Suchergebnisse - "Sanders, Mathijs A."

Molecular characterization of mutant TP53 acute myeloid leukemia and high-risk myelodysplastic syndrome von Grob, Tim, Al Hinai, Adil S A, Sanders, Mathijs A, Kavelaars, François G, Rijken, Melissa, Gradowska, Patrycja L, Biemond, Bart J, Breems, Dimitri A, Maertens, Johan, van Marwijk Kooy, Marinus, Pabst, Thomas, de Weerdt, Okke, Ossenkoppele, Gert J, van de Loosdrecht, Arjan A, Huls, Gerwin A, Cornelissen, Jan J, Beverloo, H Berna, Löwenberg, Bob, Jongen-Lavrencic, Mojca, Valk, Peter J M

“… Substantial heterogeneity within mutant TP53 acute myeloid leukemia (AML) and myelodysplastic syndrome with excess of blast (MDS-EB) precludes the exact …”
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The landscape of somatic mutation in normal colorectal epithelial cells von Lee-Six, Henry, Olafsson, Sigurgeir, Ellis, Peter, Osborne, Robert J., Sanders, Mathijs A., Moore, Luiza, Georgakopoulos, Nikitas, Torrente, Franco, Noorani, Ayesha, Goddard, Martin, Robinson, Philip, Coorens, Tim H. H., O’Neill, Laura, Alder, Christopher, Wang, Jingwei, Fitzgerald, Rebecca C., Zilbauer, Matthias, Coleman, Nicholas, Saeb-Parsy, Kourosh, Martincorena, Inigo, Campbell, Peter J., Stratton, Michael R.

“… The colorectal adenoma–carcinoma sequence has provided a paradigmatic framework for understanding the successive somatic genetic changes and consequent clonal …”
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Somatic mutations and clonal dynamics in healthy and cirrhotic human liver von Brunner, Simon F., Roberts, Nicola D., Wylie, Luke A., Moore, Luiza, Aitken, Sarah J., Davies, Susan E., Sanders, Mathijs A., Ellis, Pete, Alder, Chris, Hooks, Yvette, Abascal, Federico, Stratton, Michael R., Martincorena, Inigo, Hoare, Matthew, Campbell, Peter J.

“… The most common causes of chronic liver disease are excess alcohol intake, viral hepatitis and non-alcoholic fatty liver disease, with the clinical spectrum …”
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The mutational landscape of normal human endometrial epithelium von Moore, Luiza, Leongamornlert, Daniel, Coorens, Tim H. H., Sanders, Mathijs A., Ellis, Peter, Dentro, Stefan C., Dawson, Kevin J., Butler, Tim, Rahbari, Raheleh, Mitchell, Thomas J., Maura, Francesco, Nangalia, Jyoti, Tarpey, Patrick S., Brunner, Simon F., Lee-Six, Henry, Hooks, Yvette, Moody, Sarah, Mahbubani, Krishnaa T., Jimenez-Linan, Mercedes, Brosens, Jan J., Iacobuzio-Donahue, Christine A., Martincorena, Inigo, Saeb-Parsy, Kourosh, Campbell, Peter J., Stratton, Michael R.

“… All normal somatic cells are thought to acquire mutations, but understanding of the rates, patterns, causes and consequences of somatic mutations in normal …”
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MLL-AF9 Expression in Hematopoietic Stem Cells Drives a Highly Invasive AML Expressing EMT-Related Genes Linked to Poor Outcome von Stavropoulou, Vaia, Kaspar, Susanne, Brault, Laurent, Sanders, Mathijs A, Juge, Sabine, Morettini, Stefano, Tzankov, Alexandar, Iacovino, Michelina, Lau, I-Jun, Milne, Thomas A, Royo, Hélène, Kyba, Michael, Valk, Peter J M, Peters, Antoine H F M, Schwaller, Juerg

