Výsledky vyhľadávania - "Richardson, Tom G"

Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation Autor Richardson, Tom G., Leyden, Genevieve M., Wang, Qin, Bell, Joshua A., Elsworth, Benjamin, Davey Smith, George, Holmes, Michael V.

“…Large-scale molecular profiling and genotyping provide a unique opportunity to systematically compare the genetically predicted effects of therapeutic targets…”
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Estimation of causal effects of a time-varying exposure at multiple time points through multivariable mendelian randomization Autor Sanderson, Eleanor, Richardson, Tom G., Morris, Tim T., Tilling, Kate, Davey Smith, George

“…Mendelian Randomisation (MR) is a powerful tool in epidemiology that can be used to estimate the causal effect of an exposure on an outcome in the presence of…”
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Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis Autor Richardson, Tom G., Sanderson, Eleanor, Palmer, Tom M., Ala-Korpela, Mika, Ference, Brian A., Davey Smith, George, Holmes, Michael V.

“…Circulating lipoprotein lipids cause coronary heart disease (CHD). However, the precise way in which one or more lipoprotein lipid-related entities account for…”
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Combined Effect of PNPLA3, TM6SF2, and HSD17B13 Variants on Risk of Cirrhosis and Hepatocellular Carcinoma in the General Population Autor Gellert‐Kristensen, Helene, Richardson, Tom G., Davey Smith, George, Nordestgaard, Børge G., Tybjærg‐Hansen, Anne, Stender, Stefan

“…Background and Aims We hypothesized that a genetic risk score (GRS) for fatty liver disease influences the risk of cirrhosis and hepatocellular carcinoma…”
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Association between genetically proxied PCSK9 inhibition and prostate cancer risk: A Mendelian randomisation study Autor Fang, Si, Yarmolinsky, James, Gill, Dipender, Bull, Caroline J., Perks, Claire M., Davey Smith, George, Gaunt, Tom R., Richardson, Tom G.

“…Prostate cancer (PrCa) is the second most prevalent malignancy in men worldwide. Observational studies have linked the use of low-density lipoprotein…”
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An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome Autor Richardson, Tom G, Harrison, Sean, Hemani, Gibran, Davey Smith, George

“…The age of large-scale genome-wide association studies (GWAS) has provided us with an unprecedented opportunity to evaluate the genetic liability of complex…”
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A lifecourse mendelian randomization study highlights the long-term influence of childhood body size on later life heart structure Autor O’Nunain, Katie, Park, Chloe, Urquijo, Helena, Leyden, Genevieve M., Hughes, Alun D., Davey Smith, George, Richardson, Tom G.

“…Children with obesity typically have larger left ventricular heart dimensions during adulthood. However, whether this is due to a persistent effect of…”
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Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases Autor Zheng, Jie, Haberland, Valeriia, Baird, Denis, Walker, Venexia, Haycock, Philip C., Hurle, Mark R., Gutteridge, Alex, Erola, Pau, Liu, Yi, Luo, Shan, Robinson, Jamie, Richardson, Tom G., Staley, James R., Elsworth, Benjamin, Burgess, Stephen, Sun, Benjamin B., Danesh, John, Runz, Heiko, Maranville, Joseph C., Martin, Hannah M., Yarmolinsky, James, Laurin, Charles, Holmes, Michael V., Liu, Jimmy Z., Estrada, Karol, Santos, Rita, McCarthy, Linda, Waterworth, Dawn, Nelson, Matthew R., Smith, George Davey, Butterworth, Adam S., Hemani, Gibran, Scott, Robert A., Gaunt, Tom R.

“…The human proteome is a major source of therapeutic targets. Recent genetic association analyses of the plasma proteome enable systematic evaluation of the…”
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Genetic predictors of participation in optional components of UK Biobank Autor Tyrrell, Jessica, Zheng, Jie, Beaumont, Robin, Hinton, Kathryn, Richardson, Tom G., Wood, Andrew R., Davey Smith, George, Frayling, Timothy M., Tilling, Kate

“…Large studies such as UK Biobank are increasingly used for GWAS and Mendelian randomization (MR) studies. However, selection into and dropout from studies may…”
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A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome Autor Richardson, Tom G., Hemani, Gibran, Gaunt, Tom R., Relton, Caroline L., Davey Smith, George

“…Developing insight into tissue-specific transcriptional mechanisms can help improve our understanding of how genetic variants exert their effects on complex…”
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Associations of genetically predicted IL-6 signaling with cardiovascular disease risk across population subgroups Autor Georgakis, Marios K., Malik, Rainer, Richardson, Tom G., Howson, Joanna M. M., Anderson, Christopher D., Burgess, Stephen, Hovingh, G. Kees, Dichgans, Martin, Gill, Dipender

