Výsledky vyhledávání - "Seminars in oncology"

KRAS mutation in pancreatic cancer Autor Luo, Ji

“…Pancreatic cancer is a recalcitrant cancer with one of the lowest 5-year survival rates. A hallmark of pancreatic cancer is the prevalence of oncogenic…”
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Ovarian Cancer: An Integrated Review Autor Stewart, Christine, Ralyea, Christine, Lockwood, Suzy

“…To provide an overview of the risk factors, modifiable and non-modifiable, for ovarian cancer as well as prevention, diagnostic, treatment, and long-term…”
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Multiple myeloma epidemiology and survival: A unique malignancy Autor Kazandjian, Dickran

“…Multiple myeloma (MM), although a rare disease, is the second most common hematologic malignancy. It is found in the spectrum of plasma cell dyscrasias, which…”
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Modern radiotherapy for head and neck cancer Autor Alterio, Daniela, Marvaso, Giulia, Ferrari, Annamaria, Volpe, Stefania, Orecchia, Roberto, Jereczek-Fossa, Barbara Alicja

“…Radiation therapy (RT) plays a key role in curative-intent treatments for head and neck cancers. Its use is indicated as a sole therapy in early stage tumors…”
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Cancer and the Immune System: The History and Background of Immunotherapy Autor Abbott, Maura, Ustoyev, Yelena

“…This article will outline the link between the immune system and cancer, and provide a historical timeline of immunotherapy developmental milestones. Published…”
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Metabolic coupling and the Reverse Warburg Effect in cancer: Implications for novel biomarker and anticancer agent development Autor Wilde, Lindsay, Roche, Megan, Domingo-Vidal, Marina, Tanson, Katherina, Philp, Nancy, Curry, Joseph, Martinez-Outschoorn, Ubaldo

“…Glucose is a key metabolite used by cancer cells to generate ATP, maintain redox state and create biomass. Glucose can be catabolized to lactate in the…”
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The Next Hurdle in Cancer Immunotherapy: Overcoming the Non-T-Cell-Inflamed Tumor Microenvironment Autor Gajewski, Thomas F

“…A growing body of evidence suggests that a major subset of patients with advanced solid tumors shows evidence for a T-cell-inflamed tumor microenvironment…”
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Cervical Cancer: An Overview of Pathophysiology and Management Autor Johnson, Cynae A., James, Deepthi, Marzan, Amelita, Armaos, Mona

“…To provide an overview of the etiology, prevention, diagnosis, treatment, and long-term survivorship concerns surrounding cervical cancer. A review of articles…”
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Implications of reactive oxygen species on cancer formation and its treatment Autor Shah, Manish A, Rogoff, Harry A

“…Elevated levels of reactive oxygen species (ROS) are a hallmark of cancer. Although increased ROS concentrations play important roles in cancer formation and…”
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A molecular and preclinical comparison of the PD-1-targeted T-cell checkpoint inhibitors nivolumab and pembrolizumab Autor Fessas, Petros, Lee, Hassal, Ikemizu, Shinji, Janowitz, Tobias

“…T-cell checkpoint inhibition has a profound impact on cancer care and the programmed cell death protein 1 (PD-1)-targeted antibodies nivolumab and…”
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Axillary surgery in breast cancer: An updated historical perspective Autor Magnoni, Francesca, Galimberti, Viviana, Corso, Giovanni, Intra, Mattia, Sacchini, Virgilio, Veronesi, Paolo

“…This historical surgical retrospection focuses on the temporal de-escalation axillary surgery, focusing on the unceasing efforts of researchers toward new…”
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PARP1 roles in DNA repair and DNA replication: The basi(c)s of PARP inhibitor efficacy and resistance Autor Kanev, Petar-Bogomil, Atemin, Aleksandar, Stoynov, Stoyno, Aleksandrov, Radoslav

“…Genome integrity is under constant insult from endogenous and exogenous sources. In order to cope, eukaryotic cells have evolved an elaborate network of DNA…”
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Cancer and the Immune System: Basic Concepts and Targets for Intervention Autor Pardoll, Drew

“…A number of consensuses regarding cancer immunology have recently emerged from both preclinical immunotherapy models and analysis of cancer patients. First and…”
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Antagonists of PD-1 and PD-L1 in Cancer Treatment Autor Lipson, Evan J, Forde, Patrick M, Hammers, Hans-Joerg, Emens, Leisha A, Taube, Janis M, Topalian, Suzanne L

“…The PD-1 pathway, comprising the immune cell co-receptor Programmed Death 1 (PD-1) and its ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC), mediates local…”
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Epidemiology and Overview of Gliomas Autor Davis, Mary Elizabeth

“…To present an overview of gliomas, review risk factors, and prognostic and predictive biomarkers. Published manuscripts and textbook chapters. Molecular…”
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Managing the adverse events associated with lenvatinib therapy in radioiodine-refractory differentiated thyroid cancer Autor Cabanillas, Maria E, Takahashi, Shunji

“…Lenvatinib is a multikinase inhibitor of vascular endothelial growth factor (VEGF) receptors 1-3, fibroblast growth factor receptors 1-4, RET, KIT, and…”
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PARP inhibitors: A review of the pharmacology, pharmacokinetics, and pharmacogenetics Autor Zeng, Yi, Arisa, Oluwatobi, Peer, Cody J, Fojo, Antonio, Figg, William D

“…PARP inhibitors have emerged as a promising class of anticancer agents approved for the treatment of ovarian, breast, prostate, and pancreatic cancer. These…”
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Invasive lobular breast cancer: A review of pathogenesis, diagnosis, management, and future directions of early stage disease Autor Thomas, Mathew, Kelly, Erinn Downs, Abraham, Jame, Kruse, Megan

“…Invasive lobular carcinoma (ILC) is the second most common type of invasive breast cancer after invasive ductal carcinoma (IDC). Invasive lobular carcinoma has…”
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Cancer stem cells: the promise and the potential Autor Ajani, Jaffer A, Song, Shumei, Hochster, Howard S, Steinberg, Ira B

“…Despite the advancement of treatment modalities, many cancer patients experience tumor recurrence and metastasis at regional or distant sites. Evolving…”
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Chemotherapy-induced peripheral neuropathy and rehabilitation: A review Autor Zhang, Shangming

“…Chemotherapy-induced peripheral neuropathy (CIPN) is a common complication after chemotherapy that can damage the sensory, motor, autonomic, or cranial nerves…”
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