Suchergebnisse - "Sepulveda, Manuel A"

Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors von Kumar, Vinit, Donthireddy, Laxminarasimha, Marvel, Douglas, Condamine, Thomas, Wang, Fang, Lavilla-Alonso, Sergio, Hashimoto, Ayumi, Vonteddu, Prashanthi, Behera, Reeti, Goins, Marlee A, Mulligan, Charles, Nam, Brian, Hockstein, Neil, Denstman, Fred, Shakamuri, Shanti, Speicher, David W, Weeraratna, Ashani T, Chao, Timothy, Vonderheide, Robert H, Languino, Lucia R, Ordentlich, Peter, Liu, Qin, Xu, Xiaowei, Lo, Albert, Puré, Ellen, Zhang, Chunsheng, Loboda, Andrey, Sepulveda, Manuel A, Snyder, Linda A, Gabrilovich, Dmitry I

“… Tumor-associated macrophages (TAM) contribute to all aspects of tumor progression. Use of CSF1R inhibitors to target TAM is therapeutically appealing, but has …”
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Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients von Condamine, Thomas, Dominguez, George A, Youn, Je-In, Kossenkov, Andrew V, Mony, Sridevi, Alicea-Torres, Kevin, Tcyganov, Evgenii, Hashimoto, Ayumi, Nefedova, Yulia, Lin, Cindy, Partlova, Simona, Garfall, Alfred, Vogl, Dan T, Xu, Xiaowei, Knight, Stella C, Malietzis, George, Lee, Gui Han, Eruslanov, Evgeniy, Albelda, Steven M, Wang, Xianwei, Mehta, Jawahar L, Bewtra, Meenakshi, Rustgi, Anil, Hockstein, Neil, Witt, Robert, Masters, Gregory, Nam, Brian, Smirnov, Denis, Sepulveda, Manuel A, Gabrilovich, Dmitry I

“… Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) are important regulators of immune responses in cancer and have been directly implicated in …”
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Anti-tumor activity of a T-helper 1 multiantigen vaccine in a murine model of prostate cancer von Cecil, Denise L., Curtis, Benjamin, Gad, Ekram, Gormley, Michael, Timms, Andrew E., Corulli, Lauren, Bos, Rinke, Damle, Rajendra N., Sepulveda, Manuel A., Disis, Mary L.

“… Prostate cancer is one of the few malignancies that includes vaccination as a treatment modality. Elements of an effective cancer vaccine should include the …”
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Analysis of classical neutrophils and polymorphonuclear myeloid-derived suppressor cells in cancer patients and tumor-bearing mice von Veglia, Filippo, Hashimoto, Ayumi, Dweep, Harsh, Sanseviero, Emilio, De Leo, Alessandra, Tcyganov, Evgenii, Kossenkov, Andrew, Mulligan, Charles, Nam, Brian, Masters, Gregory, Patel, Jaymala, Bhargava, Vipul, Wilkinson, Patrick, Smirnov, Denis, Sepulveda, Manuel A, Singhal, Sunil, Eruslanov, Evgeniy B, Cristescu, Razvan, Loboda, Andrey, Nefedova, Yulia, Gabrilovich, Dmitry I

“… In this study, using single-cell RNA-seq, cell mass spectrometry, flow cytometry, and functional analysis, we characterized the heterogeneity of …”
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Engagement of the ICOS pathway markedly enhances efficacy of CTLA-4 blockade in cancer immunotherapy von Fan, Xiaozhou, Quezada, Sergio A, Sepulveda, Manuel A, Sharma, Padmanee, Allison, James P

“… Cytotoxic T lymphocyte antigen-4 (CTLA-4) blockade with a monoclonal antibody yields durable responses in a subset of cancer patients and has been approved by …”
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VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer von Gao, Jianjun, Ward, John F, Pettaway, Curtis A, Shi, Lewis Z, Subudhi, Sumit K, Vence, Luis M, Zhao, Hao, Chen, Jianfeng, Chen, Hong, Efstathiou, Eleni, Troncoso, Patricia, Allison, James P, Logothetis, Christopher J, Wistuba, Ignacio I, Sepulveda, Manuel A, Sun, Jingjing, Wargo, Jennifer, Blando, Jorge, Sharma, Padmanee

