Suchergebnisse - "Schumacher, Ton N."

Tertiary lymphoid structures in cancer von Schumacher, Ton N, Thommen, Daniela S

“… Ectopic lymphoid aggregates, termed tertiary lymphoid structures (TLSs), are formed in numerous cancer types, and, with few exceptions, their presence is …”
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Cancer Neoantigens von Schumacher, Ton N, Scheper, Wouter, Kvistborg, Pia

“… Malignant transformation of cells depends on accumulation of DNA damage. Over the past years we have learned that the T cell-based immune system frequently …”
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Neoantigens in cancer immunotherapy von Schumacher, Ton N, Schreiber, Robert D

“… The clinical relevance of T cells in the control of a diverse set of human cancers is now beyond doubt. However, the nature of the antigens that allow the …”
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Identification of CMTM6 and CMTM4 as PD-L1 protein regulators von Mezzadra, Riccardo, Sun, Chong, Jae, Lucas T., Gomez-Eerland, Raquel, de Vries, Evert, Wu, Wei, Logtenberg, Meike E. W., Slagter, Maarten, Rozeman, Elisa A., Hofland, Ingrid, Broeks, Annegien, Horlings, Hugo M., Wessels, Lodewyk F. A., Blank, Christian U., Xiao, Yanling, Heck, Albert J. R., Borst, Jannie, Brummelkamp, Thijn R., Schumacher, Ton N. M.

“… CMTM6 and CMTM4 bind to and stabilize the inhibitory receptor PD-L1 and regulate PD-L1 levels at the surface of human tumour and immune cells. Regulating …”
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Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers von Chalabi, Myriam, Fanchi, Lorenzo F., Dijkstra, Krijn K., Van den Berg, José G., Aalbers, Arend G., Sikorska, Karolina, Lopez-Yurda, Marta, Grootscholten, Cecile, Beets, Geerard L., Snaebjornsson, Petur, Maas, Monique, Mertz, Marjolijn, Veninga, Vivien, Bounova, Gergana, Broeks, Annegien, Beets-Tan, Regina G., de Wijkerslooth, Thomas R., van Lent, Anja U., Marsman, Hendrik A., Nuijten, Elvira, Kok, Niels F., Kuiper, Maria, Verbeek, Wieke H., Kok, Marleen, Van Leerdam, Monique E., Schumacher, Ton N., Voest, Emile E., Haanen, John B.

“… PD-1 plus CTLA-4 blockade is highly effective in advanced-stage, mismatch repair (MMR)-deficient (dMMR) colorectal cancers, yet not in MMR-proficient (pMMR) …”
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Mismatch Repair-Deficient Cancers Are Targets for Anti-PD-1 Therapy von Kelderman, Sander, Schumacher, Ton N, Kvistborg, Pia

“… Immune checkpoint-blocking therapies have yielded positive clinical data in a series of human malignancies. Recent work from Le and colleagues strongly …”
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The Branching Point in Erythro-Myeloid Differentiation von Perié, Leïla, Duffy, Ken R, Kok, Lianne, de Boer, Rob J, Schumacher, Ton N

“… Development of mature blood cell progenies from hematopoietic stem cells involves the transition through lineage-restricted progenitors. The first branching …”
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Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers von Scheper, Wouter, Kelderman, Sander, Fanchi, Lorenzo F, Linnemann, Carsten, Bendle, Gavin, de Rooij, Marije A J, Hirt, Christian, Mezzadra, Riccardo, Slagter, Maarten, Dijkstra, Krijn, Kluin, Roelof J C, Snaebjornsson, Petur, Milne, Katy, Nelson, Brad H, Zijlmans, Henry, Kenter, Gemma, Voest, Emile E, Haanen, John B A G, Schumacher, Ton N

“… Infiltration of human cancers by T cells is generally interpreted as a sign of immune recognition, and there is a growing effort to reactivate dysfunctional T …”
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Biomarkers in cancer immunotherapy von Schumacher, Ton N, Kesmir, Can, van Buuren, Marit M

“… Antibodies against T cell checkpoint molecules have started to revolutionize cancer treatment. Nevertheless, less than half of all patients respond to these …”
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Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold von Vredevoogd, David W, Kuilman, Thomas, Ligtenberg, Maarten A, Boshuizen, Julia, Stecker, Kelly E, de Bruijn, Beaunelle, Krijgsman, Oscar, Huang, Xinyao, Kenski, Juliana C N, Lacroix, Ruben, Mezzadra, Riccardo, Gomez-Eerland, Raquel, Yildiz, Mete, Dagidir, Ilknur, Apriamashvili, Georgi, Zandhuis, Nordin, van der Noort, Vincent, Visser, Nils L, Blank, Christian U, Altelaar, Maarten, Schumacher, Ton N, Peeper, Daniel S

“… New opportunities are needed to increase immune checkpoint blockade (ICB) benefit. Whereas the interferon (IFN)γ pathway harbors both ICB resistance factors …”
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Towards error-free profiling of immune repertoires von Shugay, Mikhail, Britanova, Olga V, Merzlyak, Ekaterina M, Turchaninova, Maria A, Mamedov, Ilgar Z, Tuganbaev, Timur R, Bolotin, Dmitriy A, Staroverov, Dmitry B, Putintseva, Ekaterina V, Plevova, Karla, Linnemann, Carsten, Shagin, Dmitriy, Pospisilova, Sarka, Lukyanov, Sergey, Schumacher, Ton N, Chudakov, Dmitriy M

