Výsledky vyhľadávania - "Scearce, Richard M"

Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination Autor Pardi, Norbert, Hogan, Michael J., Pelc, Rebecca S., Muramatsu, Hiromi, Andersen, Hanne, DeMaso, Christina R., Dowd, Kimberly A., Sutherland, Laura L., Scearce, Richard M., Parks, Robert, Wagner, Wendeline, Granados, Alex, Greenhouse, Jack, Walker, Michelle, Willis, Elinor, Yu, Jae-Sung, McGee, Charles E., Sempowski, Gregory D., Mui, Barbara L., Tam, Ying K., Huang, Yan-Jang, Vanlandingham, Dana, Holmes, Veronica M., Balachandran, Harikrishnan, Sahu, Sujata, Lifton, Michelle, Higgs, Stephen, Hensley, Scott E., Madden, Thomas D., Hope, Michael J., Karikó, Katalin, Santra, Sampa, Graham, Barney S., Lewis, Mark G., Pierson, Theodore C., Haynes, Barton F., Weissman, Drew

“…A single, low-dose intradermal immunization with lipid-nanoparticle-encapsulated nucleoside-modified mRNA encoding the pre-membrane and envelope glycoproteins…”
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Antibody light-chain-restricted recognition of the site of immune pressure in the RV144 HIV-1 vaccine trial is phylogenetically conserved Autor Wiehe, Kevin, Easterhoff, David, Luo, Kan, Nicely, Nathan I, Bradley, Todd, Jaeger, Frederick H, Dennison, S Moses, Zhang, Ruijun, Lloyd, Krissey E, Stolarchuk, Christina, Parks, Robert, Sutherland, Laura L, Scearce, Richard M, Morris, Lynn, Kaewkungwal, Jaranit, Nitayaphan, Sorachai, Pitisuttithum, Punnee, Rerks-Ngarm, Supachai, Sinangil, Faruk, Phogat, Sanjay, Michael, Nelson L, Kim, Jerome H, Kelsoe, Garnett, Montefiori, David C, Tomaras, Georgia D, Bonsignori, Mattia, Santra, Sampa, Kepler, Thomas B, Alam, S Munir, Moody, M Anthony, Liao, Hua-Xin, Haynes, Barton F

“…In HIV-1, the ability to mount antibody responses to conserved, neutralizing epitopes is critical for protection. Here we have studied the light chain usage of…”
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Immune checkpoint modulation enhances HIV-1 antibody induction Autor Bradley, Todd, Kuraoka, Masayuki, Yeh, Chen-Hao, Tian, Ming, Chen, Huan, Cain, Derek W., Chen, Xuejun, Cheng, Cheng, Ellebedy, Ali H., Parks, Robert, Barr, Maggie, Sutherland, Laura L., Scearce, Richard M., Bowman, Cindy M., Bouton-Verville, Hilary, Santra, Sampa, Wiehe, Kevin, Lewis, Mark G., Ogbe, Ane, Borrow, Persephone, Montefiori, David, Bonsignori, Mattia, Anthony Moody, M., Verkoczy, Laurent, Saunders, Kevin O., Ahmed, Rafi, Mascola, John R., Kelsoe, Garnett, Alt, Frederick W., Haynes, Barton F.

“…Eliciting protective titers of HIV-1 broadly neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development, but current vaccine strategies have yet to…”
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The role of antibody polyspecificity and lipid reactivity in binding of broadly neutralizing anti-HIV-1 envelope human monoclonal antibodies 2F5 and 4E10 to glycoprotein 41 membrane proximal envelope epitopes Autor Alam, S Munir, McAdams, Mildred, Boren, David, Rak, Michael, Scearce, Richard M, Gao, Feng, Camacho, Zenaido T, Gewirth, Daniel, Kelsoe, Garnett, Chen, Pojen, Haynes, Barton F

“…Two neutralizing human mAbs, 2F5 and 4E10, that react with the HIV-1 envelope gp41 membrane proximal region are also polyspecific autoantibodies that bind to…”
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Cardiolipin Polyspecific Autoreactivity in Two Broadly Neutralizing HIV-1 Antibodies Autor Haynes, Barton F, Fleming, Judith, St. Clair, E. William, Katinger, Herman, Stiegler, Gabriela, Kunert, Renate, Robinson, James, Scearce, Richard M, Plonk, Kelly, Staats, Herman F, Ortel, Thomas L, Liao, Hua-Xin, Alam, S. Munir