“… Prostate cancer is refractory to anti-CTLA-4 therapy, but the reason why is unclear. Padmanee Sharma and colleagues report that the inhibitory molecule VISTA, …”
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Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma von Simpson, Tyler R, Li, Fubin, Montalvo-Ortiz, Welby, Sepulveda, Manuel A, Bergerhoff, Katharina, Arce, Frederick, Roddie, Claire, Henry, Jake Y, Yagita, Hideo, Wolchok, Jedd D, Peggs, Karl S, Ravetch, Jeffrey V, Allison, James P, Quezada, Sergio A

“… Treatment with monoclonal antibody specific for cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), an inhibitory receptor expressed by T lymphocytes, has …”
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Chromatin architecture near a potential 3' end of the igh locus involves modular regulation of histone modifications during B-Cell development and in vivo occupancy at CTCF sites von Garrett, Francine E, Emelyanov, Alexander V, Sepulveda, Manuel A, Flanagan, Patrick, Volpi, Sabrina, Li, Fubin, Loukinov, Dmitry, Eckhardt, Laurel A, Lobanenkov, Victor V, Birshtein, Barbara K

“… The murine Igh locus has a 3' regulatory region (3' RR) containing four enhancers (hs3A, hs1,2, hs3B, and hs4) at DNase I-hypersensitive sites. The 3' RR …”
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The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells von Emelyanov, Alexander V, Kovac, Cecilia R, Sepulveda, Manuel A, Birshtein, Barbara K

“… Pax5 (BSAP) is essential for B cell development and acts both as a transcriptional activator and a repressor. Using a yeast two-hybrid assay to identify …”
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Calreticulin mutant myeloproliferative neoplasms induce MHC-I skewing, which can be overcome by an optimized peptide cancer vaccine von Gigoux, Mathieu, Holmström, Morten O, Zappasodi, Roberta, Park, Joseph J, Pourpe, Stephane, Bozkus, Cansu Cimen, Mangarin, Levi M B, Redmond, David, Verma, Svena, Schad, Sara, George, Mariam M, Venkatesh, Divya, Ghosh, Arnab, Hoyos, David, Molvi, Zaki, Kamaz, Baransel, Marneth, Anna E, Duke, William, Leventhal, Matthew J, Jan, Max, Ho, Vincent T, Hobbs, Gabriela S, Knudsen, Trine Alma, Skov, Vibe, Kjær, Lasse, Larsen, Thomas Stauffer, Hansen, Dennis Lund, Lindsley, R Coleman, Hasselbalch, Hans, Grauslund, Jacob H, Lisle, Thomas L, Met, Özcan, Wilkinson, Patrick, Greenbaum, Benjamin, Sepulveda, Manuel A, Chan, Timothy, Rampal, Raajit, Andersen, Mads H, Abdel-Wahab, Omar, Bhardwaj, Nina, Wolchok, Jedd D, Mullally, Ann, Merghoub, Taha

“… The majority of JAK2 -negative myeloproliferative neoplasms (MPNs) have disease-initiating frameshift mutations in calreticulin ( ), resulting in a common …”
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The DNA methylation profile of activated human natural killer cells von Wiencke, John. K., Butler, Rondi, Hsuang, George, Eliot, Melissa, Kim, Stephanie, Sepulveda, Manuel A., Siegel, Derick, Houseman, E. Andres, Kelsey, Karl T.