“… A two-step error correction process for high throughput–sequenced T- and B-cell receptors allows the elimination of most errors while not diminishing the …”
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Identification and characterization of a SARS-CoV-2 specific CD8+ T cell response with immunodominant features von Gangaev, Anastasia, Ketelaars, Steven L. C., Isaeva, Olga I., Patiwael, Sanne, Dopler, Anna, Hoefakker, Kelly, De Biasi, Sara, Gibellini, Lara, Mussini, Cristina, Guaraldi, Giovanni, Girardis, Massimo, Ormeno, Cami M. P. Talavera, Hekking, Paul J. M., Lardy, Neubury M., Toebes, Mireille, Balderas, Robert, Schumacher, Ton N., Ovaa, Huib, Cossarizza, Andrea, Kvistborg, Pia

“… The COVID-19 pandemic caused by SARS-CoV-2 is a continuous challenge worldwide, and there is an urgent need to map the landscape of immunogenic and …”
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Identification of patient-specific CD4+ and CD8+ T cell neoantigens through HLA-unbiased genetic screens von Cattaneo, Chiara M., Battaglia, Thomas, Urbanus, Jos, Moravec, Ziva, Voogd, Rhianne, de Groot, Rosa, Hartemink, Koen J., Haanen, John B. A. G., Voest, Emile E., Schumacher, Ton N., Scheper, Wouter

“… Cancer neoantigens that arise from tumor mutations are drivers of tumor-specific T cell responses, but identification of T cell-recognized neoantigens in …”
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T Cell Fate at the Single-Cell Level von Buchholz, Veit R, Schumacher, Ton N M, Busch, Dirk H

“… T cell responses display two key characteristics. First, a small population of epitope-specific naive T cells expands by several orders of magnitude. Second, …”
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Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma von Zaretsky, Jesse M, Garcia-Diaz, Angel, Shin, Daniel S, Escuin-Ordinas, Helena, Hugo, Willy, Hu-Lieskovan, Siwen, Torrejon, Davis Y, Abril-Rodriguez, Gabriel, Sandoval, Salemiz, Barthly, Lucas, Saco, Justin, Homet Moreno, Blanca, Mezzadra, Riccardo, Chmielowski, Bartosz, Ruchalski, Kathleen, Shintaku, I. Peter, Sanchez, Phillip J, Puig-Saus, Cristina, Cherry, Grace, Seja, Elizabeth, Kong, Xiangju, Pang, Jia, Berent-Maoz, Beata, Comin-Anduix, Begoña, Graeber, Thomas G, Tumeh, Paul C, Schumacher, Ton N.M, Lo, Roger S, Ribas, Antoni

“… Whole-exome sequencing was performed on four patients' tumors before exposure to pembrolizumab and after disease progression following a response to treatment …”
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Regulation and Function of the PD-L1 Checkpoint von Sun, Chong, Mezzadra, Riccardo, Schumacher, Ton N

“… Expression of programmed death-ligand 1 (PD-L1) is frequently observed in human cancers. Binding of PD-L1 to its receptor PD-1 on activated T cells inhibits …”
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Long-distance modulation of bystander tumor cells by CD8+ T-cell-secreted IFN-γ von Hoekstra, Mirjam E., Bornes, Laura, Dijkgraaf, Feline E., Philips, Daisy, Pardieck, Iris N., Toebes, Mireille, Thommen, Daniela S., van Rheenen, Jacco, Schumacher, Ton N. M.

“… T cell-secreted IFNγ can exert pleiotropic effects on tumor cells that include induction of immune checkpoints and antigen presentation machinery components, …”
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SLFN11 can sensitize tumor cells towards IFN-γ-mediated T cell killing von Mezzadra, Riccardo, de Bruijn, Marjolein, Jae, Lucas T., Gomez-Eerland, Raquel, Duursma, Anja, Scheeren, Ferenc A., Brummelkamp, Thijn R., Schumacher, Ton N.

“… Experimental and clinical observations have highlighted the role of cytotoxic T cells in human tumor control. However, the parameters that control tumor cell …”
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DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age von Urbanus, Jos, Cosgrove, Jason, Beltman, Joost B., Elhanati, Yuval, Moral, Rafael A., Conrad, Cecile, van Heijst, Jeroen W., Tubeuf, Emilie, Velds, Arno, Kok, Lianne, Merle, Candice, Magnusson, Jens P., Guyonnet, Léa, Frisén, Jonas, Fre, Silvia, Walczak, Aleksandra M., Mora, Thierry, Jacobs, Heinz, Schumacher, Ton N., Perié, Leïla

“… Ageing is associated with changes in the cellular composition of the immune system. During ageing, hematopoietic stem and progenitor cells (HSPCs) that produce …”
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Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells von Matas-Rico, Elisa, Frijlink, Elselien, van der Haar Àvila, Irene, Menegakis, Apostolos, van Zon, Maaike, Morris, Andrew J., Koster, Jan, Salgado-Polo, Fernando, de Kivit, Sander, Lança, Telma, Mazzocca, Antonio, Johnson, Zoë, Haanen, John, Schumacher, Ton N., Perrakis, Anastassis, Verbrugge, Inge, van den Berg, Joost H., Borst, Jannie, Moolenaar, Wouter H.

“… Autotaxin (ATX; ENPP2) produces lysophosphatidic acid (LPA) that regulates multiple biological functions via cognate G protein-coupled receptors LPAR1-6 …”
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