Suchergebnisse - "Semba, Richard D"

Perspective: The Potential Role of Circulating Lysophosphatidylcholine in Neuroprotection against Alzheimer Disease von Semba, Richard D

“… Alzheimer disease (AD), the most common cause of dementia, is a progressive disorder involving cognitive impairment, loss of learning and memory, and …”
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Plasma proteomic signature of age in healthy humans von Tanaka, Toshiko, Biancotto, Angelique, Moaddel, Ruin, Moore, Ann Zenobia, Gonzalez‐Freire, Marta, Aon, Miguel A., Candia, Julián, Zhang, Pingbo, Cheung, Foo, Fantoni, Giovanna, Semba, Richard D., Ferrucci, Luigi, Stagliano, Katie E. R., Sellers, Brian, Kotliarov, Yuri

“… To characterize the proteomic signature of chronological age, 1,301 proteins were measured in plasma using the SOMAscan assay (SomaLogic, Boulder, CO, USA) in …”
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Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria von Ubaida-Mohien, Ceereena, Lyashkov, Alexey, Gonzalez-Freire, Marta, Tharakan, Ravi, Shardell, Michelle, Moaddel, Ruin, Semba, Richard D, Chia, Chee W, Gorospe, Myriam, Sen, Ranjan, Ferrucci, Luigi

“… A decline of skeletal muscle strength with aging is a primary cause of mobility loss and frailty in older persons, but the molecular mechanisms of such decline …”
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Motoric cognitive risk syndrome: Integration of two early harbingers of dementia in older adults von Semba, Richard D., Tian, Qu, Carlson, Michelle C., Xue, Qian-Li, Ferrucci, Luigi

“… [Display omitted] •Slow gait speed and subjective memory complaint are strong independent predictors of cognitive decline and dementia.•The motoric cognitive …”
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Association between Soluble Klotho and Change in Kidney Function: The Health Aging and Body Composition Study von Drew, David A, Katz, Ronit, Kritchevsky, Stephen, Ix, Joachim, Shlipak, Michael, Gutiérrez, Orlando M, Newman, Anne, Hoofnagle, Andy, Fried, Linda, Semba, Richard D, Sarnak, Mark

“… CKD appears to be a condition of soluble klotho deficiency. Despite known associations between low soluble klotho levels and conditions that promote kidney …”
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The Human Eye Proteome Project: Updates on an Emerging Proteome von Ahmad, Meleha T., Zhang, Pingbo, Dufresne, Craig, Ferrucci, Luigi, Semba, Richard D.

“… The human eye is a complex organ consisting of multiple compartments with unique and specialized properties that reflect their varied functions. Although there …”
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Plasma proteomic signature of the risk of developing mobility disability: A 9‐year follow‐up von Osawa, Yusuke, Semba, Richard D., Fantoni, Giovanna, Candia, Julián, Biancotto, Angélique, Tanaka, Toshiko, Bandinelli, Stefania, Ferrucci, Luigi

“… Introduction Mobility disability is a powerful indicator of poor health in older adults. The biological and pathophysiological mechanism underlying the …”
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The discovery of the vitamins von Semba, Richard D

“… The discovery of the vitamins was a major scientific achievement in our understanding of health and disease. In 1912, Casimir Funk originally coined the term …”
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Targeted Metabolomics Shows Low Plasma Lysophosphatidylcholine 18:2 Predicts Greater Decline of Gait Speed in Older Adults: The Baltimore Longitudinal Study of Aging von Gonzalez-Freire, Marta, Moaddel, Ruin, Sun, Kai, Fabbri, Elisa, Zhang, Pingbo, Khadeer, Mohammed, Salem, Jr, Norman, Ferrucci, Luigi, Semba, Richard D

“… Gait speed is an important measure of lower extremity physical performance in older adults and is predictive of disability and mortality. The biological …”
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Patient Reported Differences in Dry Eye Disease between Men and Women: Impact, Management, and Patient Satisfaction von Schaumberg, Debra A., Uchino, Miki, Christen, William G., Semba, Richard D., Buring, Julie E., Li, Jim Z.

