Výsledky vyhľadávania - "Roelofs, J J T H"

Female sex protects against renal edema, but not lung edema, in mice with partial deletion of the endothelial barrier regulator Tie2 compared to male sex Autor van Leeuwen, Anoek L. I., Beijer, Elise, Ibelings, Roselique, Dekker, Nicole A. M., van der Steen, Marjolein R. A., Roelofs, Joris J. T. H., van Meurs, Matijs, Molema, Grietje, van den Brom, Charissa E.

“…Background The endothelial angiopoietin/Tie2 system is an important regulator of endothelial permeability and targeting Tie2 reduces hemorrhagic shock-induced…”
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Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection Autor Qin, Wanhai, Brands, Xanthe, van’t Veer, Cornelis, F. de Vos, Alex, Sirard, Jean-Claude, J. T. H. Roelofs, Joris, P. Scicluna, Brendon, van der Poll, Tom

“…DNA methyltransferase (Dnmt)3b mediates de novo DNA methylation and modulation of Dnmt3b in respiratory epithelial cells has been shown to affect the…”
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The role of platelets in acute kidney injury Autor Jansen, Marcel P B, Florquin, Sandrine, Roelofs, Joris J T H

“…Acute kidney injury (AKI), a major public health problem associated with high mortality and increased risk of progression towards end-stage renal disease, is…”
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Optical coherence tomography for identification and quantification of human airway wall layers Autor d’Hooghe, Julia N. S., Goorsenberg, Annika W. M., de Bruin, Daniel M., Roelofs, Joris J. T. H., Annema, Jouke T., Bonta, Peter I.

“…High-resolution computed tomography has limitations in the assessment of airway wall layers and related remodeling in obstructive lung diseases. Near…”
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The gut microbiota as a modulator of innate immunity during melioidosis Autor Lankelma, Jacqueline M., Birnie, Emma, Weehuizen, Tassili A. F., Scicluna, Brendon P., Belzer, Clara, Houtkooper, Riekelt H., Roelofs, Joris J. T. H., de Vos, Alex F., van der Poll, Tom, Budding, Andries E., Wiersinga, W. Joost

“…Melioidosis, caused by the Gram-negative bacterium Burkholderia pseudomallei, is an emerging cause of pneumonia-derived sepsis in the tropics. The gut…”
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Hypoxia-Inducible Factor-1α in Macrophages, but Not in Neutrophils, Is Important for Host Defense during Klebsiella pneumoniae-Induced Pneumosepsis Autor Otto, Natasja A., Pereverzeva, Liza, Leopold, Valentine, Ramirez-Moral, Ivan, Roelofs, Joris J. T. H., van Heijst, Jeroen W. J., de Vos, Alex F., van der Poll, Tom

“…Hypoxia-inducible factor- (HIF-) 1α has been implicated in the ability of cells to adapt to alterations in oxygen levels. Bacterial stimuli can induce HIF1α in…”
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Combining streptozotocin and unilateral nephrectomy is an effective method for inducing experimental diabetic nephropathy in the ‘resistant’ C57Bl/6J mouse strain Autor Uil, Melissa, Scantlebery, Angelique M. L., Butter, Loes M., Larsen, Per W. B., de Boer, Onno J., Leemans, Jaklien C., Florquin, Sandrine, Roelofs, Joris J. T. H.

“…Diabetic nephropathy (DN) is the leading cause of chronic kidney disease. Animal models are essential tools for designing new strategies to prevent DN. C57Bl/6…”
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Transfusion of female blood in a rat model is associated with red blood cells entrapment in organs Autor Alshalani, Abdulrahman, de Wissel, Marit B., Tuip-de Boer, Anita M., Roelofs, Joris J. T. H., van Bruggen, Robin, Acker, Jason P., Juffermans, Nicole P.

“…Transfusion of red blood cells (RBCs) has been associated with adverse outcomes. Mechanisms may be related to donor sex and biological age of RBC. This study…”
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Effect of antibody-mediated connective tissue growth factor neutralization on lung edema in ventilator-induced lung injury in rats Autor van den Brom, Charissa E., Bozic, Caitlin, Polet, Chantal A., Bongers, Annabel, Tuip-de Boer, Anita M., Ibelings, Roselique, Roelofs, Joris J. T. H., Juffermans, Nicole P.

“…Background Acute respiratory distress syndrome (ARDS) is characterized by alveolar edema that can progress to septal fibrosis. Mechanical ventilation can…”
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Obesity aggravates acute kidney injury resulting from ischemia and reperfusion in mice Autor da Silva, Igor Oliveira, de Menezes, Nicole K., Jacobina, Heloisa D., Parra, Antonio Carlos, Souza, Felipe Lima, Castro, Leticia Cardoso, Roelofs, Joris J. T. H., Tammaro, Alessandra, Gomes, Samirah Abreu, Sanches, Talita Rojas, Andrade, Lucia

“…In critically ill patients, overweight and obesity are associated with acute respiratory distress syndrome and acute kidney injury (AKI). However, the effect…”
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Vendor effects on murine gut microbiota and its influence on lipopolysaccharide-induced lung inflammation and Gram-negative pneumonia Autor Wolff, Nora S., Jacobs, Max C., Haak, Bastiaan W., Roelofs, Joris J. T. H., de Vos, Alex F., Hugenholtz, Floor, Wiersinga, W. Joost