“… To address the impact of cellular origin on acute myeloid leukemia (AML), we generated an inducible transgenic mouse model for MLL-AF9-driven leukemia. MLL-AF9 …”
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Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia von Zambetti, Noemi A, Ping, Zhen, Chen, Si, Kenswil, Keane J G, Mylona, Maria A, Sanders, Mathijs A, Hoogenboezem, Remco M, Bindels, Eric M J, Adisty, Maria N, Van Strien, Paulina M H, van der Leije, Cindy S, Westers, Theresia M, Cremers, Eline M P, Milanese, Chiara, Mastroberardino, Pier G, van Leeuwen, Johannes P T M, van der Eerden, Bram C J, Touw, Ivo P, Kuijpers, Taco W, Kanaar, Roland, van de Loosdrecht, Arjan A, Vogl, Thomas, Raaijmakers, Marc H G P

“… Mesenchymal niche cells may drive tissue failure and malignant transformation in the hematopoietic system, but the underlying molecular mechanisms and …”
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Somatic Evolution in Non-neoplastic IBD-Affected Colon von Olafsson, Sigurgeir, McIntyre, Rebecca E, Coorens, Tim, Butler, Timothy, Jung, Hyunchul, Robinson, Philip S, Lee-Six, Henry, Sanders, Mathijs A, Arestang, Kenneth, Dawson, Claire, Tripathi, Monika, Strongili, Konstantina, Hooks, Yvette, Stratton, Michael R, Parkes, Miles, Martincorena, Inigo, Raine, Tim, Campbell, Peter J, Anderson, Carl A

“… Inflammatory bowel disease (IBD) is a chronic inflammatory disease associated with increased risk of gastrointestinal cancers. We whole-genome sequenced 446 …”
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A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia von Gröschel, Stefan, Sanders, Mathijs A, Hoogenboezem, Remco, de Wit, Elzo, Bouwman, Britta A M, Erpelinck, Claudia, van der Velden, Vincent H J, Havermans, Marije, Avellino, Roberto, van Lom, Kirsten, Rombouts, Elwin J, van Duin, Mark, Döhner, Konstanze, Beverloo, H Berna, Bradner, James E, Döhner, Hartmut, Löwenberg, Bob, Valk, Peter J M, Bindels, Eric M J, de Laat, Wouter, Delwel, Ruud

“… Chromosomal rearrangements without gene fusions have been implicated in leukemogenesis by causing deregulation of proto-oncogenes via relocation of cryptic …”
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The mutational landscape of human somatic and germline cells von Moore, Luiza, Cagan, Alex, Coorens, Tim H. H., Neville, Matthew D. C., Sanghvi, Rashesh, Sanders, Mathijs A., Oliver, Thomas R. W., Leongamornlert, Daniel, Ellis, Peter, Noorani, Ayesha, Mitchell, Thomas J., Butler, Timothy M., Hooks, Yvette, Warren, Anne Y., Jorgensen, Mette, Dawson, Kevin J., Menzies, Andrew, O’Neill, Laura, Latimer, Calli, Teng, Mabel, van Boxtel, Ruben, Iacobuzio-Donahue, Christine A., Martincorena, Inigo, Heer, Rakesh, Campbell, Peter J., Fitzgerald, Rebecca C., Stratton, Michael R., Rahbari, Raheleh

“… Over the course of an individual’s lifetime, normal human cells accumulate mutations 1 . Here we compare the mutational landscape in 29 cell types from the …”
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Convergent somatic mutations in metabolism genes in chronic liver disease von Ng, Stanley W. K., Rouhani, Foad J., Brunner, Simon F., Brzozowska, Natalia, Aitken, Sarah J., Yang, Ming, Abascal, Federico, Moore, Luiza, Nikitopoulou, Efterpi, Chappell, Lia, Leongamornlert, Daniel, Ivovic, Aleksandra, Robinson, Philip, Butler, Timothy, Sanders, Mathijs A., Williams, Nicholas, Coorens, Tim H. H., Teague, Jon, Raine, Keiran, Butler, Adam P., Hooks, Yvette, Wilson, Beverley, Birtchnell, Natalie, Naylor, Huw, Davies, Susan E., Stratton, Michael R., Martincorena, Iñigo, Rahbari, Raheleh, Frezza, Christian, Hoare, Matthew, Campbell, Peter J.

