Výsledky vyhledávání - "SOD1(G93A) mice"

Wnt and extraocular muscle sparing in amyotrophic lateral sclerosis Autor McLoon, Linda K, Harandi, Vahid M, Brännström, Thomas, Andersen, Peter M, Liu, Jing-Xia

“… Extraocular muscle and limb muscle axons, neuromuscular junctions, and myofibers from control, aging, and ALS subjects and the SOD1(G93A…”
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VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death Autor Lambrechts, Diether, Storkebaum, Erik, Morimoto, Masafumi, Del-Favero, Jurgen, Desmet, Frederik, Marklund, Stefan L, Wyns, Sabine, Thijs, Vincent, Andersson, Jörgen, van Marion, Ingrid, Al-Chalabi, Ammar, Bornes, Stephanie, Musson, Rhiannon, Hansen, Valerie, Beckman, Lars, Adolfsson, Rolf, Pall, Hardev Singh, Prats, Hervé, Vermeire, Severine, Rutgeerts, Paul, Katayama, Shigehiro, Awata, Takuya, Leigh, Nigel, Lang-Lazdunski, Loïc, Dewerchin, Mieke, Shaw, Christopher, Moons, Lieve, Vlietinck, Robert, Morrison, Karen E, Robberecht, Wim, Van Broeckhoven, Christine, Collen, Désiré, Andersen, Peter M, Carmeliet, Peter

“… . Moreover, SOD1 G93A mice crossbred with Vegfa δ/δ mice died earlier due to more severe motoneuron degeneration. Vegfa δ/δ…”
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siRNA for REST ameliorates symptoms in ALS mice and serum REST predicts disease prognosis and survival in ALS patients Autor Guida, Natascia, Valsecchi, Valeria, Anzilotti, Serenella, Dubbioso, Raffaele, Cuomo, Ornella, Ruggiero, Silvia, Senerchia, Gianmaria, Iuzzolino, Valentina Virginia, Kolici, Xhesika, De Iesu, Nunzia, Pignataro, Giuseppe, Annunziato, Lucio, Formisano, Luigi

“…)-G93A mice compared with wild-type mice, both during early and late symptomatic phases of the disease…”
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siRNA for REST ameliorates symptoms and prolongs survival in ALS mice and serum REST predicts disease prognosis and survival in patients Autor Guida, Natascia, Valsecchi, Valeria, Anzilotti, Serenella, Dubbioso, Raffaele, Cuomo, Ornella, Ruggiero, Silvia, Senerchia, Gianmaria, Iuzzolino, Valentina Virginia, Kolici, Xhesika, De Iesu, Nunzia, Pignataro, Giuseppe, Annunziato, Lucio, misano, Luigi

“…)-G93A mice compared to wild-type mice, both during early- and late-symptomatic phases of the disease…”
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Ribonuclease 4 protects neuron degeneration by promoting angiogenesis, neurogenesis, and neuronal survival under stress Autor Li, Shuping, Sheng, Jinghao, Hu, Jamie K., Yu, Wenhao, Kishikawa, Hiroko, Hu, Miaofen G., Shima, Kaori, Wu, David, Xu, Zhengping, Xin, Winnie, Sims, Katherine B., Landers, John E., Brown, Robert H., Hu, Guo-fu

“… and control subjects and characterized…”
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Elevated serum creatine kinase in the early stage of sporadic amyotrophic lateral sclerosis Autor Ito, Daisuke, Hashizume, Atsushi, Hijikata, Yasuhiro, Yamada, Shinichiro, Iguchi, Yohei, Iida, Madoka, Kishimoto, Yoshiyuki, Moriyoshi, Hideyuki, Hirakawa, Akihiro, Katsuno, Masahisa

“… Methods Thirty-nine subjects with sporadic amyotrophic lateral sclerosis and 20 healthy controls were enrolled and longitudinally evaluated…”
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Preliminary Investigation of a Novel 18F Radiopharmaceutical for Imaging CB2 Receptors in a SOD Mouse Model Autor Pascali, Giancarlo, Panetta, Daniele, De Simone, Mariarosaria, Burchielli, Silvia, Lucchesi, Valentina, Sanguinetti, Elena, Zanoni, Simone, Iozzo, Patricia, Saccomanni, Giuseppe, Manera, Clementina, Salvadori, Piero A.

“…% radiochemical yield and >95% radiochemically pure. SOD1(G93A) mice were used as model of overexpression of CB2 receptors…”
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A potential role for neuronal connexin 36 in the pathogenesis of amyotrophic lateral sclerosis Autor Belousov, Andrei B., Nishimune, Hiroshi, Denisova, Janna V., Fontes, Joseph D.

“… We show here that the expression of Cx36 is significantly decreased in lumbar segments of the spinal cord of both human ALS subjects and SOD1G93A mice as compared to healthy…”
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Spinal motoneuron excitability is homeostatically-regulated through β-adrenergic neuromodulation in wild-type and presymptomatic SOD1 mice Autor Antonucci, Stefano, Caron, Guillaume, Dikwella, Natalie, Krishnamurty, Sruthi Sankari, Harster, Anthony, Zarrin, Hina, Tahanis, Aboud, Heuvel, Florian Olde, Danner, Simon M, Ludolph, Albert C, Grycz, Kamil, Bączyk, Marcin, Zytnicki, Daniel, Roselli, Francesco

“…) and contribute to the pathogenesis. Here, we investigated how the neuromodulation of MN intrinsic properties is homeostatically controlled in presymptomatic adult SOD1(G93A…”
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Preventing Age-Related Alpha-Motor Neuron Loss Autor Piekarz, Katarzyna Malgorzata

“… those concerning alpha-motor neurons. Spinal cord aging, however, is an understudied subject, and the work presented in this dissertation aims to fill this gap, to describe the changes occurring in the aging spinal cord…”
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The vitamin D activator CYP27B1 is upregulated in muscle fibers in denervating disease and can track progression in amyotrophic lateral sclerosis Autor Si, Ying, Kazamel, Mohamed, Kwon, Yuri, Lee, Ikjae, Anderson, Tina, Zhou, Siyu, Bamman, Marcas, Wiggins, Derek, Kwan, Thaddaeus, King, Peter H.

“…•CYP27B1 is upregulated in muscle fibers in denervating disease, especially ALS.•CYP27B1 expression progressively increases with disease progression in the…”
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