Suchergebnisse - "Ripatti, Samuli"

Genome-wide association analysis of plasma lipidome identifies 495 genetic associations von Ottensmann, Linda, Tabassum, Rubina, Ruotsalainen, Sanni E., Gerl, Mathias J., Klose, Christian, Widén, Elisabeth, Simons, Kai, Ripatti, Samuli, Pirinen, Matti

“… The human plasma lipidome captures risk for cardiometabolic diseases. To discover new lipid-associated variants and understand the link between lipid species …”
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FINEMAP: efficient variable selection using summary data from genome-wide association studies von Benner, Christian, Spencer, Chris C.A., Havulinna, Aki S., Salomaa, Veikko, Ripatti, Samuli, Pirinen, Matti

“… Motivation: The goal of fine-mapping in genomic regions associated with complex diseases and traits is to identify causal variants that point to molecular …”
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Systematic comparison of family history and polygenic risk across 24 common diseases von Mars, Nina, Lindbohm, Joni V, Della Briotta Parolo, Pietro, Widén, Elisabeth, Kaprio, Jaakko, Palotie, Aarno, Ripatti, Samuli

“… Family history is the standard indirect measure of inherited susceptibility in clinical care, whereas polygenic risk scores (PRSs) have more recently …”
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Prospects of Fine-Mapping Trait-Associated Genomic Regions by Using Summary Statistics from Genome-wide Association Studies von Benner, Christian, Havulinna, Aki S, Järvelin, Marjo-Riitta, Salomaa, Veikko, Ripatti, Samuli, Pirinen, Matti

“… During the past few years, various novel statistical methods have been developed for fine-mapping with the use of summary statistics from genome-wide …”
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Genetics of 35 blood and urine biomarkers in the UK Biobank von Sinnott-Armstrong, Nasa, Tanigawa, Yosuke, Amar, David, Mars, Nina, Benner, Christian, Aguirre, Matthew, Venkataraman, Guhan Ram, Wainberg, Michael, Ollila, Hanna M., Kiiskinen, Tuomo, Havulinna, Aki S., Pirruccello, James P., Qian, Junyang, Shcherbina, Anna, Rodriguez, Fatima, Assimes, Themistocles L., Agarwala, Vineeta, Tibshirani, Robert, Hastie, Trevor, Ripatti, Samuli, Pritchard, Jonathan K., Daly, Mark J., Rivas, Manuel A.

“… Clinical laboratory tests are a critical component of the continuum of care. We evaluate the genetic basis of 35 blood and urine laboratory measurements in the …”
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Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps von Adeyemo, Adebowale, Balaconis, Mary K., Darnes, Deanna R., Fatumo, Segun, Granados Moreno, Palmira, Hodonsky, Chani J., Inouye, Michael, Kanai, Masahiro, Kato, Kazuto, Knoppers, Bartha M., Lewis, Anna C. F., Martin, Alicia R., McCarthy, Mark I., Meyer, Michelle N., Okada, Yukinori, Richards, J. Brent, Richter, Lucas, Ripatti, Samuli, Rotimi, Charles N., Sanderson, Saskia C., Sturm, Amy C., Verdugo, Ricardo A., Widen, Elisabeth, Willer, Cristen J., Wojcik, Genevieve L., Zhou, Alicia

“… Polygenic risk scores (PRSs) aggregate the many small effects of alleles across the human genome to estimate the risk of a disease or disease-related trait for …”
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Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors von Ahola-Olli, Ari V, Würtz, Peter, Havulinna, Aki S, Aalto, Kristiina, Pitkänen, Niina, Lehtimäki, Terho, Kähönen, Mika, Lyytikäinen, Leo-Pekka, Raitoharju, Emma, Seppälä, Ilkka, Sarin, Antti-Pekka, Ripatti, Samuli, Palotie, Aarne, Perola, Markus, Viikari, Jorma S, Jalkanen, Sirpa, Maksimow, Mikael, Salomaa, Veikko, Salmi, Marko, Kettunen, Johannes, Raitakari, Olli T

“… Circulating cytokines and growth factors are regulators of inflammation and have been implicated in autoimmune and metabolic diseases. In this genome-wide …”
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Genome-wide association meta-analysis of nicotine metabolism and cigarette consumption measures in smokers of European descent von Buchwald, Jadwiga, Chenoweth, Meghan J, Palviainen, Teemu, Zhu, Gu, Benner, Christian, Gordon, Scott, Korhonen, Tellervo, Ripatti, Samuli, Madden, Pamela A F, Lehtimäki, Terho, Raitakari, Olli T, Salomaa, Veikko, Rose, Richard J, George, Tony P, Lerman, Caryn, Pirinen, Matti, Martin, Nicholas G, Kaprio, Jaakko, Loukola, Anu, Tyndale, Rachel F

“… Smoking behaviors, including amount smoked, smoking cessation, and tobacco-related diseases, are altered by the rate of nicotine clearance. Nicotine clearance …”
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Regularized Machine Learning in the Genetic Prediction of Complex Traits von Okser, Sebastian, Pahikkala, Tapio, Airola, Antti, Salakoski, Tapio, Ripatti, Samuli, Aittokallio, Tero

“…   [...]we discuss some key future advances, open questions and challenges in this developing field, when moving toward low-frequency variants and …”
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Genetic risk prediction and a 2-stage risk screening strategy for coronary heart disease von Tikkanen, Emmi, Havulinna, Aki S, Palotie, Aarno, Salomaa, Veikko, Ripatti, Samuli