“…Background Interleukin 6 (IL-6) signaling is being investigated as a therapeutic target for atherosclerotic cardiovascular disease (CVD). While changes in…”
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Childhood body size directly increases type 1 diabetes risk based on a lifecourse Mendelian randomization approach Autor Richardson, Tom G., Crouch, Daniel J. M., Power, Grace M., Morales-Berstein, Fernanda, Hazelwood, Emma, Fang, Si, Cho, Yoonsu, Inshaw, Jamie R. J., Robertson, Catherine C., Sidore, Carlo, Cucca, Francesco, Rich, Steven S., Todd, John A., Davey Smith, George

“…The rising prevalence of childhood obesity has been postulated as an explanation for the increasing rate of individuals diagnosed with type 1 diabetes (T1D)…”
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Investigating the causal effects of childhood and adulthood adiposity on later life mental health outcome: a Mendelian randomization study Autor Pathak, Sweta, Richardson, Tom G., Sanderson, Eleanor, Åsvold, Bjørn Olav, Bhatta, Laxmi, Brumpton, Ben M.

“…Background Obesity particularly during childhood is considered a global public health crisis and has been linked with later life health consequences including…”
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Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study Autor Morales Berstein, Fernanda, McCartney, Daniel L, Lu, Ake T, Tsilidis, Konstantinos K, Bouras, Emmanouil, Haycock, Philip, Burrows, Kimberley, Phipps, Amanda I, Buchanan, Daniel D, Cheng, Iona, Martin, Richard M, Davey Smith, George, Relton, Caroline L, Horvath, Steve, Marioni, Riccardo E, Richardson, Tom G, Richmond, Rebecca C

“…Have you noticed that some people seem to get older faster than others? Scientists have previously found that a chemical tag on DNA known as DNA methylation…”
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Adiposity may confound the association between vitamin D and disease risk – a lifecourse Mendelian randomization study Autor Richardson, Tom G, Power, Grace M, Davey Smith, George

“…Vitamin D supplements are widely prescribed to help reduce disease risk. However, this strategy is based on findings using conventional epidemiological methods…”
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Mammographic density mediates the protective effect of early-life body size on breast cancer risk Autor Vabistsevits, Marina, Davey Smith, George, Richardson, Tom G., Richmond, Rebecca C., Sieh, Weiva, Rothstein, Joseph H., Habel, Laurel A., Alexeeff, Stacey E., Lloyd-Lewis, Bethan, Sanderson, Eleanor

“…The unexplained protective effect of childhood adiposity on breast cancer risk may be mediated via mammographic density (MD). Here, we investigate a complex…”
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Identifying drug targets for neurological and psychiatric disease via genetics and the brain transcriptome Autor Baird, Denis A., Liu, Jimmy Z., Zheng, Jie, Sieberts, Solveig K., Perumal, Thanneer, Elsworth, Benjamin, Richardson, Tom G., Chen, Chia-Yen, Carrasquillo, Minerva M., Allen, Mariet, Reddy, Joseph S., De Jager, Philip L., Ertekin-Taner, Nilufer, Mangravite, Lara M., Logsdon, Ben, Estrada, Karol, Haycock, Philip C., Hemani, Gibran, Runz, Heiko, Smith, George Davey, Gaunt, Tom R.

“…Discovering drugs that efficiently treat brain diseases has been challenging. Genetic variants that modulate the expression of potential drug targets can be…”
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Distinct pathway-based effects of blood pressure and body mass index on cardiovascular traits: comparison of novel Mendelian randomization approaches Autor Leyden, Genevieve M., Sobczyk, Maria K., Richardson, Tom G., Gaunt, Tom R.

“…Background Mendelian randomization (MR) leverages trait associated genetic variants as instrumental variables (IVs) to determine causal relationships in…”
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Time-varying and tissue-dependent effects of adiposity on leptin levels: A Mendelian randomization study Autor Richardson, Tom G, Leyden, Genevieve M, Davey Smith, George

“…Findings from Mendelian randomization (MR) studies are conventionally interpreted as lifelong effects, which typically do not provide insight into the…”
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Mendelian Randomization Analyses Suggest Childhood Body Size Indirectly Influences End Points From Across the Cardiovascular Disease Spectrum Through Adult Body Size Autor Power, Grace M., Tyrrell, Jessica, Frayling, Timothy M., Davey Smith, George, Richardson, Tom G.

“…Background Obesity is associated with long-term health consequences including cardiovascular disease. Separating the independent effects of childhood and…”
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