Suchergebnisse - "Sabio, Erich"

Improved prediction of immune checkpoint blockade efficacy across multiple cancer types von Chowell, Diego, Yoo, Seong-Keun, Valero, Cristina, Pastore, Alessandro, Krishna, Chirag, Lee, Mark, Hoen, Douglas, Shi, Hongyu, Kelly, Daniel W., Patel, Neal, Makarov, Vladimir, Ma, Xiaoxiao, Vuong, Lynda, Sabio, Erich Y., Weiss, Kate, Kuo, Fengshen, Lenz, Tobias L., Samstein, Robert M., Riaz, Nadeem, Adusumilli, Prasad S., Balachandran, Vinod P., Plitas, George, Ari Hakimi, A., Abdel-Wahab, Omar, Shoushtari, Alexander N., Postow, Michael A., Motzer, Robert J., Ladanyi, Marc, Zehir, Ahmet, Berger, Michael F., Gönen, Mithat, Morris, Luc G. T., Weinhold, Nils, Chan, Timothy A.

“… Only a fraction of patients with cancer respond to immune checkpoint blockade (ICB) treatment, but current decision-making procedures have limited accuracy. In …”
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Genetic diversity of tumors with mismatch repair deficiency influences anti-PD-1 immunotherapy response von Mandal, Rajarsi, Samstein, Robert M, Lee, Ken-Wing, Havel, Jonathan J, Wang, Hao, Krishna, Chirag, Sabio, Erich Y, Makarov, Vladimir, Kuo, Fengshen, Blecua, Pedro, Ramaswamy, Apoorva T, Durham, Jennifer N, Bartlett, Bjarne, Ma, Xiaoxiao, Srivastava, Raghvendra, Middha, Sumit, Zehir, Ahmet, Hechtman, Jaclyn F, Morris, Luc Gt, Weinhold, Nils, Riaz, Nadeem, Le, Dung T, Diaz, Jr, Luis A, Chan, Timothy A

“… Tumors with mismatch repair deficiency (MMR-d) are characterized by sequence alterations in microsatellites and can accumulate thousands of mutations. This …”
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Functional landscapes of POLE and POLD1 mutations in checkpoint blockade-dependent antitumor immunity von Ma, Xiaoxiao, Riaz, Nadeem, Samstein, Robert M., Lee, Mark, Makarov, Vladimir, Valero, Cristina, Chowell, Diego, Kuo, Fengshen, Hoen, Douglas, Fitzgerald, Conall W. R., Jiang, Hui, Alektiar, Jonathan, Alban, Tyler J., Juric, Ivan, Parthasarathy, Prerana Bangalore, Zhao, Yu, Sabio, Erich Y., Verma, Richa, Srivastava, Raghvendra M., Vuong, Lynda, Yang, Wei, Zhang, Xiao, Wang, Jingming, Chu, Lawrence K., Wang, Stephen L., Kelly, Daniel W., Pei, Xin, Chen, Jiapeng, Yaeger, Rona, Zamarin, Dmitriy, Zehir, Ahmet, Gönen, Mithat, Morris, Luc G. T., Chan, Timothy A.

“… Defects in pathways governing genomic fidelity have been linked to improved response to immune checkpoint blockade therapy (ICB). Pathogenic POLE/POLD1 …”
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An Integrated Systems Biology Approach Identifies TRIM25 as a Key Determinant of Breast Cancer Metastasis von Walsh, Logan A., Alvarez, Mariano J., Sabio, Erich Y., Reyngold, Marsha, Makarov, Vladimir, Mukherjee, Suranjit, Lee, Ken-Wing, Desrichard, Alexis, Turcan, Şevin, Dalin, Martin G., Rajasekhar, Vinagolu K., Chen, Shuibing, Vahdat, Linda T., Califano, Andrea, Chan, Timothy A.

“… At the root of most fatal malignancies are aberrantly activated transcriptional networks that drive metastatic dissemination. Although …”
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The good, the bad, and the ugly: hyperprogression in cancer patients following immune checkpoint therapy von Sabio, Erich, Chan, Timothy A.