“… Natural killer (NK) cells are now recognized to exhibit characteristics akin to cells of the adaptive immune system. The generation of adaptive memory is …”
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A novel human Ada2 homologue functions with Gcn5 or Brg1 to coactivate transcription von Barlev, Nickolai A, Emelyanov, Alexander V, Castagnino, Paola, Zegerman, Philip, Bannister, Andrew J, Sepulveda, Manuel A, Robert, Flavie, Tora, Laszlo, Kouzarides, Tony, Birshtein, Barbara K, Berger, Shelley L

“… In yeast, the transcriptional adaptor yeast Ada2 (yAda2) is a part of the multicomponent SAGA complex, which possesses histone acetyltransferase activity …”
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Impact of Cell-surface Antigen Expression on Target Engagement and Function of an Epidermal Growth Factor Receptor × c-MET Bispecific Antibody von Jarantow, Stephen W, Bushey, Barbara S, Pardinas, Jose R, Boakye, Ken, Lacy, Eilyn R, Sanders, Renouard, Sepulveda, Manuel A, Moores, Sheri L, Chiu, Mark L

“… The efficacy of engaging multiple drug targets using bispecific antibodies (BsAbs) is affected by the relative cell-surface protein levels of the respective …”
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Cutting edge: chronic inflammatory liver disease in mice expressing a CD28-specific ligand von Corse, Emily, Gottschalk, Rachel A, Park, Joon Seok, Sepulveda, Manuel A, Loke, P'ng, Sullivan, Timothy J, Johnson, Linda K, Allison, James P

“… Inflammation of the normally tolerant liver microenvironment precedes the development of chronic liver disease. Study of the pathogenesis of autoimmune liver …”
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NF-kappa B and Oct-2 synergize to activate the human 3' Igh hs4 enhancer in B cells von Sepulveda, Manuel A, Emelyanov, Alexander V, Birshtein, Barbara K

“… In B cells, the Igh gene locus contains several DNase I-hypersensitive (hs) sites with enhancer activity. These include the 3' Igh enhancers, which are located …”
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Comparative analysis of human and mouse 3′ Igh regulatory regions identifies distinctive structural features von Sepulveda, Manuel A., Garrett, Francine E., Price-Whelan, Alexa, Birshtein, Barbara K.

“… Immunoglobulin heavy chain ( Igh) locus rearrangements are controlled in part by an ∼30 kb complex 3′ regulatory region located 3′ of Cα: this region contains …”
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Changes in replication, nuclear location, and expression of the Igh locus after fusion of a pre-B cell line with a T cell line von Zhou, Jie, Saleque, Shireen, Ermakova, Olga, Sepulveda, Manuel A, Yang, Qiaoxin, Eckhardt, Laurel A, Schildkraut, Carl L, Birshtein, Barbara K

“… We have previously observed that replication and nuclear location of the murine Igh locus are developmentally regulated during B cell differentiation. In …”
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Gastric cancer screening in Chile. Results of the National Health Survey 2016-2017 von Corsi Sotelo, Oscar, Fuentes-López, Eduardo, Latorre Selvat, Gonzalo, Espinoza Sepúlveda, Manuel A, Margozzini Maira, Paula, Monrroy Bravo, Hugo, Espino Espino, Alberto, Riquelme Pérez, Arnoldo

“… Gastric cancer (GC) is the leading cause of oncologic death in Chile. Since 2006, the health authority has recommended upper gastrointestinal endoscopy (UGE) …”
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Costos intrahospitalarios de prematuros de muy bajo peso al nacer con displasia broncopulmonar von Pettinelli Díaz, Gonzalo A., Abuhadba Venegas, Pilar V., D'Apremont Ormeño, Ivone, Dominguez de Landa, Angélica, Donoso Macuada, Rodrigo O., Espinoza Sepúlveda, Manuel A., Tapia Illanes, Jose L.

“… A nivel mundial el costo de los pacientes con displasia broncopulmonar (DBP) es mayor que el de los pacientes sin DBP. Sin embargo, se desconoce la magnitud de …”
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Textbooks and Achievement in Developing Countries: What we Know von Heyneman, Stephen P., Farrell, Joseph P., Sepulveda-Stuardo, Manuel A.

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