Suchergebnisse - "Scheet, Paul"

Single-Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression von Bernard, Vincent, Semaan, Alexander, Huang, Jonathan, San Lucas, F Anthony, Mulu, Feven C, Stephens, Bret M, Guerrero, Paola A, Huang, Yanqing, Zhao, Jun, Kamyabi, Nabiollah, Sen, Subrata, Scheet, Paul A, Taniguchi, Cullen M, Kim, Michael P, Tzeng, Ching-Wei, Katz, Matthew H, Singhi, Aatur D, Maitra, Anirban, Alvarez, Hector A

“… Early detection of pancreatic ductal adenocarcinoma (PDAC) remains elusive. Precursor lesions of PDAC, specifically intraductal papillary mucinous neoplasms …”
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A fast and flexible statistical model for large-scale population genotype data: applications to inferring missing genotypes and haplotypic phase von Scheet, Paul, Stephens, Matthew

“… We present a statistical model for patterns of genetic variation in samples of unrelated individuals from natural populations. This model is based on the idea …”
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Accounting for decay of linkage disequilibrium in haplotype inference and missing-data imputation von Stephens, Matthew, Scheet, Paul

“… Although many algorithms exist for estimating haplotypes from genotype data, none of them take full account of both the decay of linkage disequilibrium (LD) …”
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Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes von Riquelme, Erick, Zhang, Yu, Zhang, Liangliang, Montiel, Maria, Zoltan, Michelle, Dong, Wenli, Quesada, Pompeyo, Sahin, Ismet, Chandra, Vidhi, San Lucas, Anthony, Scheet, Paul, Xu, Hanwen, Hanash, Samir M, Feng, Lei, Burks, Jared K, Do, Kim-Anh, Peterson, Christine B, Nejman, Deborah, Tzeng, Ching-Wei D, Kim, Michael P, Sears, Cynthia L, Ajami, Nadim, Petrosino, Joseph, Wood, Laura D, Maitra, Anirban, Straussman, Ravid, Katz, Matthew, White, James Robert, Jenq, Robert, Wargo, Jennifer, McAllister, Florencia

“… Most patients diagnosed with resected pancreatic adenocarcinoma (PDAC) survive less than 5 years, but a minor subset survives longer. Here, we dissect the role …”
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Clonal evolution in breast cancer revealed by single nucleus genome sequencing von Wang, Yong, Waters, Jill, Leung, Marco L., Unruh, Anna, Roh, Whijae, Shi, Xiuqing, Chen, Ken, Scheet, Paul, Vattathil, Selina, Liang, Han, Multani, Asha, Zhang, Hong, Zhao, Rui, Michor, Franziska, Meric-Bernstam, Funda, Navin, Nicholas E.

“… Sequencing studies of breast tumour cohorts have identified many prevalent mutations, but provide limited insight into the genomic diversity within tumours …”
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MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes von Li, Yun, Willer, Cristen J., Ding, Jun, Scheet, Paul, Abecasis, Gonçalo R.

“… Genome‐wide association studies (GWAS) can identify common alleles that contribute to complex disease susceptibility. Despite the large number of SNPs assessed …”
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Somatic mutation load of estrogen receptor-positive breast tumors predicts overall survival: an analysis of genome sequence data von Haricharan, Svasti, Bainbridge, Matthew N., Scheet, Paul, Brown, Powel H.

“… Breast cancer is one of the most commonly diagnosed cancers in women. While there are several effective therapies for breast cancer and important single gene …”
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Early Events in the Molecular Pathogenesis of Lung Cancer von Kadara, Humam, Scheet, Paul, Wistuba, Ignacio I, Spira, Avrum E

“… The majority of cancer-related deaths in the United States and worldwide are attributed to lung cancer. There are more than 90 million smokers in the United …”
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Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular features von Dejima, Hitoshi, Hu, Xin, Chen, Runzhe, Zhang, Jiexin, Fujimoto, Junya, Parra, Edwin R., Haymaker, Cara, Hubert, Shawna M., Duose, Dzifa, Solis, Luisa M., Su, Dan, Fukuoka, Junya, Tabata, Kazuhiro, Pham, Hoa H. N., Mcgranahan, Nicholas, Zhang, Baili, Ye, Jie, Ying, Lisha, Little, Latasha, Gumbs, Curtis, Chow, Chi-Wan, Estecio, Marcos Roberto, Godoy, Myrna C. B., Antonoff, Mara B., Sepesi, Boris, Pass, Harvey I., Behrens, Carmen, Zhang, Jianhua, Vaporciyan, Ara A., Heymach, John V., Scheet, Paul, Lee, J. Jack, Wu, Jia, Futreal, P. Andrew, Reuben, Alexandre, Kadara, Humam, Wistuba, Ignacio I., Zhang, Jianjun