“… Editorial summary Immune checkpoint blockade therapy can elicit robust and durable responses in a variety of cancer types. While many patients do not respond, …”
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Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias von Kim, Won Jun, Crosse, Edie I, De Neef, Emma, Etxeberria, Inaki, Sabio, Erich Y, Wang, Eric, Bewersdorf, Jan Philipp, Lin, Kuan-Ting, Lu, Sydney X, Belleville, Andrea, Fox, Nina, Castro, Cynthia, Zhang, Pu, Fujino, Takeshi, Lewis, Jennifer, Rahman, Jahan, Zhang, Beatrice, Winick, Jacob H, Lewis, Alexander M, Stanley, Robert F, DeWolf, Susan, Urben, Brigita Meškauskaitė, Takizawa, Meril, Krause, Tobias, Molina, Henrik, Chaligne, Ronan, Koppikar, Priya, Molldrem, Jeffrey, Gigoux, Mathieu, Merghoub, Taha, Daniyan, Anthony, Chandran, Smita S, Greenbaum, Benjamin D, Klebanoff, Christopher A, Bradley, Robert K, Abdel-Wahab, Omar

“… Mutations in RNA splicing factors are prevalent across cancers and generate recurrently mis-spliced mRNA isoforms. Here, we identified a series of bona fide …”
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Genome‐wide identification of genes directly regulated by ChvI and a consensus sequence for ChvI binding in Sinorhizobium meliloti von Ratib, Nicole R., Sabio, Erich Y., Mendoza, Carolina, Barnett, Melanie J., Clover, Sarah B., Ortega, Jesus A., Dela Cruz, Francesca M., Balderas, David, White, Holly, Long, Sharon R., Chen, Esther J.

“… Summary ExoS/ChvI two‐component signaling in the nitrogen‐fixing α‐proteobacterium Sinorhizobium meliloti is required for symbiosis and regulates …”
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A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis von Olive, Virginie, Sabio, Erich, Bennett, Margaux J, De Jong, Caitlin S, Biton, Anne, McGann, James C, Greaney, Samantha K, Sodir, Nicole M, Zhou, Alicia Y, Balakrishnan, Asha, Foth, Mona, Luftig, Micah A, Goga, Andrei, Speed, Terence P, Xuan, Zhenyu, Evan, Gerard I, Wan, Ying, Minella, Alex C, He, Lin

“… mir-17-92, a potent polycistronic oncomir, encodes six mature miRNAs with complex modes of interactions. In the Eμ-myc Burkitt’s lymphoma model, mir-17-92 …”
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The periplasmic regulator ExoR inhibits ExoS/ChvI two‐component signalling in Sinorhizobium meliloti von Chen, Esther J., Sabio, Erich A., Long, Sharon R.

“… Summary Sinorhizobium meliloti requires ExoS/ChvI two‐component signalling to establish a nitrogen‐fixing symbiosis with legume hosts. The importance of …”
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Identification of direct transcriptional target genes of ExoS/ChvI two-component signaling in Sinorhizobium meliloti von Chen, Esther J, Fisher, Robert F, Perovich, Virginia M, Sabio, Erich A, Long, Sharon R

“… The Sinorhizobium meliloti ExoS/ChvI two-component signaling pathway is required for the development of a nitrogen-fixing symbiosis between S. meliloti and its …”
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Pharmacologic modulation of RNA splicing enhances anti-tumor immunity von Lu, Sydney X, De Neef, Emma, Thomas, James D, Sabio, Erich, Rousseau, Benoit, Gigoux, Mathieu, Knorr, David A, Greenbaum, Benjamin, Elhanati, Yuval, Hogg, Simon J, Chow, Andrew, Ghosh, Arnab, Xie, Abigail, Zamarin, Dmitriy, Cui, Daniel, Erickson, Caroline, Singer, Michael, Cho, Hana, Wang, Eric, Lu, Bin, Durham, Benjamin H, Shah, Harshal, Chowell, Diego, Gabel, Austin M, Shen, Yudao, Liu, Jing, Jin, Jian, Rhodes, Matthew C, Taylor, Richard E, Molina, Henrik, Wolchok, Jedd D, Merghoub, Taha, Diaz, Jr, Luis A, Abdel-Wahab, Omar, Bradley, Robert K