“…The design of a human immunodeficiency virus-1 (HIV-1) immunogen that can induce broadly reactive neutralizing antibodies is a major goal of HIV-1 vaccine…”
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Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates Autor Saunders, Kevin O., Nicely, Nathan I., Wiehe, Kevin, Bonsignori, Mattia, Meyerhoff, R. Ryan, Parks, Robert, Walkowicz, William E., Aussedat, Baptiste, Wu, Nelson R., Cai, Fangping, Vohra, Yusuf, Park, Peter K., Eaton, Amanda, Go, Eden P., Sutherland, Laura L., Scearce, Richard M., Barouch, Dan H., Zhang, Ruijun, Von Holle, Tarra, Overman, R. Glenn, Anasti, Kara, Sanders, Rogier W., Moody, M. Anthony, Kepler, Thomas B., Korber, Bette, Desaire, Heather, Santra, Sampa, Letvin, Norman L., Nabel, Gary J., Montefiori, David C., Tomaras, Georgia D., Liao, Hua-Xin, Alam, S. Munir, Danishefsky, Samuel J., Haynes, Barton F.

“…Induction of broadly neutralizing antibodies (bnAbs) that target HIV-1 envelope (Env) is a goal of HIV-1 vaccine development. A bnAb target is the Env third…”
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Antigenicity and immunogenicity of transmitted/founder, consensus, and chronic envelope glycoproteins of human immunodeficiency virus type 1 Autor Liao, Hua-Xin, Tsao, Chun-Yen, Alam, S Munir, Muldoon, Mark, Vandergrift, Nathan, Ma, Ben-Jiang, Lu, Xiaozhi, Sutherland, Laura L, Scearce, Richard M, Bowman, Cindy, Parks, Robert, Chen, Haiyan, Blinn, Julie H, Lapedes, Alan, Watson, Sydeaka, Xia, Shi-Mao, Foulger, Andrew, Hahn, Beatrice H, Shaw, George M, Swanstrom, Ron, Montefiori, David C, Gao, Feng, Haynes, Barton F, Korber, Bette

“…Human immunodeficiency virus type 1 (HIV-1) vaccine development requires selection of appropriate envelope (Env) immunogens. Twenty HIV-1 Env glycoproteins…”
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Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site Autor Bradley, Todd, Fera, Daniela, Bhiman, Jinal, Eslamizar, Leila, Lu, Xiaozhi, Anasti, Kara, Zhang, Ruijung, Sutherland, Laura L., Scearce, Richard M., Bowman, Cindy M., Stolarchuk, Christina, Lloyd, Krissey E., Parks, Robert, Eaton, Amanda, Foulger, Andrew, Nie, Xiaoyan, Karim, Salim S. Abdool, Barnett, Susan, Kelsoe, Garnett, Kepler, Thomas B., Alam, S. Munir, Montefiori, David C., Moody, M. Anthony, Liao, Hua-Xin, Morris, Lynn, Santra, Sampa, Harrison, Stephen C., Haynes, Barton F.

“…Antibodies that neutralize autologous transmitted/founder (TF) HIV occur in most HIV-infected individuals and can evolve to neutralization breadth. Autologous…”
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Envelope Deglycosylation Enhances Antigenicity of HIV-1 gp41 Epitopes for Both Broad Neutralizing Antibodies and Their Unmutated Ancestor Antibodies Autor Ma, Ben-Jiang, Alam, S. Munir, Go, Eden P., Lu, Xiaozhi, Desaire, Heather, Tomaras, Georgia D., Bowman, Cindy, Sutherland, Laura L., Scearce, Richard M., Santra, Sampa, Letvin, Norman L., Kepler, Thomas B., Liao, Hua-Xin, Haynes, Barton F.

