Výsledky vyhľadávania - "Salomaa, Veikko"

Atlas of plasma NMR biomarkers for health and disease in 118,461 individuals from the UK Biobank Autor Julkunen, Heli, Cichońska, Anna, Tiainen, Mika, Koskela, Harri, Nybo, Kristian, Mäkelä, Valtteri, Nokso-Koivisto, Jussi, Kristiansson, Kati, Perola, Markus, Salomaa, Veikko, Jousilahti, Pekka, Lundqvist, Annamari, Kangas, Antti J., Soininen, Pasi, Barrett, Jeffrey C., Würtz, Peter

“…Blood lipids and metabolites are markers of current health and future disease risk. Here, we describe plasma nuclear magnetic resonance (NMR) biomarker data…”
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Circulating Ceramides Predict Cardiovascular Outcomes in the Population-Based FINRISK 2002 Cohort Autor Havulinna, Aki S, Sysi-Aho, Marko, Hilvo, Mika, Kauhanen, Dimple, Hurme, Reini, Ekroos, Kim, Salomaa, Veikko, Laaksonen, Reijo

“…Ceramides are molecular lipids implicated in apoptosis, inflammation, obesity, and insulin resistance. An earlier study reported that ceramides were associated…”
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Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort Autor Qin, Youwen, Havulinna, Aki S., Liu, Yang, Jousilahti, Pekka, Ritchie, Scott C., Tokolyi, Alex, Sanders, Jon G., Valsta, Liisa, Brożyńska, Marta, Zhu, Qiyun, Tripathi, Anupriya, Vázquez-Baeza, Yoshiki, Loomba, Rohit, Cheng, Susan, Jain, Mohit, Niiranen, Teemu, Lahti, Leo, Knight, Rob, Salomaa, Veikko, Inouye, Michael, Méric, Guillaume

“…Human genetic variation affects the gut microbiota through a complex combination of environmental and host factors. Here we characterize genetic variations…”
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Polygenic Risk Scores Predict Hypertension Onset and Cardiovascular Risk Autor Vaura, Felix, Kauko, Anni, Suvila, Karri, Havulinna, Aki S, Mars, Nina, Salomaa, Veikko, FinnGen, Cheng, Susan, Niiranen, Teemu

“…Although genetic risk scores have been used to predict hypertension, their utility in the clinical setting remains uncertain. Our study comprised N=218 792…”
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Greengenes2 unifies microbial data in a single reference tree Autor McDonald, Daniel, Jiang, Yueyu, Balaban, Metin, Cantrell, Kalen, Zhu, Qiyun, Gonzalez, Antonio, Morton, James T., Nicolaou, Giorgia, Parks, Donovan H., Karst, Søren M., Albertsen, Mads, Hugenholtz, Philip, DeSantis, Todd, Song, Se Jin, Bartko, Andrew, Havulinna, Aki S., Jousilahti, Pekka, Cheng, Susan, Inouye, Michael, Niiranen, Teemu, Jain, Mohit, Salomaa, Veikko, Lahti, Leo, Mirarab, Siavash, Knight, Rob

“…Studies using 16S rRNA and shotgun metagenomics typically yield different results, usually attributed to PCR amplification biases. We introduce Greengenes2, a…”
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FINEMAP: efficient variable selection using summary data from genome-wide association studies Autor Benner, Christian, Spencer, Chris C.A., Havulinna, Aki S., Salomaa, Veikko, Ripatti, Samuli, Pirinen, Matti

“…Motivation: The goal of fine-mapping in genomic regions associated with complex diseases and traits is to identify causal variants that point to molecular…”
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Prospects of Fine-Mapping Trait-Associated Genomic Regions by Using Summary Statistics from Genome-wide Association Studies Autor Benner, Christian, Havulinna, Aki S, Järvelin, Marjo-Riitta, Salomaa, Veikko, Ripatti, Samuli, Pirinen, Matti

“…During the past few years, various novel statistical methods have been developed for fine-mapping with the use of summary statistics from genome-wide…”
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Taxonomic signatures of cause-specific mortality risk in human gut microbiome Autor Salosensaari, Aaro, Laitinen, Ville, Havulinna, Aki S., Meric, Guillaume, Cheng, Susan, Perola, Markus, Valsta, Liisa, Alfthan, Georg, Inouye, Michael, Watrous, Jeramie D., Long, Tao, Salido, Rodolfo A., Sanders, Karenina, Brennan, Caitriona, Humphrey, Gregory C., Sanders, Jon G., Jain, Mohit, Jousilahti, Pekka, Salomaa, Veikko, Knight, Rob, Lahti, Leo, Niiranen, Teemu