“… Although mutations in DNA are the best-studied source of neoantigens that determine response to immune checkpoint blockade, alterations in RNA splicing within …”
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34Hypoxia and immune suppression shapes therapeutic outcomes and metastases in clear cell renal cell carcinoma von Vuong, Lynda, Cornish, Andrew, Khandwala, Yash, Jiang, Hui, Mascareno, Eduardo, Zheng, Doris, Rappold, Phillip, Leibold, Josef, Sabio, Erich, Weiss, Kate, Gonzalez, Carlene, Rittenhouse, Nicole, Ji, Liangliang, Zhang, Jing, Adlesic, Mojca, Akin, Oguz, Flynn, Jessica, Krishna, Chirag, Sanchez, Alejandro, Natale, Renzo Di, Blum, Kyle, Russo, Paul, Coleman, Jonathan, Frew, Ian, Chowell, Diego, Chen, Yingbei, Solit, David, Ostrovnaya, Irina, Motzer, Robert, Voss, Martin, Kotecha, Ritesh, Chan, Timothy, Kuo, Fengshen, Li, Ming, Hakimi, A Ari

“… Abstract Background Vascular endothelial growth factor receptor-targeting tyrosine kinase inhibitors (VEGFR-TKIs) and aPD1 combinations are effective in …”
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Qa-1b Modulates Resistance to Anti-PD-1 Immune Checkpoint Blockade in Tumors with Defects in Antigen Processing von Zhang, Xiao, Sabio, Erich, Krishna, Chirag, Ma, Xiaoxiao, Wang, Jingming, Jiang, Hui, Havel, Jonathan J, Chan, Timothy A

“… Immune checkpoint blockade (ICB) has improved cancer care, but ICB is only effective in some patients. The molecular mechanisms that influence ICB therapy …”
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A Targetable Myeloid Inflammatory State Governs Disease Recurrence in Clear-Cell Renal Cell Carcinoma von Rappold, Phillip M, Vuong, Lynda, Leibold, Josef, Chakiryan, Nicholas H, Curry, Michael, Kuo, Fengshen, Sabio, Erich, Jiang, Hui, Nixon, Briana G, Liu, Ming, Berglund, Anders E, Silagy, Andrew W, Mascareno, Eduardo A, Golkaram, Mahdi, Marker, Mahtab, Reising, Albert, Savchenko, Alexander, Millholland, John, Chen, Ying-Bei, Russo, Paul, Coleman, Jonathan, Reznik, Ed, Manley, Brandon J, Ostrovnaya, Irina, Makarov, Vladimir, DiNatale, Renzo G, Blum, Kyle A, Ma, Xiaoxiao, Chowell, Diego, Li, Ming O, Solit, David B, Lowe, Scott W, Chan, Timothy A, Motzer, Robert J, Voss, Martin H, Hakimi, A Ari

“… It is poorly understood how the tumor immune microenvironment influences disease recurrence in localized clear-cell renal cell carcinoma (ccRCC). Here we …”
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Qa-1 b Modulates Resistance to Anti-PD-1 Immune Checkpoint Blockade in Tumors with Defects in Antigen Processing von Zhang, Xiao, Sabio, Erich, Krishna, Chirag, Ma, Xiaoxiao, Wang, Jingming, Jiang, Hui, Havel, Jonathan J, Chan, Timothy A

“… Immune checkpoint blockade (ICB) has improved cancer care, but ICB is only effective in some patients. The molecular mechanisms that influence ICB therapy …”
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The periplasmic regulator ExoR inhibits ExoS/Chvl two-component signalling in Sinorhizobium meliloti von CHEN, Esther J, SABIO, Erich A, LONG, Sharon R

“… Sinorhizobium meliloti requires ExoS/ChvI two-component signalling to establish a nitrogen-fixing symbiosis with legume hosts. The importance of ExoS/ChvI …”
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Antagonistic Interactions between MicroRNAs Underlie Robust Tumor Suppressor Responses von Sabio, Erich Yanson

“… The oncogenic mir-17-92 cluster encodes six coordinately expressed miRNAs with a unique capacity for gene regulation. In this dissertation, we have extended …”
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Characterization of the ExoS/ChvI two-component system in Sinorhizobium meliloti, a nitrogen fixing symbiont of Medicago truncatula von Sabio, Erich

“… Sinorhizobium meliloti forms a symbiosis with Medicago truncatula in which the bacteria provide fixed nitrogen to the plant in exchange for carbon compounds …”
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