Suchergebnisse - "Ronai, Ze'ev A"

UPR, autophagy, and mitochondria crosstalk underlies the ER stress response von Senft, Daniela, Ronai, Ze’ev A.

“… •Autophagy and UPR interaction underlies ERS response outcomes.•ERS modulates mitochondrial biogenesis and function.•Ubiquitin ligases fine-tune the ERS …”
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PRMT5 control of cGAS/STING and NLRC5 pathways defines melanoma response to antitumor immunity von Kim, Hyungsoo, Kim, Heejung, Feng, Yongmei, Li, Yan, Tamiya, Hironari, Tocci, Stefania, Ronai, Ze'ev A

“… Protein arginine methyltransferase 5 (PRMT5) controls diverse cellular processes and is implicated in cancer development and progression. Here, we report an …”
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PRMT5 function and targeting in cancer von Kim, Hyungsoo, Ronai, Ze’ev A.

“… Protein methyl transferases play critical roles in numerous regulatory pathways that underlie cancer development, progression and therapy-response. Here we …”
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Regulators of mitochondrial dynamics in cancer von Senft, Daniela, Ronai, Ze’ev A

“… •The interplay of regulators of mitophagy, mitochondrial dynamics, and apoptosis controls cell fate.•Mitochondrial dynamics impacts transformation, stemness, …”
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Parkin paves the path to antitumor immunity: Expanding Parkin’s role as a tumor suppressor von Kim, Hyungsoo, Ronai, Ze’ev A.

“… Parkin, a ring-between-ring-type E3 ubiquitin ligase, first shown to play a critical role in autosomal recessive juvenile Parkinsonism, has recently emerged as …”
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Precision Oncology: The Road Ahead von Senft, Daniela, Leiserson, Mark D.M., Ruppin, Eytan, Ronai, Ze’ev A.

“… Current efforts in precision oncology largely focus on the benefit of genomics-guided therapy. Yet, advances in sequencing techniques provide an unprecedented …”
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ATF2, a paradigm of the multifaceted regulation of transcription factors in biology and disease von Watson, Gregory, Ronai, Ze’ev A., Lau, Eric

“… [Display omitted] Stringent transcriptional regulation is crucial for normal cellular biology and organismal development. Perturbations in the proper …”
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MAPK signaling regulates c-MYC for melanoma cell adaptation to asparagine restriction von Pathria, Gaurav, Verma, Sachin, Yin, Jun, Scott, David A, Ronai, Ze’ev A

“… Amino acid restriction is among promising potential cancer treatment strategies. However, cancer cells employ a multitude of mechanisms to mount resistance to …”
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Lipid metabolism: new twists to the Yin and Yang of PKM2 in cancer von Khateb, Ali, Ronai, Ze’ev A

“… While canonical and non‐canonical functions of pyruvate kinase M2 (PKM2) are recognized to mediate often‐opposing roles in cancer, its contribution to cellular …”
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Translational reprogramming marks adaptation to asparagine restriction in cancer von Pathria, Gaurav, Lee, Joo Sang, Hasnis, Erez, Tandoc, Kristofferson, Scott, David A., Verma, Sachin, Feng, Yongmei, Larue, Lionel, Sahu, Avinash D., Topisirovic, Ivan, Ruppin, Eytan, Ronai, Ze’ev A.

“… While amino acid restriction remains an attractive strategy for cancer therapy, metabolic adaptations limit its effectiveness. Here we demonstrate a role of …”
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Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia von Kim, Hyungsoo, Scimia, Maria C, Wilkinson, Deepti, Trelles, Ramon D, Wood, Malcolm R, Bowtell, David, Dillin, Andrew, Mercola, Mark, Ronai, Ze'ev A

“… Defining the mechanisms underlying the control of mitochondrial fusion and fission is critical to understanding cellular adaptation to diverse physiological …”
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Harnessing the Co-vulnerabilities of Amino Acid-Restricted Cancers von Pathria, Gaurav, Ronai, Ze'ev A

“… Sustained proliferative potential of cancer cells creates heightened energetic and biosynthetic demands. The resulting overt dependence of cancer cells on …”
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An exploitable Achilles heel of MITF? von Silva, Carolina, Ronai, Ze’ev A.

