Výsledky vyhľadávania - "Russell, David G"

Immunometabolism at the interface between macrophages and pathogens Autor Russell, David G, Huang, Lu, VanderVen, Brian C

“…It is generally regarded that the progression of an infection within host macrophages is the consequence of a failed immune response. However, recent…”
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Dual RNA-Seq of Mtb-Infected Macrophages In Vivo Reveals Ontologically Distinct Host-Pathogen Interactions Autor Pisu, Davide, Huang, Lu, Grenier, Jennifer K., Russell, David G.

“…Dissecting the in vivo host-pathogen interplay is crucial to understanding the molecular mechanisms governing control or progression of intracellular…”
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The frequency of CD38+ alveolar macrophages correlates with early control of M. tuberculosis in the murine lung Autor Pisu, Davide, Johnston, Luana, Mattila, Joshua T., Russell, David G.

“…Tuberculosis, caused by Mycobacterium tuberculosis , remains an enduring global health challenge due to the limited efficacy of existing treatments. Although…”
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Single cell analysis of M. tuberculosis phenotype and macrophage lineages in the infected lung Autor Pisu, Davide, Huang, Lu, Narang, Vipin, Theriault, Monique, Lê-Bury, Gabrielle, Lee, Bernett, Lakudzala, Agnes E, Mzinza, David T, Mhango, David V, Mitini-Nkhoma, Steven C, Jambo, Kondwani C, Singhal, Amit, Mwandumba, Henry C, Russell, David G

“…In this study, we detail a novel approach that combines bacterial fitness fluorescent reporter strains with scRNA-seq to simultaneously acquire the host…”
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Foamy macrophages and the progression of the human tuberculosis granuloma Autor Russell, David G, Cardona, Pere-Joan, Kim, Mi-Jeong, Allain, Sophie, Altare, Frédéric

“…The progression of tuberculosis from a latent, subclinical infection to active disease that culminates in the transmission of infectious bacilli is determined…”
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Linking the Transcriptional Profiles and the Physiological States of Mycobacterium tuberculosis during an Extended Intracellular Infection Autor Rohde, Kyle H., Veiga, Diogo F. T., Caldwell, Shannon, Balázsi, Gábor, Russell, David G.

“…Intracellular pathogens such as Mycobacterium tuberculosis have evolved strategies for coping with the pressures encountered inside host cells. The ability to…”
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Immune activation of the host cell induces drug tolerance in Mycobacterium tuberculosis both in vitro and in vivo Autor Liu, Yancheng, Tan, Shumin, Huang, Lu, Abramovitch, Robert B, Rohde, Kyle H, Zimmerman, Matthew D, Chen, Chao, Dartois, Véronique, VanderVen, Brian C, Russell, David G

“…Successful chemotherapy against Mycobacterium tuberculosis (Mtb) must eradicate the bacterium within the context of its host cell. However, our understanding…”
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Tuberculosis: what we don't know can, and does, hurt us Autor Russell, David G, Barry, 3rd, Clifton E, Flynn, JoAnne L

“…Mycobacterium tuberculosis has a penetrance of its host population that would be the envy of most human pathogens. About one-third of the human population…”
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Functional Genetic Diversity among Mycobacterium tuberculosis Complex Clinical Isolates: Delineation of Conserved Core and Lineage-Specific Transcriptomes during Intracellular Survival Autor Homolka, Susanne, Niemann, Stefan, Russell, David G., Rohde, Kyle H.

“…Tuberculosis exerts a tremendous burden on global health, with approximately 9 million new infections and approximately 2 million deaths annually. The…”
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Novel Inhibitors of Cholesterol Degradation in Mycobacterium tuberculosis Reveal How the Bacterium’s Metabolism Is Constrained by the Intracellular Environment Autor VanderVen, Brian C., Fahey, Ruth J., Lee, Wonsik, Liu, Yancheng, Abramovitch, Robert B., Memmott, Christine, Crowe, Adam M., Eltis, Lindsay D., Perola, Emanuele, Deininger, David D., Wang, Tiansheng, Locher, Christopher P., Russell, David G.

