Výsledky vyhľadávania - "Sanderson, Eleanor"

Testing and correcting for weak and pleiotropic instruments in two‐sample multivariable Mendelian randomization Autor Sanderson, Eleanor, Spiller, Wes, Bowden, Jack

“…Multivariable Mendelian randomization (MVMR) is a form of instrumental variable analysis which estimates the direct effect of multiple exposures on an outcome…”
Získať plný text

An examination of multivariable Mendelian randomization in the single-sample and two-sample summary data settings Autor Sanderson, Eleanor, Davey Smith, George, Windmeijer, Frank, Bowden, Jack

“…Abstract Background Mendelian randomization (MR) is a powerful tool in epidemiology that can be used to estimate the causal effect of an exposure on an outcome…”
Získať plný text

Interpretation of Mendelian randomization using a single measure of an exposure that varies over time Autor Morris, Tim T, Heron, Jon, Sanderson, Eleanor C M, Davey Smith, George, Didelez, Vanessa, Tilling, Kate

“…Mendelian randomization (MR) is a powerful tool through which the causal effects of modifiable exposures on outcomes can be estimated from observational data…”
Zistit podrobnosti o prístupe

Investigating causality in the association between DNA methylation and type 2 diabetes using bidirectional two-sample Mendelian randomisation Autor Juvinao-Quintero, Diana L., Sharp, Gemma C., Sanderson, Eleanor C. M., Relton, Caroline L., Elliott, Hannah R.

“…Aims/hypothesis Several studies have identified associations between type 2 diabetes and DNA methylation (DNAm). However, the causal role of these associations…”
Získať plný text

Estimation of causal effects of a time-varying exposure at multiple time points through multivariable mendelian randomization Autor Sanderson, Eleanor, Richardson, Tom G., Morris, Tim T., Tilling, Kate, Davey Smith, George

“…Mendelian Randomisation (MR) is a powerful tool in epidemiology that can be used to estimate the causal effect of an exposure on an outcome in the presence of…”
Získať plný text

Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis Autor Richardson, Tom G., Sanderson, Eleanor, Palmer, Tom M., Ala-Korpela, Mika, Ference, Brian A., Davey Smith, George, Holmes, Michael V.

“…Circulating lipoprotein lipids cause coronary heart disease (CHD). However, the precise way in which one or more lipoprotein lipid-related entities account for…”
Získať plný text

Estimating and visualising multivariable Mendelian randomization analyses within a radial framework Autor Spiller, Wes, Bowden, Jack, Sanderson, Eleanor

“…Mendelian randomization (MR) is a statistical approach using genetic variants as instrumental variables to estimate causal effects of a single exposure on an…”
Získať plný text

Education, intelligence and Alzheimer’s disease: evidence from a multivariable two-sample Mendelian randomization study Autor Anderson, Emma L, Howe, Laura D, Wade, Kaitlin H, Ben-Shlomo, Yoav, Hill, W David, Deary, Ian J, Sanderson, Eleanor C, Zheng, Jie, Korologou-Linden, Roxanna, Stergiakouli, Evie, Davey Smith, George, Davies, Neil M, Hemani, Gibran

“…Abstract Objectives To examine whether educational attainment and intelligence have causal effects on risk of Alzheimer’s disease (AD), independently of each…”
Získať plný text

Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework Autor Cho, Yoonsu, Haycock, Philip C., Sanderson, Eleanor, Gaunt, Tom R., Zheng, Jie, Morris, Andrew P., Davey Smith, George, Hemani, Gibran

“…In Mendelian randomization (MR) analysis, variants that exert horizontal pleiotropy are typically treated as a nuisance. However, they could be valuable in…”
Získať plný text

Associations between insomnia and pregnancy and perinatal outcomes: Evidence from mendelian randomization and multivariable regression analyses Autor Yang, Qian, Borges, Maria Carolina, Sanderson, Eleanor, Magnus, Maria C., Kilpi, Fanny, Collings, Paul J., Soares, Ana Luiza, West, Jane, Magnus, Per, Wright, John, Håberg, Siri E., Tilling, Kate, Lawlor, Deborah A.

