Suchergebnisse - "Rogers, Angela J"

Integrated analysis of multimodal single-cell data von Hao, Yuhan, Hao, Stephanie, Andersen-Nissen, Erica, Mauck, 3rd, William M, Zheng, Shiwei, Butler, Andrew, Lee, Maddie J, Wilk, Aaron J, Darby, Charlotte, Zager, Michael, Hoffman, Paul, Stoeckius, Marlon, Papalexi, Efthymia, Mimitou, Eleni P, Jain, Jaison, Srivastava, Avi, Stuart, Tim, Fleming, Lamar M, Yeung, Bertrand, Rogers, Angela J, McElrath, Juliana M, Blish, Catherine A, Gottardo, Raphael, Smibert, Peter, Satija, Rahul

“… The simultaneous measurement of multiple modalities represents an exciting frontier for single-cell genomics and necessitates computational methods that can …”
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A generalizable 29-mRNA neural-network classifier for acute bacterial and viral infections von Mayhew, Michael B., Buturovic, Ljubomir, Luethy, Roland, Midic, Uros, Moore, Andrew R., Roque, Jonasel A., Shaller, Brian D., Asuni, Tola, Rawling, David, Remmel, Melissa, Choi, Kirindi, Wacker, James, Khatri, Purvesh, Rogers, Angela J., Sweeney, Timothy E.

“… Improved identification of bacterial and viral infections would reduce morbidity from sepsis, reduce antibiotic overuse, and lower healthcare costs. Here, we …”
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Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial von Wilson, Jennifer G, Liu, Kathleen D, Zhuo, Hanjing, Caballero, Lizette, McMillan, Melanie, Fang, Xiaohui, Cosgrove, Katherine, Vojnik, Rosemary, Calfee, Carolyn S, Lee, Jae-Woo, Rogers, Angela J, Levitt, Joseph, Wiener-Kronish, Jeanine, Bajwa, Ednan K, Leavitt, Andrew, McKenna, David, Thompson, B Taylor, Matthay, Michael A

“… No effective pharmacotherapy for acute respiratory distress syndrome (ARDS) exists, and mortality remains high. Preclinical studies support the efficacy of …”
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Cytokine profile in plasma of severe COVID-19 does not differ from ARDS and sepsis von Wilson, Jennifer G., Simpson, Laura J., Ferreira, Anne-Maud, Rustagi, Arjun, Roque, Jonasel, Asuni, Adijat, Ranganath, Thanmayi, Grant, Philip M., Subramanian, Aruna, Rosenberg-Hasson, Yael, Maecker, Holden T., Holmes, Susan P., Levitt, Joseph E., Blish, Catherine A., Rogers, Angela J.

“… BACKGROUNDElevated levels of inflammatory cytokines have been associated with poor outcomes among COVID-19 patients. It is unknown, however, how these levels …”
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Metabolism, Metabolomics, and Nutritional Support of Patients with Sepsis von Englert, Joshua A, Rogers, Angela J

“… Sepsis is characterized by profound changes in systemic and cellular metabolism that disrupt normal metabolic homeostasis. These metabolic changes can serve as …”
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Effect of total cholesterol and statin therapy on mortality in ARDS patients: a secondary analysis of the SAILS and HARP-2 trials von Pienkos, Shaun M., Moore, Andrew R., Guan, Jiazhen, Levitt, Joseph E., Matthay, Michael A., Baron, Rebecca M., Conlon, John, McAuley, Daniel F., O’Kane, Cecilia M., Rogers, Angela J.

“… Background Two acute respiratory distress syndrome (ARDS) trials showed no benefit for statin therapy, though secondary analyses suggest inflammatory …”
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Network study of nasal transcriptome profiles reveals master regulator genes of asthma von Do, Anh N., Chun, Yoojin, Grishina, Galina, Grishin, Alexander, Rogers, Angela J., Raby, Benjamin A., Weiss, Scott T., Vicencio, Alfin, Schadt, Eric E., Bunyavanich, Supinda

“… Nasal transcriptomics can provide an accessible window into asthma pathobiology. Our goal was to move beyond gene signatures of asthma to identify master …”
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Baseline plasma IL-18 may predict simvastatin treatment response in patients with ARDS: a secondary analysis of the HARP-2 randomised clinical trial von Boyle, Andrew James, Ferris, Peter, Bradbury, Ian, Conlon, John, Shankar-Hari, Manu, Rogers, Angela J., O’Kane, Cecilia M., McAuley, Daniel F.

“… Background Interleukin (IL)-18 is a marker of inflammasome activation, and high baseline plasma IL-18 is associated with increased mortality in patients with …”
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Circulating N-formylmethionine and metabolic shift in critical illness: a multicohort metabolomics study von Sigurdsson, Martin Ingi, Kobayashi, Hirotada, Amrein, Karin, Nakahira, Kiichi, Rogers, Angela J., Pinilla-Vera, Mayra, Baron, Rebecca M., Fredenburgh, Laura E., Lasky-Su, Jessica A., Christopher, Kenneth B.