“… The mechanism by which anti-cancer immunity shapes early carcinogenesis of lung adenocarcinoma (ADC) is unknown. In this study, we characterize the immune …”
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The Transcriptomic Landscape of Mismatch Repair-Deficient Intestinal Stem Cells von Bommi, Prashant V, Bowen, Charles M, Reyes-Uribe, Laura, Wu, Wenhui, Katayama, Hiroyuki, Rocha, Pedro, Parra, Edwin R, Francisco-Cruz, Alejandro, Ozcan, Zuhal, Tosti, Elena, Willis, Jason A, Wu, Hong, Taggart, Melissa W, Burks, Jared K, Lynch, Patrick M, Edelmann, Winfried, Scheet, Paul A, Wistuba, Ignacio I, Sinha, Krishna M, Hanash, Samir M, Vilar, Eduardo

“… Lynch syndrome is the most common cause of hereditary colorectal cancer and is secondary to germline alterations in one of four DNA mismatch repair (MMR) …”
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Defining the Comprehensive Genomic Landscapes of Pancreatic Ductal Adenocarcinoma Using Real-World Endoscopic Aspiration Samples von Semaan, Alexander, Bernard, Vincent, Lee, Jaewon J, Wong, Justin W, Huang, Jonathan, Swartzlander, Daniel B, Stephens, Bret M, Monberg, Maria E, Weston, Brian R, Bhutani, Manoop S, Chang, Kyle, Scheet, Paul A, Maitra, Anirban, Jakubek, Yasminka A, Guerrero, Paola A

“… Most patients with pancreatic ductal adenocarcinoma (PDAC) present with surgically unresectable cancer. As a result, endoscopic ultrasound-guided fine-needle …”
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Genomic Landscape of Atypical Adenomatous Hyperplasia Reveals Divergent Modes to Lung Adenocarcinoma von Sivakumar, Smruthy, Lucas, F Anthony San, McDowell, Tina L, Lang, Wenhua, Xu, Li, Fujimoto, Junya, Zhang, Jianjun, Futreal, P Andrew, Fukuoka, Junya, Yatabe, Yasushi, Dubinett, Steven M, Spira, Avrum E, Fowler, Jerry, Hawk, Ernest T, Wistuba, Ignacio I, Scheet, Paul, Kadara, Humam

“… There is a dearth of knowledge about the pathogenesis of premalignant lung lesions, especially for atypical adenomatous hyperplasia (AAH), the only known …”
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Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas von Hu, Xin, Estecio, Marcos R., Chen, Runzhe, Reuben, Alexandre, Wang, Linghua, Fujimoto, Junya, Carrot-Zhang, Jian, McGranahan, Nicholas, Ying, Lisha, Fukuoka, Junya, Chow, Chi-Wan, Pham, Hoa H. N., Godoy, Myrna C. B., Carter, Brett W., Behrens, Carmen, Zhang, Jianhua, Antonoff, Mara B., Sepesi, Boris, Lu, Yue, Pass, Harvey I., Kadara, Humam, Scheet, Paul, Vaporciyan, Ara A., Heymach, John V., Wistuba, Ignacio I., Lee, J. Jack, Futreal, P. Andrew, Su, Dan, Issa, Jean-Pierre J., Zhang, Jianjun

“… The evolution of DNA methylome and methylation intra-tumor heterogeneity (ITH) during early carcinogenesis of lung adenocarcinoma has not been systematically …”
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Attention-deficit/hyperactivity disorder polygenic risk scores predict attention problems in a population-based sample of children von Groen-Blokhuis, Maria M, Middeldorp, Christel M, Kan, Kees-Jan, Abdellaoui, Abdel, van Beijsterveldt, Catharina E M, Ehli, Erik A, Davies, Gareth E, Scheet, Paul A, Xiao, Xiangjun, Hudziak, James J, Hottenga, Jouke-Jan, Neale, Ben M, Boomsma, Dorret I

“… Clinically, attention-deficit/hyperactivity disorder (ADHD) is characterized by hyperactivity, impulsivity, and inattention and is among the most common …”
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Leveraging existing cohort studies of Mexican women to better understand Hispanic health and cancer risk von Stern, Dalia, Gomez-Flores-Ramos, Liliana, Trabert, Britton, Setiawan, V. Wendy, Le Marchand, Loïc, Gomez, Henry, Scheet, Paul A., Parada, Humberto, Pirzada, Amber, Lajous, Martin, Farland, Leslie V.

