Search Results - "Schlessinger, David"

Eccrine sweat gland development and sweat secretion by Cui, Chang-Yi, Schlessinger, David

“…Eccrine sweat glands help to maintain homoeostasis, primarily by stabilizing body temperature. Derived from embryonic ectoderm, millions of eccrine glands are…”
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Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium by Kobayashi, Tetsuro, Voisin, Benjamin, Kim, Do Young, Kennedy, Elizabeth A, Jo, Jay-Hyun, Shih, Han-Yu, Truong, Amanda, Doebel, Thomas, Sakamoto, Keiko, Cui, Chang-Yi, Schlessinger, David, Moro, Kazuyo, Nakae, Susumu, Horiuchi, Keisuke, Zhu, Jinfang, Leonard, Warren J, Kong, Heidi H, Nagao, Keisuke

“…Immune cells and epithelium form sophisticated barrier systems in symbiotic relationships with microbiota. Evidence suggests that immune cells can sense…”
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Molecular dynamics of Dkk4 modulates Wnt action and regulates meibomian gland development by Sima, Jian, Piao, Yulan, Chen, Yaohui, Schlessinger, David

“…Secreted Dickkopf (Dkk) proteins are major Wnt pathway modulators during organ development. Dkk1 has been widely studied and acts as a general Wnt inhibitor…”
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Variation in human chromosome 21 ribosomal RNA genes characterized by TAR cloning and long-read sequencing by Kim, Jung-Hyun, Dilthey, Alexander T, Nagaraja, Ramaiah, Lee, Hee-Sheung, Koren, Sergey, Dudekula, Dawood, Wood III, William H, Piao, Yulan, Ogurtsov, Aleksey Y, Utani, Koichi, Noskov, Vladimir N, Shabalina, Svetlana A, Schlessinger, David, Phillippy, Adam M, Larionov, Vladimir

“…Abstract Despite the key role of the human ribosome in protein biosynthesis, little is known about the extent of sequence variation in ribosomal DNA (rDNA) or…”
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Assessing Mitochondrial DNA Variation and Copy Number in Lymphocytes of ~2,000 Sardinians Using Tailored Sequencing Analysis Tools by Ding, Jun, Sidore, Carlo, Butler, Thomas J., Wing, Mary Kate, Qian, Yong, Meirelles, Osorio, Busonero, Fabio, Tsoi, Lam C., Maschio, Andrea, Angius, Andrea, Kang, Hyun Min, Nagaraja, Ramaiah, Cucca, Francesco, Abecasis, Gonçalo R., Schlessinger, David

“…DNA sequencing identifies common and rare genetic variants for association studies, but studies typically focus on variants in nuclear DNA and ignore the…”
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Loss of Wnt4 and Foxl2 leads to female-to-male sex reversal extending to germ cells by Ottolenghi, Chris, Pelosi, Emanuele, Tran, Joseph, Colombino, Maria, Douglass, Eric, Nedorezov, Timur, Cao, Antonio, Forabosco, Antonino, Schlessinger, David

“…The discovery that the SRY gene induces male sex in humans and other mammals led to speculation about a possible equivalent for female sex. However, only…”
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Involvement of Wnt, Eda and Shh at defined stages of sweat gland development by Cui, Chang-Yi, Yin, Mingzhu, Sima, Jian, Childress, Victoria, Michel, Marc, Piao, Yulan, Schlessinger, David

“…To maintain body temperature, sweat glands develop from embryonic ectoderm by a poorly defined mechanism. We demonstrate a temporal cascade of regulation…”
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Constitutively active Foxo3 in oocytes preserves ovarian reserve in mice by Pelosi, Emanuele, Omari, Shakib, Michel, Marc, Ding, Jun, Amano, Tomokazu, Forabosco, Antonino, Schlessinger, David, Ottolenghi, Chris

“…During female reproductive life, ovarian follicle reserve is reduced by maturation and atresia until menopause ensues. Foxo3 is required to maintain the…”
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Genetic regulation of gene expression and splicing during a 10-year period of human aging by Balliu, Brunilda, Durrant, Matthew, Goede, Olivia de, Abell, Nathan, Li, Xin, Liu, Boxiang, Gloudemans, Michael J., Cook, Naomi L., Smith, Kevin S., Knowles, David A., Pala, Mauro, Cucca, Francesco, Schlessinger, David, Jaiswal, Siddhartha, Sabatti, Chiara, Lind, Lars, Ingelsson, Erik, Montgomery, Stephen B.

