Výsledky vyhledávání - "Science (American Association for the Advancement of Science)"

Most complete human genome yet is revealed Autor Pennisi, Elizabeth

“…Unusual cell line helps sequencers read previously indecipherable stretches of DNA…”
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Granular technologies to accelerate decarbonization Autor Wilson, C, Grubler, A, Bento, N, Healey, S, De Stercke, S, Zimm, C

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Body-centered cubic iron-nickel alloy in Earth's core Autor Dubrovinsky, L, Dubrovinskaia, N, Narygina, O, Kantor, I, Kuznetzov, A, Prakapenka, V B, Vitos, L, Johansson, B, Mikhaylushkin, A S, Simak, S I, Abrikosov, I A

“…Cosmochemical, geochemical, and geophysical studies provide evidence that Earth's core contains iron with substantial (5 to 15%) amounts of nickel. The…”
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Adversarial attacks on medical machine learning Autor Finlayson, Samuel G, Bowers, John D, Ito, Joichi, Zittrain, Jonathan L, Beam, Andrew L, Kohane, Isaac S

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Evolutionary-scale prediction of atomic-level protein structure with a language model Autor Lin, Zeming, Akin, Halil, Rao, Roshan, Hie, Brian, Zhu, Zhongkai, Lu, Wenting, Smetanin, Nikita, Verkuil, Robert, Kabeli, Ori, Shmueli, Yaniv, Dos Santos Costa, Allan, Fazel-Zarandi, Maryam, Sercu, Tom, Candido, Salvatore, Rives, Alexander

“…Recent advances in machine learning have leveraged evolutionary information in multiple sequence alignments to predict protein structure. We demonstrate direct…”
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Learning skillful medium-range global weather forecasting Autor Lam, Remi, Sanchez-Gonzalez, Alvaro, Willson, Matthew, Wirnsberger, Peter, Fortunato, Meire, Alet, Ferran, Ravuri, Suman, Ewalds, Timo, Eaton-Rosen, Zach, Hu, Weihua, Merose, Alexander, Hoyer, Stephan, Holland, George, Vinyals, Oriol, Stott, Jacklynn, Pritzel, Alexander, Mohamed, Shakir, Battaglia, Peter

“…Global medium-range weather forecasting is critical to decision-making across many social and economic domains. Traditional numerical weather prediction uses…”
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Improved charge extraction in inverted perovskite solar cells with dual-site-binding ligands Autor Chen, Hao, Liu, Cheng, Xu, Jian, Maxwell, Aidan, Zhou, Wei, Yang, Yi, Zhou, Qilin, Bati, Abdulaziz S R, Wan, Haoyue, Wang, Zaiwei, Zeng, Lewei, Wang, Junke, Serles, Peter, Liu, Yuan, Teale, Sam, Liu, Yanjiang, Saidaminov, Makhsud I, Li, Muzhi, Rolston, Nicholas, Hoogland, Sjoerd, Filleter, Tobin, Kanatzidis, Mercouri G, Chen, Bin, Ning, Zhijun, Sargent, Edward H

“…Inverted (pin) perovskite solar cells (PSCs) afford improved operating stability in comparison to their nip counterparts but have lagged in power conversion…”
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Accurate proteome-wide missense variant effect prediction with AlphaMissense Autor Cheng, Jun, Novati, Guido, Pan, Joshua, Bycroft, Clare, Žemgulytė, Akvilė, Applebaum, Taylor, Pritzel, Alexander, Wong, Lai Hong, Zielinski, Michal, Sargeant, Tobias, Schneider, Rosalia G, Senior, Andrew W, Jumper, John, Hassabis, Demis, Kohli, Pushmeet, Avsec, Žiga

“…The vast majority of missense variants observed in the human genome are of unknown clinical significance. We present AlphaMissense, an adaptation of AlphaFold…”
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Copper induces cell death by targeting lipoylated TCA cycle proteins Autor Tsvetkov, Peter, Coy, Shannon, Petrova, Boryana, Dreishpoon, Margaret, Verma, Ana, Abdusamad, Mai, Rossen, Jordan, Joesch-Cohen, Lena, Humeidi, Ranad, Spangler, Ryan D, Eaton, John K, Frenkel, Evgeni, Kocak, Mustafa, Corsello, Steven M, Lutsenko, Svetlana, Kanarek, Naama, Santagata, Sandro, Golub, Todd R