“…Insomnia is common and associated with adverse pregnancy and perinatal outcomes in observational studies. However, those associations could be vulnerable to…”
Získať plný text

A cross-platform approach identifies genetic regulators of human metabolism and health Autor Lotta, Luca A., Pietzner, Maik, Stewart, Isobel D., Wittemans, Laura B. L., Li, Chen, Bonelli, Roberto, Raffler, Johannes, Biggs, Emma K., Oliver-Williams, Clare, Auyeung, Victoria P. W., Luan, Jian’an, Wheeler, Eleanor, Paige, Ellie, Surendran, Praveen, Michelotti, Gregory A., Scott, Robert A., Burgess, Stephen, Zuber, Verena, Sanderson, Eleanor, Koulman, Albert, Imamura, Fumiaki, Forouhi, Nita G., Khaw, Kay-Tee, Griffin, Julian L., Wood, Angela M., Kastenmüller, Gabi, Danesh, John, Butterworth, Adam S., Gribble, Fiona M., Reimann, Frank, Bahlo, Melanie, Fauman, Eric, Wareham, Nicholas J., Langenberg, Claudia

“…In cross-platform analyses of 174 metabolites, we identify 499 associations ( P  < 4.9 × 10 −10 ) characterized by pleiotropy, allelic heterogeneity, large and…”
Získať plný text

Mendelian randomisation analysis of the effect of educational attainment and cognitive ability on smoking behaviour Autor Sanderson, Eleanor, Davey Smith, George, Bowden, Jack, Munafò, Marcus R.

“…Recent analyses have shown educational attainment to be associated with a number of health outcomes. This association may, in part, be due to an effect of…”
Získať plný text

Multivariable two-sample Mendelian randomization estimates of the effects of intelligence and education on health Autor Davies, Neil Martin, Hill, W David, Anderson, Emma L, Sanderson, Eleanor, Deary, Ian J, Davey Smith, George

“…Intelligence and education are predictive of better physical and mental health, socioeconomic position (SEP), and longevity. However, these associations are…”
Získať plný text

Reading and conducting instrumental variable studies: guide, glossary, and checklist Autor Walker, Venexia, Sanderson, Eleanor, Levin, Michael G, Damraurer, Scott M, Feeney, Timothy, Davies, Neil M

“…Instrumental variable analysis uses naturally occurring variation to estimate the causal effects of treatments, interventions, and risk factors on outcomes in…”
Získať plný text

A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer Autor Gormley, Mark, Dudding, Tom, Sanderson, Eleanor, Martin, Richard M., Thomas, Steven, Tyrrell, Jessica, Ness, Andrew R., Brennan, Paul, Munafò, Marcus, Pring, Miranda, Boccia, Stefania, Olshan, Andrew F., Diergaarde, Brenda, Hung, Rayjean J., Liu, Geoffrey, Davey Smith, George, Richmond, Rebecca C.

“…The independent effects of smoking and alcohol in head and neck cancer are not clear, given the strong association between these risk factors. Their apparent…”
Získať plný text

Interaction-based Mendelian randomization with measured and unmeasured gene-by-covariate interactions Autor Spiller, Wes, Hartwig, Fernando Pires, Sanderson, Eleanor, Davey Smith, George, Bowden, Jack

“…Studies leveraging gene-environment (GxE) interactions within Mendelian randomization (MR) analyses have prompted the emergence of two similar methodologies:…”
Získať plný text

Exploring the Relationship Between Schizophrenia and Cardiovascular Disease: A Genetic Correlation and Multivariable Mendelian Randomization Study Autor Veeneman, Rada R, Vermeulen, Jentien M, Abdellaoui, Abdel, Sanderson, Eleanor, Wootton, Robyn E, Tadros, Rafik, Bezzina, Connie R, Denys, Damiaan, Munafò, Marcus R, Verweij, Karin J H, Treur, Jorien L

“…Abstract Individuals with schizophrenia have a reduced life-expectancy compared to the general population, largely due to an increased risk of cardiovascular…”
Získať plný text

Identifying molecular mediators of the relationship between body mass index and endometrial cancer risk: a Mendelian randomization analysis Autor Hazelwood, Emma, Sanderson, Eleanor, Tan, Vanessa Y., Ruth, Katherine S., Frayling, Timothy M., Dimou, Niki, Gunter, Marc J., Dossus, Laure, Newton, Claire, Ryan, Neil, Pournaras, Dimitri J., O’Mara, Tracy A., Davey Smith, George, Martin, Richard M., Yarmolinsky, James

“…Background Endometrial cancer is the most common gynaecological cancer in high-income countries. Elevated body mass index (BMI) is an established modifiable…”
Získať plný text

Multivariable Mendelian Randomization and Mediation Autor Sanderson, Eleanor

“…Mendelian randomization (MR) is the use of genetic variants associated with an exposure to estimate the causal effect of that exposure on an outcome. Mediation…”
Zistit podrobnosti o prístupe

Investigating the causal effects of childhood and adulthood adiposity on later life mental health outcome: a Mendelian randomization study Autor Pathak, Sweta, Richardson, Tom G., Sanderson, Eleanor, Åsvold, Bjørn Olav, Bhatta, Laxmi, Brumpton, Ben M.

“…Background Obesity particularly during childhood is considered a global public health crisis and has been linked with later life health consequences including…”
Získať plný text