“… Genome-wide association studies have identified several genetic variants associated with coronary heart disease (CHD). The aim of this study was to evaluate …”
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Genomic prediction of coronary heart disease von Abraham, Gad, Havulinna, Aki S, Bhalala, Oneil G, Byars, Sean G, De Livera, Alysha M, Yetukuri, Laxman, Tikkanen, Emmi, Perola, Markus, Schunkert, Heribert, Sijbrands, Eric J, Palotie, Aarno, Samani, Nilesh J, Salomaa, Veikko, Ripatti, Samuli, Inouye, Michael

“… Genetics plays an important role in coronary heart disease (CHD) but the clinical utility of genomic risk scores (GRSs) relative to clinical risk scores, such …”
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Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel von Mitt, Mario, Kals, Mart, Pärn, Kalle, Gabriel, Stacey B, Lander, Eric S, Palotie, Aarno, Ripatti, Samuli, Morris, Andrew P, Metspalu, Andres, Esko, Tõnu, Mägi, Reedik, Palta, Priit

“… Genetic imputation is a cost-efficient way to improve the power and resolution of genome-wide association (GWA) studies. Current publicly accessible imputation …”
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Geographic Variation and Bias in the Polygenic Scores of Complex Diseases and Traits in Finland von Kerminen, Sini, Martin, Alicia R, Koskela, Jukka, Ruotsalainen, Sanni E, Havulinna, Aki S, Surakka, Ida, Palotie, Aarno, Perola, Markus, Salomaa, Veikko, Daly, Mark J, Ripatti, Samuli, Pirinen, Matti

“… Polygenic scores (PSs) are becoming a useful tool to identify individuals with high genetic risk for complex diseases, and several projects are currently …”
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Biomarker Profiling by Nuclear Magnetic Resonance Spectroscopy for the Prediction of All-Cause Mortality: An Observational Study of 17,345 Persons von Fischer, Krista, Kettunen, Johannes, Würtz, Peter, Haller, Toomas, Havulinna, Aki S., Kangas, Antti J., Soininen, Pasi, Esko, Tõnu, Tammesoo, Mari-Liis, Mägi, Reedik, Smit, Steven, Palotie, Aarno, Ripatti, Samuli, Salomaa, Veikko, Ala-Korpela, Mika, Perola, Markus, Metspalu, Andres

“… Early identification of ambulatory persons at high short-term risk of death could benefit targeted prevention. To identify biomarkers for all-cause mortality …”
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Clinical Prediction Model and Tool for Assessing Risk of Persistent Pain After Breast Cancer Surgery von Meretoja, Tuomo J, Andersen, Kenneth Geving, Bruce, Julie, Haasio, Lassi, Sipilä, Reetta, Scott, Neil W, Ripatti, Samuli, Kehlet, Henrik, Kalso, Eija

“… Purpose Persistent pain after breast cancer surgery is a well-recognized problem, with moderate to severe pain affecting 15% to 20% of women at 1 year from …”
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Clinical utility and implementation of polygenic risk scores for predicting cardiovascular disease von Schunkert, Heribert, Di Angelantonio, Emanuele, Inouye, Michael, Patel, Riyaz S, Ripatti, Samuli, Widen, Elisabeth, Sanderson, Saskia C, Kaski, Juan Pablo, McEvoy, John W, Vardas, Panos, Wood, Angela, Aboyans, Victor, Vassiliou, Vassilios S, Visseren, Frank L J, Lopes, Luis R, Elliott, Perry, Kavousi, Maryam

“… Genome-wide association studies have revealed hundreds of genetic variants associated with cardiovascular diseases (CVD). Polygenic risk scores (PRS) can …”
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ANGPTL8 protein-truncating variant associated with lower serum triglycerides and risk of coronary disease von Helkkula, Pyry, Kiiskinen, Tuomo, Havulinna, Aki S., Karjalainen, Juha, Koskinen, Seppo, Salomaa, Veikko, Daly, Mark J., Palotie, Aarno, Surakka, Ida, Ripatti, Samuli

“… Protein-truncating variants (PTVs) affecting dyslipidemia risk may point to therapeutic targets for cardiometabolic disease. Our objective was to identify PTVs …”
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Childhood Adversities Are Associated with Shorter Telomere Length at Adult Age both in Individuals with an Anxiety Disorder and Controls von Kananen, Laura, Surakka, Ida, Pirkola, Sami, Suvisaari, Jaana, Lönnqvist, Jouko, Peltonen, Leena, Ripatti, Samuli, Hovatta, Iiris

“… Accelerated leukocyte telomere shortening has been previously associated to self-perceived stress and psychiatric disorders, including schizophrenia and mood …”
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metaCCA: summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis von Cichonska, Anna, Rousu, Juho, Marttinen, Pekka, Kangas, Antti J., Soininen, Pasi, Lehtimäki, Terho, Raitakari, Olli T., Järvelin, Marjo-Riitta, Salomaa, Veikko, Ala-Korpela, Mika, Ripatti, Samuli, Pirinen, Matti

“… Motivation: A dominant approach to genetic association studies is to perform univariate tests between genotype-phenotype pairs. However, analyzing related …”
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A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses von Ripatti, Samuli, Tikkanen, Emmi, Orho-Melander, Marju, Havulinna, Aki S, Silander, Kaisa, Sharma, Amitabh, Guiducci, Candace, Perola, Markus, Jula, Antti, Sinisalo, Juha, Lokki, Marja-Liisa, Nieminen, Markku S, Melander, Olle, Salomaa, Veikko, Peltonen, Leena, Kathiresan, Sekar

“… Comparison of patients with coronary heart disease and controls in genome-wide association studies has revealed several single nucleotide polymorphisms (SNPs) …”
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