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The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors von Khateb, Ali, Deshpande, Anagha, Feng, Yongmei, Finlay, Darren, Lee, Joo Sang, Lazar, Ikrame, Fabre, Bertrand, Li, Yan, Fujita, Yu, Zhang, Tongwu, Yin, Jun, Pass, Ian, Livneh, Ido, Jeremias, Irmela, Burian, Carol, Mason, James R., Almog, Ronit, Horesh, Nurit, Ofran, Yishai, Brown, Kevin, Vuori, Kristiina, Jackson, Michael, Ruppin, Eytan, Deshpande, Aniruddha J., Ronai, Ze’ev A.

“… Acute myeloid leukemia (AML) remains incurable, largely due to its resistance to conventional treatments. Here, we find that increased abundance of the …”
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Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons von Welsbie, Derek S, Mitchell, Katherine L, Jaskula-Ranga, Vinod, Sluch, Valentin M, Yang, Zhiyong, Kim, Jessica, Buehler, Eugen, Patel, Amit, Martin, Scott E, Zhang, Ping-Wu, Ge, Yan, Duan, Yukan, Fuller, John, Kim, Byung-Jin, Hamed, Eman, Chamling, Xitiz, Lei, Lei, Fraser, Iain D C, Ronai, Ze'ev A, Berlinicke, Cynthia A, Zack, Donald J

“… Dual leucine zipper kinase (DLK) has been implicated in cell death signaling secondary to axonal damage in retinal ganglion cells (RGCs) and other neurons. To …”
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Dysregulation of ubiquitin ligases in cancer von Qi, Jianfei, Ronai, Ze’ev A.

“… Ubiquitin ligases (UBLs) are critical components of the ubiquitin proteasome system (UPS), which governs fundamental processes regulating normal cellular …”
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Prebiotic-Induced Anti-tumor Immunity Attenuates Tumor Growth von Li, Yan, Elmén, Lisa, Segota, Igor, Xian, Yibo, Tinoco, Roberto, Feng, Yongmei, Fujita, Yu, Segura Muñoz, Rafael R., Schmaltz, Robert, Bradley, Linda M., Ramer-Tait, Amanda, Zarecki, Raphy, Long, Tao, Peterson, Scott N., Ronai, Ze’ev A.

“… Growing evidence supports the importance of gut microbiota in the control of tumor growth and response to therapy. Here, we select prebiotics that can enrich …”
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A systematic genome-wide mapping of oncogenic mutation selection during CRISPR-Cas9 genome editing von Sinha, Sanju, Barbosa, Karina, Cheng, Kuoyuan, Leiserson, Mark D. M., Jain, Prashant, Deshpande, Anagha, Wilson, David M., Ryan, Bríd M., Luo, Ji, Ronai, Ze’ev A., Lee, Joo Sang, Deshpande, Aniruddha J., Ruppin, Eytan

“… Recent studies have reported that genome editing by CRISPR–Cas9 induces a DNA damage response mediated by p53 in primary cells hampering their growth. This …”
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Monoubiquitination in proteasomal degradation von Ronai, Ze'ev A

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NRF2 mediates melanoma addiction to GCDH by modulating apoptotic signalling von Verma, Sachin, Crawford, David, Khateb, Ali, Feng, Yongmei, Sergienko, Eduard, Pathria, Gaurav, Ma, Chen-Ting, Olson, Steven H., Scott, David, Murad, Rabi, Ruppin, Eytan, Jackson, Michael, Ronai, Ze’ev A.

“… Tumour dependency on specific metabolic signals has been demonstrated and often guided numerous therapeutic approaches. We identify melanoma addiction to the …”
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