Výsledky vyhľadávania - "Sahin, Ugur"

Personalized vaccines for cancer immunotherapy Autor Sahin, Ugur, Türeci, Özlem

“…Cancer is characterized by an accumulation of genetic alterations. Somatic mutations can generate cancer-specific neoepitopes that are recognized by autologous…”
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Development of a novel amino-silica packed column for HPLC determination of melamine in infant formula and milk powder samples Autor Kamil, Gurmen, Uğur, Şahin

“…Melamine (2,4,6-triamino-s-triazine) is a chemical widely used in the production of industrial materials and food products such as milk and baby formula. The…”
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Identification of neoantigens for individualized therapeutic cancer vaccines Autor Lang, Franziska, Schrörs, Barbara, Löwer, Martin, Türeci, Özlem, Sahin, Ugur

“…Somatic mutations in cancer cells can generate tumour-specific neoepitopes, which are recognized by autologous T cells in the host. As neoepitopes are not…”
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mRNA-based therapeutics — developing a new class of drugs Autor Sahin, Ugur, Karikó, Katalin, Türeci, Özlem

“…Key Points Messenger RNA (mRNA) is a pivotal molecule of life, involved in almost all aspects of cell biology. As the subject of basic and applied research for…”
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Neutralizing Activity of BNT162b2-Elicited Serum Autor Liu, Yang, Liu, Jianying, Xia, Hongjie, Zhang, Xianwen, Fontes-Garfias, Camila R, Swanson, Kena A, Cai, Hui, Sarkar, Ritu, Chen, Wei, Cutler, Mark, Cooper, David, Weaver, Scott C, Muik, Alexander, Sahin, Ugur, Jansen, Kathrin U, Xie, Xuping, Dormitzer, Philip R, Shi, Pei-Yong

“…How well do serum samples obtained from persons injected with the BNT162b2 vaccine neutralize the P.1, B.1.1.7, and B.1.135 lineages of SARS-CoV-2, first…”
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IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines Autor Tahtinen, Siri, Tong, Ann-Jay, Himmels, Patricia, Oh, Jaehak, Paler-Martinez, Andres, Kim, Leesun, Wichner, Sara, Oei, Yoko, McCarron, Mark J, Freund, Emily C, Amir, Zhainib Adel, de la Cruz, Cecile C, Haley, Benjamin, Blanchette, Craig, Schartner, Jill M, Ye, Weilan, Yadav, Mahesh, Sahin, Ugur, Delamarre, Lélia, Mellman, Ira

“…The use of lipid-formulated RNA vaccines for cancer or COVID-19 is associated with dose-limiting systemic inflammatory responses in humans that were not…”
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An overview of infectious complications after allogeneic hematopoietic stem cell transplantation Autor Sahin, Ugur, Toprak, Selami Kocak, Atilla, Pinar Ataca, Atilla, Erden, Demirer, Taner

“…Infections are the most common and significant cause of mortality and morbidity after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The…”
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Neutralization of BA.4–BA.5, BA.4.6, BA.2.75.2, BQ.1.1, and XBB.1 with Bivalent Vaccine Autor Zou, Jing, Kurhade, Chaitanya, Patel, Sohil, Kitchin, Nicholas, Tompkins, Kristin, Cutler, Mark, Cooper, David, Yang, Qi, Cai, Hui, Muik, Alexander, Zhang, Ying, Lee, Dung-Yang, Şahin, Ugur, Anderson, Annaliesa S., Gruber, William C., Xie, Xuping, Swanson, Kena A., Shi, Pei-Yong

“…Participants who had received three doses of BNT162b2 vaccine received either a fourth dose or a bivalent vaccine containing BA.4–BA.5 mRNA; the latter group…”
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mRNA therapeutics in cancer immunotherapy Autor Beck, Jan D., Reidenbach, Daniel, Salomon, Nadja, Sahin, Ugur, Türeci, Özlem, Vormehr, Mathias, Kranz, Lena M.

“…Synthetic mRNA provides a template for the synthesis of any given protein, protein fragment or peptide and lends itself to a broad range of pharmaceutical…”
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A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis Autor Krienke, Christina, Kolb, Laura, Diken, Elif, Streuber, Michael, Kirchhoff, Sarah, Bukur, Thomas, Akilli-Öztürk, Özlem, Kranz, Lena M, Berger, Hendrik, Petschenka, Jutta, Diken, Mustafa, Kreiter, Sebastian, Yogev, Nir, Waisman, Ari, Karikó, Katalin, Türeci, Özlem, Sahin, Ugur

“…The ability to control autoreactive T cells without inducing systemic immune suppression is the major goal for treatment of autoimmune diseases. The key…”
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A Facile Method for the Removal of dsRNA Contaminant from In Vitro-Transcribed mRNA Autor Baiersdörfer, Markus, Boros, Gábor, Muramatsu, Hiromi, Mahiny, Azita, Vlatkovic, Irena, Sahin, Ugur, Karikó, Katalin

“…The increasing importance of in vitro-transcribed (IVT) mRNA for synthesizing the encoded therapeutic protein in vivo demands the manufacturing of pure mRNA…”
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Comparison of Claudin 18.2 expression in primary tumors and lymph node metastases in Japanese patients with gastric adenocarcinoma Autor Rohde, Christoph, Yamaguchi, Rin, Mukhina, Svetlana, Sahin, Ugur, Itoh, Kyogo, Türeci, Özlem