“…Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations exceed a threshold maintained by evolutionarily conserved…”
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Competition-level code generation with AlphaCode Autor Li, Yujia, Choi, David, Chung, Junyoung, Kushman, Nate, Schrittwieser, Julian, Leblond, Rémi, Eccles, Tom, Keeling, James, Gimeno, Felix, Dal Lago, Agustin, Hubert, Thomas, Choy, Peter, de Masson d'Autume, Cyprien, Babuschkin, Igor, Chen, Xinyun, Huang, Po-Sen, Welbl, Johannes, Gowal, Sven, Cherepanov, Alexey, Molloy, James, Mankowitz, Daniel J, Sutherland Robson, Esme, Kohli, Pushmeet, de Freitas, Nando, Kavukcuoglu, Koray, Vinyals, Oriol

“…Programming is a powerful and ubiquitous problem-solving tool. Systems that can assist programmers or even generate programs themselves could make programming…”
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Twenty years of microplastic pollution research-what have we learned? Autor Thompson, Richard C, Courtene-Jones, Winnie, Boucher, Julien, Pahl, Sabine, Raubenheimer, Karen, Koelmans, Albert A

“…Twenty years after the first publication that used the term microplastic, we review current understanding, refine definitions, and consider future prospects…”
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The complete sequence of a human genome Autor Nurk, Sergey, Koren, Sergey, Rhie, Arang, Rautiainen, Mikko, Bzikadze, Andrey V, Mikheenko, Alla, Vollger, Mitchell R, Altemose, Nicolas, Uralsky, Lev, Gershman, Ariel, Aganezov, Sergey, Hoyt, Savannah J, Diekhans, Mark, Logsdon, Glennis A, Alonge, Michael, Antonarakis, Stylianos E, Borchers, Matthew, Bouffard, Gerard G, Brooks, Shelise Y, Caldas, Gina V, Chen, Nae-Chyun, Cheng, Haoyu, Chin, Chen-Shan, Chow, William, de Lima, Leonardo G, Dishuck, Philip C, Durbin, Richard, Dvorkina, Tatiana, Fiddes, Ian T, Formenti, Giulio, Fulton, Robert S, Fungtammasan, Arkarachai, Garrison, Erik, Grady, Patrick G S, Graves-Lindsay, Tina A, Hall, Ira M, Hansen, Nancy F, Hartley, Gabrielle A, Haukness, Marina, Howe, Kerstin, Hunkapiller, Michael W, Jain, Chirag, Jain, Miten, Jarvis, Erich D, Kerpedjiev, Peter, Kirsche, Melanie, Kolmogorov, Mikhail, Korlach, Jonas, Kremitzki, Milinn, Li, Heng, Maduro, Valerie V, Marschall, Tobias, McCartney, Ann M, McDaniel, Jennifer, Miller, Danny E, Mullikin, James C, Myers, Eugene W, Olson, Nathan D, Paten, Benedict, Peluso, Paul, Pevzner, Pavel A, Porubsky, David, Potapova, Tamara, Rogaev, Evgeny I, Rosenfeld, Jeffrey A, Salzberg, Steven L, Schneider, Valerie A, Sedlazeck, Fritz J, Shafin, Kishwar, Shew, Colin J, Shumate, Alaina, Sims, Ying, Smit, Arian F A, Soto, Daniela C, Sović, Ivan, Storer, Jessica M, Streets, Aaron, Sullivan, Beth A, Thibaud-Nissen, Françoise, Torrance, James, Wagner, Justin, Walenz, Brian P, Wenger, Aaron, Wood, Jonathan M D, Xiao, Chunlin, Yan, Stephanie M, Young, Alice C, Zarate, Samantha, Surti, Urvashi, McCoy, Rajiv C, Dennis, Megan Y, Alexandrov, Ivan A, Gerton, Jennifer L, O'Neill, Rachel J, Timp, Winston, Zook, Justin M, Schatz, Michael C, Eichler, Evan E, Miga, Karen H, Phillippy, Adam M

“…Since its initial release in 2000, the human reference genome has covered only the euchromatic fraction of the genome, leaving important heterochromatic…”
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Exceeding 1.5°C global warming could trigger multiple climate tipping points Autor Armstrong McKay, David I, Staal, Arie, Abrams, Jesse F, Winkelmann, Ricarda, Sakschewski, Boris, Loriani, Sina, Fetzer, Ingo, Cornell, Sarah E, Rockström, Johan, Lenton, Timothy M