“…Mycobacterium tuberculosis (Mtb) relies on a specialized set of metabolic pathways to support growth in macrophages. By conducting an extensive, unbiased…”
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Rv3723/LucA coordinates fatty acid and cholesterol uptake in Mycobacterium tuberculosis Autor Nazarova, Evgeniya V, Montague, Christine R, La, Thuy, Wilburn, Kaley M, Sukumar, Neelima, Lee, Wonsik, Caldwell, Shannon, Russell, David G, VanderVen, Brian C

“…Pathogenic bacteria have evolved highly specialized systems to extract essential nutrients from their hosts. Mycobacterium tuberculosis (Mtb) scavenges lipids…”
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Mycobacterium tuberculosis : Bacterial Fitness within the Host Macrophage Autor Huang, Lu, Nazarova, Evgeniya V., Russell, David G.

“…Mycobacterium tuberculosis has evolved to become the single greatest cause of death from an infectious agent. The pathogen spends most of its infection cycle…”
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Lnc(ing)RNAs to the “shock and kill” strategy for HIV-1 cure Autor Boliar, Saikat, Russell, David G.

“…The advent of antiretroviral therapy almost 25 years ago has transformed HIV-1 infection into a manageable chronic condition, albeit still incurable. The…”
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Genome-wide screen of Mycobacterium tuberculosis-infected macrophages revealed GID/CTLH complex-mediated modulation of bacterial growth Autor Simwela, Nelson V., Johnston, Luana, Bitar, Paulina Pavinski, Jaecklein, Eleni, Altier, Craig, Sassetti, Christopher M., Russell, David G.

“…The eukaryotic Glucose Induced Degradation/C-Terminal to LisH (GID/CTLH) complex is a highly conserved E3 ubiquitin ligase involved in a broad range of…”
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Mycobacterium tuberculosis Responds to Chloride and pH as Synergistic Cues to the Immune Status of its Host Cell Autor Tan, Shumin, Sukumar, Neelima, Abramovitch, Robert B., Parish, Tanya, Russell, David G.

“…The ability of Mycobacterium tuberculosis (Mtb) to thrive in its phagosomal niche is critical for its establishment of a chronic infection. This requires that…”
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Mycobacterium tuberculosis invasion of macrophages: linking bacterial gene expression to environmental cues Autor Rohde, Kyle H, Abramovitch, Robert B, Russell, David G

“…A central feature of Mycobacterium tuberculosis (Mtb) pathogenesis is the ability of Mtb to survive within macrophages (MØ). Despite its critical importance,…”
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Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy Autor Alonso, Sylvie, Pethe, Kevin, Russell, David G, Purdy, Georgiana E

“…Mycobacterium tuberculosis parasitizes resting macrophages yet is killed by activated macrophages through both oxidative and nonoxidative mechanisms…”
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Impaired fatty acid import or catabolism in macrophages restricts intracellular growth of Mycobacterium tuberculosis Autor Simwela, Nelson V, Jaecklein, Eleni, Sassetti, Christopher M, Russell, David G

“…Mycobacterium tuberculosis ( Mtb ) infection of macrophages reprograms cellular metabolism to promote lipid retention. While it is clearly known that…”
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Mycobacterium tuberculosis: here today, and here tomorrow Autor Russell, David G.

“…Key Points Pathogenic Mycobacterium spp. survive within the macrophages of their host. One of these, Mycobacterium tuberculosis , is a highly successful…”
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Exploitation of Mycobacterium tuberculosis Reporter Strains to Probe the Impact of Vaccination at Sites of Infection Autor Sukumar, Neelima, Tan, Shumin, Aldridge, Bree B., Russell, David G.

“…Mycobacterium tuberculosis (Mtb) remains a major public health problem, with an effective vaccine continuing to prove elusive. Progress in vaccination…”
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