Výsledky vyhľadávania - "Seeger, Karl"

Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis Autor Matlung, Hanke L., Babes, Liane, Zhao, Xi Wen, van Houdt, Michel, Treffers, Louise W., van Rees, Dieke J., Franke, Katka, Schornagel, Karin, Verkuijlen, Paul, Janssen, Hans, Halonen, Pasi, Lieftink, Cor, Beijersbergen, Roderick L., Leusen, Jeanette H.W., Boelens, Jaap J., Kuhnle, Ingrid, van der Werff Ten Bosch, Jutte, Seeger, Karl, Rutella, Sergio, Pagliara, Daria, Matozaki, Takashi, Suzuki, Eiji, Menke-van der Houven van Oordt, Catharina Willemien, van Bruggen, Robin, Roos, Dirk, van Lier, Rene A.W., Kuijpers, Taco W., Kubes, Paul, van den Berg, Timo K.

“…Destruction of cancer cells by therapeutic antibodies occurs, at least in part, through antibody-dependent cellular cytotoxicity (ADCC), and this can be…”
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β2 integrin mediates hantavirus-induced release of neutrophil extracellular traps Autor Raftery, Martin J, Lalwani, Pritesh, Krautkrӓmer, Ellen, Peters, Thorsten, Scharffetter-Kochanek, Karin, Krüger, Renate, Hofmann, Jörg, Seeger, Karl, Krüger, Detlev H, Schönrich, Günther

“…Rodent-borne hantaviruses are emerging human pathogens that cause severe human disease. The underlying mechanisms are not well understood, as hantaviruses…”
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Prenatally detected umbilical cord tumor as a sign of diffuse neonatal hemangiomatosis Autor Schwickert, Alexander, Seeger, Karl‐Heinz, Rancourt, Rebecca C., Henrich, Wolfgang

“…We report a case of a prenatally detected hemangioma of the umbilical cord as an early sign of diffuse neonatal hemangiomatosis (DNH). The newborn was…”
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Mutations and deletions of the TP53 gene predict nonresponse to treatment and poor outcome in first relapse of childhood acute lymphoblastic leukemia Autor Hof, Jana, Krentz, Stefanie, van Schewick, Claudia, Körner, Gabriele, Shalapour, Shabnam, Rhein, Peter, Karawajew, Leonid, Ludwig, Wolf-Dieter, Seeger, Karl, Henze, Günter, von Stackelberg, Arend, Hagemeier, Christian, Eckert, Cornelia, Kirschner-Schwabe, Renate

“…In the clinical management of children with relapsed acute lymphoblastic leukemia (ALL), treatment resistance remains a major challenge. Alterations of the…”
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A novel flow cytometry-based platelet aggregation assay Autor De Cuyper, Iris M, Meinders, Marjolein, van de Vijver, Edith, de Korte, Dirk, Porcelijn, Leendert, de Haas, Masja, Eble, Johannes A, Seeger, Karl, Rutella, Sergio, Pagliara, Daria, Kuijpers, Taco W, Verhoeven, Arthur J, van den Berg, Timo K, Gutiérrez, Laura

“…The main function of platelets is to maintain normal hemostasis. Inefficient platelet production and/or defective platelet function results in bleeding…”
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Pediatric Colorectal Carcinoma is Associated With Excellent Outcome in the Context of Cancer Predisposition Syndromes Autor Weber, Marie L., Schneider, Dominik T., Offenmüller, Sonja, Kaatsch, Peter, Einsiedel, Hagen Graf, Benesch, Martin, Claviez, Alexander, Ebinger, Martin, Kramm, Christof, Kratz, Christian, Lawlor, Jennifer, Leuschner, Ivo, Merkel, Susanne, Metzler, Markus, Nustede, Rainer, Petsch, Sabine, Seeger, Karl-Heinz, Schlegel, Paul-Gerhardt, Suttorp, Meinolf, Zolk, Oliver, Brecht, Ines B.

“…Introduction Colorectal carcinoma (CRC) is the second most common adult cancer in Germany, however, it is extremely rare in children and adolescents. In these…”
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Minimal residual disease analysis by eight-color flow cytometry in relapsed childhood acute lymphoblastic leukemia Autor Karawajew, L., Dworzak, M., Ratei, R., Rhein, P., Gaipa, G., Buldini, B., Basso, G., Hrusak, O., Ludwig, W.-D., Henze, G., Seeger, K., von Stackelberg, A., Mejstrikova, E., Eckert, C.

“…Multiparametric flow cytometry is an alternative approach to the polymerase chain reaction method for evaluating minimal residual disease in treatment…”
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LAD-1/variant syndrome is caused by mutations in FERMT3 Autor Kuijpers, Taco W, van de Vijver, Edith, Weterman, Marian A J, de Boer, Martin, Tool, Anton T J, van den Berg, Timo K, Moser, Markus, Jakobs, Marja E, Seeger, Karl, Sanal, Ozden, Unal, Sule, Cetin, Mualla, Roos, Dirk, Verhoeven, Arthur J, Baas, Frank

“…Leukocyte adhesion deficiency-1/variant (LAD1v) syndrome presents early in life and manifests by infections without pus formation in the presence of a…”
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The RNA-binding protein RBM3 is required for cell proliferation and protects against serum deprivation-induced cell death Autor Wellmann, Sven, Truss, Matthias, Bruder, Elisabeth, Tornillo, Luigi, Zelmer, Andrea, Seeger, Karl, Bührer, Christoph

“…Hypoxia and other adverse conditions are commonly encountered by rapidly growing cells. The RNA-binding protein RBM3 (RNA-binding motif protein 3), which is…”
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Copy number genome alterations are associated with treatment response and outcome in relapsed childhood ETV6/RUNX1-positive acute lymphoblastic leukemia Autor Bokemeyer, A., Eckert, C., Meyr, F., Koerner, G., von Stackelberg, A., Ullmann, R., Turkmen, S., Henze, G., Seeger, K.