“… Background Cell stress promotes degradation of mitochondria which release danger-associated molecular patterns that are catabolized to N -formylmethionine. We …”
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A Nasal Brush-based Classifier of Asthma Identified by Machine Learning Analysis of Nasal RNA Sequence Data von Pandey, Gaurav, Pandey, Om P., Rogers, Angela J., Ahsen, Mehmet E., Hoffman, Gabriel E., Raby, Benjamin A., Weiss, Scott T., Schadt, Eric E., Bunyavanich, Supinda

“… Asthma is a common, under-diagnosed disease affecting all ages. We sought to identify a nasal brush-based classifier of mild/moderate asthma. 190 subjects with …”
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Prolonged Hospitalization Following Acute Respiratory Failure von Marmor, Meghan, Liu, Sai, Long, Jin, Chertow, Glenn M, Rogers, Angela J

“… A better understanding of the clinical features associated with prolonged hospitalization in acute respiratory failure may allow for better-informed care …”
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Profiling of ARDS pulmonary edema fluid identifies a metabolically distinct subset von Rogers, Angela J, Contrepois, Kévin, Wu, Manhong, Zheng, Ming, Peltz, Gary, Ware, Lorraine B, Matthay, Michael A

“… There is considerable biological and physiological heterogeneity among patients who meet standard clinical criteria for acute respiratory distress syndrome …”
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Plasma mitochondrial DNA and metabolomic alterations in severe critical illness von Johansson, Pär I., Nakahira, Kiichi, Rogers, Angela J., McGeachie, Michael J., Baron, Rebecca M., Fredenburgh, Laura E., Harrington, John, Choi, Augustine M. K., Christopher, Kenneth B.

“… Background Cell-free plasma mitochondrial DNA (mtDNA) levels are associated with endothelial dysfunction and differential outcomes in critical illness. A …”
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Metabolomic Derangements Are Associated with Mortality in Critically Ill Adult Patients von Rogers, Angela J., McGeachie, Michael, Baron, Rebecca M., Gazourian, Lee, Haspel, Jeffrey A., Nakahira, Kiichi, Fredenburgh, Laura E., Hunninghake, Gary M., Raby, Benjamin A., Matthay, Michael A., Otero, Ronny M., Fowler, Vance G., Rivers, Emanuel P., Woods, Christopher W., Kingsmore, Stephen, Langley, Ray J., Choi, Augustine M. K.

“… To identify metabolomic biomarkers predictive of Intensive Care Unit (ICU) mortality in adults. Comprehensive metabolomic profiling of plasma at ICU admission …”
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Metabolome alterations in severe critical illness and vitamin D status von Lasky-Su, Jessica, Dahlin, Amber, Litonjua, Augusto A., Rogers, Angela J., McGeachie, Michael J., Baron, Rebecca M., Gazourian, Lee, Barragan-Bradford, Diana, Fredenburgh, Laura E., Choi, Augustine M. K., Mogensen, Kris M., Quraishi, Sadeq A., Amrein, Karin, Christopher, Kenneth B.

“… Background Metabolic homeostasis is substantially disrupted in critical illness. Given the pleiotropic effects of vitamin D, we hypothesized that metabolic …”
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Synthetic Siglec‑9 Agonists Inhibit Neutrophil Activation Associated with COVID-19 von Delaveris, Corleone S, Wilk, Aaron J, Riley, Nicholas M, Stark, Jessica C, Yang, Samuel S, Rogers, Angela J, Ranganath, Thanmayi, Nadeau, Kari C, Blish, Catherine A, Bertozzi, Carolyn R

“… Severe cases of coronavirus disease 2019 (COVID-19), caused by infection with SARS-CoV-2, are characterized by a hyperinflammatory immune response that leads …”
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Genetic association analysis of copy-number variation (CNV) in human disease pathogenesis von Ionita-Laza, Iuliana, Rogers, Angela J., Lange, Christoph, Raby, Benjamin A., Lee, Charles

“… Structural genetic variation, including copy-number variation (CNV), constitutes a substantial fraction of total genetic variability and the importance of …”
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Prospective validation of an 11-gene mRNA host response score for mortality risk stratification in the intensive care unit von Moore, Andrew R., Roque, Jonasel, Shaller, Brian T., Asuni, Tola, Remmel, Melissa, Rawling, David, Liesenfeld, Oliver, Khatri, Purvesh, Wilson, Jennifer G., Levitt, Joseph E., Sweeney, Timothy E., Rogers, Angela J.

“… Several clinical calculators predict intensive care unit (ICU) mortality, however these are cumbersome and often require 24 h of data to calculate …”
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16 Years and Counting? Time to Implement Noninvasive Screening for ARDS von Rogers, Angela J, Liu, Vincent X

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Association between emergency department disposition and mortality in patients with COVID‐19 acute respiratory distress syndrome von Lebold, Katie M., Moore, Andrew R., Sanchez, Pablo A., Pacheco‐Navarro, Ana E., O'Donnell, Christian, Roque, Jonasel, Parmer, Caitlin, Pienkos, Shaun, Levitt, Joseph, Collins, William J., Rogers, Angela J., Wilson, Jennifer G.

“… Patients hospitalized for COVID‐19 frequently develop hypoxemia and acute respiratory distress syndrome (ARDS) after admission. In non‐COVID‐19 ARDS studies, …”
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