Výsledky vyhľadávania - "Roden, Michael"

Nonalcoholic fatty liver disease (NAFLD) from pathogenesis to treatment concepts in humans Autor Pafili, Kalliopi, Roden, Michael

“…Nonalcoholic fatty liver disease (NAFLD) comprises hepatic alterations with increased lipid accumulation (steatosis) without or with inflammation (nonalcoholic…”
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Mechanisms of Disease: hepatic steatosis in type 2 diabetes—pathogenesis and clinical relevance Autor Roden, Michael

“…Excess free fatty acids, an imbalance of adipocytokines and mitochondrial dysfunction all contribute to abnormalities in hepatocellular lipid content in…”
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Energy metabolism of white adipose tissue and insulin resistance in humans Autor Bódis, Kálmán, Roden, Michael

“…Background Insulin resistance not only occurs in obesity, but also in lipodystrophy. Although adipose tissue mass affects metabolic fluxes and participates in…”
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The complex link between NAFLD and type 2 diabetes mellitus — mechanisms and treatments Autor Targher, Giovanni, Corey, Kathleen E., Byrne, Christopher D., Roden, Michael

“…Nonalcoholic fatty liver disease (NAFLD) has reached epidemic proportions worldwide. NAFLD and type 2 diabetes mellitus (T2DM) are known to frequently coexist…”
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Alterations of Mitochondrial Function and Insulin Sensitivity in Human Obesity and Diabetes Mellitus Autor Koliaki, Chrysi, Roden, Michael

“…Mitochondrial function refers to a broad spectrum of features such as resting mitochondrial activity, (sub)maximal oxidative phosphorylation capacity (OXPHOS),…”
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EASL–EASD–EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD) Autor Tacke, Frank, Horn, Paul, Wai-Sun Wong, Vincent, Ratziu, Vlad, Bugianesi, Elisabetta, Francque, Sven, Zelber-Sagi, Shira, Valenti, Luca, Roden, Michael, Schick, Fritz, Yki-Järvinen, Hannele, Gastaldelli, Amalia, Vettor, Roberto, Frühbeck, Gema, Dicker, Dror

“…Metabolic dysfunction-associated steatotic liver disease (MASLD), previously termed non-alcoholic fatty liver disease (NAFLD), is defined as steatotic liver…”
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The role of mitochondria in insulin resistance and type 2 diabetes mellitus Autor Szendroedi, Julia, Phielix, Esther, Roden, Michael

“…This Review discusses the association between mitochondrial function and insulin sensitivity in various tissues, such as skeletal muscle, liver and heart, with…”
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Hepatic energy metabolism in human diabetes mellitus, obesity and non-alcoholic fatty liver disease Autor Koliaki, Chrysi, Roden, Michael

“…Alterations of hepatic mitochondrial function have been observed in states of insulin resistance and non-alcoholic fatty liver disease (NAFLD). Patients with…”
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Interorgan Metabolic Crosstalk in Human Insulin Resistance Autor Gancheva, Sofiya, Jelenik, Tomas, Álvarez-Hernández, Elisa, Roden, Michael

“…Excessive energy intake and reduced energy expenditure drive the development of insulin resistance and metabolic diseases such as obesity and type 2 diabetes…”
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NAFLD and thyroid function: pathophysiological and therapeutic considerations Autor Hatziagelaki, Erifili, Paschou, Stavroula A., Schön, Martin, Psaltopoulou, Theodora, Roden, Michael

“…Nonalcoholic fatty liver disease (NAFLD) is a worldwide rising challenge because of hepatic, but also extrahepatic, complications. Thyroid hormones are master…”
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Nonalcoholic steatohepatitis: the role of peroxisome proliferator-activated receptors Autor Francque, Sven, Szabo, Gyongyi, Abdelmalek, Manal F., Byrne, Christopher D., Cusi, Kenneth, Dufour, Jean-François, Roden, Michael, Sacks, Frank, Tacke, Frank

“…The increasing epidemic of obesity worldwide is linked to serious health effects, including increased prevalence of type 2 diabetes mellitus, cardiovascular…”
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Vascular effects of advanced glycation endproducts: Clinical effects and molecular mechanisms Autor Stirban, Alin, Gawlowski, Thomas, Roden, Michael