“…The monoclonal antibody zolbetuximab (formerly IMAB362), which is being developed as a potential treatment for gastric cancer (GC), targets Claudin 18.2…”
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OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation Autor Schöpf, Bernd, Weissensteiner, Hansi, Schäfer, Georg, Fazzini, Federica, Charoentong, Pornpimol, Naschberger, Andreas, Rupp, Bernhard, Fendt, Liane, Bukur, Valesca, Giese, Irina, Sorn, Patrick, Sant’Anna-Silva, Ana Carolina, Iglesias-Gonzalez, Javier, Sahin, Ugur, Kronenberg, Florian, Gnaiger, Erich, Klocker, Helmut

“…Rewiring of energy metabolism and adaptation of mitochondria are considered to impact on prostate cancer development and progression. Here, we report on…”
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SARS-CoV-2 Neutralization with BNT162b2 Vaccine Dose 3 Autor Falsey, Ann R, Frenck, Robert W, Walsh, Edward E, Kitchin, Nicholas, Absalon, Judith, Gurtman, Alejandra, Lockhart, Stephen, Bailey, Ruth, Swanson, Kena A, Xu, Xia, Koury, Kenneth, Kalina, Warren, Cooper, David, Zou, Jing, Xie, Xuping, Xia, Hongjie, Türeci, Özlem, Lagkadinou, Eleni, Tompkins, Kristin R, Shi, Pei-Yong, Jansen, Kathrin U, Şahin, Uğur, Dormitzer, Philip R, Gruber, William C

“…A third dose of the BNT162b2 vaccine was administered to 23 volunteers 8 to 9 months after the second dose, and the immune response was assessed. Local…”
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BNT162b2-elicited neutralization of B.1.617 and other SARS-CoV-2 variants Autor Liu, Jianying, Liu, Yang, Xia, Hongjie, Zou, Jing, Weaver, Scott C., Swanson, Kena A., Cai, Hui, Cutler, Mark, Cooper, David, Muik, Alexander, Jansen, Kathrin U., Sahin, Ugur, Xie, Xuping, Dormitzer, Philip R., Shi, Pei-Yong

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuing to evolve around the world, generating new variants that are of concern on the basis…”
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CLDN6-specific CAR-T cells plus amplifying RNA vaccine in relapsed or refractory solid tumors: the phase 1 BNT211-01 trial Autor Mackensen, Andreas, Haanen, John B.A.G., Koenecke, Christian, Alsdorf, Winfried, Wagner-Drouet, Eva, Borchmann, Peter, Heudobler, Daniel, Ferstl, Barbara, Klobuch, Sebastian, Bokemeyer, Carsten, Desuki, Alexander, Lüke, Florian, Kutsch, Nadine, Müller, Fabian, Smit, Eveline, Hillemanns, Peter, Karagiannis, Panagiotis, Wiegert, Erol, He, Ying, Ho, Thang, Kang-Fortner, Qing, Schlitter, Anna Melissa, Schulz-Eying, Catrine, Finlayson, Andrew, Flemmig, Carina, Kühlcke, Klaus, Preußner, Liane, Rengstl, Benjamin, Türeci, Özlem, Şahin, Uğur

“…The oncofetal antigen Claudin 6 (CLDN6) is highly and specifically expressed in many solid tumors, and could be a promising treatment target. We report dose…”
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The Impact of Evolving SARS-CoV-2 Mutations and Variants on COVID-19 Vaccines Autor McLean, Gary, Kamil, Jeremy, Lee, Benhur, Moore, Penny, Schulz, Thomas F., Muik, Alexander, Sahin, Ugur, Türeci, Özlem, Pather, Shanti

“…The emergence of several new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in recent months has raised concerns around the potential…”
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A Trans-amplifying RNA Vaccine Strategy for Induction of Potent Protective Immunity Autor Beissert, Tim, Perkovic, Mario, Vogel, Annette, Erbar, Stephanie, Walzer, Kerstin C, Hempel, Tina, Brill, Silke, Haefner, Erik, Becker, René, Türeci, Özlem, Sahin, Ugur

“…Here, we present a potent RNA vaccine approach based on a novel bipartite vector system using trans-amplifying RNA (taRNA). The vector cassette encoding the…”
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Elimination of large tumors in mice by mRNA-encoded bispecific antibodies Autor Stadler, Christiane R, Bähr-Mahmud, Hayat, Celik, Leyla, Hebich, Bernhard, Roth, Alexandra S, Roth, René P, Karikó, Katalin, Türeci, Özlem, Sahin, Ugur

“…Bispecific antibodies that connect T cells with tumor cells can be delivered in the form of in vitro –transcribed pharmacologically optimized mRNA; when…”
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A multivalent mRNA monkeypox virus vaccine (BNT166) protects mice and macaques from orthopoxvirus disease Autor Zuiani, Adam, Dulberger, Charles L, De Silva, Nilushi S, Marquette, Meghan, Lu, Yu-Jung, Palowitch, Gavin M, Dokic, Anja, Sanchez-Velazquez, Ricardo, Schlatterer, Katja, Sarkar, Sanjay, Kar, Swagata, Chawla, Bhavna, Galeev, Alibek, Lindemann, Claudia, Rothenberg, Daniel A, Diao, Huitian, Walls, Alexandra C, Addona, Theresa A, Mensa, Federico, Vogel, Annette B, Stuart, Lynda M, van der Most, Robbert, Srouji, John R, Türeci, Özlem, Gaynor, Richard B, Şahin, Uğur, Poran, Asaf

“…In response to the 2022 outbreak of mpox driven by unprecedented human-to-human monkeypox virus (MPXV) transmission, we designed BNT166, aiming to create a…”
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