“…The collection of fecal material and developments in sequencing technologies have enabled standardised and non-invasive gut microbiome profiling. Microbiome…”
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Risks of Light and Moderate Alcohol Use in Fatty Liver Disease: Follow‐Up of Population Cohorts Autor Åberg, Fredrik, Puukka, Pauli, Salomaa, Veikko, Männistö, Satu, Lundqvist, Annamari, Valsta, Liisa, Perola, Markus, Färkkilä, Martti, Jula, Antti

“…Background and Aims The effects of alcohol use in nonalcoholic fatty liver disease are unclear. We investigated the impact of alcohol use in fatty liver…”
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Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors Autor Ahola-Olli, Ari V, Würtz, Peter, Havulinna, Aki S, Aalto, Kristiina, Pitkänen, Niina, Lehtimäki, Terho, Kähönen, Mika, Lyytikäinen, Leo-Pekka, Raitoharju, Emma, Seppälä, Ilkka, Sarin, Antti-Pekka, Ripatti, Samuli, Palotie, Aarne, Perola, Markus, Viikari, Jorma S, Jalkanen, Sirpa, Maksimow, Mikael, Salomaa, Veikko, Salmi, Marko, Kettunen, Johannes, Raitakari, Olli T

“…Circulating cytokines and growth factors are regulators of inflammation and have been implicated in autoimmune and metabolic diseases. In this genome-wide…”
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Genome-wide association meta-analysis of nicotine metabolism and cigarette consumption measures in smokers of European descent Autor Buchwald, Jadwiga, Chenoweth, Meghan J, Palviainen, Teemu, Zhu, Gu, Benner, Christian, Gordon, Scott, Korhonen, Tellervo, Ripatti, Samuli, Madden, Pamela A F, Lehtimäki, Terho, Raitakari, Olli T, Salomaa, Veikko, Rose, Richard J, George, Tony P, Lerman, Caryn, Pirinen, Matti, Martin, Nicholas G, Kaprio, Jaakko, Loukola, Anu, Tyndale, Rachel F

“…Smoking behaviors, including amount smoked, smoking cessation, and tobacco-related diseases, are altered by the rate of nicotine clearance. Nicotine clearance…”
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A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals Autor Deelen, Joris, Kettunen, Johannes, Fischer, Krista, van der Spek, Ashley, Trompet, Stella, Kastenmüller, Gabi, Boyd, Andy, Zierer, Jonas, van den Akker, Erik B., Ala-Korpela, Mika, Amin, Najaf, Demirkan, Ayse, Ghanbari, Mohsen, van Heemst, Diana, Ikram, M. Arfan, van Klinken, Jan Bert, Mooijaart, Simon P., Peters, Annette, Salomaa, Veikko, Sattar, Naveed, Spector, Tim D., Tiemeier, Henning, Verhoeven, Aswin, Waldenberger, Melanie, Würtz, Peter, Davey Smith, George, Metspalu, Andres, Perola, Markus, Menni, Cristina, Geleijnse, Johanna M., Drenos, Fotios, Beekman, Marian, Jukema, J. Wouter, van Duijn, Cornelia M., Slagboom, P. Eline

“…Predicting longer-term mortality risk requires collection of clinical data, which is often cumbersome. Therefore, we use a well-standardized metabolomics…”
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Sex, Smoking, and Risk for Subarachnoid Hemorrhage Autor Lindbohm, Joni Valdemar, Kaprio, Jaakko, Jousilahti, Pekka, Salomaa, Veikko, Korja, Miikka

“…Women are at higher risk for subarachnoid hemorrhage (SAH) than men for unknown reasons. Also cumulative effects of smoking have been neglected among…”
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Genetic risk prediction and a 2-stage risk screening strategy for coronary heart disease Autor Tikkanen, Emmi, Havulinna, Aki S, Palotie, Aarno, Salomaa, Veikko, Ripatti, Samuli

