, Verstappen, Francel, Bugg, Timothy D.H, Thompson, Andrew J, Ruyter-Spira, Carolien, Bouwmeester, Harro

“… Strigolactones are considered a novel class of plant hormones that, in addition to their endogenous signalling function, are exuded into the rhizosphere acting …”
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Immunity profiles of wild-type and recombinant shiga-like toxin-encoding bacteriophages and characterization of novel double lysogens von Allison, Heather E, Sergeant, Martin J, James, Chloë E, Saunders, Jon R, Smith, Darren L, Sharp, Richard J, Marks, Trevor S, McCarthy, Alan J

“… The pathogenicity of Shiga-like toxin (stx)-producing Escherichia coli (STEC), notably serotype O157, the causative agent of hemorrhagic colitis, …”
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Impact of human-associated Escherichia coli clonal groups in Antarctic pinnipeds: presence of ST73, ST95, ST141 and ST131 von Mora, Azucena, García-Peña, Francisco Javier, Alonso, María Pilar, Pedraza-Diaz, Susana, Ortega-Mora, Luis Miguel, Garcia-Parraga, Daniel, López, Cecilia, Viso, Susana, Dahbi, Ghizlane, Marzoa, Juan, Sergeant, Martin J., García, Vanesa, Blanco, Jorge

“… There is growing concern about the spreading of human microorganisms in relatively untouched ecosystems such as the Antarctic region. For this reason, three …”
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Metagenomic Analysis of Tuberculosis in a Mummy von Chan, Jacqueline Z.-M, Sergeant, Martin J, Lee, Oona Y.-C, Minnikin, David E, Besra, Gurdyal S, Pap, Ilidkó, Spigelman, Mark, Donoghue, Helen D, Pallen, Mark J

“… Metagenomic analysis, which involves the sequencing of unenriched DNA from uncultured samples, is probably best known for its use in the analysis of microbes …”
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Promotion of Germination Using Hydroxamic Acid Inhibitors of 9-cis-Epoxycarotenoid Dioxygenase von Awan, Sajjad Z., Chandler, Jake O., Harrison, Peter J., Sergeant, Martin J., Bugg, Timothy D. H., Thompson, Andrew J.

“… Abscisic acid (ABA) inhibits seed germination and the regulation of ABA biosynthesis has a role in maintenance of seed dormancy. The key rate-limiting step in …”
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Selective inhibition of carotenoid cleavage dioxygenases: phenotypic effects on shoot branching von Sergeant, Martin J, Li, Jian-Jun, Fox, Christine, Brookbank, Nicola, Rea, Dean, Bugg, Timothy D H, Thompson, Andrew J

“… Members of the carotenoid cleavage dioxygenase family catalyze the oxidative cleavage of carotenoids at various chain positions, leading to the formation of a …”
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Resequencing at ≥40-Fold Depth of the Parental Genomes of a Solanum lycopersicum × S. pimpinellifolium Recombinant Inbred Line Population and Characterization of Frame-Shift InDels That Are Highly Likely to Perturb Protein Function von Kevei, Zoltan, King, Robert C, Mohareb, Fady, Sergeant, Martin J, Awan, Sajjad Z, Thompson, Andrew J

“… Abstract A recombinant in-bred line population derived from a cross between Solanum lycopersicum var. cerasiforme (E9) and S. pimpinellifolium (L5) has been …”
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Draft Genome Sequences of Six Novel Bacterial Isolates from Chicken Ceca von Duggett, Nicholas A., Kay, Gemma L., Sergeant, Martin J., Bedford, Michael, Constantinidou, Chrystala I., Penn, Charles W., Millard, Andrew D., Pallen, Mark J.

“… The chicken is the most common domesticated animal and the most abundant bird in the world. However, the chicken gut is home to many previously uncharacterized …”
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