“… Background Hispanics have been historically underrepresented in epidemiologic cancer research. Existing cohort studies focused on recruiting Hispanic …”
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RAD21 promotes oncogenesis and lethal progression of prostate cancer von Su, Xiaofeng A, Stopsack, Konrad H, Schmidt, Daniel R, Ma, Duanduan, Li, Zhe, Scheet, Paul A, Penney, Kathryn L, Lotan, Tamara L, Abida, Wassim, DeArment, Elise G, Lu, Kate, Janas, Thomas, Hu, Sofia, Vander Heiden, Matthew G, Loda, Massimo, Boselli, Monica, Amon, Angelika, Mucci, Lorelei A

“… Higher levels of aneuploidy, characterized by imbalanced chromosome numbers, are associated with lethal progression in prostate cancer. However, how aneuploidy …”
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Augmented Lipocalin-2 Is Associated with Chronic Obstructive Pulmonary Disease and Counteracts Lung Adenocarcinoma Development von Treekitkarnmongkol, Warapen, Hassane, Maya, Sinjab, Ansam, Chang, Kyle, Hara, Kieko, Rahal, Zahraa, Zhang, Jiexin, Lu, Wei, Sivakumar, Smruthy, McDowell, Tina L, Kantrowitz, Jacob, Zhou, Jianling, Lang, Wenhua, Xu, Li, Ochieng, Joshua K, Nunomura-Nakamura, Sayuri, Deng, Shanshan, Behrens, Carmen, Raso, Maria Gabriela, Fukuoka, Junya, Reuben, Alexandre, Ostrin, Edwin J, Parra, Edwin, Solis, Luisa M, Spira, Avrum E, McAllister, Florencia, Cascone, Tina, Wistuba, Ignacio I, Moghaddam, Seyed Javad, Scheet, Paul A, Fujimoto, Junya, Kadara, Humam

“… Early pathogenesis of lung adenocarcinoma (LUAD) remains largely unknown. We found that, relative to wild-type littermates, the innate immunomodulator …”
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Mutational Heterogeneity in APC and KRAS Arises at the Crypt Level and Leads to Polyclonality in Early Colorectal Tumorigenesis von Gausachs, Mireia, Borras, Ester, Chang, Kyle, Gonzalez, Sara, Azuara, Daniel, Delgado Amador, Axel, Lopez-Doriga, Adriana, San Lucas, F Anthony, Sanjuan, Xavier, Paules, Maria J, Taggart, Melissa W, Davies, Gareth E, Ehli, Erik A, Fowler, Jerry, Moreno, Victor, Pineda, Marta, You, Y Nancy, Lynch, Patrick M, Lazaro, Conxi, Navin, Nicholas E, Scheet, Paul A, Hawk, Ernest T, Capella, Gabriel, Vilar, Eduardo

“… The majority of genomic alterations causing intratumoral heterogeneity (ITH) in colorectal cancer are thought to arise during early stages of carcinogenesis as …”
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Causes of Clonal Hematopoiesis: a Review von Joo, LiJin, Bradley, Catherine C., Lin, Steven H., Scheet, Paul A., Nead, Kevin T.

“… Purpose of Review Clonal hematopoiesis (CH) is an age-dependent process detectable using advanced sequencing technologies and is associated with multiple …”
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Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition von Ramsey, Laura B, Bruun, Gitte H, Yang, Wenjian, Treviño, Lisa R, Vattathil, Selina, Scheet, Paul, Cheng, Cheng, Rosner, Gary L, Giacomini, Kathleen M, Fan, Yiping, Sparreboom, Alex, Mikkelsen, Torben S, Corydon, Thomas J, Pui, Ching-Hon, Evans, William E, Relling, Mary V

“… Methotrexate is used to treat autoimmune diseases and malignancies, including acute lymphoblastic leukemia (ALL). Inter-individual variation in clearance of …”
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