“…Genome-wide association studies have identified several genetic variants associated with coronary heart disease (CHD). The aim of this study was to evaluate…”
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Genetic Associations of Chronotype in the Finnish General Population Autor Maukonen, Mirkka, Havulinna, Aki S, Männistö, Satu, Kanerva, Noora, Salomaa, Veikko, Partonen, Timo

“…Individuals with a later chronotype (evening types) tend to have unhealthier behaviors and increased morbidity and mortality as compared with those with an…”
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Genomic prediction of coronary heart disease Autor Abraham, Gad, Havulinna, Aki S, Bhalala, Oneil G, Byars, Sean G, De Livera, Alysha M, Yetukuri, Laxman, Tikkanen, Emmi, Perola, Markus, Schunkert, Heribert, Sijbrands, Eric J, Palotie, Aarno, Samani, Nilesh J, Salomaa, Veikko, Ripatti, Samuli, Inouye, Michael

“…Genetics plays an important role in coronary heart disease (CHD) but the clinical utility of genomic risk scores (GRSs) relative to clinical risk scores, such…”
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Associations of healthy food choices with gut microbiota profiles Autor Koponen, Kari K, Salosensaari, Aaro, Ruuskanen, Matti O, Havulinna, Aki S, Männistö, Satu, Jousilahti, Pekka, Palmu, Joonatan, Salido, Rodolfo, Sanders, Karenina, Brennan, Caitriona, Humphrey, Gregory C, Sanders, Jon G, Meric, Guillaume, Cheng, Susan, Inouye, Michael, Jain, Mohit, Niiranen, Teemu J, Valsta, Liisa M, Knight, Rob, Salomaa, Veikko V

“…ABSTRACT Background Diet has a major influence on the human gut microbiota, which has been linked to health and disease. However, epidemiological studies on…”
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Risk Factors of Sudden Death From Subarachnoid Hemorrhage Autor Lindbohm, Joni Valdemar, Kaprio, Jaakko, Jousilahti, Pekka, Salomaa, Veikko, Korja, Miikka

“…One in every 4 subarachnoid hemorrhage (SAH) patients dies suddenly outside hospital, but most SAH risk factor studies focus on hospitalized patients. We…”
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Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis Autor Bouras, Emmanouil, Karhunen, Ville, Gill, Dipender, Huang, Jian, Haycock, Philip C., Gunter, Marc J., Johansson, Mattias, Brennan, Paul, Key, Tim, Lewis, Sarah J., Martin, Richard M., Murphy, Neil, Platz, Elizabeth A., Travis, Ruth, Yarmolinsky, James, Zuber, Verena, Martin, Paul, Katsoulis, Michail, Freisling, Heinz, Nøst, Therese Haugdahl, Schulze, Matthias B., Dossus, Laure, Hung, Rayjean J., Amos, Christopher I., Ahola-Olli, Ari, Palaniswamy, Saranya, Männikkö, Minna, Auvinen, Juha, Herzig, Karl-Heinz, Keinänen-Kiukaanniemi, Sirkka, Lehtimäki, Terho, Salomaa, Veikko, Raitakari, Olli, Salmi, Marko, Jalkanen, Sirpa, Jarvelin, Marjo-Riitta, Dehghan, Abbas, Tsilidis, Konstantinos K.

“…Background Epidemiological and experimental evidence has linked chronic inflammation to cancer aetiology. It is unclear whether associations for specific…”
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Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes Autor Csengeri, Dora, Sprünker, Ngoc-Anh, Di Castelnuovo, Augusto, Niiranen, Teemu, Vishram-Nielsen, Julie Kk, Costanzo, Simona, Söderberg, Stefan, Jensen, Steen M, Vartiainen, Erkki, Donati, Maria Benedetta, Magnussen, Christina, Camen, Stephan, Gianfagna, Francesco, Løchen, Maja-Lisa, Kee, Frank, Kontto, Jukka, Mathiesen, Ellisiv B, Koenig, Wolfgang, Blankenberg, Stefan, de Gaetano, Giovanni, Jørgensen, Torben, Kuulasmaa, Kari, Zeller, Tanja, Salomaa, Veikko, Iacoviello, Licia, Schnabel, Renate B

“…Abstract Aims  There is inconsistent evidence on the relation of alcohol intake with incident atrial fibrillation (AF), in particular at lower doses. We…”
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