“… Dry eye disease affects women twice as often as men, but there is little information on whether dry eye treatments, treatment satisfaction, or the impact of …”
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Plasma Biomarkers of Poor Muscle Quality in Older Men and Women from the Baltimore Longitudinal Study of Aging von Moaddel, Ruin, Fabbri, Elisa, Khadeer, Mohammed A, Carlson, Olga D, Gonzalez-Freire, Marta, Zhang, Pingbo, Semba, Richard D, Ferrucci, Luigi

“… Aging is characterized by progressive decline in muscle mass, strength, and quality all of which contribute to functional impairment, falls, mobility …”
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Plasma Klotho and Cardiovascular Disease in Adults von Semba, Richard D., Cappola, Anne R., Sun, Kai, Bandinelli, Stefania, Dalal, Mansi, Crasto, Candace, Guralnik, Jack M., Ferrucci, Luigi

“… OBJECTIVES: To determine whether plasma klotho, a recently discovered hormone that has been implicated in atherosclerosis, is related to prevalent …”
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Serum antioxidants and inflammation predict red cell distribution width in older women: The Women's Health and Aging Study I von Semba, Richard D., Patel, Kushang V., Ferrucci, Luigi, Sun, Kai, Roy, Cindy N., Guralnik, Jack M., Fried, Linda P.

“… Red cell distribution width (RDW), a measure of heterogeneity in the size of circulating erythrocytes, is associated with some chronic diseases and predicts …”
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Effect of parental formal education on risk of child stunting in Indonesia and Bangladesh: a cross-sectional study von Semba, Richard D, de Pee, Saskia, Sun, Kai, Sari, Mayang, Akhter, Nasima, Bloem, Martin W

“… Child stunting is associated with poor child development and increased mortality. Our aim was to determine the effect of length of maternal and paternal …”
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Elevated Plasma Growth and Differentiation Factor 15 Predicts Incident Anemia in Older Adults Aged 60 Years and Older von Yamaguchi, Yuko, Zampino, Marta, Tanaka, Toshiko, Bandinelli, Stefania, Osawa, Yusuke, Ferrucci, Luigi, Semba, Richard D

“… Anemia is common in older adults and associated with greater morbidity and mortality. The causes of anemia in older adults have not been completely …”
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Predictors of maternal and child double burden of malnutrition in rural Indonesia and Bangladesh von Oddo, Vanessa M, Rah, Jee H, Semba, Richard D, Sun, Kai, Akhter, Nasima, Sari, Mayang, de Pee, Saskia, Moench-Pfanner, Regina, Bloem, Martin, Kraemer, Klaus

“… Many developing countries now face the double burden of malnutrition, defined as the coexistence of a stunted child and overweight mother within the same …”
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Relationship of cash transfers with risk of overweight and obesity in children and adults: a systematic review von Semba, Richard D., Manley, James, Rosman, Lori, Rahman, Nihaal, Bloem, Martin W.

“… Background Cash transfer (CT) programs are an important type of social protection meant to reduce poverty. Whether CT programs increase the risk of overweight …”
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Tetra-linoleoyl cardiolipin depletion plays a major role in the pathogenesis of sarcopenia von Semba, Richard D., Moaddel, Ruin, Zhang, Pingbo, Ramsden, Christopher E., Ferrucci, Luigi

“… Sarcopenia, the progressive loss of muscle mass, strength, and physical performance that occurs during aging, is highly prevalent among the elderly. Sarcopenia …”
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On the ‘Discovery’ of Vitamin A von Semba, Richard D.

“… Vitamin A is essential for normal growth, reproduction, immunity, and vision. The characterization of vitamin A spanned a period of about 130 years. During …”
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Proinflammatory state, hepcidin, and anemia in older persons von Ferrucci, Luigi, Semba, Richard D, Guralnik, Jack M, Ershler, William B, Bandinelli, Stefania, Patel, Kushang V, Sun, Kai, Woodman, Richard C, Andrews, Nancy C, Cotter, Robert J, Ganz, Tomas, Nemeth, Elizabeta, Longo, Dan L

“… In patients with overt inflammatory diseases, up-regulated hepcidin impairs iron absorption and macrophage release, causing anemia. Whether the mild …”
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