“…The HIV-1 gp41 envelope (Env) membrane proximal external region (MPER) is an important vaccine target that in rare subjects can elicit neutralizing antibodies…”
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Induction of Antibodies in Rhesus Macaques That Recognize a Fusion-Intermediate Conformation of HIV-1 gp41 Autor Dennison, S. Moses, Sutherland, Laura L., Jaeger, Frederick H., Anasti, Kara M., Parks, Robert, Stewart, Shelley, Bowman, Cindy, Xia, Shi-Mao, Zhang, Ruijun, Shen, Xiaoying, Scearce, Richard M., Ofek, Gilad, Yang, Yongping, Kwong, Peter D., Santra, Sampa, Liao, Hua-Xin, Tomaras, Georgia, Letvin, Norman L., Chen, Bing, Alam, S. Munir, Haynes, Barton F.

“…A component to the problem of inducing broad neutralizing HIV-1 gp41 membrane proximal external region (MPER) antibodies is the need to focus the antibody…”
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Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity Autor Li, Dapeng, Brackenridge, Simon, Walters, Lucy C., Swanson, Olivia, Harlos, Karl, Rozbesky, Daniel, Cain, Derek W., Wiehe, Kevin, Scearce, Richard M., Barr, Maggie, Mu, Zekun, Parks, Robert, Quastel, Max, Edwards, Robert J., Wang, Yunfei, Rountree, Wes, Saunders, Kevin O., Ferrari, Guido, Borrow, Persephone, Jones, E. Yvonne, Alam, S. Munir, Azoitei, Mihai L., Gillespie, Geraldine M., McMichael, Andrew J., Haynes, Barton F.

“…The non-classical class Ib molecule human leukocyte antigen E (HLA-E) has limited polymorphism and can bind HLA class Ia leader peptides (VL9). HLA-E-VL9…”
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Human immunodeficiency virus type 1 gp41 antibodies that mask membrane proximal region epitopes: antibody binding kinetics, induction, and potential for regulation in acute infection Autor Alam, S Munir, Scearce, Richard M, Parks, Robert J, Plonk, Kelly, Plonk, Steven G, Sutherland, Laura L, Gorny, Miroslaw K, Zolla-Pazner, Susan, Vanleeuwen, Stacie, Moody, M Anthony, Xia, Shi-Mao, Montefiori, David C, Tomaras, Georgia D, Weinhold, Kent J, Karim, Salim Abdool, Hicks, Charles B, Liao, Hua-Xin, Robinson, James, Shaw, George M, Haynes, Barton F

“…Two human monoclonal antibodies (MAbs) (2F5 and 4E10) against the human immunodeficiency virus type 1 (HIV-1) envelope g41 cluster II membrane proximal…”
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Antigenicity and immunogenicity of a synthetic human immunodeficiency virus type 1 group m consensus envelope glycoprotein Autor Gao, Feng, Weaver, Eric A, Lu, Zhongjing, Li, Yingying, Liao, Hua-Xin, Ma, Benjiang, Alam, S Munir, Scearce, Richard M, Sutherland, Laura L, Yu, Jae-Sung, Decker, Julie M, Shaw, George M, Montefiori, David C, Korber, Bette T, Hahn, Beatrice H, Haynes, Barton F

“…Genetic variation of human immunodeficiency virus (HIV-1) represents a major obstacle for AIDS vaccine development. To decrease the genetic distances between…”
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Nonneutralizing HIV-1 gp41 envelope cluster II human monoclonal antibodies show polyreactivity for binding to phospholipids and protein autoantigens Autor Dennison, S Moses, Anasti, Kara, Scearce, Richard M, Sutherland, Laura, Parks, Robert, Xia, Shi-Mao, Liao, Hua-Xin, Gorny, Miroslaw K, Zolla-Pazner, Susan, Haynes, Barton F, Alam, S Munir

“…HIV-1 gp41 envelope antibodies, which are frequently induced in HIV-1-infected individuals, are predominantly nonneutralizing. The rare and difficult-to-induce…”
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Amino Acid Changes in the HIV-1 gp41 Membrane Proximal Region Control Virus Neutralization Sensitivity Autor Bradley, Todd, Trama, Ashley, Tumba, Nancy, Gray, Elin, Lu, Xiaozhi, Madani, Navid, Jahanbakhsh, Fatemeh, Eaton, Amanda, Xia, Shi-Mao, Parks, Robert, Lloyd, Krissey E., Sutherland, Laura L., Scearce, Richard M., Bowman, Cindy M., Barnett, Susan, Abdool-Karim, Salim S., Boyd, Scott D., Melillo, Bruno, Smith, Amos B., Sodroski, Joseph, Kepler, Thomas B., Alam, S.Munir, Gao, Feng, Bonsignori, Mattia, Liao, Hua-Xin, Moody, M. Anthony, Montefiori, David, Santra, Sampa, Morris, Lynn, Haynes, Barton F.