“… The progression of chronic liver disease to hepatocellular carcinoma is caused by the acquisition of somatic mutations that affect 20–30 cancer genes 1 – 8  …”
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Increased somatic mutation burdens in normal human cells due to defective DNA polymerases von Robinson, Philip S., Coorens, Tim H. H., Palles, Claire, Mitchell, Emily, Abascal, Federico, Olafsson, Sigurgeir, Lee, Bernard C. H., Lawson, Andrew R. J., Lee-Six, Henry, Moore, Luiza, Sanders, Mathijs A., Hewinson, James, Martin, Lynn, Pinna, Claudia M. A., Galavotti, Sara, Rahbari, Raheleh, Campbell, Peter J., Martincorena, Iñigo, Tomlinson, Ian, Stratton, Michael R.

“… Mutation accumulation in somatic cells contributes to cancer development and is proposed as a cause of aging. DNA polymerases Pol ε and Pol δ replicate DNA …”
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Integrative genomic and transcriptomic analysis of leiomyosarcoma von Chudasama, Priya, Mughal, Sadaf S., Sanders, Mathijs A., Hübschmann, Daniel, Chung, Inn, Deeg, Katharina I., Wong, Siao-Han, Rabe, Sophie, Hlevnjak, Mario, Zapatka, Marc, Ernst, Aurélie, Kleinheinz, Kortine, Schlesner, Matthias, Sieverling, Lina, Klink, Barbara, Schröck, Evelin, Hoogenboezem, Remco M., Kasper, Bernd, Heilig, Christoph E., Egerer, Gerlinde, Wolf, Stephan, von Kalle, Christof, Eils, Roland, Stenzinger, Albrecht, Weichert, Wilko, Glimm, Hanno, Gröschel, Stefan, Kopp, Hans-Georg, Omlor, Georg, Lehner, Burkhard, Bauer, Sebastian, Schimmack, Simon, Ulrich, Alexis, Mechtersheimer, Gunhild, Rippe, Karsten, Brors, Benedikt, Hutter, Barbara, Renner, Marcus, Hohenberger, Peter, Scholl, Claudia, Fröhling, Stefan

“… Leiomyosarcoma (LMS) is an aggressive mesenchymal malignancy with few therapeutic options. The mechanisms underlying LMS development, including clinically …”
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Reliable detection of somatic mutations in solid tissues by laser-capture microdissection and low-input DNA sequencing von Ellis, Peter, Moore, Luiza, Sanders, Mathijs A., Butler, Timothy M., Brunner, Simon F., Lee-Six, Henry, Osborne, Robert, Farr, Ben, Coorens, Tim H. H., Lawson, Andrew R. J., Cagan, Alex, Stratton, Mike R., Martincorena, Inigo, Campbell, Peter J.

“… Somatic mutations accumulate in healthy tissues as we age, giving rise to cancer and potentially contributing to ageing. To study somatic mutations in …”
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Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia von Li, Sheng, Garrett-Bakelman, Francine E, Chung, Stephen S, Sanders, Mathijs A, Hricik, Todd, Rapaport, Franck, Patel, Jay, Dillon, Richard, Vijay, Priyanka, Brown, Anna L, Perl, Alexander E, Cannon, Joy, Bullinger, Lars, Luger, Selina, Becker, Michael, Lewis, Ian D, To, Luen Bik, Delwel, Ruud, Löwenberg, Bob, Döhner, Hartmut, Döhner, Konstanze, Guzman, Monica L, Hassane, Duane C, Roboz, Gail J, Grimwade, David, Valk, Peter J M, D'Andrea, Richard J, Carroll, Martin, Park, Christopher Y, Neuberg, Donna, Levine, Ross, Melnick, Ari M, Mason, Christopher E

