Suchergebnisse - "Selhub, Jacob"

The many facets of hyperhomocysteinemia: studies from the Framingham cohorts von Selhub, Jacob

“… Homocysteine is a sulfur amino acid whose metabolism stands at the intersection of 2 pathways: remethylation, which requires folic acid and B-12 coenzymes, and …”
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Excessive folic acid intake and relation to adverse health outcome von Selhub, Jacob, Rosenberg, Irwin H.

“… The recent increase in the intake of folic acid by the general public through fortified foods and supplements, has raised safety concern based on early reports …”
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Public health significance of elevated homocysteine von Selhub, Jacob

“… Homocysteine is a sulfur amino acid whose metabolism stands at the intersection of two pathways: remethylation, which requires folic acid and vitamin B12 …”
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Knowledge gaps in understanding the metabolic and clinical effects of excess folates/folic acid: a summary, and perspectives, from an NIH workshop von Maruvada, Padma, Stover, Patrick J, Mason, Joel B, Bailey, Regan L, Davis, Cindy D, Field, Martha S, Finnell, Richard H, Garza, Cutberto, Green, Ralph, Gueant, Jean-Louis, Jacques, Paul F, Klurfeld, David M, Lamers, Yvonne, MacFarlane, Amanda J, Miller, Joshua W, Molloy, Anne M, O'Connor, Deborah L, Pfeiffer, Christine M, Potischman, Nancy A, Rodricks, Joseph V, Rosenberg, Irwin H, Ross, Sharon A, Shane, Barry, Selhub, Jacob, Stabler, Sally P, Trasler, Jacquetta, Yamini, Sedigheh, Zappalà, Giovanna

“… Folate, an essential nutrient found naturally in foods in a reduced form, is present in dietary supplements and fortified foods in an oxidized synthetic form …”
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In vitamin B12 deficiency, higher serum folate is associated with increased total homocysteine and methylmalonic acid concentrations von Selhub, Jacob, Morris, Martha Savaria, Jacques, Paul F

“… In a recent study of older participants (age >/=60 years) in the 1999-2002 National Health and Nutrition Examination Survey (NHANES), we showed that a …”
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Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification von Morris, Martha Savaria, Jacques, Paul F, Rosenberg, Irwin H, Selhub, Jacob

“… Historic reports on the treatment of pernicious anemia with folic acid suggest that high-level folic acid fortification delays the diagnosis of or exacerbates …”
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Noncanonical function of folate through folate receptor 1 during neural tube formation von Balashova, Olga A., Panoutsopoulos, Alexios A., Visina, Olesya, Selhub, Jacob, Knoepfler, Paul S., Borodinsky, Laura N.

“… Folate supplementation reduces the occurrence of neural tube defects (NTDs), birth defects consisting in the failure of the neural tube to form and close. The …”
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Multiple Biomarkers for the Prediction of First Major Cardiovascular Events and Death von Wang, Thomas J, Gona, Philimon, Larson, Martin G, Tofler, Geoffrey H, Levy, Daniel, Newton-Cheh, Christopher, Jacques, Paul F, Rifai, Nader, Selhub, Jacob, Robins, Sander J, Benjamin, Emelia J, D'Agostino, Ralph B, Vasan, Ramachandran S

“… In an analysis from the Framingham Heart Study, 10 biomarkers were evaluated for their ability to predict clinical outcomes. The addition of biomarkers to …”
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Redox homeostasis in stomach medium by foods: The Postprandial Oxidative Stress Index (POSI) for balancing nutrition and human health von Kanner, Joseph, Selhub, Jacob, Shpaizer, Adi, Rabkin, Boris, Shacham, Inbal, Tirosh, Oren

“… Red-meat lipid peroxidation in the stomach results in postprandial oxidative stress (POS) which is characterized by the generation of a variety of reactive …”
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Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors von Morris, Martha Savaria, Jacques, Paul F, Rosenberg, Irwin H, Selhub, Jacob

“… Folate deficiency has serious consequences for the fetus. Folic acid fortification of food addresses this problem. However, clinical consequences of vitamin …”
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A specific folate activates serotonergic neurons to control C. elegans behavior von Peesapati, Ria S., Austin-Byler, Brianna L., Nawaz, Fathima Zahra, Stevenson, Jonathan B., Mais, Stanelle A., Kaya, Rabia N., Hassan, Michael G., Khanal, Nabraj, Wells, Alexandra C., Ghiai, Deena, Garikapati, Anish K., Selhub, Jacob, Kipreos, Edward T.