“…Background The microbiome has emerged as an important player in the pathophysiology of a whole spectrum of diseases that affect the critically ill. We…”
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Author Correction: Obesity aggravates acute kidney injury resulting from ischemia and reperfusion in mice Autor da Silva, Igor Oliveira, de Menezes, Nicole K., Jacobina, Heloisa D., Parra, Antonio Carlos, Souza, Felipe Lima, Castro, Leticia Cardoso, Roelofs, Joris J. T. H., Tammaro, Alessandra, Gomes, Samirah Abreu, Sanches, Talita Rojas, Andrade, Lucia

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Myeloid liver kinase B1 contributes to lung inflammation induced by lipoteichoic acid but not by viable Streptococcus pneumoniae Autor Pereverzeva, Liza, Otto, Natasja A., Roelofs, Joris J. T. H., de Vos, Alex F., van der Poll, Tom

“…Background Liver kinase B1 (Lkb1, gene name Stk11 ) functions as a tumor suppressor in cancer. Myeloid cell Lkb1 potentiates lung inflammation induced by the…”
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Therapeutic application of recombinant human ADAMTS-13 improves shock reversal and coagulation status in a trauma hemorrhage and transfusion rat model Autor Wirtz, Mathijs R., van den Brink, Daan P., Roelofs, Joris J. T. H., Goslings, J. Carel, Juffermans, Nicole P.

“…Introduction In hemorrhaging trauma patients, the endothelium is activated, resulting in excessive endothelial synthesis of von Willebrand Factor (vWF), which…”
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Role of Myeloid Cell Glucose Transporter 1 in the Host Response During Pneumonia Caused by Streptococcus pneumoniae Autor Pereverzeva, Liza, Léopold, Valentine, Saris, Anno, Schuurman, Alex R., Butler, Joe M., Reijnders, Tom D. Y., Roelofs, Joris J. T. H., Faber, Daniël R., Wiersinga, W. Joost, van’t Veer, Cornelis, de Vos, Alex F., van der Poll, Tom

“…During infection, myeloid cells are subjected to a fast increase in energy demand. Glucose transporter 1 (GLUT1) is a key mediator of glucose metabolism,…”
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Ventilator-induced lung injury is mediated by the NLRP3 inflammasome Autor Kuipers, Maria T, Aslami, Hamid, Janczy, John R, van der Sluijs, Koenraad F, Vlaar, Alexander P J, Wolthuis, Esther K, Choi, Goda, Roelofs, Joris J T H, Flavell, Richard A, Sutterwala, Fayyaz S, Bresser, Paul, Leemans, Jaklien C, van der Poll, Tom, Schultz, Marcus J, Wieland, Catharina W

“…The innate immune response is important in ventilator-induced lung injury (VILI) but the exact pathways involved are not elucidated. The authors studied the…”
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The effect of targeting Tie2 on hemorrhagic shock-induced renal perfusion disturbances in rats Autor van Leeuwen, Anoek L. I., Dekker, Nicole A. M., Van Slyke, Paul, de Groot, Esther, Vervloet, Marc G., Roelofs, Joris J. T. H., van Meurs, Matijs, van den Brom, Charissa E.

“…Background Hemorrhagic shock is associated with acute kidney injury and increased mortality. Targeting the endothelial angiopoietin/Tie2 system, which…”
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The role of Mannose Binding Lectin in the immune response against Borrelia burgdorferi sensu lato Autor Coumou, Jeroen, Wagemakers, Alex, Narasimhan, Sukanya, Schuijt, Tim J., Ersoz, Jasmin I., Oei, Anneke, de Boer, Onno J., Roelofs, Joris J. T. H., Fikrig, Erol, Hovius, Joppe W.

“…The causative agents of Lyme borreliosis, spirochetes belonging to the Borrelia burgdorferi sensu lato group, have developed several ways to protect themselves…”
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Recombinant activated protein C attenuates coagulopathy and inflammation when administered early in murine pneumococcal pneumonia Autor Schouten, Marcel, van 't Veer, Cornelis, Roelofs, Joris J T H, Gerlitz, Bruce, Grinnell, Brian W, Levi, Marcel, van der Poll, Tom

“…Recombinant human activated protein C (APC), which has both anticoagulant and anti-inflammatory properties, improves survival of patients with severe sepsis…”
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Prophylactic furosemide to prevent transfusion-associated circulatory overload: a randomized controlled study in rats Autor Klanderman, Robert B., Bosboom, Joachim J., Veelo, Denise P., Roelofs, Joris J. T. H., de Korte, Dirk, van Bruggen, Robin, Vogt, Liffert, van Buul, Jaap D., Hollmann, Markus W., Vroom, Margreeth B., Juffermans, Nicole P., Geerts, Bart F., Vlaar, Alexander P. J.

“…Transfusion-associated circulatory overload (TACO) is the leading cause of transfusion related morbidity and mortality. The only treatment is empirical use of…”
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