“…Climate tipping points occur when change in a part of the climate system becomes self-perpetuating beyond a warming threshold, leading to substantial Earth…”
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Robust deep learning-based protein sequence design using ProteinMPNN Autor Dauparas, J, Anishchenko, I, Bennett, N, Bai, H, Ragotte, R J, Milles, L F, Wicky, B I M, Courbet, A, de Haas, R J, Bethel, N, Leung, P J Y, Huddy, T F, Pellock, S, Tischer, D, Chan, F, Koepnick, B, Nguyen, H, Kang, A, Sankaran, B, Bera, A K, King, N P, Baker, D

“…Although deep learning has revolutionized protein structure prediction, almost all experimentally characterized de novo protein designs have been generated…”
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Accurate prediction of protein structures and interactions using a three-track neural network Autor Baek, Minkyung, DiMaio, Frank, Anishchenko, Ivan, Dauparas, Justas, Ovchinnikov, Sergey, Lee, Gyu Rie, Wang, Jue, Cong, Qian, Kinch, Lisa N, Schaeffer, R Dustin, Millán, Claudia, Park, Hahnbeom, Adams, Carson, Glassman, Caleb R, DeGiovanni, Andy, Pereira, Jose H, Rodrigues, Andria V, van Dijk, Alberdina A, Ebrecht, Ana C, Opperman, Diederik J, Sagmeister, Theo, Buhlheller, Christoph, Pavkov-Keller, Tea, Rathinaswamy, Manoj K, Dalwadi, Udit, Yip, Calvin K, Burke, John E, Garcia, K Christopher, Grishin, Nick V, Adams, Paul D, Read, Randy J, Baker, David

“…DeepMind presented notably accurate predictions at the recent 14th Critical Assessment of Structure Prediction (CASP14) conference. We explored network…”
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Generalized biomolecular modeling and design with RoseTTAFold All-Atom Autor Krishna, Rohith, Wang, Jue, Ahern, Woody, Sturmfels, Pascal, Venkatesh, Preetham, Kalvet, Indrek, Lee, Gyu Rie, Morey-Burrows, Felix S, Anishchenko, Ivan, Humphreys, Ian R, McHugh, Ryan, Vafeados, Dionne, Li, Xinting, Sutherland, George A, Hitchcock, Andrew, Hunter, C Neil, Kang, Alex, Brackenbrough, Evans, Bera, Asim K, Baek, Minkyung, DiMaio, Frank, Baker, David

“…Deep-learning methods have revolutionized protein structure prediction and design but are presently limited to protein-only systems. We describe RoseTTAFold…”
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Inactive (PbI2)2RbCl stabilizes perovskite films for efficient solar cells Autor Zhao, Yang, Ma, Fei, Qu, Zihan, Yu, Shiqi, Shen, Tao, Deng, Hui-Xiong, Chu, Xinbo, Peng, Xinxin, Yuan, Yongbo, Zhang, Xingwang, You, Jingbi

“…In halide perovskite solar cells the formation of secondary-phase excess lead iodide (PbI2) has some positive effects on power conversion efficiency (PCE) but…”
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ChatGPT is fun, but not an author Autor Thorp, H Holden

“…In less than 2 months, the artificial intelligence (AI) program ChatGPT has become a cultural sensation. It is freely accessible through a web portal created…”
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The reemergence of yellow fever Autor Barrett, Alan D T

“…Since 2016, yellow fever has become a major public health concern…”
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An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19 Autor Owen, Dafydd R, Allerton, Charlotte M N, Anderson, Annaliesa S, Aschenbrenner, Lisa, Avery, Melissa, Berritt, Simon, Boras, Britton, Cardin, Rhonda D, Carlo, Anthony, Coffman, Karen J, Dantonio, Alyssa, Di, Li, Eng, Heather, Ferre, RoseAnn, Gajiwala, Ketan S, Gibson, Scott A, Greasley, Samantha E, Hurst, Brett L, Kadar, Eugene P, Kalgutkar, Amit S, Lee, Jack C, Lee, Jisun, Liu, Wei, Mason, Stephen W, Noell, Stephen, Novak, Jonathan J, Obach, R Scott, Ogilvie, Kevin, Patel, Nandini C, Pettersson, Martin, Rai, Devendra K, Reese, Matthew R, Sammons, Matthew F, Sathish, Jean G, Singh, Ravi Shankar P, Steppan, Claire M, Stewart, Al E, Tuttle, Jamison B, Updyke, Lawrence, Verhoest, Patrick R, Wei, Liuqing, Yang, Qingyi, Zhu, Yuao

“…The worldwide outbreak of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic. Alongside vaccines,…”
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