“…Most HIV-1 vaccines elicit neutralizing antibodies that are active against highly sensitive (tier-1) viruses or rare cases of vaccine-matched…”
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In vitro and in vivo characterization of anthrax anti-protective antigen and anti-lethal factor monoclonal antibodies after passive transfer in a mouse lethal toxin challenge model to define correlates of immunity Autor Staats, Herman F, Alam, S Munir, Scearce, Richard M, Kirwan, Shaun M, Zhang, Julia Xianzhi, Gwinn, William M, Haynes, Barton F

“…Passive transfer of antibody may be useful for preexposure prophylaxis against biological agents used as weapons of terror, such as Bacillus anthracis. Studies…”
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Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses Autor Pardi, Norbert, Hogan, Michael J, Naradikian, Martin S, Parkhouse, Kaela, Cain, Derek W, Jones, Letitia, Moody, M Anthony, Verkerke, Hans P, Myles, Arpita, Willis, Elinor, LaBranche, Celia C, Montefiori, David C, Lobby, Jenna L, Saunders, Kevin O, Liao, Hua-Xin, Korber, Bette T, Sutherland, Laura L, Scearce, Richard M, Hraber, Peter T, Tombácz, István, Muramatsu, Hiromi, Ni, Houping, Balikov, Daniel A, Li, Charles, Mui, Barbara L, Tam, Ying K, Krammer, Florian, Karikó, Katalin, Polacino, Patricia, Eisenlohr, Laurence C, Madden, Thomas D, Hope, Michael J, Lewis, Mark G, Lee, Kelly K, Hu, Shiu-Lok, Hensley, Scott E, Cancro, Michael P, Haynes, Barton F, Weissman, Drew

“…T follicular helper (Tfh) cells are required to develop germinal center (GC) responses and drive immunoglobulin class switch, affinity maturation, and…”
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Activation‐induced deaminase–deficient MRL/lpr mice secrete high levels of protective antibodies against lupus nephritis Autor Jiang, Chuancang, Zhao, Ming‐Lang, Scearce, Richard M., Diaz, Marilyn

“…Objective We previously generated MRL/lpr mice deficient in activation‐induced deaminase (AID) that lack isotype switching and immunoglobulin hypermutation…”
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Induction of HIV-1 broad neutralizing antibodies in 2F5 knock-in mice: selection against membrane proximal external region-associated autoreactivity limits T-dependent responses Autor Verkoczy, Laurent, Chen, Yao, Zhang, Jinsong, Bouton-Verville, Hilary, Newman, Amanda, Lockwood, Bradley, Scearce, Richard M, Montefiori, David C, Dennison, S Moses, Xia, Shi-Mao, Hwang, Kwan-Ki, Liao, Hua-Xin, Alam, S Munir, Haynes, Barton F

“…A goal of HIV-1 vaccine development is to elicit broadly neutralizing Abs (BnAbs). Using a knock-in (KI) model of 2F5, a human HIV-1 gp41 membrane proximal…”
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Functional, Non-Clonal IgMa-Restricted B Cell Receptor Interactions with the HIV-1 Envelope gp41 Membrane Proximal External Region Autor Verkoczy, Laurent, Moody, M. Anthony, Holl, T. Matt, Bouton-Verville, Hilary, Scearce, Richard M., Hutchinson, Jennifer, Alam, S. Munir, Kelsoe, Garnett, Haynes, Barton F.

“…The membrane proximal external region (MPER) of HIV-1 gp41 has several features that make it an attractive antibody-based vaccine target, but eliciting an…”
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