“… Folates are B-group vitamins that function in one-carbon metabolism. Here we show that a specific folate can activate serotonergic neurons in C. elegans to …”
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A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesis von Mason, Joel B, Dickstein, Aaron, Jacques, Paul F, Haggarty, Paul, Selhub, Jacob, Dallal, Gerard, Rosenberg, Irwin H

“… Nationwide fortification of enriched uncooked cereal grains with folic acid began in the United States and Canada in 1996 and 1997, respectively, and became …”
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Folate-vitamin B-12 interaction in relation to cognitive impairment, anemia, and biochemical indicators of vitamin B-12 deficiency von Selhub, Jacob, Morris, Martha Savaria, Jacques, Paul F, Rosenberg, Irwin H

“… Previous reports on pernicious anemia treatment suggested that high folic acid intake adversely influences the natural history of vitamin B-12 deficiency, …”
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Dietary vitamin B6 intake modulates colonic inflammation in the IL10−/− model of inflammatory bowel disease von Selhub, Jacob, Byun, Alexander, Liu, Zhenhua, Mason, Joel B., Bronson, Roderick T., Crott, Jimmy W.

“… Pyridoxal-5-phosphate, the biologically active form of vitamin B6, is a cofactor for over 140 biochemical reactions. Although severe vitamin B6 deficiency is …”
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Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway von Hazra, Aditi, Kraft, Peter, Lazarus, Ross, Chen, Constance, Chanock, Stephen J, Jacques, Paul, Selhub, Jacob, Hunter, David J

“… Low plasma B-vitamin levels and elevated homocysteine have been associated with cancer, cardiovascular disease and neurodegenerative disorders. Common variants …”
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Relations of biomarkers of distinct pathophysiological pathways and atrial fibrillation incidence in the community von Schnabel, Renate B, Larson, Martin G, Yamamoto, Jennifer F, Sullivan, Lisa M, Pencina, Michael J, Meigs, James B, Tofler, Geoffrey H, Selhub, Jacob, Jacques, Paul F, Wolf, Philip A, Magnani, Jared W, Ellinor, Patrick T, Wang, Thomas J, Levy, Daniel, Vasan, Ramachandran S, Benjamin, Emelia J

“… Biomarkers of multiple pathophysiological pathways have been related to incident atrial fibrillation (AF), but their predictive ability remains controversial …”
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Biomarkers of vitamin B-12 status in NHANES: a roundtable summary von Yetley, Elizabeth A, Pfeiffer, Christine M, Phinney, Karen W, Bailey, Regan L, Blackmore, Sheena, Bock, Jay L, Brody, Lawrence C, Carmel, Ralph, Curtin, L Randy, Durazo-Arvizu, Ramón A, Eckfeldt, John H, Green, Ralph, Gregory, 3rd, Jesse F, Hoofnagle, Andrew N, Jacobsen, Donald W, Jacques, Paul F, Lacher, David A, Molloy, Anne M, Massaro, Joseph, Mills, James L, Nexo, Ebba, Rader, Jeanne I, Selhub, Jacob, Sempos, Christopher, Shane, Barry, Stabler, Sally, Stover, Patrick, Tamura, Tsunenobu, Tedstone, Alison, Thorpe, Susan J, Coates, Paul M, Johnson, Clifford L, Picciano, Mary Frances

“… A roundtable to discuss the measurement of vitamin B-12 (cobalamin) status biomarkers in NHANES took place in July 2010. NHANES stopped measuring vitamin …”
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Plasma pyridoxal 5'-phosphate in the US population: the National Health and Nutrition Examination Survey, 2003-2004 von Morris, Martha Savaria, Picciano, Mary Frances, Jacques, Paul F, Selhub, Jacob

“… No large-scale, population-based study has considered the descriptive epidemiology of vitamin B-6 status with use of plasma pyridoxal 5'-phosphate (PLP), the …”
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Prenatal folic acid use associated with decreased risk of myelomeningocele: A case-control study offers further support for folic acid fortification in Bangladesh von Kancherla, Vijaya, Ibne Hasan, Md Omar Sharif, Hamid, Rezina, Paul, Ligi, Selhub, Jacob, Oakley, Godfrey, Quamruzzaman, Quazi, Mazumdar, Maitreyi

“… Neural tube defects contribute to severe morbidity and mortality in children and adults; however, they are largely preventable through maternal intake of folic …”
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C-reactive protein and reclassification of cardiovascular risk in the Framingham Heart Study von Wilson, Peter W F, Pencina, Michael, Jacques, Paul, Selhub, Jacob, D'Agostino, Sr, Ralph, O'Donnell, Christopher J

“… The relationship of circulating levels of high-sensitivity C-reactive protein (CRP) with cardiovascular disease (CVD) risk, particularly with consideration of …”
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