“…The clinical heterogeneity among first relapses of childhood ETV6/RUNX1-positive acute lymphoblastic leukemia indicates that further genetic alterations in…”
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Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism Autor Wellmann, Sven, Bührer, Christoph, Moderegger, Eva, Zelmer, Andrea, Kirschner, Renate, Koehne, Petra, Fujita, Jun, Seeger, Karl

“…The transcriptional regulation of several dozen genes in response to low oxygen tension is mediated by hypoxia-inducible factor 1 (HIF-1), a heterodimeric…”
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High VLA-4 expression is associated with adverse outcome and distinct gene expression changes in childhood B-cell precursor acute lymphoblastic leukemia at first relapse Autor Shalapour, S., Hof, J., Kirschner-Schwabe, R., Bastian, L., Eckert, C., Prada, J., Henze, G., von Stackelberg, A., Seeger, K.

“…Resistance to therapy and subsequent relapse remain major challenges in the clinical management of relapsed childhood acute lymphoblastic leukemia. As the bone…”
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Natural history and early diagnosis of LAD-1/variant syndrome Autor Kuijpers, Taco W, van Bruggen, Robin, Kamerbeek, Nanne, Tool, Anton T J, Hicsonmez, Gonul, Gurgey, Aytemiz, Karow, Axel, Verhoeven, Arthur J, Seeger, Karl, Sanal, Ozden, Niemeyer, Charlotte, Roos, Dirk

“…The syndrome of leukocyte adhesion deficiency (LAD) combined with a severe Glanzmann-type bleeding disorder has been recognized as a separate disease entity…”
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Submicroscopic bone marrow involvement in isolated extramedullary relapses in childhood acute lymphoblastic leukemia: a more precise definition of "isolated" and its possible clinical implications, a collaborative study of the Resistant Disease Committee of the International BFM study group Autor Hagedorn, Nikola, Acquaviva, Cécile, Fronkova, Eva, von Stackelberg, Arend, Barth, Andrea, zur Stadt, Udo, Schrauder, André, Trka, Jan, Gaspar, Nathalie, Seeger, Karl, Henze, Günter, Cavé, Hélène, Eckert, Cornelia

“…This study investigates the extent of bone marrow (BM) involvement at diagnosis of apparent isolated extramedullary (AIEM) relapses of childhood acute…”
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Kindlin-3–independent adhesion of neutrophils from patients with leukocyte adhesion deficiency type III Autor van de Vijver, Edith, Tool, Anton T.J., Sanal, Özden, Çetin, Mualla, Ünal, Sule, Aytac, Selin, Seeger, Karl, Pagliara, Daria, Rutella, Sergio, van den Berg, Timo K., Kuijpers, Taco W.

“…Activation of hematopoietic integrins to a high-affinity ligand-binding conformation requires interaction with several cytoplasmic proteins, including…”
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Interphase FISH on TEL/AML1 positive acute lymphoblastic leukemia relapses - analysis of clinical relevance of additional TEL and AML1 copy number changes Autor Peter, Anita, Heiden, Thomas, Taube, Tillmann, Körner, Gabriele, Seeger, Karl

“…Objectives:  TEL/AML1 (ETV6/RUNX1) fusion resulting from the translocation t(12;21)(p13;q22) constitutes the most common chimeric fusion gene in initial…”
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Expression of late cell cycle genes and an increased proliferative capacity characterize very early relapse of childhood acute lymphoblastic leukemia Autor Kirschner-Schwabe, Renate, Lottaz, Claudio, Tödling, Jörn, Rhein, Peter, Karawajew, Leonid, Eckert, Cornelia, von Stackelberg, Arend, Ungethüm, Ute, Kostka, Dennis, Kulozik, Andreas E, Ludwig, Wolf-Dieter, Henze, Günter, Spang, Rainer, Hagemeier, Christian, Seeger, Karl

“…In childhood acute lymphoblastic leukemia (ALL), approximately 25% of patients suffer from relapse. In recurrent disease, despite intensified therapy, overall…”
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Histone deacetylase inhibition improves differentiation of dendritic cells from leukemic blasts of patients with TEL/AML1-positive acute lymphoblastic leukemia Autor Schmidt, Kerstin, Seeger, Karl, Scheibenbogen, Carmen, Bender, Roderich, Abdulla, Majd, Süssmilch, Sina, Salama, Abdulgabar, Moldenhauer, Anja

“…Histone deacetylase inhibitors (HdI) could potentially improve the differentiation of leukemic dendritic cells (DC). Therefore, bone marrow samples from 100…”
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The thalidomide analogue, CC-4047, induces apoptosis signaling and growth arrest in childhood acute lymphoblastic leukemia cells in vitro and in vivo Autor Shalapour, Shabnam, Zelmer, Andrea, Pfau, Madlen, Moderegger, Eva, Costa-Blechschmidt, Cristiane, van Landeghem, Frank K H, Taube, Tillmann, Fichtner, Iduna, Bührer, Christoph, Henze, Günter, Seeger, Karl, Wellmann, Sven

“…Thalidomide and its analogues have shown promise in the treatment of multiple myeloma but their therapeutic potential has not been evaluated in models of acute…”
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Expression of interleukin-10 splicing variants is a positive prognostic feature in relapsed childhood acute lymphoblastic leukemia Autor Wu, Shuling, Gessner, Reinhard, Taube, Tillmann, von Stackelberg, Arend, Henze, Günter, Seeger, Karl

“…Biologic features of hematologic malignancies have prognostic implications and are essential elements in the design of current therapeutic trials. This study…”
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