“… Genome-wide methylome sequencing of serial samples obtained from patients with acute myeloid leukemia reveals that epigenetic alleles and genetic alleles …”
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Widespread chromatin context-dependencies of DNA double-strand break repair proteins von Vergara, Xabier, Manjón, Anna G., de Haas, Marcel, Morris, Ben, Schep, Ruben, Leemans, Christ, Friskes, Anoek, Beijersbergen, Roderick L., Sanders, Mathijs A., Medema, René H., van Steensel, Bas

“… DNA double-strand breaks are repaired by multiple pathways, including non-homologous end-joining (NHEJ) and microhomology-mediated end-joining (MMEJ). The …”
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Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells von Robinson, Philip S., Thomas, Laura E., Abascal, Federico, Jung, Hyunchul, Harvey, Luke M. R., West, Hannah D., Olafsson, Sigurgeir, Lee, Bernard C. H., Coorens, Tim H. H., Lee-Six, Henry, Butlin, Laura, Lander, Nicola, Truscott, Rebekah, Sanders, Mathijs A., Lensing, Stefanie V., Buczacki, Simon J. A., ten Hoopen, Rogier, Coleman, Nicholas, Brunton-Sim, Roxanne, Rushbrook, Simon, Saeb-Parsy, Kourosh, Lalloo, Fiona, Campbell, Peter J., Martincorena, Iñigo, Sampson, Julian R., Stratton, Michael R.

“… Cellular DNA damage caused by reactive oxygen species is repaired by the base excision repair (BER) pathway which includes the DNA glycosylase MUTYH. Inherited …”
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Mutational landscape of normal epithelial cells in Lynch Syndrome patients von Lee, Bernard C. H., Robinson, Philip S., Coorens, Tim H. H., Yan, Helen H. N., Olafsson, Sigurgeir, Lee-Six, Henry, Sanders, Mathijs A., Siu, Hoi Cheong, Hewinson, James, Yue, Sarah S. K., Tsui, Wai Yin, Chan, Annie S. Y., Chan, Anthony K. W., Ho, Siu Lun, Campbell, Peter J., Martincorena, Inigo, Buczacki, Simon J. A., Yuen, Siu Tsan, Leung, Suet Yi, Stratton, Michael R.

“… Lynch Syndrome (LS) is an autosomal dominant disease conferring a high risk of colorectal cancer due to germline heterozygous mutations in a DNA mismatch …”
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Autophagy inhibition as a potential future targeted therapy for ETV6-RUNX1-driven B-cell precursor acute lymphoblastic leukemia von Polak, Roel, Bierings, Marc B., van der Leije, Cindy S., Sanders, Mathijs A., Roovers, Onno, Marchante, João R. M., Boer, Judith M., Cornelissen, Jan J., Pieters, Rob, den Boer, Monique L., Buitenhuis, Miranda

“… Translocation t(12;21), resulting in the ETV6-RUNX1 (or TEL-AML1) fusion protein, is present in 25% of pediatric patients with B-cell precursor acute …”
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The etiology of clonal mosaicism in human aging and disease von Massaar, Sanne, Sanders, Mathijs A.

“… Our DNA is consistently assaulted by a variety of intrinsic and extrinsic mutational factors. Fortunately, DNA repair provides for protective barriers that …”
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An inflammatory T-cell-stromal axis contributes to hematopoietic stem/progenitor cell failure and clonal evolution in human myelodysplastic syndrome von Chen, Lanpeng, Bian, Yujie, Pronk, Eline, van Dijk, Claire, V.D. van Tienhoven, Tim, Hoogenboezem, Remco M., Bindels, Eric M., Bosch, Dennis, Fazeli, Sadaf, de Graaf, Aniek O., Westers, Theresia M., Kholmatov, Maksim, Zaugg, Judith B., Moura, Pedro L., Hellström-Lindberg, Eva, van de Loosdrecht, Arjan A., Jansen, Joop H., Sanders, Mathijs A., Raaijmakers, Marc H.G.P.

“… Myelodysplastic syndrome (MDS) is characterized by bone marrow failure, clonal evolution and leukemic progression, but the pathophysiologic processes driving …”
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