“…Background Molecular and cellular changes are intrinsic to aging and age-related diseases. Prior cross-sectional studies have investigated the combined effects…”
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Evidence of Polygenic Adaptation in Sardinia at Height-Associated Loci Ascertained from the Biobank Japan by Chen, Minhui, Sidore, Carlo, Akiyama, Masato, Ishigaki, Kazuyoshi, Kamatani, Yoichiro, Schlessinger, David, Cucca, Francesco, Okada, Yukinori, Chiang, Charleston W K

“…Adult height is one of the earliest putative examples of polygenic adaptation in humans. However, this conclusion was recently challenged because residual…”
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DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease by Lettre, Guillaume, Sankaran, Vijay G, Bezerra, Marcos André C, Araújo, Aderson S, Uda, Manuela, Sanna, Serena, Cao, Antonio, Schlessinger, David, Costa, Fernando F, Hirschhorn, Joel N, Orkin, Stuart H

“…Sickle cell disease (SCD) is a debilitating monogenic blood disorder with a highly variable phenotype characterized by severe pain crises, acute clinical…”
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Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits by Scuteri, Angelo, Sanna, Serena, Chen, Wei-Min, Uda, Manuela, Albai, Giuseppe, Strait, James, Najjar, Samer, Nagaraja, Ramaiah, Orrú, Marco, Usala, Gianluca, Dei, Mariano, Lai, Sandra, Maschio, Andrea, Busonero, Fabio, Mulas, Antonella, Ehret, Georg B, Fink, Ashley A, Weder, Alan B, Cooper, Richard S, Galan, Pilar, Chakravarti, Aravinda, Schlessinger, David, Cao, Antonio, Lakatta, Edward, Abecasis, Gonçalo R

“…The obesity epidemic is responsible for a substantial economic burden in developed countries and is a major risk factor for type 2 diabetes and cardiovascular…”
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FOXL2 and BMP2 act cooperatively to regulate follistatin gene expression during ovarian development by Kashimada, Kenichi, Pelosi, Emanuele, Chen, Huijun, Schlessinger, David, Wilhelm, Dagmar, Koopman, Peter

“…Follistatin is a secreted glycoprotein required for female sex determination and early ovarian development, but the precise mechanisms regulating follistatin…”
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EDA ligand triggers plasma membrane trafficking of its receptor EDAR via PKA activation and SNAP23-containing complexes by Yao, Yuyuan, Yang, Ruihan, Zhu, Jian, Schlessinger, David, Sima, Jian

“…Background Ectodysplasin-A (EDA), a skin-specific TNF ligand, interacts with its membrane receptor EDAR to trigger EDA signaling in skin appendage formation…”
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Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia by Uda, Manuela, Galanello, Renzo, Sanna, Serena, Lettre, Guillaume, Sankaran, Vijay G, Chen, Weimin, Usala, Gianluca, Busonero, Fabio, Maschio, Andrea, Albai, Giuseppe, Piras, Maria Grazia, Sestu, Natascia, Lai, Sandra, Dei, Mariano, Mulas, Antonella, Crisponi, Laura, Naitza, Silvia, Asunis, Isadora, Deiana, Manila, Nagaraja, Ramaiah, Perseu, Lucia, Satta, Stefania, Cipollina, Maria Dolores, Sollaino, Carla, Moi, Paolo, Hirschhorn, Joel N, Orkin, Stuart H, Abecasis, Gonçalo R, Schlessinger, David, Cao, Antonio

“…beta-Thalassemia and sickle cell disease both display a great deal of phenotypic heterogeneity, despite being generally thought of as simple Mendelian…”
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Age-related changes of the retinal microvasculature by Orlov, Nikita V., Coletta, Cristopher, van Asten, Freekje, Qian, Yong, Ding, Jun, AlGhatrif, Majd, Lakatta, Edward, Chew, Emily, Wong, Wai, Swaroop, Anand, Fiorillo, Edoardo, Delitala, Alessandro, Marongiu, Michele, Goldberg, Ilya G., Schlessinger, David

“…Blood vessels of the retina provide an easily-accessible, representative window into the condition of microvasculature. We investigated how retinal vessel…”
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ExAtlas: An interactive online tool for meta-analysis of gene expression data by Sharov, Alexei A, Schlessinger, David, Ko, Minoru S H

“…We have developed ExAtlas, an on-line software tool for meta-analysis and visualization of gene expression data. In contrast to existing software tools,…”
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Transcriptome organization of white blood cells through gene co-expression network analysis in a large RNA-seq dataset by Forabosco, Paola, Pala, Mauro, Crobu, Francesca, Diana, Maria Antonietta, Marongiu, Mara, Cusano, Roberto, Angius, Andrea, Steri, Maristella, Orrù, Valeria, Schlessinger, David, Fiorillo, Edoardo, Devoto, Marcella, Cucca, Francesco

“…Gene co-expression network analysis enables identification of biologically meaningful clusters of co-regulated genes (modules) in an unsupervised manner. We…”
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EDA Signaling and Skin Appendage Development by Cui, Chang-Yi, Schlessinger, David

“…The same morphogenetic signals are often involved in the development of different organs. For developing skin appendages, a model for tissue-specific…”
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Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations by Tanaka, Toshiko, Scheet, Paul, Giusti, Betti, Bandinelli, Stefania, Piras, Maria Grazia, Usala, Gianluca, Lai, Sandra, Mulas, Antonella, Corsi, Anna Maria, Vestrini, Anna, Sofi, Francesco, Gori, Anna Maria, Abbate, Rosanna, Guralnik, Jack, Singleton, Andrew, Abecasis, Goncalo R, Schlessinger, David, Uda, Manuela, Ferrucci, Luigi

“…The B vitamins are components of one-carbon metabolism (OCM) that contribute to DNA synthesis and methylation. Homocysteine, a by-product of OCM, has been…”
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