“…The enhanced generation and accumulation of advanced glycation endproducts (AGEs) have been linked to increased risk for macrovascular and microvascular…”
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Specific Hepatic Sphingolipids Relate to Insulin Resistance, Oxidative Stress, and Inflammation in Nonalcoholic Steatohepatitis Autor Apostolopoulou, Maria, Gordillo, Ruth, Koliaki, Chrysi, Gancheva, Sofia, Jelenik, Tomas, De Filippo, Elisabetta, Herder, Christian, Markgraf, Daniel, Jankowiak, Frank, Esposito, Irene, Schlensak, Matthias, Scherer, Philipp E, Roden, Michael

“…Insulin resistance and nonalcoholic fatty liver disease have been linked to several lipid metabolites in animals, but their role in humans remains unclear…”
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Empagliflozin Effectively Lowers Liver Fat Content in Well-Controlled Type 2 Diabetes: A Randomized, Double-Blind, Phase 4, Placebo-Controlled Trial Autor Kahl, Sabine, Gancheva, Sofiya, Straßburger, Klaus, Herder, Christian, Machann, Jürgen, Katsuyama, Hisayuki, Kabisch, Stefan, Henkel, Elena, Kopf, Stefan, Lagerpusch, Merit, Kantartzis, Konstantinos, Kupriyanova, Yuliya, Markgraf, Daniel, van Gemert, Theresa, Knebel, Birgit, Wolkersdorfer, Martin F, Kuss, Oliver, Hwang, Jong-Hee, Bornstein, Stefan R, Kasperk, Christian, Stefan, Norbert, Pfeiffer, Andreas, Birkenfeld, Andreas L, Roden, Michael

“…To evaluate whether the sodium-glucose cotransporter 2 inhibitor empagliflozin (EMPA) reduces liver fat content (LFC) in recent-onset and metabolically…”
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Mitochondrial plasticity in obesity and diabetes mellitus Autor Jelenik, Tomas, Roden, Michael

“…Insulin resistance and its related diseases, obesity and type 2 diabetes mellitus (T2DM), have been linked to changes in aerobic metabolism, pointing to a…”
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Effects of Blood Flow Restriction Exercise and Possible Applications in Type 2 Diabetes Autor Saatmann, Nina, Zaharia, Oana-Patricia, Loenneke, Jeremy P., Roden, Michael, Pesta, Dominik H.

“…Blood flow restriction resistance training (BFRT) employs partial vascular occlusion of exercising muscles via inflation cuffs. Compared with high-load…”
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Early detection of nerve fiber loss by corneal confocal microscopy and skin biopsy in recently diagnosed type 2 diabetes Autor Ziegler, Dan, Papanas, Nikolaos, Zhivov, Andrey, Allgeier, Stephan, Winter, Karsten, Ziegler, Iris, Brüggemann, Jutta, Strom, Alexander, Peschel, Sabine, Köhler, Bernd, Stachs, Oliver, Guthoff, Rudolf F, Roden, Michael

“…We sought to determine whether early nerve damage may be detected by corneal confocal microscopy (CCM), skin biopsy, and neurophysiological tests in 86…”
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Lipid-mediated muscle insulin resistance: different fat, different pathways? Autor Ritter, Olesja, Jelenik, Tomas, Roden, Michael

“…Increased dietary fat intake and lipolysis result in excessive lipid availability, which relates to impaired insulin sensitivity. Over the last years, several…”
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Mechanosensing by β1 integrin induces angiocrine signals for liver growth and survival Autor Lorenz, Linda, Axnick, Jennifer, Buschmann, Tobias, Henning, Carina, Urner, Sofia, Fang, Shentong, Nurmi, Harri, Eichhorst, Nicole, Holtmeier, Richard, Bódis, Kálmán, Hwang, Jong-Hee, Müssig, Karsten, Eberhard, Daniel, Stypmann, Jörg, Kuss, Oliver, Roden, Michael, Alitalo, Kari, Häussinger, Dieter, Lammert, Eckhard

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Short-term dietary reduction of branched-chain amino acids reduces meal-induced insulin secretion and modifies microbiome composition in type 2 diabetes: a randomized controlled crossover trial Autor Karusheva, Yanislava, Koessler, Theresa, Strassburger, Klaus, Markgraf, Daniel, Mastrototaro, Lucia, Jelenik, Tomas, Simon, Marie-Christine, Pesta, Dominik, Zaharia, Oana-Patricia, Bódis, Kálmán, Bärenz, Felix, Schmoll, Dieter, Wolkersdorfer, Martin, Tura, Andrea, Pacini, Giovanni, Burkart, Volker, Müssig, Karsten, Szendroedi, Julia, Roden, Michael

“…ABSTRACT Background Epidemiological studies have shown that increased circulating branched-chain amino acids (BCAAs) are associated with insulin resistance and…”
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